Details for: NECTIN1

Gene ID: 5818

Symbol: NECTIN1

Ensembl ID: ENSG00000110400

Description: nectin cell adhesion molecule 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 7.2107
    Cell Significance Index: 98.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.3297
    Cell Significance Index: 276.8600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.6924
    Cell Significance Index: 6.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.5877
    Cell Significance Index: 178.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1867
    Cell Significance Index: 59.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.1801
    Cell Significance Index: 215.6600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.9276
    Cell Significance Index: 27.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8791
    Cell Significance Index: 338.7500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.8693
    Cell Significance Index: 23.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.7866
    Cell Significance Index: 49.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4688
    Cell Significance Index: 159.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4439
    Cell Significance Index: -3.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4134
    Cell Significance Index: 173.7900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1945
    Cell Significance Index: 11.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9881
    Cell Significance Index: 198.2200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.9473
    Cell Significance Index: 8.1400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.8316
    Cell Significance Index: 6.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7126
    Cell Significance Index: 20.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6761
    Cell Significance Index: 78.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6537
    Cell Significance Index: 289.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6353
    Cell Significance Index: 18.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6277
    Cell Significance Index: 15.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6159
    Cell Significance Index: 220.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5314
    Cell Significance Index: 33.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5290
    Cell Significance Index: 11.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5073
    Cell Significance Index: 82.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4107
    Cell Significance Index: 81.5100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.3300
    Cell Significance Index: 4.0000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.3244
    Cell Significance Index: 2.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2650
    Cell Significance Index: 12.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2609
    Cell Significance Index: 16.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2583
    Cell Significance Index: 5.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2262
    Cell Significance Index: 3.3900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.2230
    Cell Significance Index: 2.2500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2068
    Cell Significance Index: 4.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1998
    Cell Significance Index: 11.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1758
    Cell Significance Index: 12.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1750
    Cell Significance Index: 6.1500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.1438
    Cell Significance Index: 0.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1419
    Cell Significance Index: 7.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1305
    Cell Significance Index: 3.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1126
    Cell Significance Index: 101.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1112
    Cell Significance Index: 18.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1097
    Cell Significance Index: 14.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1018
    Cell Significance Index: 70.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0900
    Cell Significance Index: 17.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0827
    Cell Significance Index: 4.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0696
    Cell Significance Index: 130.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0626
    Cell Significance Index: 34.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0616
    Cell Significance Index: 0.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0544
    Cell Significance Index: 6.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0489
    Cell Significance Index: 6.2700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0207
    Cell Significance Index: 0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0198
    Cell Significance Index: 26.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0087
    Cell Significance Index: -5.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0106
    Cell Significance Index: -7.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0116
    Cell Significance Index: -0.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0161
    Cell Significance Index: -11.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0165
    Cell Significance Index: -12.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0166
    Cell Significance Index: -9.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0169
    Cell Significance Index: -2.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0173
    Cell Significance Index: -1.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0225
    Cell Significance Index: -1.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0258
    Cell Significance Index: -11.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0274
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0298
    Cell Significance Index: -18.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0309
    Cell Significance Index: -2.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0401
    Cell Significance Index: -5.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0403
    Cell Significance Index: -0.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0471
    Cell Significance Index: -13.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0476
    Cell Significance Index: -2.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0590
    Cell Significance Index: -1.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0663
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0736
    Cell Significance Index: -15.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0868
    Cell Significance Index: -5.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0875
    Cell Significance Index: -2.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0974
    Cell Significance Index: -3.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1149
    Cell Significance Index: -11.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1407
    Cell Significance Index: -16.5900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1491
    Cell Significance Index: -0.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1513
    Cell Significance Index: -15.7500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1604
    Cell Significance Index: -1.6600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1838
    Cell Significance Index: -1.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1904
    Cell Significance Index: -15.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2238
    Cell Significance Index: -4.7500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2331
    Cell Significance Index: -4.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2365
    Cell Significance Index: -10.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2414
    Cell Significance Index: -8.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2446
    Cell Significance Index: -6.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2559
    Cell Significance Index: -13.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2579
    Cell Significance Index: -15.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2591
    Cell Significance Index: -4.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2694
    Cell Significance Index: -8.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2711
    Cell Significance Index: -7.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2782
    Cell Significance Index: -8.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2790
    Cell Significance Index: -3.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2839
    Cell Significance Index: -10.7500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2903
    Cell Significance Index: -3.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Nectin1 is a type I transmembrane protein with an extracellular domain that contains two immunoglobulin-like domains, which are responsible for binding to other nectin family members. The protein has a single cytoplasmic tail, which interacts with the cytoskeleton and other signaling molecules to regulate cellular processes. Nectin1 is highly expressed in neural progenitor cells, where it plays a critical role in the development and organization of the nervous system. Additionally, Nectin1 is also expressed in epithelial cells, where it participates in the formation of adherens junctions and desmosomes. **Pathways and Functions** Nectin1 is involved in several signaling pathways, including the regulation of synaptic transmission, cell adhesion, and cell migration. The protein mediates homophilic interactions with Nectin3, which is involved in the formation of synapses and the organization of the neural circuitry. Nectin1 also interacts with other adhesion molecules, such as cadherins and integrins, to regulate cell-cell adhesion and the formation of adherens junctions. Additionally, Nectin1 has been implicated in the regulation of immune responses, including the interaction with innate lymphoid cells and the regulation of inflammation. **Clinical Significance** Dysregulation of Nectin1 has been implicated in several diseases, including neurological disorders, such as epilepsy and schizophrenia, as well as epithelial cancers, such as esophageal cancer. Mutations in the NECT1 gene have been associated with an increased risk of developing these diseases. Furthermore, Nectin1 has been used as a therapeutic target in the treatment of various diseases, including cancer and autoimmune disorders. Research on Nectin1 has also highlighted its potential as a biomarker for disease diagnosis and prognosis. In conclusion, Nectin1 is a critical adhesion molecule that plays a vital role in the development and maintenance of tissues, including the nervous system, eye, and epithelial tissues. Its dysregulation has been implicated in several diseases, and research on Nectin1 holds promise for the development of new therapeutic strategies and diagnostic tools.

