Details for: RCVRN

Gene ID: 5957

Symbol: RCVRN

Ensembl ID: ENSG00000109047

Description: recoverin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 17.2007
    Cell Significance Index: 241.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 11.7018
    Cell Significance Index: 737.5300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 4.6941
    Cell Significance Index: 41.3500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.8387
    Cell Significance Index: 29.1700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.7853
    Cell Significance Index: 13.7400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.7226
    Cell Significance Index: 21.5100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.3376
    Cell Significance Index: 10.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0452
    Cell Significance Index: 14.2600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.4430
    Cell Significance Index: 5.3700
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: 0.3074
    Cell Significance Index: 3.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2844
    Cell Significance Index: 3.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2640
    Cell Significance Index: 13.8600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.2009
    Cell Significance Index: 2.2700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1806
    Cell Significance Index: 2.2400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.1541
    Cell Significance Index: 1.9300
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.1361
    Cell Significance Index: 1.5600
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: 0.0912
    Cell Significance Index: 1.1200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0823
    Cell Significance Index: 1.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0652
    Cell Significance Index: 13.0700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0588
    Cell Significance Index: 0.7600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0521
    Cell Significance Index: 0.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0381
    Cell Significance Index: 13.6800
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.0299
    Cell Significance Index: 0.3800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0178
    Cell Significance Index: 0.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0173
    Cell Significance Index: 0.9700
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: 0.0107
    Cell Significance Index: 0.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0050
    Cell Significance Index: 3.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0011
    Cell Significance Index: 0.1400
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3000
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0017
    Cell Significance Index: -2.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0041
    Cell Significance Index: -2.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0044
    Cell Significance Index: -3.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0047
    Cell Significance Index: -3.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0048
    Cell Significance Index: -2.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0055
    Cell Significance Index: -3.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0063
    Cell Significance Index: -2.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0076
    Cell Significance Index: -2.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0118
    Cell Significance Index: -2.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0120
    Cell Significance Index: -0.8100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0125
    Cell Significance Index: -0.2000
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0133
    Cell Significance Index: -0.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0139
    Cell Significance Index: -1.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0166
    Cell Significance Index: -2.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0180
    Cell Significance Index: -2.0600
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0186
    Cell Significance Index: -0.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0195
    Cell Significance Index: -2.8400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0197
    Cell Significance Index: -0.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0204
    Cell Significance Index: -4.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0210
    Cell Significance Index: -0.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0228
    Cell Significance Index: -1.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0239
    Cell Significance Index: -0.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0243
    Cell Significance Index: -2.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0249
    Cell Significance Index: -3.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0250
    Cell Significance Index: -3.0800
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: -0.0270
    Cell Significance Index: -0.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0303
    Cell Significance Index: -3.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0321
    Cell Significance Index: -1.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0342
    Cell Significance Index: -1.1200
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.0348
    Cell Significance Index: -0.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0393
    Cell Significance Index: -1.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0405
    Cell Significance Index: -2.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0431
    Cell Significance Index: -3.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0437
    Cell Significance Index: -1.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0438
    Cell Significance Index: -2.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0456
    Cell Significance Index: -3.5000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0499
    Cell Significance Index: -0.5200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0500
    Cell Significance Index: -0.8100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0510
    Cell Significance Index: -0.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0510
    Cell Significance Index: -2.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0513
    Cell Significance Index: -2.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0514
    Cell Significance Index: -0.8600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0514
    Cell Significance Index: -0.5600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0525
    Cell Significance Index: -1.3100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0527
    Cell Significance Index: -0.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0545
    Cell Significance Index: -2.5400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0551
    Cell Significance Index: -1.1900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0561
    Cell Significance Index: -0.7000
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: -0.0562
    Cell Significance Index: -0.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0578
    Cell Significance Index: -2.1200
  • Cell Name: S cone cell (CL0003050)
    Fold Change: -0.0583
    Cell Significance Index: -0.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0586
    Cell Significance Index: -1.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0621
    Cell Significance Index: -2.3500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0625
    Cell Significance Index: -1.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0640
    Cell Significance Index: -3.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0652
    Cell Significance Index: -1.2900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0711
    Cell Significance Index: -0.8300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0741
    Cell Significance Index: -1.8000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0742
    Cell Significance Index: -0.9900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0753
    Cell Significance Index: -0.9500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0758
    Cell Significance Index: -1.0900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0765
    Cell Significance Index: -1.9100
  • Cell Name: giant bipolar cell (CL4033035)
    Fold Change: -0.0778
    Cell Significance Index: -0.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0789
    Cell Significance Index: -2.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0797
    Cell Significance Index: -1.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0802
    Cell Significance Index: -2.3000
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0803
    Cell Significance Index: -0.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** Recoverin is primarily expressed in photoreceptor cells, including retinal rod cells, and in certain types of immune cells, such as hematopoietic stem cells and megakaryocyte-erythroid progenitor cells. 2. **Function:** Recoverin acts as a calcium-sensitive guanylate cyclase activator, regulating the recovery and regulation of the phototransduction cascade. 3. **Cellular Localization:** Recoverin is localized to the photoreceptor inner segment and outer segment, where it plays a critical role in the phototransduction cascade. 4. **Regulation:** Recoverin is subject to regulation by various factors, including calcium ions, which modulate its activity. **Pathways and Functions:** 1. **Phototransduction Cascade:** Recoverin is a key component of the phototransduction cascade, which converts light into electrical signals in the retina. It acts as a calcium-sensitive guanylate cyclase activator, regulating the recovery and regulation of this cascade. 2. **Calcium Ion Transport:** Recoverin is involved in regulating calcium ion transport, which is essential for various cellular processes, including muscle contraction, neurotransmitter release, and cell signaling. 3. **Sensory Perception:** Recoverin has been implicated in sensory perception, including visual perception, auditory perception, and mechanoreception. 4. **Signal Transduction:** Recoverin is involved in signal transduction pathways, including those mediated by calcium ions, which play a crucial role in regulating various cellular processes. **Clinical Significance:** Dysregulation of recoverin has been implicated in various retinal disorders, including photoreceptor degeneration and visual impairment. Mutations in the recoverin gene have been associated with certain forms of retinitis pigmentosa, a group of inherited eye disorders characterized by progressive vision loss. Additionally, recoverin has been shown to have potential therapeutic applications in the treatment of various diseases, including cancer, where it may play a role in regulating calcium ion transport and signal transduction pathways. In conclusion, recoverin is a critical gene involved in the regulation of the phototransduction cascade, calcium ion transport, sensory perception, and signal transduction. Its dysregulation has been implicated in various retinal disorders and diseases, highlighting the importance of further research into its function and therapeutic potential.

