Details for: RALB

Gene ID: 5899

Symbol: RALB

Ensembl ID: ENSG00000144118

Description: RAS like proto-oncogene B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 163.1680
    Cell Significance Index: -25.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 83.3059
    Cell Significance Index: -21.1300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 65.0811
    Cell Significance Index: -26.8100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.5190
    Cell Significance Index: -24.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 57.8028
    Cell Significance Index: -27.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 51.6636
    Cell Significance Index: -26.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.3786
    Cell Significance Index: -24.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.8280
    Cell Significance Index: -25.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7160
    Cell Significance Index: -20.6700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.5567
    Cell Significance Index: -14.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5382
    Cell Significance Index: -25.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.1306
    Cell Significance Index: -18.8300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1773
    Cell Significance Index: 20.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0008
    Cell Significance Index: 108.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7418
    Cell Significance Index: 13.7100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.6502
    Cell Significance Index: 4.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6295
    Cell Significance Index: 29.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5906
    Cell Significance Index: 6.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4850
    Cell Significance Index: 13.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4598
    Cell Significance Index: 92.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4422
    Cell Significance Index: 12.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4357
    Cell Significance Index: 53.5800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.4184
    Cell Significance Index: 3.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3320
    Cell Significance Index: 9.7500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.3287
    Cell Significance Index: 2.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3273
    Cell Significance Index: 8.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3263
    Cell Significance Index: 21.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3115
    Cell Significance Index: 14.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3103
    Cell Significance Index: 59.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3029
    Cell Significance Index: 20.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3022
    Cell Significance Index: 41.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3009
    Cell Significance Index: 54.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3000
    Cell Significance Index: 15.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2913
    Cell Significance Index: 6.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2865
    Cell Significance Index: 156.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2863
    Cell Significance Index: 4.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2800
    Cell Significance Index: 5.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2753
    Cell Significance Index: 35.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2682
    Cell Significance Index: 13.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2655
    Cell Significance Index: 6.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2042
    Cell Significance Index: 15.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2000
    Cell Significance Index: 5.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1838
    Cell Significance Index: 8.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1766
    Cell Significance Index: 78.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1729
    Cell Significance Index: 119.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1670
    Cell Significance Index: 33.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1004
    Cell Significance Index: 12.9700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0977
    Cell Significance Index: 0.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0745
    Cell Significance Index: 7.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0728
    Cell Significance Index: 26.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0037
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0033
    Cell Significance Index: -0.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0077
    Cell Significance Index: -5.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0097
    Cell Significance Index: -18.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0103
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0116
    Cell Significance Index: -8.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0120
    Cell Significance Index: -0.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0123
    Cell Significance Index: -22.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0126
    Cell Significance Index: -19.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0151
    Cell Significance Index: -11.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0163
    Cell Significance Index: -22.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0167
    Cell Significance Index: -10.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0209
    Cell Significance Index: -13.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0239
    Cell Significance Index: -13.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0308
    Cell Significance Index: -3.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0441
    Cell Significance Index: -20.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0718
    Cell Significance Index: -20.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0739
    Cell Significance Index: -5.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0766
    Cell Significance Index: -8.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0777
    Cell Significance Index: -9.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0854
    Cell Significance Index: -17.9800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0904
    Cell Significance Index: -1.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0909
    Cell Significance Index: -13.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0944
    Cell Significance Index: -11.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1070
    Cell Significance Index: -5.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1335
    Cell Significance Index: -4.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1401
    Cell Significance Index: -8.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1488
    Cell Significance Index: -11.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1498
    Cell Significance Index: -7.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1702
    Cell Significance Index: -3.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2140
    Cell Significance Index: -13.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2183
    Cell Significance Index: -24.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2444
    Cell Significance Index: -19.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2484
    Cell Significance Index: -25.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2585
    Cell Significance Index: -17.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2803
    Cell Significance Index: -7.1600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2995
    Cell Significance Index: -5.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3085
    Cell Significance Index: -9.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3156
    Cell Significance Index: -17.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3185
    Cell Significance Index: -8.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3281
    Cell Significance Index: -11.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3292
    Cell Significance Index: -9.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3558
    Cell Significance Index: -8.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3603
    Cell Significance Index: -22.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3921
    Cell Significance Index: -5.3500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4185
    Cell Significance Index: -5.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4205
    Cell Significance Index: -18.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4287
    Cell Significance Index: -12.2900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4458
    Cell Significance Index: -4.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4612
    Cell Significance Index: -13.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RALB is a member of the Ras superfamily, characterized by its GTP-binding and GTPase activity domains. This protein is involved in regulating cell growth, differentiation, and survival. Its expression is tightly regulated, with oscillations in intracellular GTP levels influencing its activity. RALB's ability to interact with various proteins, including guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), and RalBP1, underscores its complex signaling mechanisms. **Pathways and Functions:** RALB is implicated in numerous signaling pathways, including: 1. **Apoptotic Process:** RALB regulates apoptosis by modulating the activity of pro-apoptotic proteins, such as Bax and Bak. 2. **Cell Cycle Regulation:** RALB influences cell cycle progression by regulating the activity of cyclin-dependent kinases (CDKs) and the G1/S checkpoint. 3. **Cell Division:** RALB's involvement in cell division is mediated through its interaction with the spindle apparatus and microtubule dynamics. 4. **Cellular Response to Exogenous dsRNA:** RALB plays a role in the innate immune response by regulating the activity of interferon regulatory factors (IRFs). 5. **Extracellular Exosome:** RALB is involved in the regulation of exosome formation and function, influencing cellular communication and waste management. **Clinical Significance:** RALB's dysregulation has been implicated in various diseases, including: 1. **Cancer:** Overexpression of RALB has been observed in several types of cancer, including lung, breast, and colon cancer, suggesting its potential as a therapeutic target. 2. **Immunological Disorders:** RALB's role in regulating immune cell function and apoptosis makes it a potential target for the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurological Disorders:** RALB's involvement in neuronal survival and apoptosis suggests its potential as a therapeutic target for neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, RALB is a complex protein with far-reaching implications in immunology, cancer, and neurological disorders. Further research is needed to fully elucidate its mechanisms of action and its potential therapeutic applications.

