RPS20 | ENSG00000008988 | NCBI 6224

Details for: RPS20

Gene ID: 6224

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RPS20

Ensembl ID: ENSG00000008988

Description: ribosomal protein S20

Cell Significance Landscape

Display Count:

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Extracellular exosome
(GO:0070062)
Mdm2/mdm4 family protein binding
(GO:0097371)
Membrane
(GO:0016020)
Nucleoplasm
(GO:0005654)
Positive regulation of signal transduction by p53 class mediator
(GO:1901798)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)
Ubiquitin ligase inhibitor activity
(GO:1990948)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

hematopoietic stem cell CL0000037

CSI 113.15

rCSI 75.21%

PRS 1.83
keratinocyte CL0000312

CSI 96.09

rCSI 80.55%

PRS 1.85
fallopian tube secretory epithelial cell CL4030006

CSI 90.33

rCSI 86.96%

PRS 1.61
intestinal epithelial cell CL0002563

CSI 87.14

rCSI 91.07%

PRS 1.66
CD4-positive, alpha-beta thymocyte CL0000810

CSI 86.52

rCSI 69.31%

PRS 2.89
epithelial cell of lower respiratory tract CL0002632

CSI 80.49

rCSI 62.4%

PRS 1.47
pancreatic A cell CL0000171

CSI 79.68

rCSI 83.47%

PRS 1.66
epithelial cell of lung CL0000082

CSI 78.63

rCSI 65.18%

PRS 1.44
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 77.47

rCSI 52.19%

PRS 1.86
granulocyte monocyte progenitor cell CL0000557

CSI 76.99

rCSI 66.66%

PRS 1.72
common dendritic progenitor CL0001029

CSI 76.7

rCSI 96.26%

PRS 1.95
pancreatic D cell CL0000173

CSI 71.67

rCSI 70.49%

PRS 1.7
extravillous trophoblast CL0008036

CSI 71.02

rCSI 87.86%

PRS 1.36
common myeloid progenitor CL0000049

CSI 70.75

rCSI 57.2%

PRS 1.51
ciliated epithelial cell CL0000067

CSI 67.92

rCSI 59.73%

PRS 1.12
transit amplifying cell of colon CL0009011

CSI 67.49

rCSI 79.27%

PRS 1.88
megakaryocyte-erythroid progenitor cell CL0000050

CSI 66.5

rCSI 60.06%

PRS 1.35
CD4-positive helper T cell CL0000492

CSI 64.33

rCSI 48.66%

PRS 2.16
mucous neck cell CL0000651

CSI 59.54

rCSI 85.81%

PRS 2.51
pancreatic acinar cell CL0002064

CSI 56.74

rCSI 75.42%

PRS 1.69
placental villous trophoblast CL2000060

CSI 55.17

rCSI 85.24%

PRS 1.46
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 51.91

rCSI 36.46%

PRS 4.71
memory B cell CL0000787

CSI 50.38

rCSI 49.75%

PRS 6.84
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 49.84

rCSI 29.43%

PRS 2.15
elicited macrophage CL0000861

CSI 49.69

rCSI 45.63%

PRS 1.75
myeloid leukocyte CL0000766

CSI 48.91

rCSI 45.13%

PRS 1.56
peripheral nervous system neuron CL2000032

CSI 48.19

rCSI 65.66%

PRS 1.41
intestine goblet cell CL0019031

CSI 47.65

rCSI 42.29%

PRS 1.54
T-helper 1 cell CL0000545

CSI 46.62

rCSI 84.15%

PRS 4.87
skin fibroblast CL0002620

CSI 46.35

rCSI 39.95%

PRS 2.58
mature T cell CL0002419

CSI 46.28

rCSI 36%

PRS 2.21
enteroendocrine cell CL0000164

CSI 46.19

rCSI 63.12%

PRS 1.7
unswitched memory B cell CL0000970

CSI 45.8

rCSI 38.53%

PRS 2.6
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 45.64

rCSI 57.35%

PRS 8.5
T follicular helper cell CL0002038

CSI 44.89

rCSI 33.59%

PRS 2.53
T-helper 17 cell CL0000899

CSI 44.33

rCSI 35.2%

PRS 2.74
group 3 innate lymphoid cell CL0001071

CSI 43.65

rCSI 32.8%

PRS 1.58
kidney epithelial cell CL0002518

CSI 43.59

rCSI 83.21%

PRS 3.82
mature B cell CL0000785

CSI 43.36

rCSI 37.69%

PRS 1.89
promyelocyte CL0000836

CSI 43.16

rCSI 62.26%

PRS 2.14
acinar cell CL0000622

CSI 42.42

rCSI 62.2%

PRS 2.04
naive B cell CL0000788

CSI 41.9

rCSI 35.94%

PRS 5.01
CD1c-positive myeloid dendritic cell CL0002399

CSI 41.77

rCSI 50.46%

PRS 1.77
enterocyte CL0000584

CSI 41.27

rCSI 66.55%

