Details for: RASA1

Gene ID: 5921

Symbol: RASA1

Ensembl ID: ENSG00000145715

Description: RAS p21 protein activator 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 408.6271
    Cell Significance Index: -63.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 254.2152
    Cell Significance Index: -64.4800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 164.5112
    Cell Significance Index: -67.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 123.7148
    Cell Significance Index: -50.2600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 113.2031
    Cell Significance Index: -58.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.6739
    Cell Significance Index: -50.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.3985
    Cell Significance Index: -64.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.7037
    Cell Significance Index: -60.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.3556
    Cell Significance Index: -44.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.4050
    Cell Significance Index: -56.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 16.9007
    Cell Significance Index: 451.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.4874
    Cell Significance Index: -65.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 6.1745
    Cell Significance Index: 148.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 5.0696
    Cell Significance Index: 311.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.3308
    Cell Significance Index: 57.0800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.2182
    Cell Significance Index: 62.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.2083
    Cell Significance Index: 180.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.6913
    Cell Significance Index: 965.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6204
    Cell Significance Index: 525.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1265
    Cell Significance Index: 422.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.9901
    Cell Significance Index: 1376.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.8293
    Cell Significance Index: 123.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6149
    Cell Significance Index: 123.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3533
    Cell Significance Index: 157.7100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.3090
    Cell Significance Index: 21.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.2805
    Cell Significance Index: 32.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2394
    Cell Significance Index: 122.6000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.1154
    Cell Significance Index: 13.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9383
    Cell Significance Index: 35.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9013
    Cell Significance Index: 39.8700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8837
    Cell Significance Index: 18.8900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.7693
    Cell Significance Index: 4.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7405
    Cell Significance Index: 120.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6864
    Cell Significance Index: 74.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5403
    Cell Significance Index: 1017.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4762
    Cell Significance Index: 733.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3811
    Cell Significance Index: 22.8800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.3574
    Cell Significance Index: 4.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3346
    Cell Significance Index: 60.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3051
    Cell Significance Index: 562.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2964
    Cell Significance Index: 8.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2949
    Cell Significance Index: 36.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2893
    Cell Significance Index: 183.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2502
    Cell Significance Index: 7.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2179
    Cell Significance Index: 5.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1896
    Cell Significance Index: 257.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1806
    Cell Significance Index: 163.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1799
    Cell Significance Index: 98.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1560
    Cell Significance Index: 4.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1477
    Cell Significance Index: 67.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1024
    Cell Significance Index: 4.6400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0994
    Cell Significance Index: 1.4300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0522
    Cell Significance Index: 0.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0521
    Cell Significance Index: 1.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0503
    Cell Significance Index: 22.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0025
    Cell Significance Index: 0.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0603
    Cell Significance Index: -44.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0684
    Cell Significance Index: -50.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0775
    Cell Significance Index: -1.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0834
    Cell Significance Index: -63.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0891
    Cell Significance Index: -12.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1099
    Cell Significance Index: -62.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1121
    Cell Significance Index: -69.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1567
    Cell Significance Index: -8.1600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1754
    Cell Significance Index: -1.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1948
    Cell Significance Index: -28.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1975
    Cell Significance Index: -56.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2350
    Cell Significance Index: -40.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2389
    Cell Significance Index: -11.2300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2487
    Cell Significance Index: -5.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2527
    Cell Significance Index: -17.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2612
    Cell Significance Index: -26.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2679
    Cell Significance Index: -12.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2707
    Cell Significance Index: -34.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3040
    Cell Significance Index: -35.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3213
    Cell Significance Index: -67.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3444
    Cell Significance Index: -35.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3870
    Cell Significance Index: -50.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4243
    Cell Significance Index: -22.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4634
    Cell Significance Index: -2.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4757
    Cell Significance Index: -30.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5063
    Cell Significance Index: -58.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5228
    Cell Significance Index: -32.9500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.5254
    Cell Significance Index: -4.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5299
    Cell Significance Index: -4.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6585
    Cell Significance Index: -13.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6824
    Cell Significance Index: -54.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6868
    Cell Significance Index: -51.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7080
    Cell Significance Index: -50.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7854
    Cell Significance Index: -25.1600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7871
    Cell Significance Index: -11.6200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8026
    Cell Significance Index: -15.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8259
    Cell Significance Index: -27.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8268
    Cell Significance Index: -22.1600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.8428
    Cell Significance Index: -10.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8434
    Cell Significance Index: -17.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8698
    Cell Significance Index: -45.6700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.8717
    Cell Significance Index: -9.0800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9038
    Cell Significance Index: -11.2700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9718
    Cell Significance Index: -19.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RASA1 is a GAP protein that specifically activates the RAS small GTPase, which in turn regulates a wide range of cellular processes. The RAS/RASA1 complex is involved in signal transduction pathways that control cell growth, differentiation, migration, and survival. RASA1 is a negative regulator of various signaling pathways, including those mediated by receptor tyrosine kinases, non-receptor tyrosine kinases, and growth factor receptors. Its expression is tightly regulated, and its dysregulation has been linked to several diseases. **Pathways and Functions** RASA1 is involved in several signaling pathways that regulate cellular processes, including: 1. **Eph-ephrin signaling**: RASA1 regulates the Eph-ephrin signaling pathway, which is involved in cell-cell interactions and axon guidance. 2. **Mapk1/mapk3 signaling**: RASA1 regulates the MAPK1/3 signaling cascade, which is involved in cell growth, differentiation, and survival. 3. **Raf/map kinase cascade**: RASA1 regulates the Raf/MAPK cascade, which is involved in cell growth, differentiation, and survival. 4. **Regulation of actin filament polymerization**: RASA1 regulates the polymerization of actin filaments, which is involved in cell migration and shape changes. 5. **Regulation of cell shape**: RASA1 regulates cell shape through its interaction with the cytoskeleton. RASA1's functions include: 1. **Negative regulation of apoptosis**: RASA1 regulates the apoptotic process by inhibiting pro-apoptotic signals. 2. **Negative regulation of cell-matrix adhesion**: RASA1 regulates cell-matrix adhesion by inhibiting integrin signaling. 3. **Negative regulation of neuron apoptotic process**: RASA1 regulates the apoptotic process in neurons. 4. **Regulation of vasculogenesis**: RASA1 regulates the formation of new blood vessels. **Clinical Significance** Dysregulation of RASA1 has been implicated in several diseases, including: 1. **Cancer**: RASA1 is often downregulated in various types of cancer, including breast, lung, and colon cancer. 2. **Cardiovascular disorders**: RASA1 is involved in the regulation of cardiovascular function, and its dysregulation has been linked to cardiovascular disorders, including hypertension and atherosclerosis. 3. **Neurological conditions**: RASA1 is involved in the regulation of neuronal function, and its dysregulation has been linked to neurological conditions, including Parkinson's disease and Alzheimer's disease. In conclusion, RASA1 is a critical regulator of various cellular processes, including cell signaling, cytoskeleton dynamics, and cell survival. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 1098451894

