Details for: RAD51D

Gene ID: 5892

Symbol: RAD51D

Ensembl ID: ENSG00000185379

Description: RAD51 paralog D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 79.4624
    Cell Significance Index: -12.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 44.3536
    Cell Significance Index: -11.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.7871
    Cell Significance Index: -13.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9424
    Cell Significance Index: -13.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.5386
    Cell Significance Index: -13.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4237
    Cell Significance Index: -13.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9955
    Cell Significance Index: 189.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9695
    Cell Significance Index: 194.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8383
    Cell Significance Index: 82.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6068
    Cell Significance Index: 36.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4920
    Cell Significance Index: 53.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4864
    Cell Significance Index: 174.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4163
    Cell Significance Index: 67.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4085
    Cell Significance Index: 18.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3964
    Cell Significance Index: 15.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3893
    Cell Significance Index: 269.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3878
    Cell Significance Index: 350.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1919
    Cell Significance Index: 9.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1881
    Cell Significance Index: 13.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1775
    Cell Significance Index: 11.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1690
    Cell Significance Index: 23.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1613
    Cell Significance Index: 9.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1461
    Cell Significance Index: 4.2100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1361
    Cell Significance Index: 2.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1199
    Cell Significance Index: 34.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1106
    Cell Significance Index: 8.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1096
    Cell Significance Index: 4.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1029
    Cell Significance Index: 2.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0904
    Cell Significance Index: 16.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0766
    Cell Significance Index: 33.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0611
    Cell Significance Index: 7.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0501
    Cell Significance Index: 1.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0491
    Cell Significance Index: 26.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0389
    Cell Significance Index: 2.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0280
    Cell Significance Index: 3.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0239
    Cell Significance Index: 2.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0001
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0072
    Cell Significance Index: -13.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0095
    Cell Significance Index: -6.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0129
    Cell Significance Index: -9.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0139
    Cell Significance Index: -10.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0183
    Cell Significance Index: -10.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0194
    Cell Significance Index: -12.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0230
    Cell Significance Index: -0.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0271
    Cell Significance Index: -1.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0315
    Cell Significance Index: -14.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0330
    Cell Significance Index: -4.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0390
    Cell Significance Index: -6.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0443
    Cell Significance Index: -5.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0471
    Cell Significance Index: -4.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0480
    Cell Significance Index: -1.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0540
    Cell Significance Index: -1.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0634
    Cell Significance Index: -2.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0667
    Cell Significance Index: -4.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0740
    Cell Significance Index: -1.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0740
    Cell Significance Index: -8.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0743
    Cell Significance Index: -3.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0778
    Cell Significance Index: -16.3900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0778
    Cell Significance Index: -1.0500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0792
    Cell Significance Index: -1.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0848
    Cell Significance Index: -12.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0906
    Cell Significance Index: -6.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0924
    Cell Significance Index: -4.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1111
    Cell Significance Index: -7.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1297
    Cell Significance Index: -2.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1324
    Cell Significance Index: -8.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1440
    Cell Significance Index: -3.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1460
    Cell Significance Index: -11.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1494
    Cell Significance Index: -5.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1719
    Cell Significance Index: -4.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2312
    Cell Significance Index: -6.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2314
    Cell Significance Index: -6.2000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2322
    Cell Significance Index: -3.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2449
    Cell Significance Index: -6.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2668
    Cell Significance Index: -4.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2788
    Cell Significance Index: -6.9700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2850
    Cell Significance Index: -3.5400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2862
    Cell Significance Index: -5.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2865
    Cell Significance Index: -9.3800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3007
    Cell Significance Index: -4.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3036
    Cell Significance Index: -7.2800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3150
    Cell Significance Index: -3.9800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.3168
    Cell Significance Index: -1.9600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3210
    Cell Significance Index: -6.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3231
    Cell Significance Index: -10.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3287
    Cell Significance Index: -7.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3326
    Cell Significance Index: -12.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3384
    Cell Significance Index: -9.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3407
    Cell Significance Index: -10.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3505
    Cell Significance Index: -12.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3509
    Cell Significance Index: -3.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3511
    Cell Significance Index: -4.7900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3569
    Cell Significance Index: -4.4500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3597
    Cell Significance Index: -5.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3697
    Cell Significance Index: -7.6700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3712
    Cell Significance Index: -4.7600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3781
    Cell Significance Index: -7.5900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3823
    Cell Significance Index: -8.2600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3835
    Cell Significance Index: -4.8400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.3946
    Cell Significance Index: -4.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RAD51D is a DNA repair protein that belongs to the RAD51 family, which is involved in the repair of DNA double-strand breaks through homologous recombination. Unlike RAD51, which is the primary protein involved in HRR, RAD51D has distinct characteristics that set it apart from its paralog. RAD51D is specifically expressed in neurons and lymphoid lineage-restricted progenitor cells, where it plays a critical role in maintaining genomic integrity. RAD51D has also been shown to interact with other proteins, such as BRCA2 and PALB2, which are involved in the repair of DNA double-strand breaks. **Pathways and Functions** RAD51D is involved in several cellular pathways, including: 1. **Homologous Recombination Repair (HRR)**: RAD51D is involved in the repair of DNA double-strand breaks through HRR, which is a critical process for maintaining genomic integrity. 2. **Telomere Maintenance**: RAD51D is involved in the maintenance of telomeres, which are essential for preventing genomic instability and cancer. 3. **Cell Cycle Regulation**: RAD51D is involved in the regulation of the cell cycle, particularly in the G2/M phase, where it helps to ensure the accurate replication of DNA. 4. **Transcriptional Regulation**: RAD51D is involved in the transcriptional regulation of DNA repair genes, including BRCA1 and BRCA2. **Clinical Significance** RAD51D is clinically significant because it plays a critical role in maintaining genomic integrity. Mutations in RAD51D have been associated with various diseases, including: 1. **Cancer**: RAD51D mutations have been associated with an increased risk of cancer, particularly in neurons and lymphoid lineage-restricted progenitor cells. 2. **Neurodegenerative Diseases**: RAD51D mutations have been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Immunodeficiency**: RAD51D mutations have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, RAD51D is a critical gene involved in homologous recombination repair and telomere maintenance. Its dysregulation has been associated with various diseases, including cancer, neurodegenerative diseases, and immunodeficiency disorders. Further research is needed to fully understand the role of RAD51D in human disease and to develop therapeutic strategies for the treatment of RAD51D-related disorders.

