Details for: RFNG

Gene ID: 5986

Symbol: RFNG

Ensembl ID: ENSG00000169733

Description: RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 156.4175
    Cell Significance Index: -24.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 93.7931
    Cell Significance Index: -23.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 52.0204
    Cell Significance Index: -24.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.4523
    Cell Significance Index: -23.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.1183
    Cell Significance Index: -24.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.3608
    Cell Significance Index: -25.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.3395
    Cell Significance Index: -16.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2156
    Cell Significance Index: 141.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9423
    Cell Significance Index: 153.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7282
    Cell Significance Index: 20.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7247
    Cell Significance Index: 33.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7136
    Cell Significance Index: 141.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5710
    Cell Significance Index: 12.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5646
    Cell Significance Index: 36.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5269
    Cell Significance Index: 72.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5224
    Cell Significance Index: 104.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4552
    Cell Significance Index: 248.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4299
    Cell Significance Index: 22.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4139
    Cell Significance Index: 28.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3962
    Cell Significance Index: 10.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3735
    Cell Significance Index: 6.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3351
    Cell Significance Index: 9.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3345
    Cell Significance Index: 33.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3028
    Cell Significance Index: 38.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2800
    Cell Significance Index: 12.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2790
    Cell Significance Index: 100.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2701
    Cell Significance Index: 119.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2686
    Cell Significance Index: 242.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2448
    Cell Significance Index: 44.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2213
    Cell Significance Index: 6.3500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.1972
    Cell Significance Index: 1.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1952
    Cell Significance Index: 24.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1888
    Cell Significance Index: 13.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1780
    Cell Significance Index: 33.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1640
    Cell Significance Index: 21.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1413
    Cell Significance Index: 6.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1028
    Cell Significance Index: 6.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0862
    Cell Significance Index: 59.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0706
    Cell Significance Index: 5.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0493
    Cell Significance Index: 1.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0469
    Cell Significance Index: 2.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0434
    Cell Significance Index: 1.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0433
    Cell Significance Index: 1.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0418
    Cell Significance Index: 7.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0367
    Cell Significance Index: 1.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0204
    Cell Significance Index: 38.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0017
    Cell Significance Index: 1.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0018
    Cell Significance Index: -2.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0127
    Cell Significance Index: -17.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0145
    Cell Significance Index: -10.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0154
    Cell Significance Index: -0.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0212
    Cell Significance Index: -16.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0234
    Cell Significance Index: -6.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0237
    Cell Significance Index: -10.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0285
    Cell Significance Index: -21.1400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0312
    Cell Significance Index: -0.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0323
    Cell Significance Index: -0.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0402
    Cell Significance Index: -22.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0458
    Cell Significance Index: -28.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0559
    Cell Significance Index: -1.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0665
    Cell Significance Index: -6.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0693
    Cell Significance Index: -10.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0744
    Cell Significance Index: -8.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0877
    Cell Significance Index: -6.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1036
    Cell Significance Index: -3.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1080
    Cell Significance Index: -2.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1140
    Cell Significance Index: -13.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1192
    Cell Significance Index: -2.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1220
    Cell Significance Index: -8.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1278
    Cell Significance Index: -26.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2086
    Cell Significance Index: -6.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2160
    Cell Significance Index: -22.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2406
    Cell Significance Index: -13.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2540
    Cell Significance Index: -11.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2585
    Cell Significance Index: -20.4700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2631
    Cell Significance Index: -2.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2715
    Cell Significance Index: -2.5000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2716
    Cell Significance Index: -1.8400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2986
    Cell Significance Index: -4.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3042
    Cell Significance Index: -8.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3153
    Cell Significance Index: -11.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3187
    Cell Significance Index: -19.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3441
    Cell Significance Index: -7.9500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3727
    Cell Significance Index: -2.4300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3763
    Cell Significance Index: -4.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3788
    Cell Significance Index: -19.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3811
    Cell Significance Index: -20.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4300
    Cell Significance Index: -9.4200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4304
    Cell Significance Index: -3.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4552
    Cell Significance Index: -6.2100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4690
    Cell Significance Index: -4.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4803
    Cell Significance Index: -11.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5021
    Cell Significance Index: -15.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5142
    Cell Significance Index: -18.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5211
    Cell Significance Index: -17.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5400
    Cell Significance Index: -13.8800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5418
    Cell Significance Index: -7.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5544
    Cell Significance Index: -20.3500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5642
    Cell Significance Index: -8.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RFNG is a member of the glycosyltransferase family, specifically involved in the transfer of O-fucose and N-acetylglucosamine (GlcNAc) residues to specific peptides. This post-translational modification plays a crucial role in protein function, stability, and interactions. RFNG exhibits high specificity, targeting specific substrates and displaying a high degree of substrate selectivity. Its activity is tightly regulated, with evidence suggesting that RFNG is subject to feedback inhibition and modulation by other signaling pathways. **Pathways and Functions:** RFNG is intricately involved in various cellular processes, including: 1. **Notch Signaling Pathway:** RFNG is a key player in the regulation of Notch signaling, a critical pathway involved in cell fate decisions, differentiation, and development. The enzyme modulates the processing and activity of Notch receptors, influencing the outcome of these signaling events. 2. **Cell Differentiation:** RFNG's involvement in Notch signaling and other pathways underscores its role in cellular differentiation, particularly in neural and epithelial cells. 3. **Immune Regulation:** RFNG has been implicated in immune responses, with studies suggesting its involvement in the regulation of immune cell function and the modulation of inflammatory responses. 4. **Golgi Membrane Function:** RFNG's activity is also linked to the functioning of the Golgi apparatus, a critical organelle involved in protein modification, sorting, and transport. **Clinical Significance:** RFNG's involvement in Notch signaling and immune regulation raises important questions regarding its potential role in various diseases, including: 1. **Cancer:** Dysregulation of Notch signaling has been implicated in cancer development and progression. RFNG's involvement in this pathway suggests its potential as a therapeutic target. 2. **Neurological Disorders:** RFNG's role in neural development and function highlights its potential as a therapeutic target for neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immunological Disorders:** RFNG's involvement in immune regulation suggests its potential as a therapeutic target for immunological disorders, such as autoimmune diseases and inflammatory conditions. In conclusion, RFNG is a multifaceted enzyme with far-reaching implications for our understanding of immune regulation, development, and disease. Further research is necessary to fully elucidate the mechanisms underlying RFNG's functions and to explore its potential as a therapeutic target.