Symbol: RASA1_HUMAN

Name: Ras GTPase-activating protein 1

UniProtKB Accession Codes:

P20936 B2R6W3 B4DTL2 Q68CU6 Q9UDI1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 6 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 2 PRINTS 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SASBDB 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3201259

Title: Molecular cloning of two types of GAP complementary DNA from human placenta.

PubMed ID: 3201259

DOI: 10.1126/science.3201259

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8360177

Title: Purification, characterization, and cellular localization of the 100-kDa human placental GTPase-activating protein.

PubMed ID: 8360177

DOI: 10.1016/s0021-9258(17)46708-1

PubMed ID: 2123878

Title: Purification, characterization, and western blot analysis of human GTPase-activating protein from native and recombinant sources.

PubMed ID: 2123878

DOI: 10.1016/s0021-9258(18)45826-7

PubMed ID: 11389730

Title: Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm.

PubMed ID: 11389730

DOI: 10.1046/j.1432-1327.2001.02230.x

PubMed ID: 1375321

Title: GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.

PubMed ID: 1375321

DOI: 10.1128/mcb.12.6.2534-2544.1992

PubMed ID: 8618896

Title: Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.

PubMed ID: 8618896

DOI: 10.1073/pnas.92.26.12338

PubMed ID: 12091389

Title: Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.

PubMed ID: 12091389

DOI: 10.1074/jbc.m204367200

PubMed ID: 15504032

Title: Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).

PubMed ID: 15504032

DOI: 10.1021/bi049295+

PubMed ID: 15713673

Title: The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway.

PubMed ID: 15713673

DOI: 10.1074/jbc.m413897200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18024423

Title: Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.

PubMed ID: 18024423

DOI: 10.1074/jbc.m706361200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21664272

Title: Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity.

PubMed ID: 21664272

DOI: 10.1016/j.cellsig.2011.05.019

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30578106

Title: Mutations in chromatin modifier and ephrin signaling genes in vein of Galen malformation.

PubMed ID: 30578106

DOI: 10.1016/j.neuron.2018.11.041

PubMed ID: 8137811

Title: Solution structure of GAP SH3 domain by 1H NMR and spatial arrangement of essential Ras signaling-involved sequence.

PubMed ID: 8137811

DOI: 10.1002/j.1460-2075.1994.tb06379.x

PubMed ID: 8955277

Title: Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras.

PubMed ID: 8955277

DOI: 10.1038/384591a0

PubMed ID: 9219684

Title: The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.

PubMed ID: 9219684

DOI: 10.1126/science.277.5324.333

PubMed ID: 8275088

Title: Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours.

PubMed ID: 8275088

DOI: 10.1038/ng1193-242

PubMed ID: 14639529

Title: Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations.

PubMed ID: 14639529

DOI: 10.1086/379793

PubMed ID: 24038909

Title: RASA1 mutations and associated phenotypes in 68 families with capillary malformation-arteriovenous malformation.

