MAP2K6 | ENSG00000108984 | NCBI 5608

Details for: MAP2K6

Gene ID: 5608

Symbol: MAP2K6

Ensembl ID: ENSG00000108984

Description: mitogen-activated protein kinase kinase 6

Associated with

Activated tak1 mediates p38 mapk activation
(R-HSA-450302)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Bacterial infection pathways
(R-HSA-9824439)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interferon signaling
(R-HSA-913531)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-17 signaling
(R-HSA-448424)
Map kinase activation
(R-HSA-450294)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Myogenesis
(R-HSA-525793)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Oxidative stress induced senescence
(R-HSA-2559580)
Pi5p regulates tp53 acetylation
(R-HSA-6811555)
Pkr-mediated signaling
(R-HSA-9833482)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through acetylation
(R-HSA-6804758)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by interleukins
(R-HSA-449147)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Transcriptional regulation by tp53
(R-HSA-3700989)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Uptake and actions of bacterial toxins
(R-HSA-5339562)
Uptake and function of anthrax toxins
(R-HSA-5210891)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Bone development
(GO:0060348)
Cardiac muscle contraction
(GO:0060048)
Cellular response to sorbitol
(GO:0072709)
Cellular senescence
(GO:0090398)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Identical protein binding
(GO:0042802)
Mapk cascade
(GO:0000165)
Map kinase kinase activity
(GO:0004708)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Nucleoplasm
(GO:0005654)
Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
(GO:0035872)
Osteoblast differentiation
(GO:0001649)
Ovulation cycle process
(GO:0022602)
P38mapk cascade
(GO:0038066)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of nitric-oxide synthase biosynthetic process
(GO:0051770)
Positive regulation of prostaglandin secretion
(GO:0032308)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of cell cycle
(GO:0051726)
Regulation of signal transduction by p53 class mediator
(GO:1901796)
Response to ischemia
(GO:0002931)
Response to xenobiotic stimulus
(GO:0009410)
Signal transduction
(GO:0007165)
Signal transduction in response to dna damage
(GO:0042770)
Stress-activated mapk cascade
(GO:0051403)
Stress-activated protein kinase signaling cascade
(GO:0031098)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 149.2813
Cell Significance Index: -23.2200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 87.9976
Cell Significance Index: -22.3200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 49.8084
Cell Significance Index: -20.2400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 18.8896
Cell Significance Index: -23.2900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.4962
Cell Significance Index: -22.7600
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.9360
Cell Significance Index: -15.1800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.9427
Cell Significance Index: -23.4500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.6239
Cell Significance Index: 99.8100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.5165
Cell Significance Index: 91.0400
Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.3422
Cell Significance Index: 32.1900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0343
Cell Significance Index: 207.4700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.0224
Cell Significance Index: 57.3700
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.9251
Cell Significance Index: 107.8100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8704
Cell Significance Index: 172.7300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8455
Cell Significance Index: 763.4300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8203
Cell Significance Index: 294.2300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6676
Cell Significance Index: 30.2600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6309
Cell Significance Index: 344.5300
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.6217
Cell Significance Index: 15.1700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4793
Cell Significance Index: 91.2100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4646
Cell Significance Index: 20.5500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4026
Cell Significance Index: 278.4700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.3842
Cell Significance Index: 14.5500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3365
Cell Significance Index: 9.7000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3356
Cell Significance Index: 7.2700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.3343
Cell Significance Index: 42.8600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2548
Cell Significance Index: 7.1200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2324
Cell Significance Index: 4.9500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2151
Cell Significance Index: 6.8900
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 0.1827
Cell Significance Index: 2.3000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.1411
Cell Significance Index: 1.9300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1410
Cell Significance Index: 25.4200
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1395
Cell Significance Index: 2.3900
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.1040
Cell Significance Index: 2.0300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1036
Cell Significance Index: 6.9700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1034
Cell Significance Index: 16.8300
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.1023
Cell Significance Index: 2.9200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0709
Cell Significance Index: 2.4900
Cell Name: peg cell (CL4033014)
Fold Change: 0.0610
Cell Significance Index: 1.4100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0489
Cell Significance Index: 4.8400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0344
Cell Significance Index: 15.2100
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0216
Cell Significance Index: 2.7900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0167
Cell Significance Index: 0.3500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0165
Cell Significance Index: 31.1500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0118
Cell Significance Index: 1.4500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0079
Cell Significance Index: 5.8200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0055
Cell Significance Index: 8.4300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0009
Cell Significance Index: -1.6000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0031
Cell Significance Index: -1.9400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0038