Genular Protein ID: 3840196290

Symbol: RFNG_HUMAN

Name: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

UniProtKB Accession Codes:

Q9Y644 O00588

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 13 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 10341080

Title: Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes.

PubMed ID: 10341080

DOI: 10.1007/s003359901039

PubMed ID: 9187150

Title: A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.

PubMed ID: 9187150

DOI: 10.1242/dev.124.11.2245

Sequence Information:

  • Length: 331
  • Mass: 36424
  • Checksum: 986270FFA7C13573
  • Sequence:
    • MSRARGALCR ACLALAAALA ALLLLPLPLP RAPAPARTPA PAPRAPPSRP AAPSLRPDDV 
FIAVKTTRKN HGPRLRLLLR TWISRARQQT FIFTDGDDPE LELQGGDRVI NTNCSAVRTR 
QALCCKMSVE YDKFIESGRK WFCHVDDDNY VNARSLLHLL SSFSPSQDVY LGRPSLDHPI 
EATERVQGGR TVTTVKFWFA TGGAGFCLSR GLALKMSPWA SLGSFMSTAE QVRLPDDCTV 
GYIVEGLLGA RLLHSPLFHS HLENLQRLPP DTLLQQVTLS HGGPENPHNV VNVAGGFSLH 
QDPTRFKSIH CLLYPDTDWC PRQKQGAPTS R

Genular Protein ID: 3739245859

Symbol: Q8N9R1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N9R1

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 11 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 3 Gene3D 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 Rhea 6 SAM 1 SMR 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 197
  • Mass: 20903
  • Checksum: C548D161D0D7143B
  • Sequence:
    • MSVEYDKFIE SGRKWFCHVD DDNYVNARSL LHLLSSFSPS QDVYLGRPSL DHPIEATERV 
QGGRTVSVGA DAIGADAFLD TSPGGTAEGV ESWLEKGIGL GAQADPPRWF ACGVSGAGQE 
ALTVLGREGV SGPGGEGLEA TGQWPAEAPG SFCSKKLLLP GWDLLRGSLR KMPGESHEES 
GVRSPVLGSS DHHPIFR

Genular Protein ID: 4070615169

Symbol: F5H3H7_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H3H7

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 6 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 205
  • Mass: 22804
  • Checksum: FFB1B9D30AB704D9
  • Sequence:
    • MSVEYDKFIE SGRKWFCHVD DDNYVNARSL LHLLSSFSPS QDVYLGRPSL DHPIEATERV 
QGGRTVTTVK FWFATGGAGF CLSRGLALKM SPWASLGSFM STAEQVRLPD DCTVGYIVEG 
LLGARLLHSP LFHSHLENLQ RLPPDTLLQQ VTLSHGGPEN PHNVVNVAGG FSLHQDPTRF 
KSIHCLLYPD TDWCPRQKQG APTSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.