Details for: RPS6KB2

Gene ID: 6199

Symbol: RPS6KB2

Ensembl ID: ENSG00000175634

Description: ribosomal protein S6 kinase B2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 68.7709
    Cell Significance Index: -28.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.8297
    Cell Significance Index: -23.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 58.6500
    Cell Significance Index: -27.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.0062
    Cell Significance Index: -27.7800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 41.3697
    Cell Significance Index: -27.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.4676
    Cell Significance Index: -24.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5275
    Cell Significance Index: -20.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.7398
    Cell Significance Index: 189.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.5011
    Cell Significance Index: 116.6200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.9708
    Cell Significance Index: 24.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8681
    Cell Significance Index: 783.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8663
    Cell Significance Index: 11.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7321
    Cell Significance Index: 72.4200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.7064
    Cell Significance Index: 6.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6674
    Cell Significance Index: 13.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.6585
    Cell Significance Index: 67.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6422
    Cell Significance Index: 18.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5913
    Cell Significance Index: 12.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5876
    Cell Significance Index: 105.9300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5810
    Cell Significance Index: 5.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5527
    Cell Significance Index: 244.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5245
    Cell Significance Index: 24.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5002
    Cell Significance Index: 273.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4892
    Cell Significance Index: 25.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4503
    Cell Significance Index: 55.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4441
    Cell Significance Index: 11.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4435
    Cell Significance Index: 28.6200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4429
    Cell Significance Index: 3.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4387
    Cell Significance Index: 11.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4260
    Cell Significance Index: 19.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4123
    Cell Significance Index: 11.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4049
    Cell Significance Index: 47.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3827
    Cell Significance Index: 11.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3822
    Cell Significance Index: 52.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3499
    Cell Significance Index: 70.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3427
    Cell Significance Index: 68.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3327
    Cell Significance Index: 63.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3322
    Cell Significance Index: 24.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3101
    Cell Significance Index: 16.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3076
    Cell Significance Index: 10.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2997
    Cell Significance Index: 38.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2608
    Cell Significance Index: 16.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2110
    Cell Significance Index: 14.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1867
    Cell Significance Index: 129.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1637
    Cell Significance Index: 20.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1425
    Cell Significance Index: 51.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1291
    Cell Significance Index: 6.7300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0883
    Cell Significance Index: 0.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0690
    Cell Significance Index: 1.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0641
    Cell Significance Index: 0.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0359
    Cell Significance Index: 6.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0265
    Cell Significance Index: 0.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0143
    Cell Significance Index: 10.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0015
    Cell Significance Index: -0.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0032
    Cell Significance Index: -6.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0100
    Cell Significance Index: -18.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0109
    Cell Significance Index: -16.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0166
    Cell Significance Index: -22.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0196
    Cell Significance Index: -14.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0259
    Cell Significance Index: -16.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0286
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0295
    Cell Significance Index: -21.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0421
    Cell Significance Index: -19.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0430
    Cell Significance Index: -24.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0461
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0494
    Cell Significance Index: -30.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0781
    Cell Significance Index: -22.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1257
    Cell Significance Index: -18.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1449
    Cell Significance Index: -30.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1569
    Cell Significance Index: -2.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1651
    Cell Significance Index: -4.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1768
    Cell Significance Index: -13.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2413
    Cell Significance Index: -25.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2488
    Cell Significance Index: -16.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2622
    Cell Significance Index: -7.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2966
    Cell Significance Index: -18.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2979
    Cell Significance Index: -23.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3582
    Cell Significance Index: -21.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3729
    Cell Significance Index: -3.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3960
    Cell Significance Index: -9.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4010
    Cell Significance Index: -11.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4063
    Cell Significance Index: -22.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4355
    Cell Significance Index: -19.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4841
    Cell Significance Index: -12.1000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.5455
    Cell Significance Index: -9.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5477
    Cell Significance Index: -20.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5723
    Cell Significance Index: -20.0500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5824
    Cell Significance Index: -4.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5940
    Cell Significance Index: -10.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6091
    Cell Significance Index: -22.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6100
    Cell Significance Index: -6.9300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6102
    Cell Significance Index: -15.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6223
    Cell Significance Index: -12.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6359
    Cell Significance Index: -20.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6405
    Cell Significance Index: -20.4000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6564
    Cell Significance Index: -11.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6827
    Cell Significance Index: -23.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6917
    Cell Significance Index: -19.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPS6KB2 is a member of the ribosomal protein S6 kinase family, which plays a crucial role in regulating protein synthesis and cell growth. The gene is highly expressed in various cell types, including keratinocytes, myeloid dendritic cells, and epithelial cells. Notably, RPS6KB2 is primarily localized to the cytoplasm, where it interacts with ribosomal proteins to regulate protein synthesis. **Pathways and Functions:** RPS6KB2 is implicated in multiple signaling pathways, including the PI3K/Akt pathway, which is a key regulator of cell growth and survival. The gene is also involved in the regulation of translational initiation, a process critical for protein synthesis. Furthermore, RPS6KB2 interacts with other signaling molecules, such as AKT1 and TOR, to modulate cell growth and metabolism. These interactions suggest that RPS6KB2 plays a pivotal role in integrating multiple signaling pathways to regulate cellular processes. **Clinical Significance:** RPS6KB2 has been implicated in various diseases, including cancer, where it is often overexpressed. The gene's role in regulating protein synthesis and cell growth makes it a potential target for cancer therapy. Additionally, RPS6KB2 has been linked to autoimmune diseases, such as rheumatoid arthritis, where it may contribute to the regulation of immune responses. Furthermore, the gene's involvement in metabolic disorders, such as obesity and diabetes, highlights its potential as a therapeutic target. **Implications for Immunology:** RPS6KB2's role in regulating protein synthesis and cell growth has significant implications for immunology. The gene's interaction with immune cells, such as myeloid dendritic cells, suggests that it may play a critical role in modulating immune responses. Furthermore, RPS6KB2's involvement in autoimmune diseases highlights the need for further research into its role in immune regulation and potential therapeutic applications. **Conclusion:** In conclusion, RPS6KB2 is a complex gene with far-reaching implications for cellular signaling, protein synthesis, and immune response. While its specific functions remain somewhat elusive, the gene's involvement in multiple signaling pathways and its role in regulating protein synthesis make it a promising target for therapeutic interventions. Further research is needed to fully elucidate the mysteries of RPS6KB2 and its role in human disease.

