Details for: RPN1

Gene ID: 6184

Symbol: RPN1

Ensembl ID: ENSG00000163902

Description: ribophorin I

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 118.2796
    Cell Significance Index: -48.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 107.4935
    Cell Significance Index: -43.6700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 100.9166
    Cell Significance Index: -47.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 94.7344
    Cell Significance Index: -48.7300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 71.1303
    Cell Significance Index: -47.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.1276
    Cell Significance Index: -44.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.0031
    Cell Significance Index: -42.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.8994
    Cell Significance Index: -39.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.3244
    Cell Significance Index: -16.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.7894
    Cell Significance Index: 303.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.7458
    Cell Significance Index: 164.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.3120
    Cell Significance Index: 62.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.1129
    Cell Significance Index: 110.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.8287
    Cell Significance Index: 42.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6264
    Cell Significance Index: 75.8300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.6245
    Cell Significance Index: 20.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.5956
    Cell Significance Index: 42.6800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.5615
    Cell Significance Index: 11.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.5321
    Cell Significance Index: 45.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.5169
    Cell Significance Index: 154.9600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3110
    Cell Significance Index: 24.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2222
    Cell Significance Index: 91.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1219
    Cell Significance Index: 612.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0145
    Cell Significance Index: 27.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9762
    Cell Significance Index: 134.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9322
    Cell Significance Index: 168.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9023
    Cell Significance Index: 146.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8713
    Cell Significance Index: 107.1400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.8401
    Cell Significance Index: 5.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8103
    Cell Significance Index: 160.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6768
    Cell Significance Index: 19.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6741
    Cell Significance Index: 87.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6728
    Cell Significance Index: 19.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6547
    Cell Significance Index: 234.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6066
    Cell Significance Index: 28.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5803
    Cell Significance Index: 57.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5343
    Cell Significance Index: 107.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5068
    Cell Significance Index: 22.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4421
    Cell Significance Index: 52.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4121
    Cell Significance Index: 3.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3837
    Cell Significance Index: 10.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3723
    Cell Significance Index: 164.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3704
    Cell Significance Index: 47.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3400
    Cell Significance Index: 17.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3338
    Cell Significance Index: 57.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3092
    Cell Significance Index: 58.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3045
    Cell Significance Index: 274.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2456
    Cell Significance Index: 5.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2028
    Cell Significance Index: 5.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1639
    Cell Significance Index: 5.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1150
    Cell Significance Index: 87.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1108
    Cell Significance Index: 3.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0793
    Cell Significance Index: 5.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0775
    Cell Significance Index: 0.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0378
    Cell Significance Index: 2.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0181
    Cell Significance Index: 13.2800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0116
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0060
    Cell Significance Index: 11.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0059
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0068
    Cell Significance Index: -5.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0099
    Cell Significance Index: -18.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0120
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0123
    Cell Significance Index: -7.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0136
    Cell Significance Index: -20.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0212
    Cell Significance Index: -13.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0221
    Cell Significance Index: -30.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0379
    Cell Significance Index: -1.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0526
    Cell Significance Index: -23.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0555
    Cell Significance Index: -31.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0598
    Cell Significance Index: -1.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0784
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1015
    Cell Significance Index: -21.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1157
    Cell Significance Index: -8.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1372
    Cell Significance Index: -39.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1829
    Cell Significance Index: -20.9500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1882
    Cell Significance Index: -2.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2026
    Cell Significance Index: -29.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2292
    Cell Significance Index: -4.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2312
    Cell Significance Index: -26.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2367
    Cell Significance Index: -8.2300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3057
    Cell Significance Index: -34.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3461
    Cell Significance Index: -23.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3470
    Cell Significance Index: -24.0000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3532
    Cell Significance Index: -2.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3543
    Cell Significance Index: -21.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3603
    Cell Significance Index: -22.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4174
    Cell Significance Index: -43.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4242
    Cell Significance Index: -22.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4848
    Cell Significance Index: -6.6200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5462
    Cell Significance Index: -10.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5670
    Cell Significance Index: -44.9000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5807
    Cell Significance Index: -8.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6010
    Cell Significance Index: -10.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6029
    Cell Significance Index: -15.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6280
    Cell Significance Index: -38.5000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.6354
    Cell Significance Index: -6.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6502
    Cell Significance Index: -28.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6620
    Cell Significance Index: -9.9200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.7040
    Cell Significance Index: -4.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7266
    Cell Significance Index: -15.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPN1 is a 67-kDa subunit of the OTC, a hetero-oligomeric enzyme complex responsible for the transfer of N-linked glycans to nascent polypeptides in the ER. The OTC consists of two catalytic subunits, RPN1 and RPN2, which work in concert to assemble and modify glycoproteins. RPN1 is specifically involved in the transfer of N-linked glycans to asparagine residues, a critical step in protein maturation. The protein is highly conserved across species and is primarily expressed in cells of the immune system, including endothelial cells, B cells, and T regulatory cells. **Pathways and Functions:** RPN1 plays a central role in several cellular pathways, including: 1. **Asparagine N-linked glycosylation**: RPN1 is essential for the transfer of N-linked glycans to asparagine residues, a critical step in protein maturation. 2. **Endoplasmic reticulum function**: RPN1 is involved in the assembly and modification of proteins destined for the secretory pathway, regulating protein folding, quality control, and ER homeostasis. 3. **Immune response**: RPN1 is expressed in cells of the immune system, where it is involved in the regulation of immune responses, including the maturation of B cells and T regulatory cells. 4. **Viral infection pathways**: RPN1 is implicated in the maturation of the SARS-CoV-2 spike protein, highlighting its importance in viral infection and disease. **Clinical Significance:** Dysregulation of RPN1 has been implicated in various diseases, including: 1. **SARS-CoV-2 infection**: RPN1 is essential for the maturation of the viral spike protein, making it a potential target for therapeutic intervention in SARS-CoV-2 infection. 2. **Immunodeficiency disorders**: RPN1 is expressed in cells of the immune system, where it is involved in the regulation of immune responses. Dysregulation of RPN1 may contribute to immunodeficiency disorders, such as autoimmune diseases and cancer. 3. **Cancer**: RPN1 is overexpressed in various types of cancer, where it is involved in the regulation of protein folding and quality control, contributing to tumorigenesis. In conclusion, RPN1 is a critical protein component of the oligosaccharyltransferase complex, playing a pivotal role in the biogenesis of glycoproteins in the endoplasmic reticulum. Its dysregulation has been implicated in various diseases, including SARS-CoV-2 infection, immunodeficiency disorders, and cancer. Further research is necessary to fully elucidate the mechanisms by which RPN1 regulates cellular processes and to develop therapeutic strategies targeting this protein.

