Details for: RFC3

Gene ID: 5983

Symbol: RFC3

Ensembl ID: ENSG00000133119

Description: replication factor C subunit 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 85.1842
    Cell Significance Index: -13.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 78.8509
    Cell Significance Index: -20.0000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.8546
    Cell Significance Index: -17.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 39.8534
    Cell Significance Index: -20.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.6105
    Cell Significance Index: -20.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7346
    Cell Significance Index: -20.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4181
    Cell Significance Index: -21.3800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6103
    Cell Significance Index: -10.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.1232
    Cell Significance Index: 175.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1658
    Cell Significance Index: 57.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7919
    Cell Significance Index: 355.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3175
    Cell Significance Index: 130.3300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.2670
    Cell Significance Index: 15.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0268
    Cell Significance Index: 69.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8296
    Cell Significance Index: 166.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7347
    Cell Significance Index: 45.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6844
    Cell Significance Index: 111.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5311
    Cell Significance Index: 23.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5309
    Cell Significance Index: 190.4100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5241
    Cell Significance Index: 12.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5201
    Cell Significance Index: 39.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5168
    Cell Significance Index: 60.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5002
    Cell Significance Index: 18.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4739
    Cell Significance Index: 9.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4625
    Cell Significance Index: 6.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4117
    Cell Significance Index: 9.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4093
    Cell Significance Index: 25.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4036
    Cell Significance Index: 11.2800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3873
    Cell Significance Index: 5.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3441
    Cell Significance Index: 40.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3388
    Cell Significance Index: 8.7100
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.3217
    Cell Significance Index: 2.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2671
    Cell Significance Index: 50.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2659
    Cell Significance Index: 7.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.2529
    Cell Significance Index: 7.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2201
    Cell Significance Index: 120.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2152
    Cell Significance Index: 5.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2052
    Cell Significance Index: 36.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2021
    Cell Significance Index: 182.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1952
    Cell Significance Index: 86.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1669
    Cell Significance Index: 2.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1436
    Cell Significance Index: 4.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1304
    Cell Significance Index: 9.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1297
    Cell Significance Index: 3.7000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1079
    Cell Significance Index: 0.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1006
    Cell Significance Index: 4.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0971
    Cell Significance Index: 13.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0919
    Cell Significance Index: 11.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0839
    Cell Significance Index: 154.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0789
    Cell Significance Index: 121.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0643
    Cell Significance Index: 2.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0609
    Cell Significance Index: 1.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0604
    Cell Significance Index: 27.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0560
    Cell Significance Index: 105.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0467
    Cell Significance Index: 29.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0457
    Cell Significance Index: 1.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0376
    Cell Significance Index: 0.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0287
    Cell Significance Index: 19.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0253
    Cell Significance Index: 1.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0227
    Cell Significance Index: 30.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0188
    Cell Significance Index: 0.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0117
    Cell Significance Index: -1.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0151
    Cell Significance Index: -1.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0182
    Cell Significance Index: -13.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0198
    Cell Significance Index: -14.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0279
    Cell Significance Index: -20.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0346
    Cell Significance Index: -2.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0354
    Cell Significance Index: -19.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0372
    Cell Significance Index: -23.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0457
    Cell Significance Index: -13.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0632
    Cell Significance Index: -10.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0760
    Cell Significance Index: -3.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0806
    Cell Significance Index: -10.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0920
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0932
    Cell Significance Index: -10.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0956
    Cell Significance Index: -1.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1011
    Cell Significance Index: -10.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1015
    Cell Significance Index: -1.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1084
    Cell Significance Index: -5.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1106
    Cell Significance Index: -23.3000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1142
    Cell Significance Index: -1.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1152
    Cell Significance Index: -6.0500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1307
    Cell Significance Index: -1.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1318
    Cell Significance Index: -8.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1397
    Cell Significance Index: -3.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1652
    Cell Significance Index: -12.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1681
    Cell Significance Index: -17.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1808
    Cell Significance Index: -9.4200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1987
    Cell Significance Index: -2.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2324
    Cell Significance Index: -18.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2484
    Cell Significance Index: -15.2300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2646
    Cell Significance Index: -1.5700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2814
    Cell Significance Index: -1.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3100
    Cell Significance Index: -10.1500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.3166
    Cell Significance Index: -2.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3247
    Cell Significance Index: -8.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3324
    Cell Significance Index: -4.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3526
    Cell Significance Index: -11.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3526
    Cell Significance Index: -7.3800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3555
    Cell Significance Index: -7.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RFC3 is a highly conserved protein that is expressed in various cell types, including cerebellar granule cell precursors, oogonial cells, and cardiac muscle myoblasts. The protein has a molecular weight of 37 kDa and is composed of three subunits: α, β, and γ. The RFC3 protein is characterized by its ability to bind to DNA and interact with other proteins involved in DNA replication and repair. Notably, RFC3 is involved in the activation of the A-T syndrome pathway in response to replication stress and has been implicated in defective homologous recombination repair due to BRCA2 loss of function. **Pathways and Functions** RFC3 is involved in several DNA replication and repair pathways, including: 1. **Activation of A-T syndrome pathway**: RFC3 plays a crucial role in the activation of the A-T syndrome pathway in response to replication stress, which is characterized by the formation of A-T complex and the recruitment of DNA polymerase δ. 2. **DNA replication**: RFC3 is involved in the initiation and elongation of DNA replication, specifically in the recruitment of DNA polymerase δ and the unwinding of DNA. 3. **DNA repair**: RFC3 is involved in the repair of DNA double-strand breaks, including homologous recombination repair (HRR) and non-homologous end joining (NHEJ). 4. **Cell cycle regulation**: RFC3 is involved in the regulation of the cell cycle, specifically in the G2/M checkpoint, which ensures that DNA damage is repaired before cell division. 5. **Telomere maintenance**: RFC3 is involved in the synthesis and maintenance of telomeres, which are essential for maintaining genome stability. **Clinical Significance** RFC3 has been implicated in several diseases, including: 1. **A-T syndrome**: RFC3 has been shown to be mutated in patients with A-T syndrome, a rare genetic disorder characterized by DNA replication defects. 2. **BRCA2-related disorders**: RFC3 has been implicated in defective homologous recombination repair due to BRCA2 loss of function, which increases the risk of breast and ovarian cancer. 3. **Cancer**: RFC3 has been shown to be overexpressed in certain types of cancer, including breast and colon cancer, suggesting its potential role in tumorigenesis. 4. **Neurodegenerative diseases**: RFC3 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, suggesting its potential role in maintaining genome stability in the nervous system. In conclusion, RFC3 is a crucial protein that plays a pivotal role in DNA replication, repair, and maintenance. Its involvement in various diseases highlights its importance in maintaining genome stability and its potential as a therapeutic target for the treatment of genetic disorders and cancer.

