Details for: PRRG2

Gene ID: 5639

Symbol: PRRG2

Ensembl ID: ENSG00000126460

Description: proline rich and Gla domain 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 33.4308
    Cell Significance Index: -5.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.7127
    Cell Significance Index: -5.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.2662
    Cell Significance Index: -5.2600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.1362
    Cell Significance Index: 51.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.9561
    Cell Significance Index: -5.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6403
    Cell Significance Index: 74.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5516
    Cell Significance Index: 80.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.3482
    Cell Significance Index: -5.3200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3421
    Cell Significance Index: 20.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2656
    Cell Significance Index: 1142.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0689
    Cell Significance Index: 64.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0026
    Cell Significance Index: 109.0500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.9457
    Cell Significance Index: 5.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9295
    Cell Significance Index: 108.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8040
    Cell Significance Index: 130.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7738
    Cell Significance Index: 22.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6291
    Cell Significance Index: 13.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5651
    Cell Significance Index: 39.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4208
    Cell Significance Index: 19.6200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.4169
    Cell Significance Index: 0.9400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.4023
    Cell Significance Index: 4.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3876
    Cell Significance Index: 10.5500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.3820
    Cell Significance Index: 4.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3397
    Cell Significance Index: 64.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2977
    Cell Significance Index: 13.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2867
    Cell Significance Index: 51.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2847
    Cell Significance Index: 155.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2785
    Cell Significance Index: 19.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2671
    Cell Significance Index: 6.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2456
    Cell Significance Index: 30.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2321
    Cell Significance Index: 22.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2290
    Cell Significance Index: 17.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2143
    Cell Significance Index: 5.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2136
    Cell Significance Index: 94.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1922
    Cell Significance Index: 1.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1831
    Cell Significance Index: 3.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1703
    Cell Significance Index: 22.0100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1615
    Cell Significance Index: 2.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1558
    Cell Significance Index: 4.9900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1518
    Cell Significance Index: 0.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1372
    Cell Significance Index: 4.8200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1349
    Cell Significance Index: 1.9200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0947
    Cell Significance Index: 0.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0924
    Cell Significance Index: 1.0500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0647
    Cell Significance Index: 0.6700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0628
    Cell Significance Index: 0.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0579
    Cell Significance Index: 11.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0403
    Cell Significance Index: 2.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0355
    Cell Significance Index: 6.0700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0332
    Cell Significance Index: 0.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0244
    Cell Significance Index: 4.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0133
    Cell Significance Index: 10.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0082
    Cell Significance Index: 6.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0045
    Cell Significance Index: 0.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0023
    Cell Significance Index: 0.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0018
    Cell Significance Index: 0.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0012
    Cell Significance Index: 0.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -2.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0032
    Cell Significance Index: -4.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0042
    Cell Significance Index: -2.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0062
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0087
    Cell Significance Index: -5.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0089
    Cell Significance Index: -2.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0116
    Cell Significance Index: -1.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0117
    Cell Significance Index: -5.2900
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.0126
    Cell Significance Index: -0.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0127
    Cell Significance Index: -1.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0128
    Cell Significance Index: -1.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0169
    Cell Significance Index: -0.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0216
    Cell Significance Index: -2.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0232
    Cell Significance Index: -4.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0237
    Cell Significance Index: -0.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0276
    Cell Significance Index: -4.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0288
    Cell Significance Index: -0.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0341
    Cell Significance Index: -2.1500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0343
    Cell Significance Index: -0.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0419
    Cell Significance Index: -2.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0489
    Cell Significance Index: -5.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0517
    Cell Significance Index: -1.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0532
    Cell Significance Index: -4.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0615
    Cell Significance Index: -4.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0618
    Cell Significance Index: -3.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0668
    Cell Significance Index: -3.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0726
    Cell Significance Index: -4.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0729
    Cell Significance Index: -4.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0753
    Cell Significance Index: -4.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0791
    Cell Significance Index: -2.7500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0812
    Cell Significance Index: -0.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0820
    Cell Significance Index: -3.3600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0838
    Cell Significance Index: -2.6500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0842
    Cell Significance Index: -0.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0906
    Cell Significance Index: -2.6700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0931
    Cell Significance Index: -0.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0959
    Cell Significance Index: -2.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0982
    Cell Significance Index: -3.6100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1017
    Cell Significance Index: -2.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1044
    Cell Significance Index: -4.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1115
    Cell Significance Index: -1.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRRG2 is a transmembrane protein that contains a proline-rich domain and a gamma-carboxyglutamic acid (Gla) domain. The proline-rich domain is characterized by a high content of proline residues, which are known to play a crucial role in protein-protein interactions and signaling pathways. The Gla domain, on the other hand, is involved in calcium ion binding, which is essential for various cellular processes, including cell signaling and gene regulation. PRRG2 is highly expressed in various cell types, including pancreatic A cells, cerebral cortex GABAergic interneurons, and intestinal epithelial cells. **Pathways and Functions:** PRRG2 is implicated in several signaling pathways, including calcium ion binding, protein binding, and cell signaling. The Gla domain of PRRG2 interacts with calcium ions, which triggers a series of downstream signaling events that regulate cellular functions, including gene expression, cell proliferation, and differentiation. PRRG2 also interacts with various proteins, including receptors, kinases, and transcription factors, which modulate its activity and influence cellular responses. In the context of the immune system, PRRG2 is expressed in immature innate lymphoid cells and has been implicated in the regulation of immune responses. **Clinical Significance:** PRRG2 has been identified as a potential biomarker for various diseases, including cancer, neurological disorders, and inflammatory conditions. For instance, studies have shown that PRRG2 is upregulated in pancreatic cancer and is associated with tumor progression and metastasis. Additionally, PRRG2 has been implicated in the regulation of immune responses in autoimmune diseases, such as multiple sclerosis and type 1 diabetes. Furthermore, PRRG2 has been identified as a potential target for therapeutic interventions, including cancer therapy and immunotherapy. In conclusion, PRRG2 is a gene that plays a crucial role in modulating cellular functions, particularly in the context of the immune system and epithelial tissues. Its involvement in various signaling pathways, including calcium ion binding and protein binding, makes it an attractive target for therapeutic interventions. Further research is necessary to fully elucidate the function and significance of PRRG2 in human health and disease. **Recommendations for Future Research:** 1. Investigate the role of PRRG2 in various disease models, including cancer, neurological disorders, and inflammatory conditions. 2. Elucidate the molecular mechanisms underlying PRRG2-mediated signaling pathways, including calcium ion binding and protein binding. 3. Explore the potential of PRRG2 as a biomarker for disease diagnosis and monitoring. 4. Investigate the therapeutic potential of PRRG2 as a target for cancer therapy and immunotherapy. By further exploring the function and significance of PRRG2, we can gain a deeper understanding of its role in human health and disease, and potentially develop new therapeutic strategies for the treatment of various diseases.

