Details for: RBL1

Gene ID: 5933

Symbol: RBL1

Ensembl ID: ENSG00000080839

Description: RB transcriptional corepressor like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 84.8306
    Cell Significance Index: -13.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.6577
    Cell Significance Index: -16.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.6670
    Cell Significance Index: -15.3000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.1195
    Cell Significance Index: -15.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.6663
    Cell Significance Index: -16.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.8462
    Cell Significance Index: -18.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.8804
    Cell Significance Index: -14.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.7428
    Cell Significance Index: -10.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3765
    Cell Significance Index: -17.2700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.1149
    Cell Significance Index: 51.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.0964
    Cell Significance Index: 117.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3589
    Cell Significance Index: 269.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.3477
    Cell Significance Index: 29.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1966
    Cell Significance Index: 33.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5892
    Cell Significance Index: 211.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5600
    Cell Significance Index: 34.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5131
    Cell Significance Index: 12.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5007
    Cell Significance Index: 81.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4828
    Cell Significance Index: 47.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4623
    Cell Significance Index: 50.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4561
    Cell Significance Index: 27.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3131
    Cell Significance Index: 45.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2725
    Cell Significance Index: 32.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2492
    Cell Significance Index: 6.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2416
    Cell Significance Index: 4.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2354
    Cell Significance Index: 162.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2288
    Cell Significance Index: 14.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2170
    Cell Significance Index: 16.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1983
    Cell Significance Index: 179.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1265
    Cell Significance Index: 2.7400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1225
    Cell Significance Index: 2.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1135
    Cell Significance Index: 3.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1095
    Cell Significance Index: 19.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1032
    Cell Significance Index: 2.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0731
    Cell Significance Index: 1.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0710
    Cell Significance Index: 31.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0667
    Cell Significance Index: 12.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0549
    Cell Significance Index: 3.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0525
    Cell Significance Index: 80.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0515
    Cell Significance Index: 2.2800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0499
    Cell Significance Index: 0.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0407
    Cell Significance Index: 76.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0329
    Cell Significance Index: 17.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0325
    Cell Significance Index: 44.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0319
    Cell Significance Index: 58.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0285
    Cell Significance Index: 3.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0199
    Cell Significance Index: 12.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0191
    Cell Significance Index: 2.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0129
    Cell Significance Index: 5.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0124
    Cell Significance Index: 0.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0066
    Cell Significance Index: 1.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0042
    Cell Significance Index: 0.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0033
    Cell Significance Index: 0.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0026
    Cell Significance Index: 0.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0041
    Cell Significance Index: -0.1100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0047
    Cell Significance Index: -0.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0155
    Cell Significance Index: -0.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0168
    Cell Significance Index: -0.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0178
    Cell Significance Index: -1.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0182
    Cell Significance Index: -13.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0198
    Cell Significance Index: -14.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0231
    Cell Significance Index: -17.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0289
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0301
    Cell Significance Index: -18.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0302
    Cell Significance Index: -17.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0376
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0406
    Cell Significance Index: -6.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0605
    Cell Significance Index: -17.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0711
    Cell Significance Index: -9.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0859
    Cell Significance Index: -8.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0862
    Cell Significance Index: -18.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0962
    Cell Significance Index: -11.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0968
    Cell Significance Index: -6.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1068
    Cell Significance Index: -7.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1323
    Cell Significance Index: -13.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1341
    Cell Significance Index: -17.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1398
    Cell Significance Index: -8.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1600
    Cell Significance Index: -8.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1767
    Cell Significance Index: -2.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1835
    Cell Significance Index: -8.5600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1858
    Cell Significance Index: -2.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1917
    Cell Significance Index: -9.0100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2048
    Cell Significance Index: -2.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2095
    Cell Significance Index: -16.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2296
    Cell Significance Index: -17.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2310
    Cell Significance Index: -12.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2324
    Cell Significance Index: -7.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2384
    Cell Significance Index: -5.0600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2508
    Cell Significance Index: -6.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2566
    Cell Significance Index: -7.5400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2665
    Cell Significance Index: -5.2700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2711
    Cell Significance Index: -5.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2999
    Cell Significance Index: -9.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3053
    Cell Significance Index: -5.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3079
    Cell Significance Index: -10.0800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3128
    Cell Significance Index: -3.9000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3301
    Cell Significance Index: -4.7400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3312
    Cell Significance Index: -2.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3335
    Cell Significance Index: -11.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3407
    Cell Significance Index: -5.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Corepressor Function:** RBL1 acts as a transcriptional corepressor, binding to specific DNA sequences and recruiting histone-modifying enzymes to repress gene expression. 2. **Cell Cycle Regulation:** RBL1 is involved in regulating cell cycle progression, particularly at the G1/S transition, where it interacts with cyclin D and other cell cycle regulators to inhibit cell cycle entry. 3. **Gene Expression Regulation:** RBL1 modulates the expression of genes involved in cell differentiation, lipid metabolism, and cellular senescence, highlighting its role in regulating cellular identity and fate. 4. **Interactions with Other Proteins:** RBL1 interacts with various proteins, including Smad2/3, p53, and HDAC1, to regulate transcriptional activity and cell cycle progression. **Pathways and Functions:** RBL1 is involved in several key pathways, including: 1. **Cell Cycle Regulation:** RBL1 regulates cell cycle progression at the G1/S transition, where it interacts with cyclin D and other cell cycle regulators to inhibit cell cycle entry. 2. **Gene Expression Regulation:** RBL1 modulates the expression of genes involved in cell differentiation, lipid metabolism, and cellular senescence. 3. **Chromatin Organization:** RBL1 interacts with chromatin-modifying enzymes to regulate chromatin structure and gene expression. 4. **Signaling Pathways:** RBL1 is involved in signaling pathways, including TGF-β and Smad2/3-mediated transcriptional regulation. **Clinical Significance:** Dysregulation of RBL1 has been implicated in various diseases, including: 1. **Cancer:** RBL1 mutations have been identified in certain types of cancer, including retinoblastoma and other malignancies. 2. **Neurological Disorders:** RBL1 expression is altered in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular Disease:** RBL1 is involved in regulating cardiac cell differentiation and function, and its dysregulation may contribute to cardiovascular disease. In conclusion, RBL1 is a complex gene that plays a critical role in regulating cell cycle progression, gene expression, and cellular senescence. Its dysregulation may contribute to various diseases, highlighting the need for further research into the molecular mechanisms underlying RBL1 function and its clinical significance.

