Details for: RAD51

Gene ID: 5888

Symbol: RAD51

Ensembl ID: ENSG00000051180

Description: RAD51 recombinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.4798
    Cell Significance Index: -4.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.5457
    Cell Significance Index: -4.3400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.5731
    Cell Significance Index: 58.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.2442
    Cell Significance Index: -4.0000
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 3.0083
    Cell Significance Index: 1.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.7657
    Cell Significance Index: -4.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4073
    Cell Significance Index: -3.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.1556
    Cell Significance Index: -4.5600
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 1.1268
    Cell Significance Index: 0.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6418
    Cell Significance Index: 20.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4651
    Cell Significance Index: 27.9200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.3769
    Cell Significance Index: 5.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2682
    Cell Significance Index: 9.3200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.2486
    Cell Significance Index: 3.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2004
    Cell Significance Index: 11.2500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1961
    Cell Significance Index: 3.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1710
    Cell Significance Index: 7.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1591
    Cell Significance Index: 17.3000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.1393
    Cell Significance Index: 1.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1321
    Cell Significance Index: 6.8600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1198
    Cell Significance Index: 3.2100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0840
    Cell Significance Index: 1.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0785
    Cell Significance Index: 2.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0689
    Cell Significance Index: 6.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0682
    Cell Significance Index: 1.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0611
    Cell Significance Index: 1.7600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0565
    Cell Significance Index: 0.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0485
    Cell Significance Index: 26.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0480
    Cell Significance Index: 9.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0414
    Cell Significance Index: 4.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0366
    Cell Significance Index: 5.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0357
    Cell Significance Index: 4.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0286
    Cell Significance Index: 0.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0196
    Cell Significance Index: 7.0300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0194
    Cell Significance Index: 0.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0191
    Cell Significance Index: 2.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0143
    Cell Significance Index: 0.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0042
    Cell Significance Index: 0.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0039
    Cell Significance Index: 0.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0039
    Cell Significance Index: 7.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0038
    Cell Significance Index: 5.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0010
    Cell Significance Index: 1.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0006
    Cell Significance Index: 1.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0021
    Cell Significance Index: -1.3500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0038
    Cell Significance Index: -0.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0047
    Cell Significance Index: -2.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0049
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0066
    Cell Significance Index: -4.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0090
    Cell Significance Index: -5.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0106
    Cell Significance Index: -0.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0124
    Cell Significance Index: -3.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0133
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0156
    Cell Significance Index: -2.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0167
    Cell Significance Index: -0.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0179
    Cell Significance Index: -2.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0180
    Cell Significance Index: -1.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0195
    Cell Significance Index: -3.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0213
    Cell Significance Index: -1.3400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0222
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0231
    Cell Significance Index: -4.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0240
    Cell Significance Index: -2.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0270
    Cell Significance Index: -0.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0336
    Cell Significance Index: -2.5800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0366
    Cell Significance Index: -0.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0384
    Cell Significance Index: -4.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0400
    Cell Significance Index: -1.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0430
    Cell Significance Index: -2.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0508
    Cell Significance Index: -2.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0551
    Cell Significance Index: -0.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0553
    Cell Significance Index: -3.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0557
    Cell Significance Index: -2.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0659
    Cell Significance Index: -3.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0671
    Cell Significance Index: -2.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0699
    Cell Significance Index: -4.8400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0725
    Cell Significance Index: -1.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0740
    Cell Significance Index: -2.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0813
    Cell Significance Index: -3.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0891
    Cell Significance Index: -4.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0935
    Cell Significance Index: -3.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0945
    Cell Significance Index: -3.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0996
    Cell Significance Index: -3.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1005
    Cell Significance Index: -2.2000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1005
    Cell Significance Index: -1.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1028
    Cell Significance Index: -2.7500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1032
    Cell Significance Index: -0.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1047
    Cell Significance Index: -3.6800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1070
    Cell Significance Index: -0.9700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1071
    Cell Significance Index: -0.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1081
    Cell Significance Index: -2.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1131
    Cell Significance Index: -4.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1140
    Cell Significance Index: -0.9300
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1210
    Cell Significance Index: -0.8800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1231
    Cell Significance Index: -3.0700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1238
    Cell Significance Index: -2.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Function**: RAD51 is a recombinase protein that catalyzes the exchange of genetic information between homologous DNA strands, facilitating the repair of DNA DSBs. 2. **Expression**: RAD51 is highly expressed in various cell types, including hematopoietic cells, epithelial cells, and neurons. 3. **Cellular localization**: RAD51 is primarily localized to the nucleus, where it interacts with other proteins involved in DNA repair and replication. 4. **Interactions**: RAD51 interacts with other proteins, including BRCA1 and BRCA2, to facilitate the repair of DNA DSBs. 5. **Disease association**: Alterations in RAD51 expression or function have been associated with several diseases, including cancer. **Pathways and Functions** RAD51 is involved in several cellular pathways, including: 1. **Homologous Recombination Repair (HRR)**: RAD51 plays a central role in the HRR pathway, which is responsible for the repair of DNA DSBs. 2. **Cell Cycle**: RAD51 is involved in the regulation of the cell cycle, particularly during the G2/M phase, where it helps to maintain genome stability. 3. **DNA Damage Response**: RAD51 is activated in response to DNA damage, where it facilitates the repair of DNA DSBs. 4. **Meiotic Recombination**: RAD51 is involved in meiotic recombination, where it facilitates the exchange of genetic information between homologous chromosomes. **Functions** RAD51 has several functional roles, including: 1. **DNA Strand Exchange**: RAD51 catalyzes the exchange of genetic information between homologous DNA strands. 2. **DNA Repair**: RAD51 facilitates the repair of DNA DSBs through the HRR pathway. 3. **Genome Stability**: RAD51 maintains genome stability by facilitating the repair of DNA DSBs and preventing genomic instability. **Clinical Significance** Alterations in RAD51 expression or function have been associated with several diseases, including: 1. **Cancer**: RAD51 deficiency or overexpression has been linked to an increased risk of cancer, particularly breast and ovarian cancer. 2. **Genetic Disorders**: RAD51 mutations have been associated with genetic disorders, such as Fanconi anemia, a rare genetic disorder characterized by bone marrow failure and increased risk of cancer. 3. **DNA Repair Deficiencies**: RAD51 deficiency has been linked to DNA repair deficiencies, which can lead to genomic instability and increased risk of cancer. In conclusion, RAD51 is a crucial gene involved in the repair of DNA double-strand breaks through the homologous recombination repair pathway. Alterations in RAD51 expression or function have been associated with several diseases, highlighting the importance of this gene in maintaining genome stability.