Genular Protein ID: 3725872472

Symbol: TMG2_HUMAN

Name: Transmembrane gamma-carboxyglutamic acid protein 2

UniProtKB Accession Codes:

O14669 Q6IBF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9256434

Title: Primary structure and tissue distribution of two novel proline-rich gamma-carboxyglutamic acid proteins.

PubMed ID: 9256434

DOI: 10.1073/pnas.94.17.9058

PubMed ID: 17502622

Title: Proline-rich Gla protein 2 is a cell-surface vitamin K-dependent protein that binds to the transcriptional coactivator Yes-associated protein.

PubMed ID: 17502622

DOI: 10.1073/pnas.0703195104

PubMed ID: 23873930

Title: Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.

PubMed ID: 23873930

DOI: 10.1074/jbc.m113.484683

Sequence Information:

  • Length: 202
  • Mass: 22393
  • Checksum: BC79400C98492060
  • Sequence:
    • MRGHPSLLLL YMALTTCLDT SPSEETDQEV FLGPPEAQSF LSSHTRIPRA NHWDLELLTP 
GNLERECLEE RCSWEEAREY FEDNTLTERF WESYIYNGKG GRGRVDVASL AVGLTGGILL 
IVLAGLGAFW YLRWRQHRGQ QPCPQEAGLI SPLSPLNPLG PPTPLPPPPP PPPGLPTYEQ 
ALAASGVHDA PPPPYTSLRR PH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.