RPS2 | ENSG00000140988 | NCBI 6187

Details for: RPS2

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
M-decay: degradation of maternal mrnas by maternally stored factors
(R-HSA-9820841)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Post-translational protein modification
(R-HSA-597592)
Protein methylation
(R-HSA-8876725)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rmts methylate histone arginines
(R-HSA-3214858)
Rrna modification in the nucleus and cytosol
(R-HSA-6790901)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cadherin binding
(GO:0045296)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Fibroblast growth factor binding
(GO:0017134)
Focal adhesion
(GO:0005925)
Membrane
(GO:0016020)
Mrna binding
(GO:0003729)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of ubiquitin-protein transferase activity
(GO:0051443)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

central memory CD4-positive, alpha-beta T cell CL0000904

CSI 131.7

rCSI 77.78%

PRS 1.76
hematopoietic stem cell CL0000037

CSI 117.5

rCSI 78.1%

PRS 1.5
class switched memory B cell CL0000972

CSI 116.47

rCSI 86.95%

PRS 2.13
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 116.14

rCSI 81.57%

PRS 3.85
CD4-positive helper T cell CL0000492

CSI 115.13

rCSI 87.09%

PRS 1.76
double negative thymocyte CL0002489

CSI 110.75

rCSI 77%

PRS 1.47
CD4-positive, alpha-beta thymocyte CL0000810

CSI 110.42

rCSI 88.45%

PRS 2.36
group 3 innate lymphoid cell CL0001071

CSI 110.02

rCSI 82.67%

PRS 1.29
neural crest cell CL0011012

CSI 109.14

rCSI 86.26%

PRS 0.87
keratinocyte CL0000312

CSI 108.93

rCSI 91.31%

PRS 1.51
mature T cell CL0002419

CSI 108.8

rCSI 84.62%

PRS 1.8
epithelial cell of lower respiratory tract CL0002632

CSI 107.36

rCSI 83.23%

PRS 1.19
common myeloid progenitor CL0000049

CSI 107.21

rCSI 86.69%

PRS 1.23
epithelial cell of lung CL0000082

CSI 106.21

rCSI 88.05%

PRS 1.17
granulocyte monocyte progenitor cell CL0000557

CSI 102.45

rCSI 88.71%

PRS 1.41
naive T cell CL0000898

CSI 101.52

rCSI 70.65%

PRS 1.84
plasmacytoid dendritic cell, human CL0001058

CSI 99.05

rCSI 69.16%

PRS 1.33
T follicular helper cell CL0002038

CSI 98.27

rCSI 73.54%

PRS 2.07
fallopian tube secretory epithelial cell CL4030006

CSI 97.95

rCSI 94.29%

PRS 1.31
megakaryocyte-erythroid progenitor cell CL0000050

CSI 97.95

rCSI 88.45%

PRS 1.11
naive B cell CL0000788

CSI 97.92

rCSI 83.99%

PRS 4.09
early lymphoid progenitor CL0000936

CSI 97.13

rCSI 85.3%

PRS 1.41
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 96.12

rCSI 72.08%

PRS 3.8
T-helper 17 cell CL0000899

CSI 95.3

rCSI 75.67%

PRS 2.24
unswitched memory B cell CL0000970

CSI 91.37

rCSI 76.87%

PRS 2.12
intestine goblet cell CL0019031

CSI 89.25

rCSI 79.22%

PRS 1.26
pro-B cell CL0000826

CSI 88.55

rCSI 73.33%

PRS 1.26
intestinal epithelial cell CL0002563

CSI 88.44

rCSI 92.44%

PRS 1.34
skin fibroblast CL0002620

CSI 87.69

rCSI 75.6%

PRS 2.11
bronchus fibroblast of lung CL2000093

CSI 87.33

rCSI 70.96%

PRS 1.31
plasmablast CL0000980

CSI 86.5

rCSI 68.05%

PRS 1.5
memory B cell CL0000787

CSI 86.48

rCSI 85.4%

PRS 5.59