Genular Protein ID: 1346680381

Symbol: RFC3_HUMAN

Name: Replication factor C subunit 3

UniProtKB Accession Codes:

P40938 C9JU95 O15252 Q5W0E8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 13 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 21 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8441605

Title: Homology in accessory proteins of replicative polymerases -- E. coli to humans.

PubMed ID: 8441605

DOI: 10.1093/nar/21.1.1

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10884395

Title: The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9.

PubMed ID: 10884395

DOI: 10.1074/jbc.m005782200

PubMed ID: 11572977

Title: Purification and characterization of human DNA damage checkpoint Rad complexes.

PubMed ID: 11572977

DOI: 10.1073/pnas.201373498

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 356
  • Mass: 40556
  • Checksum: 820C11675A2C63A5
  • Sequence:
    • MSLWVDKYRP CSLGRLDYHK EQAAQLRNLV QCGDFPHLLV YGPSGAGKKT RIMCILRELY 
GVGVEKLRIE HQTITTPSKK KIEISTIASN YHLEVNPSDA GNSDRVVIQE MLKTVAQSQQ 
LETNSQRDFK VVLLTEVDKL TKDAQHALRR TMEKYMSTCR LILCCNSTSK VIPPIRSRCL 
AVRVPAPSIE DICHVLSTVC KKEGLNLPSQ LAHRLAEKSC RNLRKALLMC EACRVQQYPF 
TADQEIPETD WEVYLRETAN AIVSQQTPQR LLEVRGRLYE LLTHCIPPEI IMKGLLSELL 
HNCDGQLKGE VAQMAAYYEH RLQLGSKAIY HLEAFVAKFM ALYKKFMEDG LEGMMF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.