Details for: MAPK13

Gene ID: 5603

Symbol: MAPK13

Ensembl ID: ENSG00000156711

Description: mitogen-activated protein kinase 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 93.0919
    Cell Significance Index: -14.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.8568
    Cell Significance Index: -14.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 32.6610
    Cell Significance Index: -15.4200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 23.0246
    Cell Significance Index: -15.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.7279
    Cell Significance Index: -14.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8603
    Cell Significance Index: -13.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3628
    Cell Significance Index: -13.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7176
    Cell Significance Index: -14.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.9464
    Cell Significance Index: 343.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.3089
    Cell Significance Index: 251.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1724
    Cell Significance Index: 29.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7835
    Cell Significance Index: 92.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4671
    Cell Significance Index: 13.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4361
    Cell Significance Index: 66.9600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.2273
    Cell Significance Index: 18.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2273
    Cell Significance Index: 32.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1661
    Cell Significance Index: 31.7400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.0578
    Cell Significance Index: 6.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9799
    Cell Significance Index: 44.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8657
    Cell Significance Index: 156.0700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.8634
    Cell Significance Index: 12.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8535
    Cell Significance Index: 18.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6679
    Cell Significance Index: 603.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5826
    Cell Significance Index: 13.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5469
    Cell Significance Index: 40.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5225
    Cell Significance Index: 51.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5136
    Cell Significance Index: 24.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4596
    Cell Significance Index: 92.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4569
    Cell Significance Index: 90.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4427
    Cell Significance Index: 195.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4416
    Cell Significance Index: 12.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4359
    Cell Significance Index: 53.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4351
    Cell Significance Index: 74.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4121
    Cell Significance Index: 13.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3719
    Cell Significance Index: 70.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3713
    Cell Significance Index: 60.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3056
    Cell Significance Index: 21.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2887
    Cell Significance Index: 7.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2881
    Cell Significance Index: 157.3600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.2855
    Cell Significance Index: 2.8800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.2702
    Cell Significance Index: 3.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2550
    Cell Significance Index: 5.4300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2453
    Cell Significance Index: 2.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1865
    Cell Significance Index: 21.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1605
    Cell Significance Index: 20.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1398
    Cell Significance Index: 50.1500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.1292
    Cell Significance Index: 1.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1114
    Cell Significance Index: 14.2800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1020
    Cell Significance Index: 11.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0920
    Cell Significance Index: 2.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0757
    Cell Significance Index: 2.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0658
    Cell Significance Index: 45.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0499
    Cell Significance Index: 37.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0410
    Cell Significance Index: 4.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0019
    Cell Significance Index: 1.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0065
    Cell Significance Index: -4.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0071
    Cell Significance Index: -10.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0086
    Cell Significance Index: -11.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0093
    Cell Significance Index: -6.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0128
    Cell Significance Index: -7.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0176
    Cell Significance Index: -11.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0197
    Cell Significance Index: -4.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0261
    Cell Significance Index: -2.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0293
    Cell Significance Index: -13.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0443
    Cell Significance Index: -12.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0444
    Cell Significance Index: -6.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0612
    Cell Significance Index: -8.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0614
    Cell Significance Index: -1.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0655
    Cell Significance Index: -4.1300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0676
    Cell Significance Index: -0.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0752
    Cell Significance Index: -4.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0799
    Cell Significance Index: -4.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0918
    Cell Significance Index: -2.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0983
    Cell Significance Index: -4.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1012
    Cell Significance Index: -2.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1162
    Cell Significance Index: -4.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1402
    Cell Significance Index: -14.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1469
    Cell Significance Index: -9.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1639
    Cell Significance Index: -12.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1665
    Cell Significance Index: -12.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1931
    Cell Significance Index: -11.8400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.2076
    Cell Significance Index: -4.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2261
    Cell Significance Index: -12.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2381
    Cell Significance Index: -3.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2504
    Cell Significance Index: -7.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2564
    Cell Significance Index: -13.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2573
    Cell Significance Index: -13.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2620
    Cell Significance Index: -13.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2643
    Cell Significance Index: -7.0700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2660
    Cell Significance Index: -1.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2736
    Cell Significance Index: -5.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2859
    Cell Significance Index: -10.5000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2926
    Cell Significance Index: -10.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2969
    Cell Significance Index: -9.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3001
    Cell Significance Index: -8.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3081
    Cell Significance Index: -5.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3137
    Cell Significance Index: -12.8500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3311
    Cell Significance Index: -8.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAPK13 is a serine/threonine kinase that belongs to the MAPK family, which is characterized by its ability to phosphorylate and activate downstream targets. MAPK13 is specifically activated in response to various stimuli, including osmotic stress, anisomycin, hydrogen peroxide, and interleukin-1. It exhibits a unique substrate specificity, phosphorylating and activating specific proteins involved in immune response and cellular signaling. MAPK13 is also known to interact with various proteins, including NLRP3 inflammasome components and MAPKs, modulating its activity and regulating downstream signaling pathways. **Pathways and Functions:** MAPK13 is involved in various signaling pathways, including: 1. **Inflammatory response:** MAPK13 is activated in response to inflammatory stimuli, such as interleukin-1, and regulates the production of pro-inflammatory cytokines, including interleukin-6. 2. **Cellular stress response:** MAPK13 is activated in response to osmotic stress, anisomycin, and hydrogen peroxide, and regulates stress-activated MAPK cascades. 3. **Immune system:** MAPK13 is expressed in immune cells, including macrophages and dendritic cells, and regulates immune responses, including the activation of NLRP3 inflammasome. 4. **Cellular differentiation:** MAPK13 is involved in the regulation of cellular differentiation, including the development of epithelial cells and stem cells. **Clinical Significance:** MAPK13 has been implicated in various diseases, including: 1. **Inflammatory disorders:** MAPK13 is overexpressed in inflammatory disorders, such as rheumatoid arthritis and inflammatory bowel disease, and its activity is associated with disease severity. 2. **Cancer:** MAPK13 is involved in the regulation of cancer cell growth and survival, and its overexpression is associated with tumorigenesis. 3. **Neurological disorders:** MAPK13 is implicated in the regulation of neuronal survival and differentiation, and its dysregulation is associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, MAPK13 is a key regulator of immune response and cellular signaling, and its dysregulation is associated with various diseases. Further studies are needed to elucidate the mechanisms of MAPK13 in immune response and cellular signaling, and to explore its therapeutic potential in treating inflammatory disorders and cancer. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms of MAPK13 in immune response and cellular signaling. 2. Investigate the therapeutic potential of MAPK13 inhibitors in treating inflammatory disorders and cancer. 3. Explore the role of MAPK13 in regulating cellular differentiation and development. 4. Develop novel therapeutic strategies targeting MAPK13 in treating neurological disorders. **References:** 1. [Insert references to studies on MAPK13] 2. [Insert references to studies on inflammatory disorders] 3. [Insert references to studies on cancer] 4. [Insert references to studies on neurological disorders] **Disclosures:** The author declares no conflicts of interest.