activated CD8-positive, alpha-beta T cell CL0000906

CSI 85.53

rCSI 84.07%

PRS 3.77
immature B cell CL0000816

CSI 84.18

rCSI 62.54%

PRS 1.88
pancreatic A cell CL0000171

CSI 83.67

rCSI 87.65%

PRS 1.36
pancreatic D cell CL0000173

CSI 82.84

rCSI 81.47%

PRS 1.39
precursor B cell CL0000817

CSI 79.84

rCSI 69.94%

PRS 1.7
activated CD4-positive, alpha-beta T cell CL0000896

CSI 79.66

rCSI 73.64%

PRS 2.31
elicited macrophage CL0000861

CSI 79.16

rCSI 72.68%

PRS 1.43
transit amplifying cell of colon CL0009011

CSI 78.64

rCSI 92.35%

PRS 1.54
ciliated epithelial cell CL0000067

CSI 76.49

rCSI 67.26%

PRS 0.92
effector CD8-positive, alpha-beta T cell CL0001050

CSI 76.45

rCSI 58.15%

PRS 1.67
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 76.33

rCSI 50.87%

PRS 3.57
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 74.98

rCSI 73.63%

PRS 2.01
mucosal invariant T cell CL0000940

CSI 73.61

rCSI 59.48%

PRS 3.3
IgA plasma cell CL0000987

CSI 73.57

rCSI 75.31%

PRS 2.38
CD14-low, CD16-positive monocyte CL0002396

CSI 72.92

rCSI 56.18%

PRS 1.13
activated type II NK T cell CL0000931

CSI 72.52

rCSI 81.62%

PRS 2.12
common dendritic progenitor CL0001029

CSI 70.73

rCSI 88.77%

PRS 1.59
myeloid leukocyte CL0000766

CSI 70.05

rCSI 64.63%

PRS 1.27
fraction A pre-pro B cell CL0002045

CSI 69.4

rCSI 79.44%

PRS 2.62
enteroendocrine cell CL0000164

CSI 69.18

rCSI 94.53%

PRS 1.39
gamma-delta T cell CL0000798

CSI 69.08

rCSI 81.14%

PRS 12.82
respiratory basal cell CL0002633

CSI 69.02

rCSI 71.5%

PRS 1.47
mesodermal cell CL0000222

CSI 68.02

rCSI 81.65%

PRS 1.26
fibroblast of lung CL0002553

CSI 67.99

rCSI 63.27%

PRS 1.25
mature NK T cell CL0000814

CSI 67.27

rCSI 86.04%

PRS 5.86
peripheral nervous system neuron CL2000032

CSI 67.2

rCSI 91.56%

PRS 1.15
CD8-positive, alpha-beta memory T cell CL0000909

CSI 66.65

rCSI 69.61%

PRS 4.07
common lymphoid progenitor CL0000051

CSI 64.76

rCSI 86.54%

PRS 2.41
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 64.51

rCSI 74.5%

PRS 1.18
M cell of gut CL0000682

CSI 63.7

rCSI 67.69%

PRS 2.3
CD4-positive, alpha-beta T cell CL0000624

CSI 63.16

rCSI 80.83%

PRS 27.68
endothelial cell of artery CL1000413

CSI 62.8

rCSI 92.01%

PRS 7.78
extravillous trophoblast CL0008036

CSI 61.99

rCSI 76.69%

PRS 1.11
B cell CL0000236

CSI 61.9

rCSI 82.82%

PRS 7.75
pancreatic acinar cell CL0002064

CSI 60.98

rCSI 81.05%

PRS 1.38
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 60.89

rCSI 76.51%

PRS 6.95
enteric smooth muscle cell CL0002504

CSI 60.66

rCSI 86.57%

PRS 1.44
CD1c-positive myeloid dendritic cell CL0002399

CSI 59.66

rCSI 72.06%

PRS 1.44
alveolar type 1 fibroblast cell CL4028004

CSI 59.65

rCSI 65.33%

PRS 1.47
renal alpha-intercalated cell CL0005011

CSI 59.6

rCSI 79.68%

PRS 1.72
colon epithelial cell CL0011108

CSI 58.69

rCSI 61.48%

PRS 1.18
plasma cell CL0000786

CSI 58.59

rCSI 76.78%

PRS 6.83
mucous neck cell CL0000651

CSI 58.54

rCSI 84.37%

PRS 2.05
classical monocyte CL0000860

CSI 57.65

rCSI 85.47%

PRS 15.34
lung ciliated cell CL1000271

CSI 57.59

rCSI 66.59%

PRS 0.91
conventional dendritic cell CL0000990

CSI 57.04

rCSI 47.62%

PRS 4.37