Cell Significance Index: -5.2000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0061
Cell Significance Index: -0.3200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0100
Cell Significance Index: -1.1800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0216
Cell Significance Index: -16.0200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0296
Cell Significance Index: -22.4100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0335
Cell Significance Index: -15.1900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0355
Cell Significance Index: -4.8700
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0356
Cell Significance Index: -0.7800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0390
Cell Significance Index: -21.9800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0402
Cell Significance Index: -25.0800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0485
Cell Significance Index: -8.2800
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.0585
Cell Significance Index: -0.5900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0706
Cell Significance Index: -20.3000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1057
Cell Significance Index: -15.3600
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.1121
Cell Significance Index: -0.6700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1146
Cell Significance Index: -24.1300
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1161
Cell Significance Index: -1.7400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1208
Cell Significance Index: -12.3400
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.1225
Cell Significance Index: -0.8300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1242
Cell Significance Index: -7.8300
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1418
Cell Significance Index: -9.1500
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.1467
Cell Significance Index: -1.8200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1519
Cell Significance Index: -17.4100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1583
Cell Significance Index: -5.5000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1721
Cell Significance Index: -8.0900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1724
Cell Significance Index: -12.1900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1798
Cell Significance Index: -9.3400
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1831
Cell Significance Index: -2.6300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1860
Cell Significance Index: -14.2700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2033
Cell Significance Index: -4.3500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2093
Cell Significance Index: -21.7900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2173
Cell Significance Index: -10.1300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2375
Cell Significance Index: -18.8100
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2534
Cell Significance Index: -5.0100
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.2564
Cell Significance Index: -3.9000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2571
Cell Significance Index: -19.1600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2682
Cell Significance Index: -14.0800
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2709
Cell Significance Index: -3.8800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3038
Cell Significance Index: -5.0900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3205
Cell Significance Index: -19.6500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3317
Cell Significance Index: -10.8600
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.3341
Cell Significance Index: -2.8400
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3639
Cell Significance Index: -11.5900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4076
Cell Significance Index: -10.1900
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4118
Cell Significance Index: -8.7400
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.4220
Cell Significance Index: -5.6300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4348
Cell Significance Index: -11.6300
Cell Name: glioblast (CL0000030)
Fold Change: -0.4622
Cell Significance Index: -2.9000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.4717
Cell Significance Index: -12.8400
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4774
Cell Significance Index: -10.3200
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4984
Cell Significance Index: -17.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** MAP2K6 is a non-coding gene that encodes a protein with dual specificity kinase activity, allowing it to phosphorylate both serine/threonine and tyrosine residues on target proteins. The gene is highly conserved across species and is expressed in numerous cell types, including immune cells, neural progenitor cells, and muscle cells. MAP2K6 is also known to interact with various proteins, including MAPK kinases, transcription factors, and kinases, to regulate signaling pathways. **Pathways and Functions:** MAP2K6 is involved in numerous signaling pathways, including: 1. **p38 MAPK cascade:** MAP2K6 activates the p38 MAPK cascade, which regulates cell proliferation, differentiation, and apoptosis. 2. **Apoptotic process:** MAP2K6 is involved in the regulation of apoptosis, particularly in response to stress signals. 3. **Immune responses:** MAP2K6 is expressed in immune cells and is implicated in the regulation of immune responses, including the activation of immune cells and the production of cytokines. 4. **Cell survival:** MAP2K6 is involved in the regulation of cell survival, particularly in response to stress signals. 5. **Stress-activated signaling:** MAP2K6 is activated in response to various stress signals, including heat shock, oxidative stress, and DNA damage. **Clinical Significance:** MAP2K6 has been implicated in various diseases, including: 1. **Autoimmune disorders:** MAP2K6 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Cancer:** MAP2K6 is involved in the regulation of cell proliferation and apoptosis, and its dysregulation has been implicated in various types of cancer, including breast and lung cancer. 3. **Neurological disorders:** MAP2K6 has been implicated in the regulation of neural signaling pathways, and its dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases:** MAP2K6 is involved in the regulation of immune responses, and its dysregulation has been implicated in infectious diseases, such as tuberculosis and malaria. In conclusion, MAP2K6 is a multifaceted gene that plays a crucial role in various immunological and cellular processes. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand its role in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Dual specificity mitogen-activated protein kinase kinase 6