Genular Protein ID: 798253911

Symbol: RAD51_HUMAN

Name: RAD51 homolog A

UniProtKB Accession Codes:

Q06609 B0FXP0 B2R8T6 Q6FHX9 Q6ZNA8 Q9BV60

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 ELM 1 EMBL 27 EMDB 23 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 58 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 25 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 13 RefSeq 10 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8358431

Title: Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA.

PubMed ID: 8358431

DOI: 10.1038/ng0793-239

PubMed ID: 8479919

Title: Cloning and sequence of the human RecA-like gene cDNA.

PubMed ID: 8479919

DOI: 10.1093/nar/21.7.1665

PubMed ID: 10493508

Title: Characterization of the human Rad51 genomic locus and examination of tumors with 15q14-15 loss of heterozygosity (LOH).

PubMed ID: 10493508

PubMed ID: 11535547

Title: A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers.

PubMed ID: 11535547

PubMed ID: 18417535

Title: Identification of a novel human Rad51 variant that promotes DNA strand exchange.

PubMed ID: 18417535

DOI: 10.1093/nar/gkn171

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7988572

Title: Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA.

PubMed ID: 7988572

DOI: 10.1002/j.1460-2075.1994.tb06914.x

PubMed ID: 9321665

Title: Interaction of human recombination proteins Rad51 and Rad54.

PubMed ID: 9321665

DOI: 10.1093/nar/25.20.4106

PubMed ID: 9396801

Title: A novel nucleic acid-binding protein that interacts with human rad51 recombinase.