Genular Protein ID: 4236965337

Symbol: RECO_HUMAN

Name: Recoverin

UniProtKB Accession Codes:

P35243 Q53XL0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1387789

Title: Isolation of human retinal genes: recoverin cDNA and gene.

PubMed ID: 1387789

DOI: 10.1016/s0006-291x(05)81483-4

PubMed ID: 8500558

Title: Molecular cloning and nucleotide sequence of a cDNA encoding recoverin from human retina.

PubMed ID: 8500558

DOI: 10.1006/exer.1993.1059

PubMed ID: 1388144

Title: The cancer-associated retinopathy antigen is a recoverin-like protein.

PubMed ID: 1388144

PubMed ID: 8912538

Title: Expression of a photoreceptor protein, recoverin, as a cancer-associated retinopathy autoantigen in human lung cancer cell lines.

PubMed ID: 8912538

DOI: 10.1038/bjc.1996.558

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1999465

Title: A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy.

PubMed ID: 1999465

DOI: 10.1083/jcb.112.5.981

Sequence Information:

  • Length: 200
  • Mass: 23130
  • Checksum: 7B1FA91EF19E6122
  • Sequence:
    • MGNSKSGALS KEILEELQLN TKFSEEELCS WYQSFLKDCP TGRITQQQFQ SIYAKFFPDT 
DPKAYAQHVF RSFDSNLDGT LDFKEYVIAL HMTTAGKTNQ KLEWAFSLYD VDGNGTISKN 
EVLEIVMAIF KMITPEDVKL LPDDENTPEK RAEKIWKYFG KNDDDKLTEK EFIEGTLANK 
EILRLIQFEP QKVKEKMKNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.