Details for: RPS2

Gene ID: 6187

Symbol: RPS2

Ensembl ID: ENSG00000140988

Description: ribosomal protein S2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 771.8943
    Cell Significance Index: -317.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 650.6148
    Cell Significance Index: -307.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 617.7277
    Cell Significance Index: -317.7500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 460.3127
    Cell Significance Index: -308.8800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 29.7156
    Cell Significance Index: 174.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 24.2041
    Cell Significance Index: 618.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 18.0122
    Cell Significance Index: 1839.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.7800
    Cell Significance Index: -47.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 15.4690
    Cell Significance Index: 537.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 15.1261
    Cell Significance Index: 397.7400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 14.2624
    Cell Significance Index: 252.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 14.1435
    Cell Significance Index: 664.7300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 13.5168
    Cell Significance Index: 116.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 12.0454
    Cell Significance Index: 1556.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 12.0199
    Cell Significance Index: 251.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 11.6848
    Cell Significance Index: 132.7500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.3230
    Cell Significance Index: 145.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 10.5921
    Cell Significance Index: 749.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 10.1483
    Cell Significance Index: 1247.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 10.0957
    Cell Significance Index: 1819.9300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 9.6925
    Cell Significance Index: 223.9300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 9.6612
    Cell Significance Index: 105.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 9.5906
    Cell Significance Index: 714.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.5231
    Cell Significance Index: 1307.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.8575
    Cell Significance Index: 3916.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 8.7589
    Cell Significance Index: 4783.4300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 7.9580
    Cell Significance Index: 48.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.9551
    Cell Significance Index: 513.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 7.9091
    Cell Significance Index: 226.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.0385
    Cell Significance Index: 830.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 6.2361
    Cell Significance Index: 4720.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.1695
    Cell Significance Index: 790.9000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.9286
    Cell Significance Index: 54.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.7078
    Cell Significance Index: 974.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.6754
    Cell Significance Index: 166.6800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.4119
    Cell Significance Index: 43.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.8404
    Cell Significance Index: 225.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.5010
    Cell Significance Index: 83.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.1761
    Cell Significance Index: 219.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.0435
    Cell Significance Index: 110.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.9843
    Cell Significance Index: 3597.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.9324
    Cell Significance Index: 105.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.5196
    Cell Significance Index: 500.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.4982
    Cell Significance Index: 171.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1277
    Cell Significance Index: 51.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0531
    Cell Significance Index: 200.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0093
    Cell Significance Index: 52.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.9551
    Cell Significance Index: 700.2500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.7937
    Cell Significance Index: 5.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4657
    Cell Significance Index: 134.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3602
    Cell Significance Index: 35.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0498
    Cell Significance Index: 1.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0340
    Cell Significance Index: 2.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0423
    Cell Significance Index: -4.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0656
    Cell Significance Index: -2.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0981
    Cell Significance Index: -184.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1265
    Cell Significance Index: -7.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1286
    Cell Significance Index: -95.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1766
    Cell Significance Index: -325.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2075
    Cell Significance Index: -74.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.2190
    Cell Significance Index: -337.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2271
    Cell Significance Index: -11.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2772
    Cell Significance Index: -376.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2787
    Cell Significance Index: -157.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2888
    Cell Significance Index: -180.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3626
    Cell Significance Index: -14.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3830
    Cell Significance Index: -76.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.4124
    Cell Significance Index: -261.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6209
    Cell Significance Index: -281.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6639
    Cell Significance Index: -139.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.9783
    Cell Significance Index: -159.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2119
    Cell Significance Index: -38.8200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.4021
    Cell Significance Index: -24.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.4608
    Cell Significance Index: -101.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.9109
    Cell Significance Index: -277.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.1397
    Cell Significance Index: -35.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.6419
    Cell Significance Index: -66.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.7227
    Cell Significance Index: -16.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.9365
    Cell Significance Index: -305.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -3.2307
    Cell Significance Index: -203.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -4.1929
    Cell Significance Index: -321.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.3031
    Cell Significance Index: -263.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -4.4624
    Cell Significance Index: -267.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -6.0290
    Cell Significance Index: -177.5800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -6.0971
    Cell Significance Index: -91.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -6.1081
    Cell Significance Index: -132.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -6.2021
    Cell Significance Index: -84.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.9748
    Cell Significance Index: -308.5100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.1952
    Cell Significance Index: -264.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -7.9044
    Cell Significance Index: -211.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -7.9560
    Cell Significance Index: -94.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -7.9655
    Cell Significance Index: -204.7500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -8.0764
    Cell Significance Index: -50.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -8.1765
    Cell Significance Index: -309.6300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -8.2929
    Cell Significance Index: -38.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -8.3986
    Cell Significance Index: -274.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -8.4777
    Cell Significance Index: -296.9900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -8.7661
    Cell Significance Index: -47.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -8.7668
    Cell Significance Index: -181.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -9.0006
    Cell Significance Index: -286.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Ribosomal protein S2 (RPS2) is a small subunit protein of the 40S ribosomal subunit, which is responsible for the initiation of protein synthesis. It is composed of 125 amino acids and is highly conserved across species. RPS2 is a crucial component of the 40S subunit, and its dysfunction can lead to various cellular and developmental abnormalities. The gene is highly expressed in various cell types, including epithelial cells, immune cells, and stem cells, suggesting its widespread importance in cellular processes. **Pathways and Functions** RPS2 is involved in multiple cellular pathways, including: 1. **Translation initiation**: RPS2 is essential for the initiation of protein synthesis, where it binds to mRNA and recruits the small ribosomal subunit to the mRNA. 2. **Translation elongation**: RPS2 is also involved in the elongation phase of translation, where it helps to facilitate the movement of the ribosome along the mRNA. 3. **mRNA processing**: RPS2 is involved in the regulation of mRNA processing, including nonsense-mediated decay (NMD) and the formation of a pool of free 40S subunits. 4. **Viral infection**: RPS2 is also involved in the regulation of viral infections, such as influenza and SARS-CoV-2, where it helps to modulate the host translation machinery. 5. **Cellular responses to stress**: RPS2 is involved in the regulation of cellular responses to stress, including amino acid deficiency and starvation. **Clinical Significance** Dysregulation of RPS2 has been implicated in various diseases, including: 1. **Influenza**: RPS2 is essential for the regulation of influenza virus translation, and its dysfunction can lead to impaired viral replication. 2. **SARS-CoV-2**: RPS2 is also involved in the regulation of SARS-CoV-2 translation, and its dysfunction can lead to impaired viral replication. 3. **Cancer**: RPS2 is often downregulated in cancer cells, leading to impaired protein synthesis and tumorigenesis. 4. **Immune disorders**: RPS2 is involved in the regulation of immune responses, and its dysfunction can lead to impaired immune function. In conclusion, the RPS2 gene plays a crucial role in the regulation of protein synthesis, mRNA processing, and the modulation of viral infections. Its dysregulation has been implicated in various diseases, highlighting its importance in maintaining cellular homeostasis. Further research is needed to fully understand the mechanisms by which RPS2 regulates cellular processes and to identify potential therapeutic targets for the treatment of diseases associated with RPS2 dysfunction.

