Details for: PRPS2

Gene ID: 5634

Symbol: PRPS2

Ensembl ID: ENSG00000101911

Description: phosphoribosyl pyrophosphate synthetase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 79.7196
    Cell Significance Index: -12.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.6169
    Cell Significance Index: -12.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.1224
    Cell Significance Index: -16.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.4177
    Cell Significance Index: -18.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.2193
    Cell Significance Index: -16.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.8772
    Cell Significance Index: -17.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2672
    Cell Significance Index: -14.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6362
    Cell Significance Index: -14.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5590
    Cell Significance Index: -17.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2617
    Cell Significance Index: -4.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.2004
    Cell Significance Index: 217.6700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.1566
    Cell Significance Index: 12.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0544
    Cell Significance Index: 55.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.7612
    Cell Significance Index: 40.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7095
    Cell Significance Index: 199.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.5278
    Cell Significance Index: 39.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2167
    Cell Significance Index: 167.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2123
    Cell Significance Index: 1094.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1875
    Cell Significance Index: 193.1400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.0088
    Cell Significance Index: 14.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6814
    Cell Significance Index: 47.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6515
    Cell Significance Index: 46.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5861
    Cell Significance Index: 259.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5795
    Cell Significance Index: 71.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5740
    Cell Significance Index: 109.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5551
    Cell Significance Index: 111.3500
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.4492
    Cell Significance Index: 1.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4450
    Cell Significance Index: 20.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4429
    Cell Significance Index: 33.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3708
    Cell Significance Index: 3.4200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.3593
    Cell Significance Index: 0.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3521
    Cell Significance Index: 41.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3318
    Cell Significance Index: 65.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3166
    Cell Significance Index: 172.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2979
    Cell Significance Index: 50.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2948
    Cell Significance Index: 53.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2247
    Cell Significance Index: 10.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2223
    Cell Significance Index: 28.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2154
    Cell Significance Index: 6.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2048
    Cell Significance Index: 26.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2014
    Cell Significance Index: 9.4700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.1811
    Cell Significance Index: 2.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1717
    Cell Significance Index: 5.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1708
    Cell Significance Index: 3.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1518
    Cell Significance Index: 9.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1438
    Cell Significance Index: 7.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1198
    Cell Significance Index: 42.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1172
    Cell Significance Index: 73.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0620
    Cell Significance Index: 1.7900
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.0281
    Cell Significance Index: 0.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0172
    Cell Significance Index: 11.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0017
    Cell Significance Index: 3.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0007
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0027
    Cell Significance Index: -0.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0052
    Cell Significance Index: -3.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0066
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0083
    Cell Significance Index: -6.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0097
    Cell Significance Index: -7.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0103
    Cell Significance Index: -19.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0133
    Cell Significance Index: -20.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0154
    Cell Significance Index: -8.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0163
    Cell Significance Index: -1.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0163
    Cell Significance Index: -22.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0174
    Cell Significance Index: -0.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0273
    Cell Significance Index: -0.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0350
    Cell Significance Index: -5.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0386
    Cell Significance Index: -17.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0480
    Cell Significance Index: -10.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0488
    Cell Significance Index: -2.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0496
    Cell Significance Index: -14.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0637
    Cell Significance Index: -1.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0691
    Cell Significance Index: -3.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0714
    Cell Significance Index: -3.1600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0723
    Cell Significance Index: -0.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0748
    Cell Significance Index: -2.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0938
    Cell Significance Index: -2.6900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1028
    Cell Significance Index: -0.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1303
    Cell Significance Index: -4.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1312
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1418
    Cell Significance Index: -16.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1629
    Cell Significance Index: -12.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1685
    Cell Significance Index: -10.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1707
    Cell Significance Index: -17.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1712
    Cell Significance Index: -8.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2044
    Cell Significance Index: -3.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2048
    Cell Significance Index: -12.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2250
    Cell Significance Index: -4.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2274
    Cell Significance Index: -15.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2274
    Cell Significance Index: -5.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2425
    Cell Significance Index: -18.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2544
    Cell Significance Index: -2.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2600
    Cell Significance Index: -6.5000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2797
    Cell Significance Index: -2.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3097
    Cell Significance Index: -19.5200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3391
    Cell Significance Index: -4.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3490
    Cell Significance Index: -12.8100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3719
    Cell Significance Index: -2.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3722
    Cell Significance Index: -11.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3803
    Cell Significance Index: -12.4500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3867
    Cell Significance Index: -11.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRPS2 is a cytosolic enzyme, belonging to the ribose phosphate diphosphokinase family. It exhibits homodimeric structure and possesses kinase activity, allowing it to phosphorylate ribose-5-phosphate to form phosphoribosyl pyrophosphate (PRPP). This enzyme is highly expressed in various cell types, including decidual cells, kidney collecting duct cells, and Sertoli cells, suggesting its importance in reproductive and renal functions. **Pathways and Functions:** PRPS2 is integral to the pentose-phosphate pathway (PPP), a metabolic process that generates NADPH and pentoses from glucose-6-phosphate. The PPP is crucial for maintaining redox balance, synthesizing nucleotides, and producing ribose-5-phosphate, a precursor for nucleic acid synthesis. PRPS2 catalyzes the conversion of ribose-5-phosphate to PRPP, which is then used to synthesize nucleotides, such as ATP, NADP+, and UTP. Additionally, PRPS2 is involved in the regulation of carbohydrate metabolism, including the synthesis of glycogen and the breakdown of glycolytic intermediates. **Clinical Significance:** Dysregulation of PRPS2 has been implicated in various diseases, including: 1. **Reproductive disorders:** PRPS2 expression is essential for embryonic development and reproductive function. Abnormalities in PRPS2 expression have been linked to infertility, miscarriage, and preterm birth. 2. **Kidney disease:** PRPS2 is highly expressed in kidney collecting duct cells, suggesting its involvement in renal function and disease. Dysregulation of PRPS2 has been associated with kidney disorders, such as acute kidney injury and chronic kidney disease. 3. **Cancer:** PRPS2 has been implicated in the regulation of nucleotide metabolism, which is critical for cancer cell proliferation and survival. Abnormal expression of PRPS2 has been observed in various types of cancer, including breast, lung, and colon cancer. 4. **Neurological disorders:** PRPS2 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, which are characterized by impaired nucleotide metabolism and oxidative stress. In conclusion, PRPS2 is a multifaceted enzyme that plays a crucial role in regulating metabolic processes, including carbohydrate, nucleotide, and ribose phosphate biosynthesis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this enzyme.

