Details for: RAD9A

Gene ID: 5883

Symbol: RAD9A

Ensembl ID: ENSG00000172613

Description: RAD9 checkpoint clamp component A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 187.7910
    Cell Significance Index: -29.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.7314
    Cell Significance Index: -31.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.1604
    Cell Significance Index: -31.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.0392
    Cell Significance Index: -27.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.6676
    Cell Significance Index: -32.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.1190
    Cell Significance Index: -31.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.0841
    Cell Significance Index: -22.0700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7896
    Cell Significance Index: -26.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4464
    Cell Significance Index: -33.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.5599
    Cell Significance Index: 71.5400
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.3907
    Cell Significance Index: 14.7500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.0464
    Cell Significance Index: 18.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9789
    Cell Significance Index: 27.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6975
    Cell Significance Index: 608.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1719
    Cell Significance Index: 53.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1668
    Cell Significance Index: 51.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0888
    Cell Significance Index: 41.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9937
    Cell Significance Index: 66.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9679
    Cell Significance Index: 192.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.9444
    Cell Significance Index: 26.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9309
    Cell Significance Index: 108.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8677
    Cell Significance Index: 783.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8650
    Cell Significance Index: 598.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7888
    Cell Significance Index: 17.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6830
    Cell Significance Index: 13.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6140
    Cell Significance Index: 47.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6131
    Cell Significance Index: 66.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6054
    Cell Significance Index: 98.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5706
    Cell Significance Index: 32.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5659
    Cell Significance Index: 14.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4629
    Cell Significance Index: 92.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4351
    Cell Significance Index: 43.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4083
    Cell Significance Index: 11.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2610
    Cell Significance Index: 13.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2444
    Cell Significance Index: 30.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2383
    Cell Significance Index: 16.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2202
    Cell Significance Index: 120.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2188
    Cell Significance Index: 39.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1964
    Cell Significance Index: 10.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1949
    Cell Significance Index: 26.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1478
    Cell Significance Index: 65.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1363
    Cell Significance Index: 256.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1039
    Cell Significance Index: 159.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0900
    Cell Significance Index: 57.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0897
    Cell Significance Index: 165.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0822
    Cell Significance Index: 5.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0597
    Cell Significance Index: 7.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0566
    Cell Significance Index: 25.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0235
    Cell Significance Index: 31.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0070
    Cell Significance Index: 0.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0005
    Cell Significance Index: 0.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0007
    Cell Significance Index: -0.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0178
    Cell Significance Index: -0.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0278
    Cell Significance Index: -0.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0309
    Cell Significance Index: -22.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0311
    Cell Significance Index: -0.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0353
    Cell Significance Index: -26.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0364
    Cell Significance Index: -26.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0370
    Cell Significance Index: -4.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0450
    Cell Significance Index: -2.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0561
    Cell Significance Index: -31.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0577
    Cell Significance Index: -4.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0593
    Cell Significance Index: -37.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0626
    Cell Significance Index: -2.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0696
    Cell Significance Index: -3.2700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0898
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0915
    Cell Significance Index: -15.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0945
    Cell Significance Index: -2.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1012
    Cell Significance Index: -29.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1076
    Cell Significance Index: -15.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1087
    Cell Significance Index: -6.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1146
    Cell Significance Index: -11.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1229
    Cell Significance Index: -4.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1339
    Cell Significance Index: -3.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1611
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1658
    Cell Significance Index: -34.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1690
    Cell Significance Index: -3.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2101
    Cell Significance Index: -24.0700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2534
    Cell Significance Index: -3.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2583
    Cell Significance Index: -26.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2870
    Cell Significance Index: -20.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3048
    Cell Significance Index: -4.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3249
    Cell Significance Index: -19.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3723
    Cell Significance Index: -29.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4014
    Cell Significance Index: -24.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4059
    Cell Significance Index: -13.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4088
    Cell Significance Index: -10.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4098
    Cell Significance Index: -8.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4765
    Cell Significance Index: -7.1400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5023
    Cell Significance Index: -6.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5168
    Cell Significance Index: -26.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5904
    Cell Significance Index: -19.3300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5974
    Cell Significance Index: -8.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6223
    Cell Significance Index: -19.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6367
    Cell Significance Index: -18.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6403
    Cell Significance Index: -18.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6429
    Cell Significance Index: -5.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7159
    Cell Significance Index: -25.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7162
    Cell Significance Index: -20.5300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7394
    Cell Significance Index: -5.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Role in DNA Damage Response:** RAD9A is a key component of the RAD9 checkpoint clamp complex, which is activated in response to DNA double-strand breaks. 2. **Checkpoint Clamp Function:** RAD9A forms a clamp structure that recruits other proteins to the DNA damage site, facilitating the recruitment of DNA repair proteins and preventing the propagation of DNA damage. 3. **Homologous Recombination Repair (HRR) Deficiency:** RAD9A is involved in HRR, a critical pathway for repairing DNA double-strand breaks. Loss of function in RAD9A can lead to defective HRR, increasing the risk of genomic instability. 4. **Interactions with Other Proteins:** RAD9A interacts with various proteins, including BRCA2, TP53, and RAD51, to regulate the DNA damage response pathway. **Pathways and Functions:** 1. **3'-5' Exonuclease Activity:** RAD9A possesses 3'-5' exonuclease activity, which is essential for processing DNA double-strand breaks. 2. **Activation of ATR in Response to Replication Stress:** RAD9A activates ATR, a kinase that responds to replication stress and DNA damage. 3. **Cell Cycle Checkpoint Signaling:** RAD9A regulates cell cycle checkpoint signaling, preventing the propagation of DNA damage and allowing for DNA repair. 4. **DNA Damage Response Signaling:** RAD9A is involved in DNA damage response signaling, including the regulation of TP53 activity and the intrinsic apoptotic signaling pathway. 5. **Homologous Recombination Repair (HRR):** RAD9A is essential for HRR, a critical pathway for repairing DNA double-strand breaks. **Clinical Significance:** 1. **Cancer Association:** RAD9A is associated with various types of cancer, including breast, ovarian, and prostate cancer. 2. **Genetic Instability:** Defects in RAD9A can lead to genetic instability, increasing the risk of cancer and other diseases. 3. **Radiosensitivity:** RAD9A plays a critical role in maintaining genome stability, and defects in this gene can lead to radiosensitivity, increasing the risk of radiation-induced cancer. 4. **Neurological Disorders:** RAD9A is significantly expressed in GABAergic cortical interneurons, and defects in this gene have been associated with neurological disorders, including epilepsy and schizophrenia. In conclusion, RAD9A is a crucial component of the DNA damage response pathway, and its dysregulation can lead to genetic instability and an increased risk of cancer and other diseases. Further research is needed to understand the mechanisms by which RAD9A regulates the DNA damage response pathway and to develop therapeutic strategies for targeting this gene in cancer and other diseases.