Genular Protein ID: 705244253

Symbol: RS2_HUMAN

Name: 40S ribosomal protein S2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2308862

Title: Human cDNA sequence homologous to the mouse LLRep3 gene family.

PubMed ID: 2308862

DOI: 10.1093/nar/18.3.681

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15473865

Title: Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3).

PubMed ID: 15473865

DOI: 10.1042/bj20041466

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21584310

Title: Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2.

PubMed ID: 21584310

DOI: 10.1039/c1mb05089c

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28132843

Title: ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation.

PubMed ID: 28132843

DOI: 10.1016/j.molcel.2016.12.026

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30530495

Title: The 40S ribosomal protein uS5 (RPS2) assembles into an extraribosomal complex with human ZNF277 that competes with the PRMT3-uS5 interaction.

PubMed ID: 30530495

DOI: 10.1074/jbc.ra118.004928

PubMed ID: 32011234

Title: Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized.

PubMed ID: 32011234

DOI: 10.7554/elife.54023

PubMed ID: 31981475

Title: The G3BP1-family-USP10 deubiquitinase complex rescues ubiquitinated 40S subunits of ribosomes stalled in translation from lysosomal degradation.

PubMed ID: 31981475

DOI: 10.1016/j.molcel.2019.12.024

PubMed ID: 34348161

Title: The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation.

PubMed ID: 34348161

DOI: 10.1016/j.celrep.2021.109468

PubMed ID: 34469731

Title: iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation.

PubMed ID: 34469731

DOI: 10.1016/j.celrep.2021.109642

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 293
  • Mass: 31324
  • Checksum: 66C0DB7ED393B036
  • Sequence:
  • MADDAGAAGG PGGPGGPGMG NRGGFRGGFG SGIRGRGRGR GRGRGRGRGA RGGKAEDKEW 
    MPVTKLGRLV KDMKIKSLEE IYLFSLPIKE SEIIDFFLGA SLKDEVLKIM PVQKQTRAGQ 
    RTRFKAFVAI GDYNGHVGLG VKCSKEVATA IRGAIILAKL SIVPVRRGYW GNKIGKPHTV 
    PCKVTGRCGS VLVRLIPAPR GTGIVSAPVP KKLLMMAGID DCYTSARGCT ATLGNFAKAT 
    FDAISKTYSY LTPDLWKETV FTKSPYQEFT DHLVKTHTRV SVQRTQAPAV ATT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.