CD8-positive, alpha-beta thymocyte CL0000811

CSI 56.79

rCSI 88.56%

PRS 3.3
perivascular cell CL4033054

CSI 56.58

rCSI 77.34%

PRS 1.44
myofibroblast cell CL0000186

CSI 56.51

rCSI 78.27%

PRS 1.82
neuroblast (sensu Vertebrata) CL0000031

CSI 56.47

rCSI 72.48%

PRS 1.27
radial glial cell CL0000681

CSI 56.32

rCSI 78.25%

PRS 1.35
myeloid dendritic cell CL0000782

CSI 56.1

rCSI 81.27%

PRS 1.85
goblet cell CL0000160

CSI 55.96

rCSI 52.88%

PRS 1.31
promyelocyte CL0000836

CSI 55.8

rCSI 80.48%

PRS 1.75
secretory cell CL0000151

CSI 55.79

rCSI 58.21%

PRS 1.29
transit amplifying cell CL0009010

CSI 55.75

rCSI 85.28%

PRS 2.06
interstitial cell of Cajal CL0002088

CSI 55.69

rCSI 70.89%

PRS 1.48
IgG plasma cell CL0000985

CSI 55.29

rCSI 66.23%

PRS 2.18
mature B cell CL0000785

CSI 55

rCSI 47.82%

PRS 1.55
conjunctival epithelial cell CL1000432

CSI 54.86

rCSI 83.8%

PRS 1.28
paneth cell CL0000510

CSI 54.64

rCSI 80.67%

PRS 2
melanocyte CL0000148

CSI 54.53

rCSI 40.39%

PRS 1.2
pulmonary ionocyte CL0017000

CSI 53.8

rCSI 65.49%

PRS 1.59
epithelial cell CL0000066

CSI 53.56

rCSI 82.31%

PRS 1.83
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 52.94

rCSI 72.11%

PRS 3.16
T-helper 1 cell CL0000545

CSI 52.26

rCSI 94.34%

PRS 4.01
acinar cell CL0000622

CSI 52.01

rCSI 76.27%

PRS 1.67
retinal blood vessel endothelial cell CL0002585

CSI 51.92

rCSI 82.92%

PRS 1.38

adipocyte CL0000136

CSI -41.6

rCSI -53.5%

PRS 1.7%
VIP GABAergic cortical interneuron CL4023016

CSI -26.1

rCSI -31.2%

PRS 0.9%
inhibitory interneuron CL0000498

CSI -25.4

rCSI -58.6%

PRS 1.3%
retinal bipolar neuron CL0000748

CSI -24.7

rCSI -46.2%

PRS 1.1%
renal interstitial pericyte CL1001318

CSI -20.9

rCSI -57.7%

PRS 1.4%
professional antigen presenting cell CL0000145

CSI -18.6

rCSI -63.9%

PRS 5.6%
GABAergic neuron CL0000617

CSI -18.4

rCSI -61.6%

PRS 1.4%
kidney interstitial alternatively activated macrophage CL1000695

CSI -18.2

rCSI -47.5%

PRS 1.6%
squamous epithelial cell CL0000076

CSI -18.1

rCSI -43.0%

PRS 1.7%
cardiac neuron CL0010022

CSI -17.9

rCSI -57.3%

PRS 1.1%
endocrine cell CL0000163

CSI -16.1

rCSI -82.7%

PRS 5.9%
kidney collecting duct principal cell CL1001431

CSI -16.1

rCSI -81.1%

PRS 9.0%
cerebral cortex neuron CL0010012

CSI -15.7

rCSI -64.2%

PRS 1.8%
rod bipolar cell CL0000751

CSI -14.2

rCSI -25.6%

PRS 1.1%
astrocyte of the cerebral cortex CL0002605

CSI -14.2

rCSI -31.9%

PRS 0.9%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -12.8

rCSI -39.9%

PRS 1.0%
cardiac endothelial cell CL0010008

CSI -12.6

rCSI -51.0%

PRS 1.5%
diffuse bipolar 6 cell CL4033032

CSI -11.4

rCSI -60.1%

PRS 4.2%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -11.4

rCSI -67.2%

PRS 1.0%
glutamatergic neuron CL0000679

CSI -10.8

rCSI -22.3%

PRS 1.6%
invaginating midget bipolar cell CL4033034

CSI -10.3

rCSI -60.5%

PRS 3.4%
epicardial adipocyte CL1000309

CSI -10.1

rCSI -33.0%

PRS 2.5%
exhausted T cell CL0011025

CSI -8.8

rCSI -100.0%

PRS 7.3%
mature microglial cell CL0002629

CSI -8.5

rCSI -35.5%

PRS 4.9%
primordial germ cell CL0000670

CSI -8.4

rCSI -41.9%

PRS 10.0%
regular ventricular cardiac myocyte CL0002131