Genular Protein ID: 3039255711

Symbol: RAD9A_HUMAN

Name: Cell cycle checkpoint control protein RAD9A

UniProtKB Accession Codes:

Q99638 B2RCZ8 Q6FI29 Q96C41

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 2 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8943031

Title: A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene.

PubMed ID: 8943031

DOI: 10.1073/pnas.93.24.13890

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12709442

Title: Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling.

PubMed ID: 12709442

DOI: 10.1074/jbc.m301544200

PubMed ID: 10359610

Title: The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1.

PubMed ID: 10359610

DOI: 10.1091/mbc.10.6.1985

PubMed ID: 10777662

Title: Physical interaction among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression.

PubMed ID: 10777662

DOI: 10.1006/geno.2000.6142

PubMed ID: 10713044

Title: Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease.

PubMed ID: 10713044

DOI: 10.1074/jbc.275.11.7451

PubMed ID: 10846170

Title: HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins.

PubMed ID: 10846170

DOI: 10.1074/jbc.m000168200

PubMed ID: 10884395

Title: The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9.

PubMed ID: 10884395

DOI: 10.1074/jbc.m005782200

PubMed ID: 11573955

Title: The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9.

PubMed ID: 11573955

DOI: 10.1006/bbrc.2001.5685

PubMed ID: 11971963

Title: c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage.

PubMed ID: 11971963

DOI: 10.1128/mcb.22.10.3292-3300.2002

PubMed ID: 14500360

Title: Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue.

PubMed ID: 14500360

PubMed ID: 12628935

Title: Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9.

PubMed ID: 12628935

DOI: 10.1093/emboj/cdg134

PubMed ID: 12578958

Title: Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro.

PubMed ID: 12578958

DOI: 10.1073/pnas.0437927100

PubMed ID: 15314187

Title: The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair.

PubMed ID: 15314187

DOI: 10.1093/nar/gkh652

PubMed ID: 15556996

Title: The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1.

PubMed ID: 15556996

DOI: 10.1073/pnas.0407686101

PubMed ID: 15871698

Title: The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery.

PubMed ID: 15871698

DOI: 10.1042/bj20050211

PubMed ID: 16216273

Title: The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity.

PubMed ID: 16216273

DOI: 10.1016/j.jmb.2005.09.018

PubMed ID: 15897895

Title: Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells.

PubMed ID: 15897895

DOI: 10.1038/sj.onc.1208674

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17575048

Title: The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

PubMed ID: 17575048

DOI: 10.1101/gad.1547007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20545769

Title: Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1.

PubMed ID: 20545769

DOI: 10.1111/j.1365-2443.2010.01418.x

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21659603

Title: A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.

PubMed ID: 21659603

DOI: 10.1126/science.1203430

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31135337

Title: Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.

PubMed ID: 31135337

DOI: 10.7554/elife.44353

PubMed ID: 31776186

Title: Structure of the RAD9-RAD1-HUS1 checkpoint clamp bound to RHINO sheds light on the other side of the DNA clamp.

PubMed ID: 31776186

DOI: 10.1074/jbc.ac119.011816

PubMed ID: 36841485

Title: The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO.

PubMed ID: 36841485

DOI: 10.1016/j.jbc.2023.103061

Sequence Information:

  • Length: 391
  • Mass: 42547
  • Checksum: 4D4D6D4C6E1057D3
  • Sequence:
    • MKCLVTGGNV KVLGKAVHSL SRIGDELYLE PLEDGLSLRT VNSSRSAYAC FLFAPLFFQQ 
YQAATPGQDL LRCKILMKSF LSVFRSLAML EKTVEKCCIS LNGRSSRLVV QLHCKFGVRK 
THNLSFQDCE SLQAVFDPAS CPHMLRAPAR VLGEAVLPFS PALAEVTLGI GRGRRVILRS 
YHEEEADSTA KAMVTEMCLG EEDFQQLQAQ EGVAITFCLK EFRGLLSFAE SANLNLSIHF 
DAPGRPAIFT IKDSLLDGHF VLATLSDTDS HSQDLGSPER HQPVPQLQAH STPHPDDFAN 
DDIDSYMIAM ETTIGNEGSR VLPSISLSPG PQPPKSPGPH SEEEDEAEPS TVPGTPPPKK 
FRSLFFGSIL APVRSPQGPS PVLAEDSEGE G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.