Genular Protein ID: 2891121665

Symbol: NECT1_HUMAN

Name: Nectin-1

UniProtKB Accession Codes:

Q15223 O75465 Q2M3D3 Q9HBE6 Q9HBW2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 2 EvolutionaryTrace 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 3 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7721102

Title: cDNA characterization and chromosomal localization of a gene related to the poliovirus receptor gene.

PubMed ID: 7721102

DOI: 10.1016/0378-1119(94)00842-g

PubMed ID: 9616127

Title: Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor.

PubMed ID: 9616127

DOI: 10.1126/science.280.5369.1618

PubMed ID: 11356977

Title: Novel, soluble isoform of the herpes simplex virus (HSV) receptor nectin1 (or prr1-HIgR-Hvec) modulates positively and negatively susceptibility to hsv infection.

PubMed ID: 11356977

DOI: 10.1128/jvi.75.12.5684-5691.2001

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10932188

Title: Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia.

PubMed ID: 10932188

DOI: 10.1038/78119

PubMed ID: 9696799

Title: Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry.

PubMed ID: 9696799

DOI: 10.1128/jvi.72.9.7064-7074.1998

PubMed ID: 9657005

Title: A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus.

PubMed ID: 9657005

DOI: 10.1006/viro.1998.9218

PubMed ID: 10225955

Title: Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein.

PubMed ID: 10225955

DOI: 10.1083/jcb.145.3.539

PubMed ID: 11544254

Title: Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction.

PubMed ID: 11544254

DOI: 10.1074/jbc.m103810200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16679515

Title: Interaction of integrin alpha(v)beta3 with nectin. Implication in cross-talk between cell-matrix and cell-cell junctions.

PubMed ID: 16679515

DOI: 10.1074/jbc.m600301200

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 22146396

Title: Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion.

PubMed ID: 22146396

DOI: 10.1038/ncomms1571

PubMed ID: 21980294

Title: Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1.

PubMed ID: 21980294

DOI: 10.1371/journal.ppat.1002277

PubMed ID: 22902367

Title: Nectin ectodomain structures reveal a canonical adhesive interface.

PubMed ID: 22902367

DOI: 10.1038/nsmb.2366

Sequence Information:

  • Length: 517
  • Mass: 57158
  • Checksum: DF34C8AEC893EE6D
  • Sequence:
    • MARMGLAGAA GRWWGLALGL TAFFLPGVHS QVVQVNDSMY GFIGTDVVLH CSFANPLPSV 
KITQVTWQKS TNGSKQNVAI YNPSMGVSVL APYRERVEFL RPSFTDGTIR LSRLELEDEG 
VYICEFATFP TGNRESQLNL TVMAKPTNWI EGTQAVLRAK KGQDDKVLVA TCTSANGKPP 
SVVSWETRLK GEAEYQEIRN PNGTVTVISR YRLVPSREAH QQSLACIVNY HMDRFKESLT 
LNVQYEPEVT IEGFDGNWYL QRMDVKLTCK ADANPPATEY HWTTLNGSLP KGVEAQNRTL 
FFKGPINYSL AGTYICEATN PIGTRSGQVE VNITEFPYTP SPPEHGRRAG PVPTAIIGGV 
AGSILLVLIV VGGIVVALRR RRHTFKGDYS TKKHVYGNGY SKAGIPQHHP PMAQNLQYPD 
DSDDEKKAGP LGGSSYEEEE EEEEGGGGGE RKVGGPHPKY DEDAKRPYFT VDEAEARQDG 
YGDRTLGYQY DPEQLDLAEN MVSQNDGSFI SKKEWYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.