Genular Protein ID: 1747671395

Symbol: PRPS2_HUMAN

Name: Ribose-phosphate pyrophosphokinase 2

UniProtKB Accession Codes:

P11908 Q0VDH9 Q0VDI0 Q15245 Q2TAK7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2538352

Title: Molecular cloning and sequencing of human cDNA for phosphoribosyl pyrophosphate synthetase subunit II.

PubMed ID: 2538352

DOI: 10.1016/0014-5793(89)81159-7

PubMed ID: 2560337

Title: Deduced amino acid sequence from human phosphoribosylpyrophosphate synthetase subunit II cDNA.

PubMed ID: 2560337

DOI: 10.1007/978-1-4684-5673-8_84

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1314091

Title: Promoter regions of the human X-linked housekeeping genes PRPS1 and PRPS2 encoding phosphoribosylpyrophosphate synthetase subunit I and II isoforms.

PubMed ID: 1314091

DOI: 10.1016/0167-4781(92)90521-z

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 318
  • Mass: 34769
  • Checksum: 72A2873408250C31
  • Sequence:
    • MPNIVLFSGS SHQDLSQRVA DRLGLELGKV VTKKFSNQET SVEIGESVRG EDVYIIQSGC 
GEINDNLMEL LIMINACKIA SSSRVTAVIP CFPYARQDKK DKSRAPISAK LVANMLSVAG 
ADHIITMDLH ASQIQGFFDI PVDNLYAEPA VLQWIRENIA EWKNCIIVSP DAGGAKRVTS 
IADRLNVEFA LIHKERKKAN EVDRMVLVGD VKDRVAILVD DMADTCGTIC HAADKLLSAG 
ATKVYAILTH GIFSGPAISR INNAAFEAVV VTNTIPQEDK MKHCTKIQVI DISMILAEAI 
RRTHNGESVS YLFSHVPL

Genular Protein ID: 2150301839

Symbol: A0A140VK41_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VK41

Database IDs:

ARBA 13 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 9 Gene3D 1 HAMAP 1 IntAct 1 InterPro 6 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 3 PhylomeDB 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 UniPathway 1 VEuPathDB 1

Sequence Information:

  • Length: 321
  • Mass: 35054
  • Checksum: EDD88B9D33A55A37
  • Sequence:
    • MPNIVLFSGS SHQDLSQRVA DRLGLELGKV VTKKFSNQET SVEIGESVRG EDVYIIQSGC 
GEINDNLMEL LIMINACKIA SSSRVTAVIP CFPYARQDKK DKVGESRAPI SAKLVANMLS 
VAGADHIITM DLHASQIQGF FDIPVDNLYA EPAVLQWIRE NIAEWKNCII VSPDAGGAKR 
VTSIADRLNV EFALIHKERK KANEVDRMVL VGDVKDRVAI LVDDMADTCG TICHAADKLL 
SAGATKVYAI LTHGIFSGPA ISRINNAAFE AVVVTNTIPQ EDKMKHCTKI QVIDISMILA 
EAIRRTHNGE SVSYLFSHVP L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.