PubMed ID: 9396801

DOI: 10.1093/nar/25.24.4946

PubMed ID: 9192668

Title: RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein.

PubMed ID: 9192668

DOI: 10.1073/pnas.94.13.6927

PubMed ID: 9461559

Title: Regulation of Rad51 function by c-Abl in response to DNA damage.

PubMed ID: 9461559

DOI: 10.1074/jbc.273.7.3799

PubMed ID: 10851248

Title: A novel human Rad54 homologue, Rad54B, associates with Rad51.

PubMed ID: 10851248

DOI: 10.1074/jbc.m910306199

PubMed ID: 12205100

Title: Homologous DNA pairing by human recombination factors Rad51 and Rad54.

PubMed ID: 12205100

DOI: 10.1074/jbc.m208004200

PubMed ID: 11842113

Title: Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.

PubMed ID: 11842113

DOI: 10.1093/nar/30.4.1009

PubMed ID: 12427746

Title: Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro.

PubMed ID: 12427746

DOI: 10.1074/jbc.m211038200

PubMed ID: 14580352

Title: Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2.

PubMed ID: 14580352

DOI: 10.1016/s1097-2765(03)00394-0

PubMed ID: 16215984

Title: Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51.

PubMed ID: 16215984

DOI: 10.1002/jcb.20640

PubMed ID: 15665856

Title: The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair.

PubMed ID: 15665856

DOI: 10.1038/ncb1212

PubMed ID: 16990250

Title: RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51.

PubMed ID: 16990250

DOI: 10.1093/nar/gkl665

PubMed ID: 18449195

Title: Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.

PubMed ID: 18449195

DOI: 10.1038/nature06883

PubMed ID: 19783859

Title: Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C.

PubMed ID: 19783859

DOI: 10.1074/jbc.m109.024646

PubMed ID: 20348101

Title: Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity.

PubMed ID: 20348101

DOI: 10.1074/jbc.m110.110478

PubMed ID: 20413593

Title: Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome.

PubMed ID: 20413593

DOI: 10.1074/jbc.m109.099846

PubMed ID: 20705237

Title: Regulation of DNA repair through desumoylation and sumoylation of replication protein A complex.

PubMed ID: 20705237

DOI: 10.1016/j.molcel.2010.07.021

PubMed ID: 19995904

Title: DNA polymerase POLN participates in cross-link repair and homologous recombination.

PubMed ID: 19995904

DOI: 10.1128/mcb.01124-09

PubMed ID: 20231364

Title: RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase.

PubMed ID: 20231364

DOI: 10.1128/mcb.01583-09

PubMed ID: 20154705

Title: A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination.

PubMed ID: 20154705

DOI: 10.1038/nsmb.1769

PubMed ID: 20871615

Title: Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination.

PubMed ID: 20871615

DOI: 10.1038/nsmb.1915

PubMed ID: 21276791

Title: Homologous recombination proteins are associated with centrosomes and are required for mitotic stability.

PubMed ID: 21276791

DOI: 10.1016/j.yexcr.2011.01.021

PubMed ID: 21252223

Title: The role of human SWI5-MEI5 complex in homologous recombination repair.

PubMed ID: 21252223

DOI: 10.1074/jbc.m110.207290

PubMed ID: 21965664

Title: hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair.

PubMed ID: 21965664

DOI: 10.1074/jbc.m111.271080

PubMed ID: 22305526

Title: RAD51 haploinsufficiency causes congenital mirror movements in humans.

PubMed ID: 22305526

DOI: 10.1016/j.ajhg.2011.12.002

PubMed ID: 22153967

Title: Inhibition of homologous recombination by the PCNA-interacting protein PARI.

PubMed ID: 22153967

DOI: 10.1016/j.molcel.2011.11.010

PubMed ID: 22325354

Title: Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.

PubMed ID: 22325354

DOI: 10.1016/j.molcel.2011.12.028

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23401855

Title: The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination.

PubMed ID: 23401855

DOI: 10.1128/mcb.01503-12

PubMed ID: 24013206

Title: A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.

