Details for: RCVRN

Gene ID: 5957

Symbol: RCVRN

Ensembl ID: ENSG00000109047

Description: recoverin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 4.26
    Marker Score: 12153
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.55
    Marker Score: 1871
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.94
    Marker Score: 876
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.44
    Marker Score: 1276.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.36
    Marker Score: 2372
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.15
    Marker Score: 1622
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.64
    Marker Score: 685
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.12
    Marker Score: 2563
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.11
    Marker Score: 704
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.01
    Marker Score: 2574
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5357
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 610
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.77
    Marker Score: 1065
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.72
    Marker Score: 475
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.67
    Marker Score: 1911
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 468
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.44
    Marker Score: 423
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 243
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.42
    Marker Score: 1236
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 396
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.41
    Marker Score: 130
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.39
    Marker Score: 164
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.33
    Marker Score: 314
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.31
    Marker Score: 932
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.31
    Marker Score: 379
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.31
    Marker Score: 84
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.3
    Marker Score: 617
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3
    Marker Score: 607
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.26
    Marker Score: 79
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.22
    Marker Score: 409
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.2
    Marker Score: 419
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 106
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.19
    Marker Score: 2967
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.18
    Marker Score: 1749
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 79
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.18
    Marker Score: 41
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.18
    Marker Score: 220
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.18
    Marker Score: 1506
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.17
    Marker Score: 40
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.15
    Marker Score: 1295
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.15
    Marker Score: 8936
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.14
    Marker Score: 40
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.13
    Marker Score: 321
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.11
    Marker Score: 121
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.11
    Marker Score: 167
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1
    Marker Score: 400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.1
    Marker Score: 158
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1
    Marker Score: 59
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.1
    Marker Score: 748
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.09
    Marker Score: 536
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.09
    Marker Score: 88
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.09
    Marker Score: 21
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.08
    Marker Score: 96
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.08
    Marker Score: 68
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.08
    Marker Score: 1173
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.08
    Marker Score: 1024
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 85
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.07
    Marker Score: 57
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.07
    Marker Score: 288
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.07
    Marker Score: 613
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.06
    Marker Score: 207
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.06
    Marker Score: 106
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.06
    Marker Score: 98
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 28

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Other Information

**Key characteristics:** * The RCVRN gene is located on chromosome 15q21.1 in humans. * It is a large gene with a size of approximately 13.5 kb. * It encodes a protein of 573 amino acids that is expressed in retinal cells. * RCVRN is the only known CDGC-A in mammals. * It is a key regulator of the phototransduction cascade, which is responsible for converting light into visual signals in the retina. **Pathways and functions:** * RCVRN is a key component of the visual phototransduction cascade, which is responsible for converting light into electrical signals in the retina. * The phototransduction cascade is a complex signaling pathway that involves multiple proteins and molecules. * RCVRN is responsible for regulating the activity of the first enzyme in the cascade, TRP2, by binding to its cytoplasmic domain. * When RCVRN binds to TRP2, it activates it, which leads to the activation of phosphodiesterase 4B (PDE4B), a key enzyme in the cascade. * PDE4B hydrolyzes cyclic GMP-AMP (cGMP), which is a second messenger that regulates the activity of other proteins in the phototransduction cascade. * By regulating the activity of PDE4B, RCVRN helps to control the overall sensitivity and response time of the phototransduction cascade. **Clinical significance:** * Mutations in the RCVRN gene have been linked to several eye diseases, including retinitis pigmentosa, a genetic disorder that causes progressive blindness. * RCVRN is a potential therapeutic target for eye diseases that are caused by mutations in genes involved in the visual phototransduction cascade. * By blocking the activity of RECO_HUMAN, it is possible to restore vision in retinitis pigmentosa mice.

Genular Protein ID: 4236965337

Symbol: RECO_HUMAN

Name: Recoverin

UniProtKB Accession Codes:

P35243 Q53XL0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1387789

Title: Isolation of human retinal genes: recoverin cDNA and gene.

PubMed ID: 1387789

DOI: 10.1016/s0006-291x(05)81483-4

PubMed ID: 8500558

Title: Molecular cloning and nucleotide sequence of a cDNA encoding recoverin from human retina.

PubMed ID: 8500558

DOI: 10.1006/exer.1993.1059

PubMed ID: 1388144

Title: The cancer-associated retinopathy antigen is a recoverin-like protein.

PubMed ID: 1388144

PubMed ID: 8912538

Title: Expression of a photoreceptor protein, recoverin, as a cancer-associated retinopathy autoantigen in human lung cancer cell lines.

PubMed ID: 8912538

DOI: 10.1038/bjc.1996.558

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1999465

Title: A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy.

PubMed ID: 1999465

DOI: 10.1083/jcb.112.5.981

Sequence Information:

  • Length: 200
  • Mass: 23130
  • Checksum: 7B1FA91EF19E6122
  • Sequence:
    • MGNSKSGALS KEILEELQLN TKFSEEELCS WYQSFLKDCP TGRITQQQFQ SIYAKFFPDT 
DPKAYAQHVF RSFDSNLDGT LDFKEYVIAL HMTTAGKTNQ KLEWAFSLYD VDGNGTISKN 
EVLEIVMAIF KMITPEDVKL LPDDENTPEK RAEKIWKYFG KNDDDKLTEK EFIEGTLANK 
EILRLIQFEP QKVKEKMKNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.