Details for: PTPRJ

Gene ID: 5795

Symbol: PTPRJ

Ensembl ID: ENSG00000149177

Description: protein tyrosine phosphatase receptor type J

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 329.1004
    Cell Significance Index: -51.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 202.9621
    Cell Significance Index: -51.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 107.1243
    Cell Significance Index: -43.5200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 98.6809
    Cell Significance Index: -50.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.5882
    Cell Significance Index: -43.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.6560
    Cell Significance Index: -51.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.1723
    Cell Significance Index: -51.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.5161
    Cell Significance Index: -53.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.0434
    Cell Significance Index: -51.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.9059
    Cell Significance Index: -21.6800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 4.3527
    Cell Significance Index: 43.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2078
    Cell Significance Index: 442.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1836
    Cell Significance Index: 783.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1454
    Cell Significance Index: 425.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.8144
    Cell Significance Index: 111.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.8139
    Cell Significance Index: 101.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.7638
    Cell Significance Index: 38.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.3960
    Cell Significance Index: 93.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3132
    Cell Significance Index: 129.9000
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 1.1991
    Cell Significance Index: 12.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1991
    Cell Significance Index: 829.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1288
    Cell Significance Index: 183.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9786
    Cell Significance Index: 23.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9638
    Cell Significance Index: 104.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8689
    Cell Significance Index: 21.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8066
    Cell Significance Index: 61.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6144
    Cell Significance Index: 23.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5993
    Cell Significance Index: 380.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5760
    Cell Significance Index: 25.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5659
    Cell Significance Index: 1065.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5536
    Cell Significance Index: 64.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.5453
    Cell Significance Index: 1005.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3706
    Cell Significance Index: 570.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3033
    Cell Significance Index: 165.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1395
    Cell Significance Index: 2.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0920
    Cell Significance Index: 2.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0875
    Cell Significance Index: 118.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0709
    Cell Significance Index: 4.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0465
    Cell Significance Index: 2.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0379
    Cell Significance Index: 1.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0375
    Cell Significance Index: 4.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0221
    Cell Significance Index: 4.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0050
    Cell Significance Index: -0.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0192
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0216
    Cell Significance Index: -15.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0292
    Cell Significance Index: -4.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0366
    Cell Significance Index: -22.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0385
    Cell Significance Index: -17.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0478
    Cell Significance Index: -0.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0517
    Cell Significance Index: -37.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0598
    Cell Significance Index: -33.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0634
    Cell Significance Index: -47.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1065
    Cell Significance Index: -47.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1097
    Cell Significance Index: -18.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1406
    Cell Significance Index: -29.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1497
    Cell Significance Index: -43.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1685
    Cell Significance Index: -17.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2187
    Cell Significance Index: -6.2400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2410
    Cell Significance Index: -4.0600
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.3162
    Cell Significance Index: -3.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3180
    Cell Significance Index: -6.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3298
    Cell Significance Index: -45.2900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3308
    Cell Significance Index: -6.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3331
    Cell Significance Index: -39.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3342
    Cell Significance Index: -43.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3357
    Cell Significance Index: -6.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3443
    Cell Significance Index: -35.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3462
    Cell Significance Index: -16.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3572
    Cell Significance Index: -40.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3573
    Cell Significance Index: -7.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4006
    Cell Significance Index: -45.7300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4141
    Cell Significance Index: -5.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.4345
    Cell Significance Index: -55.7000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.5057
    Cell Significance Index: -3.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5628
    Cell Significance Index: -11.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5830
    Cell Significance Index: -43.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5960
    Cell Significance Index: -47.2000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6162
    Cell Significance Index: -9.1000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.6585
    Cell Significance Index: -8.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7182
    Cell Significance Index: -46.3400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7216
    Cell Significance Index: -31.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7765
    Cell Significance Index: -24.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7792
    Cell Significance Index: -40.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7887
    Cell Significance Index: -40.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7896
    Cell Significance Index: -25.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8151
    Cell Significance Index: -57.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8343
    Cell Significance Index: -51.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8914
    Cell Significance Index: -16.4800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9051
    Cell Significance Index: -19.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.9218
    Cell Significance Index: -25.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9239
    Cell Significance Index: -48.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9494
    Cell Significance Index: -59.8400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9977
    Cell Significance Index: -17.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0242
    Cell Significance Index: -35.8800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -1.0949
    Cell Significance Index: -8.3700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.1746
    Cell Significance Index: -29.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.1979
    Cell Significance Index: -24.8500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.2373
    Cell Significance Index: -14.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.2513
    Cell Significance Index: -34.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2664
    Cell Significance Index: -37.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PTPRJ is a member of the receptor-type tyrosine phosphatase (RPTP) family, characterized by its unique structure and substrate specificity. Its extracellular domain is composed of immunoglobulin-like domains, while the intracellular domain contains a tyrosine phosphatase catalytic site. PTPRJ is highly expressed in various cell types, including immune cells, neurons, and glial cells, highlighting its widespread involvement in different cellular processes. **Pathways and Functions:** PTPRJ's substrate specificity and catalytic activity enable it to modulate a diverse range of signaling pathways, including: 1. **Adaptive immune system**: PTPRJ regulates T cell receptor (TCR) signaling, modulating T cell activation, proliferation, and differentiation. 2. **Innate immune system**: PTPRJ is involved in the regulation of neutrophil degranulation and phagocytosis, highlighting its role in the innate immune response. 3. **Cytokine signaling**: PTPRJ modulates the activity of cytokine receptors, influencing the production of pro-inflammatory and anti-inflammatory cytokines. 4. **Neurotransmission**: PTPRJ is expressed in neuronal cells and plays a role in regulating neurotransmitter release and synaptic plasticity. **Clinical Significance:** Dysregulation of PTPRJ has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: PTPRJ's role in regulating T cell activation and cytokine production makes it a potential target for therapies in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: PTPRJ's involvement in tumor growth, invasion, and metastasis highlights its potential as a therapeutic target in cancer treatment. 3. **Neurological disorders**: PTPRJ's expression in neuronal cells and its role in neurotransmission make it a potential target for therapies in neurodegenerative diseases such as Alzheimer's and Parkinson's. In conclusion, PTPRJ is a multifunctional protein that plays a critical role in regulating immune responses and cellular processes. Its dysregulation has been implicated in various immune-related disorders, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 2567981529