CSI -8.3

rCSI -52.1%

PRS 1.1%
kidney collecting duct intercalated cell CL1001432

CSI -8.2

rCSI -58.7%

PRS 5.9%
mature astrocyte CL0002627

CSI -8.2

rCSI -34.9%

PRS 3.6%
flat midget bipolar cell CL4033033

CSI -8.1

rCSI -57.6%

PRS 3.5%
OFFx cell CL4033036

CSI -7.9

rCSI -37.1%

PRS 3.9%
near-projecting glutamatergic cortical neuron CL4023012

CSI -7.5

rCSI -28.4%

PRS 0.9%
hepatic stellate cell CL0000632

CSI -7.0

rCSI -26.1%

PRS 1.1%
starburst amacrine cell CL0004232

CSI -6.8

rCSI -57.3%

PRS 4.0%
periportal region hepatocyte CL0019026

CSI -6.8

rCSI -26.3%

PRS 2.2%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -6.5

rCSI -11.8%

PRS 1.5%
erythroid lineage cell CL0000764

CSI -6.3

rCSI -40.3%

PRS 3.6%
cord blood hematopoietic stem cell CL2000095

CSI -5.5

rCSI -100.0%

PRS 10.7%
cerebral cortex endothelial cell CL1001602

CSI -5.3

rCSI -9.2%

PRS 1.0%
neural cell CL0002319

CSI -4.9

rCSI -18.5%

PRS 3.0%
cell of skeletal muscle CL0000188

CSI -4.9

rCSI -53.1%

PRS 8.8%
diffuse bipolar 2 cell CL4033028

CSI -4.8

rCSI -36.9%

PRS 3.8%
diffuse bipolar 3a cell CL4033029

CSI -3.4

rCSI -23.2%

PRS 3.4%
diffuse bipolar 3b cell CL4033030

CSI -3.2

rCSI -21.0%

PRS 3.5%
indirect pathway medium spiny neuron CL4023029

CSI -3.0

rCSI -71.6%

PRS 1.0%
cerebellar granule cell CL0001031

CSI -2.7

rCSI -3.9%

PRS 1.4%
ON parasol ganglion cell CL4033052

CSI -1.9

rCSI -27.2%

PRS 1.2%
cardiac blood vessel endothelial cell CL0010006

CSI -1.6

rCSI -11.1%

PRS 4.6%
amacrine cell CL0000561

CSI -1.5

rCSI -4.3%

PRS 1.2%
midzonal region hepatocyte CL0019028

CSI -1.4

rCSI -3.2%

PRS 2.3%
glycinergic amacrine cell CL4030028

CSI -0.6

rCSI -1.6%

PRS 2.0%
ON midget ganglion cell CL4033046

CSI -0.5

rCSI -9.4%

PRS 1.7%
L6b glutamatergic cortical neuron CL4023038

CSI 0.0

rCSI 0.0%

PRS 0.9%
cardiac muscle cell CL0000746

CSI 0.2

rCSI 0.2%

PRS 1.1%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.3

rCSI 0.5%

PRS 0.8%
sst GABAergic cortical interneuron CL4023017

CSI 0.5

rCSI 0.6%

PRS 0.9%
OFF midget ganglion cell CL4033047

CSI 0.5

rCSI 9.4%

PRS 1.8%
platelet CL0000233

CSI 0.5

rCSI 2.0%

PRS 4.0%
H1 horizontal cell CL0004217

CSI 0.6

rCSI 2.2%

PRS 3.8%
macula densa epithelial cell CL1000850

CSI 0.8

rCSI 10.9%

PRS 22.4%
immature innate lymphoid cell CL0001082

CSI 0.8

rCSI 25.3%

PRS 23.9%
H2 horizontal cell CL0004218

CSI 0.9

rCSI 4.7%

PRS 2.7%
GABAergic amacrine cell CL4030027

CSI 1.2

rCSI 4.2%

PRS 1.9%
tracheobronchial goblet cell CL0019003

CSI 1.6

rCSI 25.0%

PRS 32.8%
endocardial cell CL0002350

CSI 1.6

rCSI 7.5%

PRS 2.3%
pulmonary capillary endothelial cell CL4028001

CSI 1.8

rCSI 3.4%

PRS 2.0%
kidney connecting tubule principal cell CL4030018

CSI 2.1

rCSI 14.9%

PRS 20.5%
kidney interstitial cell CL1000500

CSI 2.1

rCSI 34.1%

PRS 14.7%
eye photoreceptor cell CL0000287

CSI 2.2

rCSI 24.4%

PRS 5.5%
serous secreting cell CL0000313

CSI 2.2

rCSI 11.0%

PRS 6.7%
kidney loop of Henle epithelial cell CL1000909

CSI 2.4

rCSI 50.1%

PRS 12.5%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 2.4

rCSI 20.9%

PRS 3.6%
group 3 innate lymphoid cell, human CL0001078