Genular Protein ID: 4245154636

Symbol: RA51D_HUMAN

Name: DNA repair protein RAD51 homolog 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9512535

Title: Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family.

PubMed ID: 9512535

DOI: 10.1093/nar/26.7.1653

PubMed ID: 9570954

Title: Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene.

PubMed ID: 9570954

DOI: 10.1006/geno.1998.5226

PubMed ID: 10092526

Title: Multiple alternative transcripts of the human homologue of the mouse TRAD/R51H3/RAD51D gene, a member of the recA/RAD51 gene family.

PubMed ID: 10092526

DOI: 10.1006/bbrc.1999.0413

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10871607

Title: The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2.

PubMed ID: 10871607

DOI: 10.1074/jbc.m002075200

PubMed ID: 11751635

Title: Identification and purification of two distinct complexes containing the five RAD51 paralogs.

PubMed ID: 11751635

DOI: 10.1101/gad.947001

PubMed ID: 11834724

Title: Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex.

PubMed ID: 11834724

DOI: 10.1074/jbc.m105719200

PubMed ID: 11842113

Title: Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.

PubMed ID: 11842113

DOI: 10.1093/nar/30.4.1009

PubMed ID: 11744692

Title: RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51.

PubMed ID: 11744692

DOI: 10.1074/jbc.m108306200

PubMed ID: 11842112

Title: Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells.

PubMed ID: 11842112

DOI: 10.1093/nar/30.4.1001

PubMed ID: 12975363

Title: Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D).

PubMed ID: 12975363

DOI: 10.1074/jbc.m308838200

PubMed ID: 15109494

Title: Telomere maintenance requires the RAD51D recombination/repair protein.

PubMed ID: 15109494

DOI: 10.1016/s0092-8674(04)00337-x

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 16710300

Title: Sws1 is a conserved regulator of homologous recombination in eukaryotic cells.

PubMed ID: 16710300

DOI: 10.1038/sj.emboj.7601141

PubMed ID: 21276791

Title: Homologous recombination proteins are associated with centrosomes and are required for mitotic stability.

PubMed ID: 21276791

DOI: 10.1016/j.yexcr.2011.01.021

PubMed ID: 21965664

Title: hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair.

PubMed ID: 21965664

DOI: 10.1074/jbc.m111.271080

PubMed ID: 21822267

Title: Germline mutations in RAD51D confer susceptibility to ovarian cancer.

PubMed ID: 21822267

DOI: 10.1038/ng.893

PubMed ID: 23149936

Title: Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.

PubMed ID: 23149936

DOI: 10.1128/mcb.00465-12

PubMed ID: 21111057

Title: Structural and functional characterization of the N-terminal domain of human Rad51D.

PubMed ID: 21111057

DOI: 10.1016/j.biocel.2010.11.014

PubMed ID: 27932480

Title: MAGI2 mutations cause congenital nephrotic syndrome.

PubMed ID: 27932480

DOI: 10.1681/asn.2016040387

Sequence Information:

  • Length: 328
  • Mass: 35049
  • Checksum: 6038DA9356DF354A
  • Sequence:
  • MGVLRVGLCP GLTEEMIQLL RSHRIKTVVD LVSADLEEVA QKCGLSYKAL VALRRVLLAQ 
    FSAFPVNGAD LYEELKTSTA ILSTGIGSLD KLLDAGLYTG EVTEIVGGPG SGKTQVCLCM 
    AANVAHGLQQ NVLYVDSNGG LTASRLLQLL QAKTQDEEEQ AEALRRIQVV HAFDIFQMLD 
    VLQELRGTVA QQVTGSSGTV KVVVVDSVTA VVSPLLGGQQ REGLALMMQL ARELKTLARD 
    LGMAVVVTNH ITRDRDSGRL KPALGRSWSF VPSTRILLDT IEGAGASGGR RMACLAKSSR 
    QPTGFQEMVD IGTWGTSEQS ATLQGDQT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.