Details for: MAPK13
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 93.0919
Cell Significance Index: -14.4800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 57.8568
Cell Significance Index: -14.6800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 32.6610
Cell Significance Index: -15.4200 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 23.0246
Cell Significance Index: -15.4500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 11.7279
Cell Significance Index: -14.4600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.8603
Cell Significance Index: -13.0200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.3628
Cell Significance Index: -13.4000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.7176
Cell Significance Index: -14.6700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 2.9464
Cell Significance Index: 343.3700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 2.3089
Cell Significance Index: 251.1400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.1724
Cell Significance Index: 29.6400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.7835
Cell Significance Index: 92.6500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.4671
Cell Significance Index: 13.5100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.4361
Cell Significance Index: 66.9600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.2273
Cell Significance Index: 18.3900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.2273
Cell Significance Index: 32.8900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.1661
Cell Significance Index: 31.7400 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.0578
Cell Significance Index: 6.5100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.9799
Cell Significance Index: 44.4200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8657
Cell Significance Index: 156.0700 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.8634
Cell Significance Index: 12.2900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.8535
Cell Significance Index: 18.4900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6679
Cell Significance Index: 603.0800 - Cell Name: peg cell (CL4033014)
Fold Change: 0.5826
Cell Significance Index: 13.4600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.5469
Cell Significance Index: 40.7600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5225
Cell Significance Index: 51.6900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5136
Cell Significance Index: 24.1400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4596
Cell Significance Index: 92.1900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4569
Cell Significance Index: 90.6700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4427
Cell Significance Index: 195.7500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4416
Cell Significance Index: 12.3400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4359
Cell Significance Index: 53.6000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.4351
Cell Significance Index: 74.2900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.4121
Cell Significance Index: 13.2000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3719
Cell Significance Index: 70.7800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3713
Cell Significance Index: 60.3900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3056
Cell Significance Index: 21.6100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.2887
Cell Significance Index: 7.7100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2881
Cell Significance Index: 157.3600 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.2855
Cell Significance Index: 2.8800 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.2702
Cell Significance Index: 3.7900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2550
Cell Significance Index: 5.4300 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.2453
Cell Significance Index: 2.0000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.1865
Cell Significance Index: 21.3700 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1605
Cell Significance Index: 20.7400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1398
Cell Significance Index: 50.1500 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.1292
Cell Significance Index: 1.1100 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1114
Cell Significance Index: 14.2800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.1020
Cell Significance Index: 11.6400 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0920
Cell Significance Index: 2.4200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0757
Cell Significance Index: 2.6600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0658
Cell Significance Index: 45.5000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0499
Cell Significance Index: 37.8000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0410
Cell Significance Index: 4.8400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0019
Cell Significance Index: 1.3800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0009
Cell Significance Index: 1.6800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0050
Cell Significance Index: -9.1300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0065
Cell Significance Index: -4.0500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0071
Cell Significance Index: -10.9500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0086
Cell Significance Index: -11.7400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0093
Cell Significance Index: -6.8600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0128
Cell Significance Index: -7.2500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0176
Cell Significance Index: -11.1800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0197
Cell Significance Index: -4.1400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0261
Cell Significance Index: -2.6700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0293
Cell Significance Index: -13.2900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0443
Cell Significance Index: -12.7600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0444
Cell Significance Index: -6.4600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0612
Cell Significance Index: -8.4100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0614
Cell Significance Index: -1.7700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0655
Cell Significance Index: -4.1300 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0676
Cell Significance Index: -0.7000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0752
Cell Significance Index: -4.8500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0799
Cell Significance Index: -4.9100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0918
Cell Significance Index: -2.7000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0983
Cell Significance Index: -4.3500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1012
Cell Significance Index: -2.5300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1162
Cell Significance Index: -4.4000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1402
Cell Significance Index: -14.6000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1469
Cell Significance Index: -9.8800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1639
Cell Significance Index: -12.9800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1665
Cell Significance Index: -12.7800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1931
Cell Significance Index: -11.8400 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.2076
Cell Significance Index: -4.3300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2261
Cell Significance Index: -12.6900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2381
Cell Significance Index: -3.4100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2504
Cell Significance Index: -7.9700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2564
Cell Significance Index: -13.4600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2573
Cell Significance Index: -13.4000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2620
Cell Significance Index: -13.2400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2643
Cell Significance Index: -7.0700 - Cell Name: enterocyte (CL0000584)
Fold Change: -0.2660
Cell Significance Index: -1.6500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2736
Cell Significance Index: -5.9900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2859
Cell Significance Index: -10.5000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2926
Cell Significance Index: -10.2500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2969
Cell Significance Index: -9.7200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3001
Cell Significance Index: -8.8400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.3081
Cell Significance Index: -5.2800 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.3137
Cell Significance Index: -12.8500 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.3311
Cell Significance Index: -8.2700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3834061852
Symbol: MK13_HUMAN
Name: Mitogen-activated protein kinase 13
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9218798
Title: Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.
PubMed ID: 9218798
PubMed ID: 9374491
Title: Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta.
PubMed ID: 9374491
PubMed ID: 9295308
Title: Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase.
PubMed ID: 9295308
PubMed ID: 9207191
Title: Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles.
PubMed ID: 9207191
PubMed ID: 10066767
Title: Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines.
PubMed ID: 10066767
PubMed ID: 10727080
Title: Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4.
PubMed ID: 10727080
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9731215
Title: Identification of stathmin as a novel substrate for p38 delta.
PubMed ID: 9731215
PubMed ID: 10201954
Title: Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages.
PubMed ID: 10201954
PubMed ID: 11378392
Title: Fibroblast growth factor homologous factors are intracellular signaling proteins.
PubMed ID: 11378392
PubMed ID: 11500363
Title: A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.
PubMed ID: 11500363
PubMed ID: 11943212
Title: Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells.
PubMed ID: 11943212
PubMed ID: 15632108
Title: Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly.
PubMed ID: 15632108
DOI: 10.1242/jcs.01655
PubMed ID: 17256148
Title: Activation of PKCdelta and p38delta MAPK during okadaic acid dependent keratinocyte apoptosis.
PubMed ID: 17256148
PubMed ID: 18006338
Title: p38MAPK delta controls c-Myb degradation in response to stress.
PubMed ID: 18006338
PubMed ID: 18088087
PubMed ID: 18367666
Title: MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta.
PubMed ID: 18367666
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20478268
Title: Human p38 delta MAP kinase mediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL14.
PubMed ID: 20478268
PubMed ID: 20090411
Title: p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis.
PubMed ID: 20090411
DOI: 10.4161/cc.9.3.10541
PubMed ID: 20626350
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 365
- Mass: 42090
- Checksum: 52E749EDB2973DDF
- Sequence:
MSLIRKKGFY KQDVNKTAWE LPKTYVSPTH VGSGAYGSVC SAIDKRSGEK VAIKKLSRPF QSEIFAKRAY RELLLLKHMQ HENVIGLLDV FTPASSLRNF YDFYLVMPFM QTDLQKIMGM EFSEEKIQYL VYQMLKGLKY IHSAGVVHRD LKPGNLAVNE DCELKILDFG LARHADAEMT GYVVTRWYRA PEVILSWMHY NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLTQILKVTG VPGTEFVQKL NDKAAKSYIQ SLPQTPRKDF TQLFPRASPQ AADLLEKMLE LDVDKRLTAA QALTHPFFEP FRDPEEETEA QQPFDDSLEH EKLTVDEWKQ HIYKEIVNFS PIARKDSRRR SGMKL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.