PRS 2.51
mucus secreting cell CL0000319

CSI 40.66

rCSI 64.58%

PRS 2.02
mucosal invariant T cell CL0000940

CSI 39.63

rCSI 32.02%

PRS 4.04
secretory cell CL0000151

CSI 38.9

rCSI 40.59%

PRS 1.58
myeloid dendritic cell CL0000782

CSI 38.33

rCSI 55.52%

PRS 2.26
perivascular cell CL4033054

CSI 38.1

rCSI 52.08%

PRS 1.77
conjunctival epithelial cell CL1000432

CSI 38.02

rCSI 58.07%

PRS 1.57
mesodermal cell CL0000222

CSI 37.89

rCSI 45.48%

PRS 1.54
CD8-positive, alpha-beta thymocyte CL0000811

CSI 37.88

rCSI 59.06%

PRS 4.04
double-positive, alpha-beta thymocyte CL0000809

CSI 37.83

rCSI 38.55%

PRS 2.24
epithelial cell CL0000066

CSI 37.69

rCSI 57.92%

PRS 2.24
pancreatic ductal cell CL0002079

CSI 37.57

rCSI 73.07%

PRS 1.57
early lymphoid progenitor CL0000936

CSI 37.27

rCSI 32.73%

PRS 1.72
effector CD8-positive, alpha-beta T cell CL0001050

CSI 36.86

rCSI 28.04%

PRS 2.04
colon goblet cell CL0009039

CSI 36.5

rCSI 86.76%

PRS 2.36
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 36.14

rCSI 61.82%

PRS 3.5
plasmablast CL0000980

CSI 35.85

rCSI 28.2%

PRS 1.83
lung ciliated cell CL1000271

CSI 35.67

rCSI 41.25%

PRS 1.12
promonocyte CL0000559

CSI 35.53

rCSI 60.88%

PRS 2.06
double negative thymocyte CL0002489

CSI 35.41

rCSI 24.62%

PRS 1.8
common lymphoid progenitor CL0000051

CSI 35.36

rCSI 47.25%

PRS 2.95
fraction A pre-pro B cell CL0002045

CSI 34.19

rCSI 39.14%

PRS 3.21
goblet cell CL0000160

CSI 33.53

rCSI 31.68%

PRS 1.61
naive T cell CL0000898

CSI 33.22

rCSI 23.12%

PRS 2.25
B cell CL0000236

CSI 33.04

rCSI 44.21%

PRS 9.48
stromal cell of ovary CL0002132

CSI 32.7

rCSI 89.84%

PRS 2.61
CD4-positive, alpha-beta T cell CL0000624

CSI 31.72

rCSI 40.59%

PRS 33.58
muscle cell CL0000187

CSI 31.63

rCSI 64.95%

PRS 3.78
progenitor cell CL0011026

CSI 31.44

rCSI 66.86%

PRS 3.11
retinal blood vessel endothelial cell CL0002585

CSI 31.39

rCSI 50.13%

PRS 1.69
mature NK T cell CL0000814

CSI 31.36

rCSI 40.11%

PRS 7.18
intermediate monocyte CL0002393

CSI 31.33

rCSI 47.27%

PRS 1.51
natural T-regulatory cell CL0000903

CSI 31.11

rCSI 58.92%

PRS 4.43
enteric smooth muscle cell CL0002504

CSI 30.29

rCSI 43.23%

PRS 1.76
memory T cell CL0000813

CSI 30.23

rCSI 58.24%

PRS 3.54
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 30.07

rCSI 22.55%

PRS 4.65
hematopoietic multipotent progenitor cell CL0000837

CSI 29.97

rCSI 72.11%

PRS 2.33
conventional dendritic cell CL0000990

CSI 29.85

rCSI 24.92%

PRS 5.17
colonocyte CL1000347

CSI 29.76

rCSI 42.65%

PRS 2.16
endothelial cell of artery CL1000413

CSI 29.75

rCSI 43.58%

PRS 9.52
neural crest cell CL0011012

CSI 29.74

rCSI 23.51%

PRS 1.07
tendon cell CL0000388

CSI 29.61

rCSI 76.94%

PRS 4.9
CD14-low, CD16-positive monocyte CL0002396

CSI 29.35

rCSI 22.62%

PRS 1.39
intestinal crypt stem cell of small intestine CL0009017

CSI 29.15

rCSI 78.57%

PRS 2.04
respiratory hillock cell CL4030023

CSI 28.76

rCSI 51.28%

PRS 2.68
gamma-delta T cell CL0000798

CSI 28.5

rCSI 33.47%

PRS 15.68
dendritic cell CL0000451

CSI 28.4

rCSI 34.99%

PRS 5.12
type B pancreatic cell CL0000169

CSI 28.29

rCSI 62.63%

PRS 1.45
pulmonary alveolar type 2 cell CL0002063

CSI 28.17

rCSI 43.69%

PRS 2.46
microcirculation associated smooth muscle cell CL0008035

CSI 27.98

rCSI 81.01%

PRS 1.75
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 27.96

rCSI 55.73%

PRS 2.74
Hofbauer cell CL3000001

CSI 27.94

rCSI 52.75%

PRS 1.93
myofibroblast cell CL0000186

CSI 27.4

rCSI 37.96%

PRS 2.22
transitional stage B cell CL0000818

CSI 27.27

rCSI 89.27%

PRS 5.04
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 27.25