PubMed ID: 24038909

DOI: 10.1002/humu.22431

Sequence Information:

  • Length: 1047
  • Mass: 116403
  • Checksum: C35B6567F5BC5370
  • Sequence:
    • MMAAEAGSEE GGPVTAGAGG GGAAAGSSAY PAVCRVKIPA ALPVAAAPYP GLVETGVAGT 
LGGGAALGSE FLGAGSVAGA LGGAGLTGGG TAAGVAGAAA GVAGAAVAGP SGDMALTKLP 
TSLLAETLGP GGGFPPLPPP PYLPPLGAGL GTVDEGDSLD GPEYEEEEVA IPLTAPPTNQ 
WYHGKLDRTI AEERLRQAGK SGSYLIRESD RRPGSFVLSF LSQMNVVNHF RIIAMCGDYY 
IGGRRFSSLS DLIGYYSHVS CLLKGEKLLY PVAPPEPVED RRRVRAILPY TKVPDTDEIS 
FLKGDMFIVH NELEDGWMWV TNLRTDEQGL IVEDLVEEVG REEDPHEGKI WFHGKISKQE 
AYNLLMTVGQ VCSFLVRPSD NTPGDYSLYF RTNENIQRFK ICPTPNNQFM MGGRYYNSIG 
DIIDHYRKEQ IVEGYYLKEP VPMQDQEQVL NDTVDGKEIY NTIRRKTKDA FYKNIVKKGY 
LLKKGKGKRW KNLYFILEGS DAQLIYFESE KRATKPKGLI DLSVCSVYVV HDSLFGRPNC 
FQIVVQHFSE EHYIFYFAGE TPEQAEDWMK GLQAFCNLRK SSPGTSNKRL RQVSSLVLHI 
EEAHKLPVKH FTNPYCNIYL NSVQVAKTHA REGQNPVWSE EFVFDDLPPD INRFEITLSN 
KTKKSKDPDI LFMRCQLSRL QKGHATDEWF LLSSHIPLKG IEPGSLRVRA RYSMEKIMPE 
EEYSEFKELI LQKELHVVYA LSHVCGQDRT LLASILLRIF LHEKLESLLL CTLNDREISM 
EDEATTLFRA TTLASTLMEQ YMKATATQFV HHALKDSILK IMESKQSCEL SPSKLEKNED 
VNTNLTHLLN ILSELVEKIF MASEILPPTL RYIYGCLQKS VQHKWPTNTT MRTRVVSGFV 
FLRLICPAIL NPRMFNIISD SPSPIAARTL ILVAKSVQNL ANLVEFGAKE PYMEGVNPFI 
KSNKHRMIMF LDELGNVPEL PDTTEHSRTD LSRDLAALHE ICVAHSDELR TLSNERGAQQ 
HVLKKLLAIT ELLQQKQNQY TKTNDVR

Genular Protein ID: 540647553

Symbol: Q59GK3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GK3

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 4 InterPro 14 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 10 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 5 RefSeq 1 SAM 1 SMART 5 SUPFAM 5

Sequence Information:

  • Length: 871
  • Mass: 95932
  • Checksum: 0B12FCDD97F46FD3
  • Sequence:
    • RGDASGWGCS EPGPGGPWGS RAGRVGQSRA GFNMMAAEAG SEEGGPVTAG AGGGGAAAGS 
SAYPAVCRVK IPAALPVAAA PYPGLVETGV AGTLGGGAAL GSEFLGAGSV AGALGGAGLT 
GGGTAAGVAG AAAGVAGAAV AGPSGDMALT KLPTSLLAET LGPGGGFPPL PPPPYLPPLG 
AGLGTVDEGD SLDGPEYEEE EVAIPLTAPP TNQWYHGKLD RTIAEERLRQ AGKSGSYLIR 
ESDRRPGSFV LSFLSQMNVV NHFRIIAMCG DYYIGGRRFS SLSDLIGYYS HVSCLLKGEK 
LLYPVAPPEP VEDRRRVRAI LPYTKVPDTD EISFLKGDMF IVHNELEDGW MWVTNLRTDE 
QGLIVEDLVE EVGREEDPHE GKIWFHGKIS KQEAYNLLMT VGQVCSFLVR PSDNTPGDYS 
LYFRTNENIQ RFKICPTPNN QFMMGGRYYN SIGDIIDHYR KEQIVEGYYL KEPVPMQDQE 
QVLNDTVDGK EIYNTIRRKT KDAFYKNIVK KGYLLKKGKG KRWKNLYFIL EGSDAQLIYF 
ESEKRATKPK GLIDLSVCSV YVVHDSLFGR PNCFQIVVQH FSEEHYIFYF AGETPEQAED 
WMKGLQAFCN LRKSSPGTSN KRLRQVSSLV LHIEEAHKLP VKHFTNPYCN IYLNSVQVAK 
THAREGQNPV WSEEFVFDDL PPDINRFEIT LSNKTKKSKD PDILFMRCQL SRLQKGHATD 
EWFLLSSHIP LKGIEPGSLR VRARYSMEKI MPEEEYSEFK ELILQKELHV VYALSHVCGQ 
DRTLLASILL RIFLHEKLES LLLCTLNDRE ISMEDEATTL FRATTLASTL MEQYMKATAT 
QFVHHALKDS ILKIMESKQS CELSPSKLEK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.