Genular Protein ID: 175237118

Symbol: RPN1_HUMAN

Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit

UniProtKB Accession Codes:

P04843 B2R5Z0 D3DNB6 Q68DT1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 4 Ensembl 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3034581

Title: Human ribophorins I and II: the primary structure and membrane topology of two highly conserved rough endoplasmic reticulum-specific glycoproteins.

PubMed ID: 3034581

DOI: 10.1002/j.1460-2075.1987.tb04721.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 12887896

Title: Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties.

PubMed ID: 12887896

DOI: 10.1016/s1097-2765(03)00243-0

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25135935

Title: Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

PubMed ID: 25135935

DOI: 10.1083/jcb.201404083

PubMed ID: 23606741

Title: OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation.

PubMed ID: 23606741

DOI: 10.1242/jcs.115410

PubMed ID: 24337577

Title: Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.

PubMed ID: 24337577

DOI: 10.1074/jbc.m113.534602

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32160526

Title: A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-Resident UFMylation.

PubMed ID: 32160526

DOI: 10.1016/j.cell.2020.02.017

PubMed ID: 31831667

Title: Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.

PubMed ID: 31831667

DOI: 10.1126/science.aaz3505

Sequence Information:

  • Length: 607
  • Mass: 68569
  • Checksum: A2351A9CFABAEB6C
  • Sequence:
    • MEAPAAGLFL LLLLGTWAPA PGSASSEAPP LINEDVKRTV DLSSHLAKVT AEVVLAHLGG 
GSTSRATSFL LALEPELEAR LAHLGVQVKG EDEEENNLEV RETKIKGKSG RFFTVKLPVA 
LDPGAKISVI VETVYTHVLH PYPTQITQSE KQFVVFEGNH YFYSPYPTKT QTMRVKLASR 
NVESYTKLGN PTRSEDLLDY GPFRDVPAYS QDTFKVHYEN NSPFLTITSM TRVIEVSHWG 
NIAVEENVDL KHTGAVLKGP FSRYDYQRQP DSGISSIRSF KTILPAAAQD VYYRDEIGNV 
STSHLLILDD SVEMEIRPRF PLFGGWKTHY IVGYNLPSYE YLYNLGDQYA LKMRFVDHVF 
DEQVIDSLTV KIILPEGAKN IEIDSPYEIS RAPDELHYTY LDTFGRPVIV AYKKNLVEQH 
IQDIVVHYTF NKVLMLQEPL LVVAAFYILF FTVIIYVRLD FSITKDPAAE ARMKVACITE 
QVLTLVNKRI GLYRHFDETV NRYKQSRDIS TLNSGKKSLE TEHKALTSEI ALLQSRLKTE 
GSDLCDRVSE MQKLDAQVKE LVLKSAVEAE RLVAGKLKKD TYIENEKLIS GKRQELVTKI 
DHILDAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.