rCSI 18.16%

PRS 4.37
colon epithelial cell CL0011108

CSI 27.17

rCSI 28.46%

PRS 1.44
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 27.02

rCSI 32.74%

PRS 2.43

retinal bipolar neuron CL0000748

CSI -43.8

rCSI -82.0%

PRS 1.3%
cerebral cortex endothelial cell CL1001602

CSI -35.6

rCSI -61.6%

PRS 1.2%
vascular leptomeningeal cell CL4023051

CSI -29.5

rCSI -51.6%

PRS 1.3%
renal interstitial pericyte CL1001318

CSI -26.0

rCSI -71.7%

PRS 1.7%
pvalb GABAergic cortical interneuron CL4023018

CSI -24.4

rCSI -30.3%

PRS 1.0%
inhibitory interneuron CL0000498

CSI -21.2

rCSI -49.0%

PRS 1.6%
mature astrocyte CL0002627

CSI -18.6

rCSI -79.0%

PRS 4.1%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -17.5

rCSI -31.7%

PRS 1.8%
kidney interstitial alternatively activated macrophage CL1000695

CSI -16.2

rCSI -42.1%

PRS 1.9%
astrocyte of the cerebral cortex CL0002605

CSI -15.4

rCSI -34.4%

PRS 1.0%
alpha-beta T cell CL0000789

CSI -14.1

rCSI -16.5%

PRS 2.6%
cardiac endothelial cell CL0010008

CSI -13.9

rCSI -56.1%

PRS 1.9%
cerebral cortex neuron CL0010012

CSI -13.8

rCSI -56.0%

PRS 2.2%
sst GABAergic cortical interneuron CL4023017

CSI -13.3

rCSI -17.1%

PRS 1.1%
neural cell CL0002319

CSI -13.1

rCSI -49.3%

PRS 3.7%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -12.3

rCSI -30.0%

PRS 1.0%
squamous epithelial cell CL0000076

CSI -11.8

rCSI -28.1%

PRS 2.1%
rod bipolar cell CL0000751

CSI -11.6

rCSI -20.8%

PRS 1.4%
adipocyte CL0000136

CSI -11.4

rCSI -14.6%

PRS 2.1%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -11.4

rCSI -67.0%

PRS 1.2%
OFFx cell CL4033036

CSI -10.2

rCSI -47.9%

PRS 4.7%
GABAergic neuron CL0000617

CSI -9.5

rCSI -31.7%

PRS 1.7%
VIP GABAergic cortical interneuron CL4023016

CSI -9.1

rCSI -10.8%

PRS 1.1%
kidney proximal convoluted tubule epithelial cell CL1000838

CSI -9.0

rCSI -95.4%

PRS 26.1%
kidney interstitial fibroblast CL1000692

CSI -8.3

rCSI -43.9%

PRS 12.5%
Schwann cell CL0002573

CSI -6.9

rCSI -19.6%

PRS 2.1%
near-projecting glutamatergic cortical neuron CL4023012

CSI -6.8

rCSI -25.7%

PRS 1.1%
platelet CL0000233

CSI -6.7

rCSI -27.6%

PRS 4.9%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -5.9

rCSI -21.3%

PRS 0.9%
hepatic stellate cell CL0000632

CSI -5.9

rCSI -21.9%

PRS 1.4%
diffuse bipolar 2 cell CL4033028

CSI -5.7

rCSI -44.0%

PRS 4.6%
pulmonary capillary endothelial cell CL4028001

CSI -5.6

rCSI -10.6%

PRS 2.5%
glutamatergic neuron CL0000679

CSI -5.5

rCSI -11.3%

PRS 1.9%
kidney collecting duct principal cell CL1001431

CSI -4.8

rCSI -24.0%

PRS 10.9%
kidney granular cell CL0000648

CSI -4.3

rCSI -62.8%

PRS 20.6%
exhausted T cell CL0011025

CSI -4.0

rCSI -68.4%

PRS 9.0%
diffuse bipolar 3a cell CL4033029

CSI -4.0

rCSI -27.3%

PRS 4.0%
erythroid lineage cell CL0000764

CSI -3.5

rCSI -22.6%

PRS 4.5%
epicardial adipocyte CL1000309

CSI -3.5

rCSI -11.3%

PRS 2.9%
H1 horizontal cell CL0004217

CSI -3.4

rCSI -13.4%

PRS 4.6%
diffuse bipolar 3b cell CL4033030

CSI -3.1

rCSI -20.8%

PRS 4.3%
regular ventricular cardiac myocyte CL0002131

CSI -2.3

rCSI -14.6%

PRS 1.4%
amacrine cell CL0000561

CSI -2.1

rCSI -6.0%

PRS 1.5%
periportal region hepatocyte CL0019026

CSI -2.0

rCSI -7.8%

PRS 2.7%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI -2.0

rCSI -5.2%

PRS 1.5%
hepatic pit cell CL2000054

CSI -2.0

rCSI -27.1%

PRS 20.2%
cell of skeletal muscle CL0000188

CSI -1.9

rCSI -20.8%

PRS 11.1%
H2 horizontal cell CL0004218

CSI -1.5

rCSI -7.6%

PRS 3.3%
glycinergic amacrine cell CL4030028

CSI -1.3

rCSI -3.5%

PRS 2.5%
immature innate lymphoid cell CL0001082

CSI -1.3

rCSI -39.6%