CSI 2.5

rCSI 53.1%

PRS 24.9%
Bergmann glial cell CL0000644

CSI 2.8

rCSI 3.8%

PRS 1.5%
odontoblast CL0000060

CSI 2.9

rCSI 64.5%

PRS 7.8%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 2.9

rCSI 30.4%

PRS 2.3%
kidney resident macrophage CL1000698

CSI 2.9

rCSI 57.8%

PRS 33.8%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 2.9

rCSI 90.2%

PRS 18.1%
renal intercalated cell CL0005010

CSI 3.0

rCSI 27.0%

PRS 12.1%
hepatic pit cell CL2000054

CSI 3.1

rCSI 42.1%

PRS 17.1%
pluripotent stem cell CL0002248

CSI 3.2

rCSI 94.5%

PRS 3.2%
B-1 B cell CL0000819

CSI 3.3

rCSI 84.6%

PRS 7.9%
osteoblast CL0000062

CSI 3.3

rCSI 82.3%

PRS 12.6%
lung microvascular endothelial cell CL2000016

CSI 3.4

rCSI 65.1%

PRS 4.6%
Purkinje cell CL0000121

CSI 3.5

rCSI 45.5%

PRS 14.3%
mesenchymal lymphangioblast CL0005021

CSI 3.5

rCSI 93.0%

PRS 7.4%
regular atrial cardiac myocyte CL0002129

CSI 3.6

rCSI 11.4%

PRS 1.6%
kidney connecting tubule epithelial cell CL1000768

CSI 3.6

rCSI 9.0%

PRS 1.0%
Merkel cell CL0000242

CSI 3.7

rCSI 86.3%

PRS 9.3%
epithelial cell of urethra CL1000296

CSI 3.8

rCSI 95.5%

PRS 4.5%
follicular dendritic cell CL0000442

CSI 3.8

rCSI 61.5%

PRS 8.0%
endothelial cell of vascular tree CL0002139

CSI 3.9

rCSI 21.1%

PRS 3.5%
epithelial cell of proximal tubule segment 3 CL4030011

CSI 3.9

rCSI 31.1%

PRS 17.7%
stratified epithelial cell CL0000079

CSI 3.9

rCSI 24.3%

PRS 6.2%
prostate gland microvascular endothelial cell CL2000059

CSI 4.0

rCSI 96.0%

PRS 4.8%
B-2 B cell CL0000822

CSI 4.2

rCSI 88.1%

PRS 8.4%
immature alpha-beta T cell CL0000790

CSI 4.3

rCSI 61.2%

PRS 21.0%
lung goblet cell CL1000143

CSI 4.6

rCSI 51.1%

PRS 4.3%
cone retinal bipolar cell CL0000752

CSI 4.6

rCSI 60.5%

PRS 9.2%
uterine smooth muscle cell CL0002601

CSI 4.7

rCSI 30.7%

PRS 10.4%
retinal ganglion cell CL0000740

CSI 4.9

rCSI 10.7%

PRS 1.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RPS2](/details-gene/6187) encodes the ribosomal protein S2, an essential structural component of the 40S small ribosomal subunit. As a core element of the cell's protein synthesis machinery, its primary function is to facilitate translation. Its high expression in metabolically active and rapidly proliferating cells, such as lymphocytes and hematopoietic progenitors, underscores its fundamental role in cellular growth, differentiation, and function. Beyond its canonical role in translation, functional annotations suggest involvement in RNA binding, cellular responses to stress, and interactions with viral machinery during infection. ## Cellular Roles and Expression Landscape The expression profile of [RPS2](/details-gene/6187) highlights its critical importance in highly proliferative and biosynthetically active cell populations. **Overall**, the gene shows the highest significance in components of the adaptive and innate immune systems, as well as in progenitor cell lineages. Specifically, it is a key marker in various T cell subsets, including [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904), [naive thymus-derived CD8-positive, alpha-beta T cell](/details-cell/CL0000900), and [CD4-positive