Symbol: PTPRJ_HUMAN

Name: Receptor-type tyrosine-protein phosphatase eta

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7937872

Title: Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density.

PubMed ID: 7937872

DOI: 10.1073/pnas.91.21.9680

PubMed ID: 7994032

Title: Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta.

PubMed ID: 7994032

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12089527

Title: Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers.

PubMed ID: 12089527

DOI: 10.1038/ng903

PubMed ID: 8483328

Title: Identification of novel protein-tyrosine phosphatases in a human leukemia cell line, F-36P.

PubMed ID: 8483328

PubMed ID: 9531590

Title: CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes.

PubMed ID: 9531590

PubMed ID: 9780142

Title: Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148.

PubMed ID: 9780142

PubMed ID: 10821867

Title: Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1.

PubMed ID: 10821867

DOI: 10.1074/jbc.275.21.16219

PubMed ID: 11259588

Title: Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation.

PubMed ID: 11259588

DOI: 10.1128/mcb.21.7.2393-2403.2001

PubMed ID: 12062403

Title: Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1.

PubMed ID: 12062403

DOI: 10.1016/s0014-5793(02)02570-x

PubMed ID: 12370829

Title: The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn).

PubMed ID: 12370829

DOI: 10.1038/sj.onc.1205858

PubMed ID: 12475979

Title: Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.

PubMed ID: 12475979

DOI: 10.1074/jbc.m210656200

PubMed ID: 12913111

Title: The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling.

PubMed ID: 12913111

DOI: 10.1083/jcb.200303040

PubMed ID: 14709717

Title: The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation.

PubMed ID: 14709717

DOI: 10.1242/jcs.00879

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16778204

Title: The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins.

PubMed ID: 16778204

DOI: 10.1158/0008-5472.can-06-0228

PubMed ID: 30552125

Title:

PubMed ID: 30552125

DOI: 10.1158/0008-5472.can-18-3456

PubMed ID: 16682945

Title: DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients.

PubMed ID: 16682945

DOI: 10.1038/sj.onc.1209647

PubMed ID: 18348712

Title: The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase.

PubMed ID: 18348712

DOI: 10.1042/bj20071317

PubMed ID: 18603590

Title: The structure of the 5'-end of the protein-tyrosine phosphatase PTPRJ mRNA reveals a novel mechanism for translation attenuation.

PubMed ID: 18603590

DOI: 10.1093/nar/gkn391

PubMed ID: 19246339

Title: The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis.

PubMed ID: 19246339

DOI: 10.1182/blood-2008-08-174318

PubMed ID: 19836242

Title: An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.

PubMed ID: 19836242

DOI: 10.1016/j.cub.2009.09.048

PubMed ID: 19332538

Title: Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells.

PubMed ID: 19332538

DOI: 10.1074/jbc.m901901200

PubMed ID: 19494114

Title: Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases.

PubMed ID: 19494114

DOI: 10.1074/jbc.m109.002758

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 18936167

Title: New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.

PubMed ID: 18936167

DOI: 10.1128/mcb.01374-08

PubMed ID: 21091576

Title: Loss of the protein-tyrosine phosphatase DEP-1/PTPRJ drives meningioma cell motility.

PubMed ID: 21091576

DOI: 10.1111/j.1750-3639.2010.00464.x

PubMed ID: 19922411

Title: Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells.

PubMed ID: 19922411

DOI: 10.1042/bj20091413

PubMed ID: 21262971

Title: Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.

PubMed ID: 21262971

DOI: 10.1074/jbc.m110.205021

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30591527

Title: Loss-of-function mutations in PTPRJ cause a new form of inherited thrombocytopenia.

PubMed ID: 30591527

DOI: 10.1182/blood-2018-07-859496

PubMed ID: 33296397

Title: The translation attenuating arginine-rich sequence in the extended signal peptide of the protein-tyrosine phosphatase PTPRJ/DEP1 is conserved in mammals.