Genular Protein ID: 259525151

Symbol: MP2K6_HUMAN

Name: Dual specificity mitogen-activated protein kinase kinase 6

UniProtKB Accession Codes:

P52564

Database IDs:

Citations:

PubMed ID: 8622669

Title: MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.

PubMed ID: 8622669

DOI: 10.1128/mcb.16.3.1247

PubMed ID: 8626699

Title: Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade.

PubMed ID: 8626699

DOI: 10.1074/jbc.271.19.11427

PubMed ID: 8621675

Title: Characterization of the structure and function of a novel MAP kinase kinase (MKK6).

PubMed ID: 8621675

DOI: 10.1074/jbc.271.6.2886

PubMed ID: 8663074

Title: A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3.

PubMed ID: 8663074

DOI: 10.1074/jbc.271.23.13675

PubMed ID: 8861944

Title: Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells.

PubMed ID: 8861944

DOI: 10.1002/j.1460-2075.1996.tb00790.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9218798

Title: Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.

PubMed ID: 9218798

DOI: 10.1093/emboj/16.12.3563

PubMed ID: 9768359

Title: Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2.

PubMed ID: 9768359

DOI: 10.1016/s0960-9822(98)70442-7

PubMed ID: 9841871

Title: Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades.

PubMed ID: 9841871

DOI: 10.1042/bj3360599

PubMed ID: 10347227

Title: MEK kinase 3 directly activates MKK6 and MKK7, specific activators of the p38 and c-Jun NH2-terminal kinases.

PubMed ID: 10347227

DOI: 10.1074/jbc.274.23.16604

PubMed ID: 10497253

Title: Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain.

PubMed ID: 10497253

DOI: 10.1074/jbc.274.40.28803

PubMed ID: 10094049

Title: The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.

PubMed ID: 10094049

DOI: 10.1038/18465

PubMed ID: 11104681

Title: Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor.

PubMed ID: 11104681

DOI: 10.1042/bj3520739

PubMed ID: 10961885

Title: Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.

PubMed ID: 10961885

PubMed ID: 11727828

Title: The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription.

PubMed ID: 11727828

DOI: 10.1515/bc.2001.178

PubMed ID: 11689443

Title: Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.

PubMed ID: 11689443

DOI: 10.1093/emboj/20.21.6028

PubMed ID: 11279118

Title: Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2.

PubMed ID: 11279118

DOI: 10.1074/jbc.m100681200

PubMed ID: 11460167

Title: TAK1 is a ubiquitin-dependent kinase of MKK and IKK.

PubMed ID: 11460167

DOI: 10.1038/35085597

PubMed ID: 15229216

Title: Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation.

PubMed ID: 15229216

DOI: 10.1074/jbc.m406554200

PubMed ID: 15375157

Title: p150(Glued), Dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs.