PRS 28.9%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI -1.0

rCSI -4.5%

PRS 6.2%
L6b glutamatergic cortical neuron CL4023038

CSI -0.2

rCSI -0.5%

PRS 1.1%
smooth muscle cell of the pulmonary artery CL0002591

CSI -0.2

rCSI -1.3%

PRS 9.2%
parietal epithelial cell CL1000452

CSI 0.1

rCSI 0.4%

PRS 1.6%
direct pathway medium spiny neuron CL4023026

CSI 0.2

rCSI 3.9%

PRS 0.9%
endocardial cell CL0002350

CSI 0.3

rCSI 1.4%

PRS 2.8%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 0.3

rCSI 1.7%

PRS 9.6%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.5

rCSI 1.0%

PRS 1.0%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 0.6

rCSI 17.4%

PRS 22.3%
group 3 innate lymphoid cell, human CL0001078

CSI 0.6

rCSI 12.1%

PRS 31.1%
immature alpha-beta T cell CL0000790

CSI 0.6

rCSI 9.0%

PRS 25.9%
bronchiolar smooth muscle cell CL4033017

CSI 0.7

rCSI 11.0%

PRS 5.3%
airway submucosal gland duct basal cell CL4033024

CSI 0.7

rCSI 4.7%

PRS 8.0%
cytotoxic T cell CL0000910

CSI 0.8

rCSI 4.5%

PRS 2.5%
kidney connecting tubule epithelial cell CL1000768

CSI 0.8

rCSI 2.1%

PRS 1.2%
eye photoreceptor cell CL0000287

CSI 1.0

rCSI 10.9%

PRS 6.8%
fast muscle cell CL0000190

CSI 1.0

rCSI 4.0%

PRS 9.9%
osteoblast CL0000062

CSI 1.1

rCSI 26.0%

PRS 15.3%
late pro-B cell CL0002048

CSI 1.1

rCSI 2.6%

PRS 5.3%
kidney collecting duct intercalated cell CL1001432

CSI 1.1

rCSI 7.5%

PRS 7.2%
cord blood hematopoietic stem cell CL2000095

CSI 1.1

rCSI 21.6%

PRS 13.4%
neuroendocrine cell CL0000165

CSI 1.2

rCSI 4.8%

PRS 3.3%
indirect pathway medium spiny neuron CL4023029

CSI 1.3

rCSI 31.5%

PRS 1.2%
B-1 B cell CL0000819

CSI 1.4

rCSI 34.8%

PRS 9.7%
lung resident memory CD4-positive, alpha-beta T cell CL4033038

CSI 1.5

rCSI 14.8%

PRS 21.0%
cone retinal bipolar cell CL0000752

CSI 1.6

rCSI 21.0%

PRS 11.2%
neuroplacodal cell CL0000032

CSI 1.6

rCSI 15.1%

PRS 6.7%
lung interstitial macrophage CL4033043

CSI 1.6

rCSI 3.7%

PRS 4.0%
follicular dendritic cell CL0000442

CSI 1.6

rCSI 26.3%

PRS 10.1%
forebrain neuroblast CL1000042

CSI 1.8

rCSI 19.0%

PRS 24.5%
small pre-B-II cell CL0000954

CSI 1.8

rCSI 1.7%

PRS 3.4%
B-2 B cell CL0000822

CSI 1.9

rCSI 39.3%

PRS 10.3%
Purkinje cell CL0000121

CSI 1.9

rCSI 25.0%

PRS 16.5%
double negative T regulatory cell CL0011024

CSI 1.9

rCSI 36.8%

PRS 14.1%
slow muscle cell CL0000189

CSI 2.0

rCSI 26.1%

PRS 22.0%
uterine smooth muscle cell CL0002601

CSI 2.1

rCSI 13.5%

PRS 12.0%
renal principal cell CL0005009

CSI 2.2

rCSI 5.8%

PRS 2.3%
mesenchymal lymphangioblast CL0005021

CSI 2.2

rCSI 58.5%

PRS 9.0%
retinal ganglion cell CL0000740

CSI 2.3

rCSI 5.0%

PRS 1.2%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 2.3

rCSI 5.9%

PRS 5.7%
midzonal region hepatocyte CL0019028

CSI 2.3

rCSI 5.5%

PRS 2.8%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 2.4

rCSI 7.4%

PRS 3.2%
pluripotent stem cell CL0002248

CSI 2.5

rCSI 74.6%

PRS 4.0%
lung microvascular endothelial cell CL2000016

CSI 2.6

rCSI 49.3%

PRS 5.7%
kidney loop of Henle epithelial cell CL1000909

CSI 2.6

rCSI 54.2%

PRS 15.1%
kidney resident macrophage CL1000698

CSI 2.6

rCSI 51.8%

PRS 40.2%
renal beta-intercalated cell CL0002201

CSI 2.6

rCSI 6.2%

PRS 2.0%
metallothionein-positive alveolar macrophage CL4033042

CSI 2.8

rCSI 30.0%

PRS 7.7%
pre-conventional dendritic cell CL0002010

CSI 2.9

rCSI 38.3%

PRS 5.3%
odontoblast CL0000060

CSI 2.9

rCSI 66.2%