PubMed ID: 33296397

DOI: 10.1371/journal.pone.0240498

PubMed ID: 15378013

Title: The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis.

PubMed ID: 15378013

DOI: 10.1038/sj.onc.1207766

PubMed ID: 28052032

Title: A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis.

PubMed ID: 28052032

DOI: 10.18632/oncotarget.14350

Sequence Information:

  • Length: 1337
  • Mass: 145941
  • Checksum: B44F4343FC8FD1B4
  • Sequence:
  • MKPAAREARL PPRSPGLRWA LPLLLLLLRL GQILCAGGTP SPIPDPSVAT VATGENGITQ 
    ISSTAESFHK QNGTGTPQVE TNTSEDGESS GANDSLRTPE QGSNGTDGAS QKTPSSTGPS 
    PVFDIKAVSI SPTNVILTWK SNDTAASEYK YVVKHKMENE KTITVVHQPW CNITGLRPAT 
    SYVFSITPGI GNETWGDPRV IKVITEPIPV SDLRVALTGV RKAALSWSNG NGTASCRVLL 
    ESIGSHEELT QDSRLQVNIS GLKPGVQYNI NPYLLQSNKT KGDPLGTEGG LDASNTERSR 
    AGSPTAPVHD ESLVGPVDPS SGQQSRDTEV LLVGLEPGTR YNATVYSQAA NGTEGQPQAI 
    EFRTNAIQVF DVTAVNISAT SLTLIWKVSD NESSSNYTYK IHVAGETDSS NLNVSEPRAV 
    IPGLRSSTFY NITVCPVLGD IEGTPGFLQV HTPPVPVSDF RVTVVSTTEI GLAWSSHDAE 
    SFQMHITQEG AGNSRVEITT NQSIIIGGLF PGTKYCFEIV PKGPNGTEGA SRTVCNRTVP 
    SAVFDIHVVY VTTTEMWLDW KSPDGASEYV YHLVIESKHG SNHTSTYDKA ITLQGLIPGT 
    LYNITISPEV DHVWGDPNST AQYTRPSNVS NIDVSTNTTA ATLSWQNFDD ASPTYSYCLL 
    IEKAGNSSNA TQVVTDIGIT DATVTELIPG SSYTVEIFAQ VGDGIKSLEP GRKSFCTDPA 
    SMASFDCEVV PKEPALVLKW TCPPGANAGF ELEVSSGAWN NATHLESCSS ENGTEYRTEV 
    TYLNFSTSYN ISITTVSCGK MAAPTRNTCT TGITDPPPPD GSPNITSVSH NSVKVKFSGF 
    EASHGPIKAY AVILTTGEAG HPSADVLKYT YEDFKKGASD TYVTYLIRTE EKGRSQSLSE 
    VLKYEIDVGN ESTTLGYYNG KLEPLGSYRA CVAGFTNITF HPQNKGLIDG AESYVSFSRY 
    SDAVSLPQDP GVICGAVFGC IFGALVIVTV GGFIFWRKKR KDAKNNEVSF SQIKPKKSKL 
    IRVENFEAYF KKQQADSNCG FAEEYEDLKL VGISQPKYAA ELAENRGKNR YNNVLPYDIS 
    RVKLSVQTHS TDDYINANYM PGYHSKKDFI ATQGPLPNTL KDFWRMVWEK NVYAIIMLTK 
    CVEQGRTKCE EYWPSKQAQD YGDITVAMTS EIVLPEWTIR DFTVKNIQTS ESHPLRQFHF 
    TSWPDHGVPD TTDLLINFRY LVRDYMKQSP PESPILVHCS AGVGRTGTFI AIDRLIYQIE 
    NENTVDVYGI VYDLRMHRPL MVQTEDQYVF LNQCVLDIVR SQKDSKVDLI YQNTTAMTIY 
    ENLAPVTTFG KTNGYIA

Genular Protein ID: 4242355066

Symbol: Q9NPR5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 425
  • Mass: 45078
  • Checksum: BD1ACA5D345B7027
  • Sequence:
  • MKPAAREARL PPRSPGLRWA LPLLLLLLRL GQILCAGGTP SPIPDPSVAT VATGENGITQ 
    ISSTAESFHK QNGTGTPQVE TNTSEDGESS GANDSLRTPE QGSNGTDGAS QKTPSSTGPS 
    PVFDIKAVSI SPTNVILTWK SNDTAASEYK YVVKHKMENE KTITVVHQPW CNITGLRPAT 
    SYVFSITPGI GNETWGDPRV IKVITEPIPV SDLRVALTGV RKAALSWSNG NGTASCRVLL 
    ESIGSHEELT QDSRLQVNIS GLKPGVQYNI NPYLLQSNKT KGDPLGTEGG LDASNTERSR 
    AGSPTAPVHD ESLVGPVDPS SGQQSRDTEV LLVGLEPGTR YNATVYSQAA NGTEGQPQAI 
    EFRTNAIQVF DVTAVNISAT SLTLIWKVSD NESSSNYTYK IHVAGETDSS NLNVSEPRAV 
    IPGLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.