Genular Protein ID: 3834061852

Symbol: MK13_HUMAN

Name: Mitogen-activated protein kinase 13

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9218798

Title: Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.

PubMed ID: 9218798

DOI: 10.1093/emboj/16.12.3563

PubMed ID: 9374491

Title: Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta.

PubMed ID: 9374491

DOI: 10.1074/jbc.272.48.30122

PubMed ID: 9295308

Title: Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase.

PubMed ID: 9295308

DOI: 10.1074/jbc.272.38.23668

PubMed ID: 9207191

Title: Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles.

PubMed ID: 9207191

DOI: 10.1006/bbrc.1997.6849

PubMed ID: 10066767

Title: Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines.

PubMed ID: 10066767

DOI: 10.1074/jbc.274.11.7095

PubMed ID: 10727080

Title: Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4.

PubMed ID: 10727080

DOI: 10.3109/10425179909033952

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9731215

Title: Identification of stathmin as a novel substrate for p38 delta.

PubMed ID: 9731215

DOI: 10.1006/bbrc.1998.9250

PubMed ID: 10201954

Title: Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages.

PubMed ID: 10201954

PubMed ID: 11378392

Title: Fibroblast growth factor homologous factors are intracellular signaling proteins.

PubMed ID: 11378392

DOI: 10.1016/s0960-9822(01)00232-9

PubMed ID: 11500363

Title: A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.

PubMed ID: 11500363

DOI: 10.1093/emboj/20.16.4360

PubMed ID: 11943212

Title: Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells.

PubMed ID: 11943212

DOI: 10.1016/s0014-5793(02)02460-2

PubMed ID: 15632108

Title: Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly.

PubMed ID: 15632108

DOI: 10.1242/jcs.01655

PubMed ID: 17256148

Title: Activation of PKCdelta and p38delta MAPK during okadaic acid dependent keratinocyte apoptosis.

PubMed ID: 17256148

DOI: 10.1007/s00403-006-0727-4

PubMed ID: 18006338

Title: p38MAPK delta controls c-Myb degradation in response to stress.

PubMed ID: 18006338

DOI: 10.1016/j.bcmd.2007.09.010

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18367666

Title: MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta.

PubMed ID: 18367666

DOI: 10.1073/pnas.0801453105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20478268

Title: Human p38 delta MAP kinase mediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL14.

PubMed ID: 20478268

DOI: 10.1016/j.bbrc.2010.05.072

PubMed ID: 20090411

Title: p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis.

PubMed ID: 20090411

DOI: 10.4161/cc.9.3.10541

PubMed ID: 20626350

Title: Mechanisms and functions of p38 MAPK signalling.

PubMed ID: 20626350

DOI: 10.1042/bj20100323

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 365
  • Mass: 42090
  • Checksum: 52E749EDB2973DDF
  • Sequence:
  • MSLIRKKGFY KQDVNKTAWE LPKTYVSPTH VGSGAYGSVC SAIDKRSGEK VAIKKLSRPF 
    QSEIFAKRAY RELLLLKHMQ HENVIGLLDV FTPASSLRNF YDFYLVMPFM QTDLQKIMGM 
    EFSEEKIQYL VYQMLKGLKY IHSAGVVHRD LKPGNLAVNE DCELKILDFG LARHADAEMT 
    GYVVTRWYRA PEVILSWMHY NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLTQILKVTG 
    VPGTEFVQKL NDKAAKSYIQ SLPQTPRKDF TQLFPRASPQ AADLLEKMLE LDVDKRLTAA 
    QALTHPFFEP FRDPEEETEA QQPFDDSLEH EKLTVDEWKQ HIYKEIVNFS PIARKDSRRR 
    SGMKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.