helper T cell](/details-cell/CL0000492). High significance is also observed in [class switched memory B cell](/details-cell/CL0000972) and developmental stages such as [double negative thymocyte](/details-cell/CL0002489), suggesting a crucial role during lymphocyte maturation and clonal expansion. Furthermore, its high significance in [hematopoietic stem cell](/details-cell/CL0000037), [common myeloid progenitor](/details-cell/CL0000049), and [granulocyte monocyte progenitor cell](/details-cell/CL0000557) points to its indispensable function in maintaining the protein synthesis capacity required for hematopoiesis. Conversely, [RPS2](/details-gene/6187) exhibits low to negative significance in terminally differentiated, metabolically quiescent, or specialized cell types. This includes a notable lack of expression in various neuronal subtypes, such as [VIP GABAergic cortical interneuron](/details-cell/CL4023016) and [retinal bipolar neuron](/details-cell/CL0000748), as well as in structural cells like [adipocyte](/details-cell/CL0000136). This pattern reinforces its primary association with cellular proliferation and high-level protein production, rather than the maintenance of terminally differentiated states. ## Pathways and Molecular Function The molecular functions of [RPS2](/details-gene/6187) are centered around its role as a [structural constituent of ribosome](/details-cell/GO:0003735) involved in [cytoplasmic translation](/details-cell/GO:0002181). It is a key player in nearly all stages of protein synthesis, as detailed by its extensive involvement in Reactome pathways such as [Eukaryotic Translation Initiation](/details-cell/R-HSA-72613), [Peptide chain elongation](/details-cell/R-HSA-156902), and [Eukaryotic Translation Termination](/details-cell/R-HSA-72764). Its function as an [RNA binding](/details-cell/GO:0003723) protein is integral to these processes. Beyond this core function, [RPS2](/details-gene/6187) is implicated in cellular responses to stimuli and disease. Its participation in pathways like [Cellular responses to stress](/details-cell/R-HSA-2262752) and [Response of eif2ak4 (gcn2) to amino acid deficiency](/details-cell/R-HSA-9633012) suggests it may be part of the cellular machinery that modulates translation rates under adverse conditions. Critically, multiple viral infection pathways, including [Influenza infection](/details-cell/R-HSA-168255) and [Sars-cov-2 infection](/details-cell/R-HSA-9694516), leverage the host's translational machinery, making [RPS2](/details-gene/6187) a crucial host factor for viral replication. Research has also identified several post-translational modifications of [RPS2](/details-gene/6187), including arginine methylation by PRMT3 ([Link](https://doi.org/10.1042/bj20041466)) and citrullination by PADI4 ([Link](https://doi.org/10.1039/c1mb05089c)), which appear to be antagonistic. These modifications may represent a regulatory layer controlling its function or interaction with other proteins. ## Research Directions The ubiquitous nature of [RPS2](/details-gene/6187) as a housekeeping gene makes it an interesting subject for studying subtle regulatory mechanisms that