Details for: PRPSAP1

Gene ID: 5635

Symbol: PRPSAP1

Ensembl ID: ENSG00000161542

Description: phosphoribosyl pyrophosphate synthetase associated protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 214.4071
    Cell Significance Index: -33.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 124.9392
    Cell Significance Index: -31.6900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 96.7842
    Cell Significance Index: -39.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 74.2180
    Cell Significance Index: -35.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.4901
    Cell Significance Index: -36.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.3440
    Cell Significance Index: -27.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.3004
    Cell Significance Index: -36.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.8527
    Cell Significance Index: -19.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 3.4874
    Cell Significance Index: 74.5500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.3309
    Cell Significance Index: 17.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.2726
    Cell Significance Index: 157.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8126
    Cell Significance Index: 359.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3218
    Cell Significance Index: 61.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1717
    Cell Significance Index: 70.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0127
    Cell Significance Index: 203.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7901
    Cell Significance Index: 283.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7312
    Cell Significance Index: 25.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7163
    Cell Significance Index: 15.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6783
    Cell Significance Index: 31.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6241
    Cell Significance Index: 80.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5978
    Cell Significance Index: 15.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5977
    Cell Significance Index: 33.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5250
    Cell Significance Index: 67.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5058
    Cell Significance Index: 82.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4492
    Cell Significance Index: 80.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4261
    Cell Significance Index: 22.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4084
    Cell Significance Index: 223.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3984
    Cell Significance Index: 54.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3709
    Cell Significance Index: 16.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3662
    Cell Significance Index: 45.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3245
    Cell Significance Index: 9.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3143
    Cell Significance Index: 138.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3137
    Cell Significance Index: 24.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2860
    Cell Significance Index: 54.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2659
    Cell Significance Index: 7.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2532
    Cell Significance Index: 15.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2355
    Cell Significance Index: 6.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2169
    Cell Significance Index: 14.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2143
    Cell Significance Index: 11.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1939
    Cell Significance Index: 11.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1849
    Cell Significance Index: 13.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1794
    Cell Significance Index: 21.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1620
    Cell Significance Index: 304.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1443
    Cell Significance Index: 65.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1263
    Cell Significance Index: 21.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1086
    Cell Significance Index: 147.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0488
    Cell Significance Index: 89.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0479
    Cell Significance Index: 30.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0458
    Cell Significance Index: 70.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0225
    Cell Significance Index: 2.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0157
    Cell Significance Index: 1.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0091
    Cell Significance Index: 0.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0071
    Cell Significance Index: 5.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0022
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0146
    Cell Significance Index: -9.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0151
    Cell Significance Index: -11.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0205
    Cell Significance Index: -0.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0317
    Cell Significance Index: -0.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0332
    Cell Significance Index: -0.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0334
    Cell Significance Index: -25.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0438
    Cell Significance Index: -24.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0575
    Cell Significance Index: -0.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0651
    Cell Significance Index: -0.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0659
    Cell Significance Index: -6.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1034
    Cell Significance Index: -21.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1053
    Cell Significance Index: -30.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1082
    Cell Significance Index: -15.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1099
    Cell Significance Index: -12.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1168
    Cell Significance Index: -3.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1230
    Cell Significance Index: -12.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1255
    Cell Significance Index: -14.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1398
    Cell Significance Index: -9.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1542
    Cell Significance Index: -6.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2057
    Cell Significance Index: -6.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2350
    Cell Significance Index: -8.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2377
    Cell Significance Index: -5.7000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2462
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2502
    Cell Significance Index: -28.5600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2874
    Cell Significance Index: -3.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3057
    Cell Significance Index: -24.2100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3262
    Cell Significance Index: -5.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3449
    Cell Significance Index: -7.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4005
    Cell Significance Index: -11.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4080
    Cell Significance Index: -10.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4239
    Cell Significance Index: -10.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4266
    Cell Significance Index: -5.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4307
    Cell Significance Index: -9.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4961
    Cell Significance Index: -14.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5036
    Cell Significance Index: -4.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5273
    Cell Significance Index: -15.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5461
    Cell Significance Index: -6.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5648
    Cell Significance Index: -34.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5783
    Cell Significance Index: -5.3300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.5807
    Cell Significance Index: -8.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6477
    Cell Significance Index: -17.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6811
    Cell Significance Index: -18.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7379
    Cell Significance Index: -24.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7476
    Cell Significance Index: -23.8100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7614
    Cell Significance Index: -4.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7678
    Cell Significance Index: -11.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRPSAP1 is a protein associated with phosphoribosyl pyrophosphate synthetase, an enzyme crucial for the biosynthesis of purine nucleotides. Its expression is widespread, with notable presence in ciliary muscle cells, GABAergic neurons, oogonial cells, and smooth muscle cells of the sphincter of the pupil. These cells are involved in various physiological processes, including muscle contraction, neurotransmission, and reproductive functions. PRPSAP1's ability to bind to identical proteins and magnesium ions suggests its involvement in protein-protein interactions and energy metabolism. **Pathways and Functions:** PRPSAP1 is implicated in several key pathways, including: 1. **5-phosphoribose 1-diphosphate biosynthetic process**: PRPSAP1 is essential for the synthesis of 5-phosphoribose 1-diphosphate, a precursor molecule for purine nucleotide biosynthesis. 2. **Purine nucleotide biosynthetic process**: PRPSAP1's association with phosphoribosyl pyrophosphate synthetase positions it as a critical component in the biosynthesis of purine nucleotides, which are essential for DNA and RNA synthesis. 3. **Ribose phosphate diphosphokinase activity**: PRPSAP1's ability to bind to ribose phosphate diphosphokinase activity suggests its involvement in energy metabolism and the regulation of purine nucleotide biosynthesis. 4. **ATP binding**: PRPSAP1's affinity for ATP binding suggests its role in energy metabolism and the regulation of cellular processes. **Clinical Significance:** The clinical significance of PRPSAP1 is multifaceted, with potential implications in various diseases and disorders. Some potential areas of clinical significance include: 1. **Neurological disorders**: PRPSAP1's expression in GABAergic neurons and its involvement in neurotransmission suggest its potential role in neurological disorders, such as epilepsy and schizophrenia. 2. **Reproductive disorders**: PRPSAP1's expression in oogonial cells and its involvement in reproductive functions suggest its potential role in reproductive disorders, such as infertility and miscarriage. 3. **Musculoskeletal disorders**: PRPSAP1's expression in smooth muscle cells of the sphincter of the pupil and its involvement in muscle contraction suggest its potential role in musculoskeletal disorders, such as myasthenia gravis and dystonia. In conclusion, PRPSAP1 is a multifaceted gene with a wide range of cellular processes and potential clinical implications. Further research is necessary to fully elucidate the functions and pathways of PRPSAP1, as well as its role in various diseases and disorders.