PRS 9.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Ribosomal Protein S20 ([RPS20](/details-gene/6224)) is a protein-coding gene located on chromosome 8q12.1. As its name suggests, it is an integral component of the 40S small ribosomal subunit. Its primary function is as a [structural constituent of the ribosome](/details-go/GO:0003735), playing a fundamental role in the process of [translation](/details-go/GO:0006412) and protein synthesis. Consistent with this ubiquitous and essential function, [RPS20](/details-gene/6224) shows significant expression in a wide range of cell types, particularly those with high metabolic and proliferative activity. **Overall**, its expression is most significant in cell populations such as [hematopoietic stem cell](/details-cell/CL0000037), [keratinocyte](/details-cell/CL0000312), and various rapidly renewing epithelial cell types, highlighting its importance in growth, development, and tissue maintenance. ## Cellular Roles and Expression Landscape The expression profile of [RPS20](/details-gene/6224) underscores its role as a critical component of the cell's protein synthesis machinery. **Overall**, the gene's significance is highest in cells characterized by high rates of division, differentiation, or protein secretion. Top-ranking cell types include primitive progenitors like the [hematopoietic stem cell](/details-cell/CL0000037) (CSI: 113.15), [granulocyte monocyte progenitor cell](/details-cell/CL0000557) (CSI: 76.99), and [common myeloid progenitor](/details-cell/CL0000049) (CSI: 70.75), which require robust translational capacity to support rapid proliferation and differentiation into various hematopoietic lineages. High significance is also observed in epithelial barriers that undergo constant renewal, such as [keratinocyte](/details-cell/CL0000312) (CSI: 96.09), [fallopian tube secretory epithelial cell](/details-cell/CL4030006) (CSI: 90.33), and [intestinal epithelial cell](/details-cell/CL0002563) (CSI: 87.14). Its importance in the immune system is further suggested by high CSI scores in lymphoid progenitors like the [CD4-positive, alpha-beta thymocyte](/details-cell/CL0000810) (CSI: 86.52). Conversely, [RPS20](/details-gene/6224) shows markedly lower significance in many terminally differentiated, post-mitotic cell types, particularly within the central nervous system. The lowest CSI scores are found in cells such as [retinal bipolar neuron](/details-cell/CL0000748) (CSI: -43.77), [cerebral cortex endothelial cell](/details-cell/CL1001602) (CSI: -35.61), and various interneurons and glial cells. This pattern suggests that while [RPS20](/details-gene/6224) is universally essential, its relative expression levels are dynamically regulated to match the specific translational demands of a given cell type, being comparatively lower in quiescent or terminally differentiated neural tissues. ## Pathways and Molecular Function The functional annotations for [RPS20](/details-gene/6224) confirm its central role in protein metabolism. As a key component of the cytosolic small ribosomal subunit ([GO:0022627](https://www.ebi.ac.uk/QuickGO/term/GO:0022627)), it is involved in all major stages of protein synthesis, including [Eukaryotic translation initiation](/details-pathway/R-HSA-72613), [elongation](/details-pathway/R-HSA-156842), and [termination](/details-pathway/R-HSA-72764). Its molecular functions are dominated by [structural constituent of ribosome](/details-go/GO:0003735) and [RNA binding](/details-go/GO:0003723) activities. Beyond its canonical role, annotations suggest involvement in cellular regulation and stress responses. Notably, [RPS20](/details-gene/6224) is implicated in the [Positive regulation of signal transduction by p53 class mediator](/details-go/GO:1901798), suggesting an extra-ribosomal function linking ribosomal integrity to