Details for: RAB3A

Gene ID: 5864

Symbol: RAB3A

Ensembl ID: ENSG00000105649

Description: RAB3A, member RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 85.3771
    Cell Significance Index: -13.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.1742
    Cell Significance Index: -12.9800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 28.0861
    Cell Significance Index: -11.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.2057
    Cell Significance Index: -10.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.7790
    Cell Significance Index: -13.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 7.6892
    Cell Significance Index: 403.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.3664
    Cell Significance Index: 275.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.2481
    Cell Significance Index: -11.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3983
    Cell Significance Index: -13.4100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.0890
    Cell Significance Index: 23.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.4273
    Cell Significance Index: 24.4600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2755
    Cell Significance Index: 27.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2358
    Cell Significance Index: 35.2700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.8911
    Cell Significance Index: 7.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7940
    Cell Significance Index: 159.2700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7567
    Cell Significance Index: 9.3900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.6192
    Cell Significance Index: 8.2600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4751
    Cell Significance Index: 6.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4748
    Cell Significance Index: 170.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3910
    Cell Significance Index: 38.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3755
    Cell Significance Index: 22.5400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.3688
    Cell Significance Index: 4.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3634
    Cell Significance Index: 69.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2730
    Cell Significance Index: 29.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2653
    Cell Significance Index: 239.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2344
    Cell Significance Index: 14.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2258
    Cell Significance Index: 15.1800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2044
    Cell Significance Index: 4.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1928
    Cell Significance Index: 31.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1213
    Cell Significance Index: 3.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0904
    Cell Significance Index: 10.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0849
    Cell Significance Index: 1.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0822
    Cell Significance Index: 0.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0784
    Cell Significance Index: 1.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0757
    Cell Significance Index: 5.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0585
    Cell Significance Index: 2.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0548
    Cell Significance Index: 1.5800
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.0521
    Cell Significance Index: 0.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0493
    Cell Significance Index: 26.9200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0486
    Cell Significance Index: 0.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0211
    Cell Significance Index: 2.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0179
    Cell Significance Index: 0.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0169
    Cell Significance Index: 7.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0169
    Cell Significance Index: 2.1700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.0060
    Cell Significance Index: 0.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0038
    Cell Significance Index: 0.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0028
    Cell Significance Index: -2.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0056
    Cell Significance Index: -10.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0062
    Cell Significance Index: -4.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0074
    Cell Significance Index: -11.4200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0080
    Cell Significance Index: -0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0086
    Cell Significance Index: -11.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0097
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0130
    Cell Significance Index: -9.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0131
    Cell Significance Index: -8.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0135
    Cell Significance Index: -7.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0148
    Cell Significance Index: -11.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0181
    Cell Significance Index: -8.2400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0194
    Cell Significance Index: -0.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0207
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0208
    Cell Significance Index: -13.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0218
    Cell Significance Index: -2.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0276
    Cell Significance Index: -0.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0279
    Cell Significance Index: -2.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0311
    Cell Significance Index: -0.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0315
    Cell Significance Index: -0.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0368
    Cell Significance Index: -10.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0473
    Cell Significance Index: -5.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0486
    Cell Significance Index: -9.6500
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0535
    Cell Significance Index: -0.5900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0558
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0616
    Cell Significance Index: -12.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0617
    Cell Significance Index: -1.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0650
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0673
    Cell Significance Index: -11.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0673
    Cell Significance Index: -8.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0706
    Cell Significance Index: -10.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0741
    Cell Significance Index: -2.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0766
    Cell Significance Index: -1.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0779
    Cell Significance Index: -1.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0806
    Cell Significance Index: -5.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0814
    Cell Significance Index: -4.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0829
    Cell Significance Index: -1.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0867
    Cell Significance Index: -9.9300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0927
    Cell Significance Index: -0.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0974
    Cell Significance Index: -3.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1008
    Cell Significance Index: -4.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1145
    Cell Significance Index: -3.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1146
    Cell Significance Index: -3.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1190
    Cell Significance Index: -9.1400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1209
    Cell Significance Index: -0.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1222
    Cell Significance Index: -9.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1223
    Cell Significance Index: -9.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1264
    Cell Significance Index: -13.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1319
    Cell Significance Index: -8.0900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1384
    Cell Significance Index: -2.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1438
    Cell Significance Index: -8.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1517
    Cell Significance Index: -7.1300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1572
    Cell Significance Index: -2.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Small GTPase function:** RAB3A is a small GTPase that regulates the activity of various proteins involved in exocytosis, including SNARE proteins, vesicle-associated motor proteins, and guanine nucleotide exchange factors. 2. **Exocytosis regulation:** RAB3A modulates the fusion of vesicles with the plasma membrane, a critical step in neurotransmitter release, hormone secretion, and other cellular processes. 3. **Neurotransmitter release:** RAB3A is essential for the release of neurotransmitters, such as acetylcholine, dopamine, and serotonin, in neurons and other cell types. 4. **Cell type specificity:** RAB3A is expressed in various cell types, including neurons, immune cells, and epithelial cells, highlighting its pleiotropic role in different cellular contexts. **Pathways and Functions:** 1. **Acetylcholine neurotransmitter release cycle:** RAB3A regulates the fusion of acetylcholine-containing vesicles with the plasma membrane, enabling neurotransmission in the nervous system. 2. **Acrosomal vesicle exocytosis:** RAB3A is involved in the fusion of acrosomal vesicles with the plasma membrane during sperm motility and fertilization. 3. **Calcium-ion regulated exocytosis:** RAB3A modulates the release of calcium ions from intracellular stores, influencing exocytosis and cellular signaling. 4. **Clathrin-sculpted vesicle membrane formation:** RAB3A regulates the formation of clathrin-sculpted vesicles, which are essential for the transport of proteins and lipids within the cell. 5. **Regulation of exocytosis:** RAB3A positively regulates exocytosis by modulating the activity of SNARE proteins and other exocytosis-related proteins. **Clinical Significance:** 1. **Neurological disorders:** RAB3A mutations have been implicated in neurological disorders, such as epilepsy, schizophrenia, and autism spectrum disorder. 2. **Cancer:** RAB3A overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. 3. **Neuromuscular disorders:** RAB3A mutations have been associated with neuromuscular disorders, such as myasthenia gravis and Lambert-Eaton myasthenic syndrome. 4. **Immunological disorders:** RAB3A is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. In conclusion, RAB3A is a crucial regulator of exocytosis and neurotransmission, with implications for various physiological and pathological processes. Further research on this gene will provide valuable insights into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 2970739155