PubMed ID: 24013206

DOI: 10.1038/nsmb.2666

PubMed ID: 23393192

Title: Single-molecule sorting reveals how ubiquitylation affects substrate recognition and activities of FBH1 helicase.

PubMed ID: 23393192

DOI: 10.1093/nar/gkt056

PubMed ID: 24141787

Title: Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.

PubMed ID: 24141787

DOI: 10.1038/onc.2013.421

PubMed ID: 23754376

Title: FIGNL1-containing protein complex is required for efficient homologous recombination repair.

PubMed ID: 23754376

DOI: 10.1073/pnas.1220662110

PubMed ID: 23509288

Title: Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.

PubMed ID: 23509288

DOI: 10.1073/pnas.1220921110

PubMed ID: 26253028

Title: A dominant mutation in human RAD51 reveals its function in DNA interstrand crosslink repair independent of homologous recombination.

PubMed ID: 26253028

DOI: 10.1016/j.molcel.2015.07.009

PubMed ID: 25642963

Title: Homologous-recombination-deficient tumours are dependent on Poltheta-mediated repair.

PubMed ID: 25642963

DOI: 10.1038/nature14184

PubMed ID: 27797818

Title: The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress.

PubMed ID: 27797818

DOI: 10.15252/embj.201593132

PubMed ID: 26811421

Title: TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.

PubMed ID: 26811421

DOI: 10.1083/jcb.201507042

PubMed ID: 26833090

Title: Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability.

PubMed ID: 26833090

DOI: 10.1016/j.molcel.2015.12.026

PubMed ID: 28575658

Title: RFWD3-mediated ubiquitination promotes timely removal of both RPA and RAD51 from dna damage sites to facilitate homologous recombination.

PubMed ID: 28575658

DOI: 10.1016/j.molcel.2017.04.022

PubMed ID: 31844045

Title: ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress.

PubMed ID: 31844045

DOI: 10.1038/s41467-019-13667-4

PubMed ID: 32640219

Title: The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells.

PubMed ID: 32640219

DOI: 10.1016/j.celrep.2020.107849

PubMed ID: 34937945

Title: HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51.

PubMed ID: 34937945

DOI: 10.1038/s41586-021-04261-0

PubMed ID: 38459011

Title: GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer.

PubMed ID: 38459011

DOI: 10.1038/s41467-024-46283-y

PubMed ID: 10390347

Title: The N-terminal domain of the human Rad51 protein binds DNA: structure and a DNA binding surface as revealed by NMR.

PubMed ID: 10390347

DOI: 10.1006/jmbi.1999.2904

PubMed ID: 12442171

Title: Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.

PubMed ID: 12442171

DOI: 10.1038/nature01230

PubMed ID: 10807537

Title: Identification of Rad51 alteration in patients with bilateral breast cancer.

PubMed ID: 10807537

DOI: 10.1007/s100380050199

PubMed ID: 26681308

Title: A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51.

PubMed ID: 26681308

DOI: 10.1038/ncomms9829

PubMed ID: 25539919

Title: Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase.

PubMed ID: 25539919

DOI: 10.1093/nar/gku1337

Sequence Information:

  • Length: 339
  • Mass: 36966
  • Checksum: 26578E6206DEDEDA
  • Sequence:
    • MAMQMQLEAN ADTSVEEESF GPQPISRLEQ CGINANDVKK LEEAGFHTVE AVAYAPKKEL 
INIKGISEAK ADKILAEAAK LVPMGFTTAT EFHQRRSEII QITTGSKELD KLLQGGIETG 
SITEMFGEFR TGKTQICHTL AVTCQLPIDR GGGEGKAMYI DTEGTFRPER LLAVAERYGL 
SGSDVLDNVA YARAFNTDHQ TQLLYQASAM MVESRYALLI VDSATALYRT DYSGRGELSA 
RQMHLARFLR MLLRLADEFG VAVVITNQVV AQVDGAAMFA ADPKKPIGGN IIAHASTTRL 
YLRKGRGETR ICKIYDSPCL PEAEAMFAIN ADGVGDAKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.