Genular Protein ID: 4167772899

Symbol: KS6B2_HUMAN

Name: Ribosomal protein S6 kinase beta-2

UniProtKB Accession Codes:

Q9UBS0 B2RMZ9 B4DML8 O94809 Q9UEC1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 ELM 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9804755

Title: Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region.

PubMed ID: 9804755

DOI: 10.1074/jbc.273.46.30061

PubMed ID: 9878560

Title: Cloning and characterization of p70 S6Kbeta defines a novel family of p70 S6 kinases.

PubMed ID: 9878560

DOI: 10.1006/bbrc.1998.9784

PubMed ID: 10490847

Title: Characterization of S6K2, a novel kinase homologous to S6K1.

PubMed ID: 10490847

DOI: 10.1038/sj.onc.1202894

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12087098

Title: Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin.

PubMed ID: 12087098

DOI: 10.1074/jbc.m204080200

PubMed ID: 12529391

Title: Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization.

PubMed ID: 12529391

DOI: 10.1128/mcb.23.3.852-863.2003

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 29750193

Title: Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration.

PubMed ID: 29750193

DOI: 10.1126/sciadv.aao5838

Sequence Information:

  • Length: 482
  • Mass: 53455
  • Checksum: 5D33660D24A2C7BE
  • Sequence:
    • MAAVFDLDLE TEEGSEGEGE PELSPADACP LAELRAAGLE PVGHYEEVEL TETSVNVGPE 
RIGPHCFELL RVLGKGGYGK VFQVRKVQGT NLGKIYAMKV LRKAKIVRNA KDTAHTRAER 
NILESVKHPF IVELAYAFQT GGKLYLILEC LSGGELFTHL EREGIFLEDT ACFYLAEITL 
ALGHLHSQGI IYRDLKPENI MLSSQGHIKL TDFGLCKESI HEGAVTHTFC GTIEYMAPEI 
LVRSGHNRAV DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIRGKLALPP YLTPDARDLV 
KKFLKRNPSQ RIGGGPGDAA DVQRHPFFRH MNWDDLLAWR VDPPFRPCLQ SEEDVSQFDT 
RFTRQTPVDS PDDTALSESA NQAFLGFTYV APSVLDSIKE GFSFQPKLRS PRRLNSSPRA 
PVSPLKFSPF EGFRPSPSLP EPTELPLPPL LPPPPPSTTA PLPIRPPSGT KKSKRGRGRP 
GR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.