Symbol: RAB3A_HUMAN

Name: Ras-related protein Rab-3A

UniProtKB Accession Codes:

P20336 A8K0J4 Q9NYE1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 54 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 10 RefSeq 2 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2501306

Title: The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.

PubMed ID: 2501306

DOI: 10.1016/s0021-9258(18)63872-4

PubMed ID: 10574328

Title: Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND.

PubMed ID: 10574328

DOI: 10.1016/s0898-6568(99)00037-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1648736

Title: Isoprenoid modification of rab proteins terminating in CC or CXC motifs.

PubMed ID: 1648736

DOI: 10.1073/pnas.88.14.6264

PubMed ID: 7991565

Title: Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.

PubMed ID: 7991565

DOI: 10.1073/pnas.91.25.11963

PubMed ID: 15207266

Title: Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.

PubMed ID: 15207266

DOI: 10.1016/j.nbd.2004.01.001

PubMed ID: 22248876

Title: RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.

PubMed ID: 22248876

DOI: 10.1016/j.yexcr.2012.01.002

PubMed ID: 26824392

Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

PubMed ID: 26824392

DOI: 10.7554/elife.12813

PubMed ID: 27325790

Title: A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair.

PubMed ID: 27325790

DOI: 10.1083/jcb.201511093

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

PubMed ID: 30599141

Title: Grab recruitment by Rab27A-Rabphilin3a triggers Rab3A activation in human sperm exocytosis.

PubMed ID: 30599141

DOI: 10.1016/j.bbamcr.2018.12.005

Sequence Information:

  • Length: 220
  • Mass: 24984
  • Checksum: 08B59F8C9BD2EB40
  • Sequence:
    • MASATDSRYG QKESSDQNFD YMFKILIIGN SSVGKTSFLF RYADDSFTPA FVSTVGIDFK 
VKTIYRNDKR IKLQIWDTAG QERYRTITTA YYRGAMGFIL MYDITNEESF NAVQDWSTQI 
KTYSWDNAQV LLVGNKCDME DERVVSSERG RQLADHLGFE FFEASAKDNI NVKQTFERLV 
DVICEKMSES LDTADPAVTG AKQGPQLSDQ QVPPHQDCAC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.