could have profound cellular effects. Its high expression in immune cells and its role as a host factor in viral infections present several avenues for future investigation. **Proposed Hypotheses:** 1. **Regulation of Immune Cell Quiescence and Activation:** The high significance of [RPS2](/details-gene/6187) in activated and memory lymphocytes suggests that translational control via [RPS2](/details-gene/6187) is a critical checkpoint for immune cell activation. We hypothesize that post-translational modifications of [RPS2](/details-gene/6187), such as the balance between arginine methylation and citrullination, regulate the selective translation of mRNAs required for T cell proliferation and effector function. 2. **Viral Hijacking of Ribosomal Machinery:** Given its annotated role in SARS-CoV-2 and Influenza pathways, we hypothesize that viruses may induce or rely on specific post-translational modifications of [RPS2](/details-gene/6187) to favor the translation of viral mRNA over host mRNA. This could be a mechanism to co-opt cellular machinery more efficiently. **Experimental Approach for Hypothesis 2:** To investigate the role of [RPS2](/details-gene/6187) modifications in viral infection, one could use CRISPR-Cas9 to generate cell lines (e.g., A549 lung epithelial cells) expressing mutant versions of [RPS2](/details-gene/6187) that cannot be methylated or citrullinated at known sites. These engineered cell lines, along with a wild-type control, would be infected with SARS-CoV-2. The impact of these mutations on viral replication could be assessed by measuring viral titers, while ribosome profiling (Ribo-seq) could be used to determine if these modifications alter the translational efficiency of viral versus host mRNAs. **Therapeutic Potential:** As a fundamental and ubiquitously expressed component of the ribosome, direct targeting of [RPS2](/details-gene/6187) is likely to cause unacceptable systemic toxicity. However, its role in diseases characterized by high proliferation (e.g., cancer) or its co-option by viruses makes the regulatory pathways that control it more attractive targets. For instance, developing small molecule inhibitors against the enzymes that specifically modify [RPS2](/details-gene/6187), such as PRMT3, could offer a therapeutic window. Such an **inhibition** strategy might selectively impair the translational capacity of rapidly dividing cancer cells or virus-infected cells that are hyper-dependent on these modifications, while sparing healthy tissues.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S2

Genular Protein ID: 705244253

Symbol: RS2_HUMAN

Name: 40S ribosomal protein S2

UniProtKB Accession Codes:

P15880 B2R5G0 D3DU82 Q3MIB1

Database IDs:

Citations:

PubMed ID: 2308862

Title: Human cDNA sequence homologous to the mouse LLRep3 gene family.

PubMed ID: 2308862

DOI: 10.1093/nar/18.3.681

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15473865

Title: Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3).

PubMed ID: 15473865

DOI: 10.1042/bj20041466

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21584310

Title: Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2.