Genular Protein ID: 1517097426

Symbol: RALB_HUMAN

Name: Ras-related protein Ral-B

UniProtKB Accession Codes:

P11234 B4E040 Q53T32 Q6ZS74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 Rhea 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2662142

Title: Coding sequences of human ralA and ralB cDNAs.

PubMed ID: 2662142

DOI: 10.1093/nar/17.11.4380

PubMed ID: 2120779

Title: Chromosomal localization and cDNA sequence of human ralB, a GTP binding protein.

PubMed ID: 2120779

DOI: 10.1007/bf01232469

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7673236

Title: Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity.

PubMed ID: 7673236

DOI: 10.1074/jbc.270.38.22473

PubMed ID: 10393179

Title: Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors.

PubMed ID: 10393179

DOI: 10.1093/emboj/18.13.3629

PubMed ID: 14525976

Title: Ral GTPases regulate exocyst assembly through dual subunit interactions.

PubMed ID: 14525976

DOI: 10.1074/jbc.m308702200

PubMed ID: 17875936

Title: Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.

PubMed ID: 17875936

DOI: 10.1128/mcb.00057-07

PubMed ID: 18756269

Title: Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs.

PubMed ID: 18756269

DOI: 10.1038/emboj.2008.166

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 19166349

Title: Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding.

PubMed ID: 19166349

DOI: 10.1021/bi802129d

PubMed ID: 20696399

Title: The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction.

PubMed ID: 20696399

DOI: 10.1016/j.str.2010.05.013

Sequence Information:

  • Length: 206
  • Mass: 23409
  • Checksum: E0AC95130FB6452C
  • Sequence:
    • MAANKSKGQS SLALHKVIMV GSGGVGKSAL TLQFMYDEFV EDYEPTKADS YRKKVVLDGE 
EVQIDILDTA GQEDYAAIRD NYFRSGEGFL LVFSITEHES FTATAEFREQ ILRVKAEEDK 
IPLLVVGNKS DLEERRQVPV EEARSKAEEW GVQYVETSAK TRANVDKVFF DLMREIRTKK 
MSENKDKNGK KSSKNKKSFK ERCCLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.