PubMed ID: 15375157

DOI: 10.1074/jbc.c400333200

PubMed ID: 15550393

Title: Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase.

PubMed ID: 15550393

DOI: 10.1074/jbc.m406701200

PubMed ID: 15866172

Title: Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases.

PubMed ID: 15866172

DOI: 10.1016/j.molcel.2005.04.001

PubMed ID: 16728640

Title: Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation.

PubMed ID: 16728640

DOI: 10.1126/science.1126867

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20364819

Title: Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation.

PubMed ID: 20364819

DOI: 10.1021/bi100010j

PubMed ID: 20869211

Title: MKK6 increases the melanocyte dendricity through the regulation of Rho family GTPases.

PubMed ID: 20869211

DOI: 10.1016/j.jdermsci.2010.08.006

PubMed ID: 9779990

Title: Signaling by dual specificity kinases.

PubMed ID: 9779990

DOI: 10.1038/sj.onc.1202251

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22802624

Title: Serine/threonine acetylation of TGFbeta-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling.

PubMed ID: 22802624

DOI: 10.1073/pnas.1008203109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 19141286

Title: The structure of the MAP2K MEK6 reveals an autoinhibitory dimer.

PubMed ID: 19141286

DOI: 10.1016/j.str.2008.11.007

Sequence Information:

Length: 334
Mass: 37492
Checksum: 4ECA8014522216AF
Sequence:

MSQSKGKKRN PGLKIPKEAF EQPQTSSTPP RDLDSKACIS IGNQNFEVKA DDLEPIMELG 
RGAYGVVEKM RHVPSGQIMA VKRIRATVNS QEQKRLLMDL DISMRTVDCP FTVTFYGALF 
REGDVWICME LMDTSLDKFY KQVIDKGQTI PEDILGKIAV SIVKALEHLH SKLSVIHRDV 
KPSNVLINAL GQVKMCDFGI SGYLVDSVAK TIDAGCKPYM APERINPELN QKGYSVKSDI 
WSLGITMIEL AILRFPYDSW GTPFQQLKQV VEEPSPQLPA DKFSAEFVDF TSQCLKKNSK 
ERPTYPELMQ HPFFTLHESK GTDVASFVKL ILGD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MAP2K6

Associated with

Cells (max top 100)

Other Information

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. PubMed ID: 8622669

Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade. PubMed ID: 8626699

Characterization of the structure and function of a novel MAP kinase kinase (MKK6). PubMed ID: 8621675

A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. PubMed ID: 8663074

Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells. PubMed ID: 8861944

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. PubMed ID: 9218798

Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. PubMed ID: 9768359

Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades. PubMed ID: 9841871

MEK kinase 3 directly activates MKK6 and MKK7, specific activators of the p38 and c-Jun NH2-terminal kinases. PubMed ID: 10347227

Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain. PubMed ID: 10497253

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. PubMed ID: 10094049

Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor. PubMed ID: 11104681

Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. PubMed ID: 10961885

The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription. PubMed ID: 11727828

Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress. PubMed ID: 11689443

Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. PubMed ID: 11279118

TAK1 is a ubiquitin-dependent kinase of MKK and IKK. PubMed ID: 11460167

Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation. PubMed ID: 15229216

p150(Glued), Dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs. PubMed ID: 15375157

Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase. PubMed ID: 15550393

Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases. PubMed ID: 15866172

Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. PubMed ID: 16728640

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation. PubMed ID: 20364819

MKK6 increases the melanocyte dendricity through the regulation of Rho family GTPases. PubMed ID: 20869211

Signaling by dual specificity kinases. PubMed ID: 9779990

Initial characterization of the human central proteome. PubMed ID: 21269460

Serine/threonine acetylation of TGFbeta-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling. PubMed ID: 22802624

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The structure of the MAP2K MEK6 reveals an autoinhibitory dimer. PubMed ID: 19141286