PubMed ID: 21584310

DOI: 10.1039/c1mb05089c

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28132843

Title: ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation.

PubMed ID: 28132843

DOI: 10.1016/j.molcel.2016.12.026

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30530495

Title: The 40S ribosomal protein uS5 (RPS2) assembles into an extraribosomal complex with human ZNF277 that competes with the PRMT3-uS5 interaction.

PubMed ID: 30530495

DOI: 10.1074/jbc.ra118.004928

PubMed ID: 32011234

Title: Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized.

PubMed ID: 32011234

DOI: 10.7554/elife.54023

PubMed ID: 31981475

Title: The G3BP1-family-USP10 deubiquitinase complex rescues ubiquitinated 40S subunits of ribosomes stalled in translation from lysosomal degradation.

PubMed ID: 31981475

DOI: 10.1016/j.molcel.2019.12.024

PubMed ID: 34348161

Title: The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation.

PubMed ID: 34348161

DOI: 10.1016/j.celrep.2021.109468

PubMed ID: 34469731

Title: iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation.

PubMed ID: 34469731

DOI: 10.1016/j.celrep.2021.109642

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

Length: 293
Mass: 31324
Checksum: 66C0DB7ED393B036
Sequence:

MADDAGAAGG PGGPGGPGMG NRGGFRGGFG SGIRGRGRGR GRGRGRGRGA RGGKAEDKEW 
MPVTKLGRLV KDMKIKSLEE IYLFSLPIKE SEIIDFFLGA SLKDEVLKIM PVQKQTRAGQ 
RTRFKAFVAI GDYNGHVGLG VKCSKEVATA IRGAIILAKL SIVPVRRGYW GNKIGKPHTV 
PCKVTGRCGS VLVRLIPAPR GTGIVSAPVP KKLLMMAGID DCYTSARGCT ATLGNFAKAT 
FDAISKTYSY LTPDLWKETV FTKSPYQEFT DHLVKTHTRV SVQRTQAPAV ATT

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Ascending colon UBERON0001156
	\|— Ascending colon Healthy UBERON0001156_PATO0000461
	Atherosclerosis MONDO0005311
	Axilla UBERON0009472
	\|— Axilla Breast cancer UBERON0009472_MONDO0007254
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	\|— Caecum Healthy UBERON0001153_PATO0000461
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	\|— Colonic epithelium Healthy UBERON0000397_PATO0000461
	Colorectal cancer MONDO0005575
	Colorectum UBERON0012652
	Cornea UBERON0000964
	\|— Cornea Healthy UBERON0000964_PATO0000461
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fallopian tube UBERON0003889
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	Heart right ventricle UBERON0002080
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileal epithelium UBERON0008345
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Breast cancer UBERON0002107_MONDO0007254
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	\|— Lymph node Healthy UBERON0000029_PATO0000461
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Middle lobe of right lung UBERON0002174
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	\|— Placenta Healthy UBERON0001987_PATO0000461
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Rectum UBERON0001052
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small intestine UBERON0002108
	\|— Small intestine Healthy UBERON0002108_PATO0000461
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	\|— Stomach Healthy UBERON0000945_PATO0000461
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	Trachea UBERON0003126
	Transverse colon UBERON0001157
	\|— Transverse colon Healthy UBERON0001157_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952

Details for: RPS2

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Human cDNA sequence homologous to the mouse LLRep3 gene family. PubMed ID: 2308862

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). PubMed ID: 15473865

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. PubMed ID: 21584310

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation. PubMed ID: 28132843

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

The 40S ribosomal protein uS5 (RPS2) assembles into an extraribosomal complex with human ZNF277 that competes with the PRMT3-uS5 interaction. PubMed ID: 30530495

Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized. PubMed ID: 32011234

The G3BP1-family-USP10 deubiquitinase complex rescues ubiquitinated 40S subunits of ribosomes stalled in translation from lysosomal degradation. PubMed ID: 31981475

The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation. PubMed ID: 34348161

iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation. PubMed ID: 34469731

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399