Genular Protein ID: 3662273680

Symbol: KPRA_HUMAN

Name: Phosphoribosyl pyrophosphate synthase-associated protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8611620

Title: Cloning and sequencing of human complementary DNA for the phosphoribosylpyrophosphate synthetase-associated protein 39.

PubMed ID: 8611620

DOI: 10.1016/0167-4781(96)00030-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 356
  • Mass: 39394
  • Checksum: 38CC87AB2C555717
  • Sequence:
  • MNAARTGYRV FSANSTAACT ELAKRITERL GAELGKSVVY QETNGETRVE IKESVRGQDI 
    FIIQTIPRDV NTAVMELLIM AYALKTACAR NIIGVIPYFP YSKQSKMRKR GSIVCKLLAS 
    MLAKAGLTHI ITMDLHQKEI QGFFSFPVDN LRASPFLLQY IQEEIPNYRN AVIVAKSPDA 
    AKRAQSYAER LRLGLAVIHG EAQCTELDMD DGRHSPPMVK NATVHPGLEL PLMMAKEKPP 
    ITVVGDVGGR IAIIVDDIID DVESFVAAAE ILKERGAYKI YVMATHGILS AEAPRLIEES 
    SVDEVVVTNT VPHEVQKLQC PKIKTVDISL ILSEAIRRIH NGESMAYLFR NITVDD

Genular Protein ID: 674819129

Symbol: B4DP31_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 282
  • Mass: 31266
  • Checksum: 51832844BF1BF011
  • Sequence:
  • MELLIMAYAL KTACARNIIG VIPYFPYSKQ SKMRKRGSIV CKLLASMLAK AGLTHIITMD 
    LHQKEIQGFF SFPVDNLRAS PFLLQYIQEE IPNYRNAVIV AKSPDAAKRA QSYAERLRLG 
    LAVIHGEAQC TELDMDDGRH SPPMVKNATV HPGLELPLMM AKEKPPITVV GDVGGRIAII 
    VDDIIDDVES FVAAAEILKE RGAYKIYVMA THGILSAEAP RLIEESSVDE VVVTNTVPHE 
    VQKLQCPKIK TVDISLILSE AIRRIHNGES MAYLFRNITV DD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.