cell cycle control and apoptosis. This is further supported by its ability to bind MDM2 family proteins ([GO:0097371](https://www.ebi.ac.uk/QuickGO/term/GO:0097371)). The gene is also involved in cellular responses to stress ([R-HSA-2262752](https://reactome.org/content/detail/R-HSA-2262752)), including starvation ([R-HSA-9711097](https://reactome.org/content/detail/R-HSA-9711097)) and quality control pathways that degrade aberrant proteins ([R-HSA-927802](https://reactome.org/content/detail/R-HSA-927802)). Furthermore, its role in viral pathways, such as [Influenza infection](/details-pathway/R-HSA-168255) and [Sars-cov-2 infection](/details-pathway/R-HSA-9694516), highlights how viruses hijack the host's core translational machinery for their own replication, as detailed in several studies ([Link](https://doi.org/10.1016/j.molcel.2016.12.026), [Link](https://doi.org/10.1016/j.molcel.2016.11.039)). ## Research Directions Given that elevated protein synthesis is a hallmark of cancer, the high significance of [RPS20](/details-gene/6224) in proliferative cell types suggests its potential involvement in tumorigenesis. Dysregulation of ribosomal protein expression can alter the translational landscape, favoring the synthesis of oncoproteins. The gene's connection to the p53 pathway further strengthens its potential role in linking cellular metabolism to tumor suppression. ### Proposed Hypotheses 1. **Overexpression of [RPS20](/details-gene/6224) in certain malignancies, such as colorectal or hematopoietic cancers, drives oncogenesis by enhancing the translation of a specific subset of mRNAs crucial for cell growth and proliferation.** This alteration in the "specialized ribosome" composition may provide a selective advantage to cancer cells. 2. **[RPS20](/details-gene/6224) possesses an extra-ribosomal, p53-regulatory function that is critical during cellular stress.** Under conditions of ribosomal stress, free [RPS20](/details-gene/6224) may translocate to the nucleus to inhibit MDM2, thereby stabilizing p53 and inducing cell cycle arrest or apoptosis. ### Experimental Approach To test the first hypothesis, one could employ CRISPR-Cas9 to knockdown [RPS20](/details-gene/6224) in cancer cell lines derived from tissues where it is highly expressed, such as colon adenocarcinoma or acute myeloid leukemia lines. The impact on cellular phenotypes would be assessed via proliferation assays (e.g., cell counting, BrdU incorporation) and apoptosis assays (e.g., Annexin V staining). To identify the specific mRNAs whose translation is dependent on [RPS20](/details-gene/6224), polysome profiling coupled with RNA-sequencing (Ribo-Seq) could be performed on control versus knockdown cells. This would reveal changes in the translational efficiency of individual transcripts, potentially identifying key oncogenic pathways regulated by [RPS20](/details-gene/6224) levels. ### Therapeutic Potential As a core component of the ribosome, direct inhibition of [RPS20](/details-gene/6224) would likely result in profound, non-specific cytotoxicity, making it a poor therapeutic target for systemic inhibition. However, its potential as a prognostic biomarker is significant. Elevated [RPS20](/details-gene/6224) expression in tumor biopsies may correlate with higher proliferation rates and poorer patient outcomes. Furthermore, if [RPS20](/details-gene/6224) is found to be essential for the translation of specific, "undruggable" oncoproteins, therapeutic strategies could be developed to target the mechanism of its specialized translational control rather than the protein itself.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S20