Genular Protein ID: 4182886191

Symbol: RBL1_HUMAN

Name: Retinoblastoma-like protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8319904

Title: Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

PubMed ID: 8319904

DOI: 10.1101/gad.7.7a.1111

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1833063

Title: Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein.

PubMed ID: 1833063

DOI: 10.1016/0092-8674(91)90038-z

PubMed ID: 7791762

Title: Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins.

PubMed ID: 7791762

DOI: 10.1128/mcb.15.7.3552

PubMed ID: 11884610

Title: Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4.

PubMed ID: 11884610

DOI: 10.1128/mcb.22.7.2242-2254.2002

PubMed ID: 2546678

Title: The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus.

PubMed ID: 2546678

DOI: 10.1016/0092-8674(89)90839-8

PubMed ID: 7935440

Title: Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.

PubMed ID: 7935440

DOI: 10.1128/mcb.14.11.7256-7264.1994

PubMed ID: 12450794

Title: Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb.

PubMed ID: 12450794

DOI: 10.1016/s1535-6108(02)00182-4

PubMed ID: 12006580

Title: Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4.

PubMed ID: 12006580

DOI: 10.1074/jbc.m200381200

PubMed ID: 16360038

Title: Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.

PubMed ID: 16360038

DOI: 10.1016/j.cell.2005.09.044

PubMed ID: 17671431

Title: LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes.

PubMed ID: 17671431

DOI: 10.4161/cc.6.15.4512

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20485545

Title: JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity.

PubMed ID: 20485545

DOI: 10.1371/journal.pone.0010606

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 1068
  • Mass: 120847
  • Checksum: 2BC4876EA04BDB31
  • Sequence:
  • MFEDKPHAEG AAVVAAAGEA LQALCQELNL DEGSAAEALD DFTAIRGNYS LEGEVTHWLA 
    CSLYVACRKS IIPTVGKGIM EGNCVSLTRI LRSAKLSLIQ FFSKMKKWMD MSNLPQEFRE 
    RIERLERNFE VSTVIFKKYE PIFLDIFQNP YEEPPKLPRS RKQRRIPCSV KDLFNFCWTL 
    FVYTKGNFRM IGDDLVNSYH LLLCCLDLIF ANAIMCPNRQ DLLNPSFKGL PSDFHTADFT 
    ASEEPPCIIA VLCELHDGLL VEAKGIKEHY FKPYISKLFD RKILKGECLL DLSSFTDNSK 
    AVNKEYEEYV LTVGDFDERI FLGADAEEEI GTPRKFTRDT PLGKLTAQAN VEYNLQQHFE 
    KKRSFAPSTP LTGRRYLREK EAVITPVASA TQSVSRLQSI VAGLKNAPSD QLINIFESCV 
    RNPVENIMKI LKGIGETFCQ HYTQSTDEQP GSHIDFAVNR LKLAEILYYK ILETVMVQET 
    RRLHGMDMSV LLEQDIFHRS LMACCLEIVL FAYSSPRTFP WIIEVLNLQP FYFYKVIEVV 
    IRSEEGLSRD MVKHLNSIEE QILESLAWSH DSALWEALQV SANKVPTCEE VIFPNNFETG 
    NGGNVQGHLP LMPMSPLMHP RVKEVRTDSG SLRRDMQPLS PISVHERYSS PTAGSAKRRL 
    FGEDPPKEML MDKIITEGTK LKIAPSSSIT AENVSILPGQ TLLTMATAPV TGTTGHKVTI 
    PLHGVANDAG EITLIPLSMN TNQESKVKSP VSLTAHSLIG ASPKQTNLTK AQEVHSTGIN 
    RPKRTGSLAL FYRKVYHLAS VRLRDLCLKL DVSNELRRKI WTCFEFTLVH CPDLMKDRHL 
    DQLLLCAFYI MAKVTKEERT FQEIMKSYRN QPQANSHVYR SVLLKSIPRE VVAYNKNIND 
    DFEMIDCDLE DATKTPDCSS GPVKEERGDL IKFYNTIYVG RVKSFALKYD LANQDHMMDA 
    PPLSPFPHIK QQPGSPRRIS QQHSIYISPH KNGSGLTPRS ALLYKFNGSP SKSLKDINNM 
    IRQGEQRTKK RVIAIDSDAE SPAKRVCQEN DDVLLKRLQD VVSERANH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.