Genular Protein ID: 751194119

Symbol: RS20_HUMAN

Name: 40S ribosomal protein S20

UniProtKB Accession Codes:

P60866 B2R4F4 B4DW28 P17075 Q5M8S9

Database IDs:

Citations:

PubMed ID: 8479924

Title: Human ribosomal protein S20 cDNA sequence.

PubMed ID: 8479924

DOI: 10.1093/nar/21.7.1672

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28065601

Title: Initiation of quality control during poly(A) translation requires site-specific ribosome ubiquitination.

PubMed ID: 28065601

DOI: 10.1016/j.molcel.2016.11.039

PubMed ID: 28132843

Title: ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation.

PubMed ID: 28132843

DOI: 10.1016/j.molcel.2016.12.026

PubMed ID: 28685749

Title: The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

PubMed ID: 28685749

DOI: 10.1038/ncomms16056

PubMed ID: 32011234

Title: Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized.

PubMed ID: 32011234

DOI: 10.7554/elife.54023

PubMed ID: 36302773

Title: A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

PubMed ID: 36302773

DOI: 10.1038/s41467-022-34097-9

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

Length: 119
Mass: 13373
Checksum: 8802DF7894ADDF94
Sequence:

MAFKDTGKTP VEPEVAIHRI RITLTSRNVK SLEKVCADLI RGAKEKNLKV KGPVRMPTKT 
LRITTRKTPC GEGSKTWDRF QMRIHKRLID LHSPSEIVKQ ITSISIEPGV EVEVTIADA

Details for: RPS20

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Human ribosomal protein S20 cDNA sequence. PubMed ID: 8479924

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Initiation of quality control during poly(A) translation requires site-specific ribosome ubiquitination. PubMed ID: 28065601

ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation. PubMed ID: 28132843

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. PubMed ID: 28685749

Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized. PubMed ID: 32011234

A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation. PubMed ID: 36302773

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399