Details for: RPS20

Gene ID: 6224

Symbol: RPS20

Ensembl ID: ENSG00000008988

Description: ribosomal protein S20

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 552.3032
    Cell Significance Index: -227.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 476.4864
    Cell Significance Index: -224.9600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 436.7349
    Cell Significance Index: -224.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 336.6804
    Cell Significance Index: -225.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 32.4504
    Cell Significance Index: -86.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 18.3591
    Cell Significance Index: 469.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 15.5025
    Cell Significance Index: 1583.5800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 15.3399
    Cell Significance Index: 232.9800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 13.9353
    Cell Significance Index: 81.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 12.9347
    Cell Significance Index: 346.0000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 10.7994
    Cell Significance Index: 190.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 9.0485
    Cell Significance Index: 314.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 8.7582
    Cell Significance Index: 408.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 8.5674
    Cell Significance Index: 1106.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.1814
    Cell Significance Index: 171.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.1532
    Cell Significance Index: 1469.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.1468
    Cell Significance Index: 1001.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 7.8947
    Cell Significance Index: 1084.1600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 7.6925
    Cell Significance Index: 87.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 7.3234
    Cell Significance Index: 517.9400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.8911
    Cell Significance Index: 55.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.8646
    Cell Significance Index: 511.6100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 6.0875
    Cell Significance Index: 52.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 6.0427
    Cell Significance Index: 3300.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 5.8905
    Cell Significance Index: 2604.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.7926
    Cell Significance Index: 742.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.7347
    Cell Significance Index: 132.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.3846
    Cell Significance Index: 49.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.3388
    Cell Significance Index: 58.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.2827
    Cell Significance Index: 143.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.9205
    Cell Significance Index: 317.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.3366
    Cell Significance Index: 114.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.4520
    Cell Significance Index: 2612.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.3508
    Cell Significance Index: 395.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.0729
    Cell Significance Index: 88.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.8798
    Cell Significance Index: 313.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.7347
    Cell Significance Index: 466.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8359
    Cell Significance Index: 49.0200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.7843
    Cell Significance Index: 12.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6747
    Cell Significance Index: 78.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6526
    Cell Significance Index: 327.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5045
    Cell Significance Index: 1358.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 1.4975
    Cell Significance Index: 170.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0604
    Cell Significance Index: 55.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6814
    Cell Significance Index: 196.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5499
    Cell Significance Index: 54.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4702
    Cell Significance Index: 76.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3930
    Cell Significance Index: 288.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2447
    Cell Significance Index: 12.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1204
    Cell Significance Index: 24.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0518
    Cell Significance Index: -9.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0670
    Cell Significance Index: -126.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0835
    Cell Significance Index: -61.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1154
    Cell Significance Index: -212.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1188
    Cell Significance Index: -74.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1430
    Cell Significance Index: -220.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1574
    Cell Significance Index: -5.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1768
    Cell Significance Index: -63.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1841
    Cell Significance Index: -250.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1857
    Cell Significance Index: -104.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2432
    Cell Significance Index: -13.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2941
    Cell Significance Index: -186.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3140
    Cell Significance Index: -11.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4376
    Cell Significance Index: -198.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4568
    Cell Significance Index: -96.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5172
    Cell Significance Index: -9.5600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6213
    Cell Significance Index: -10.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7087
    Cell Significance Index: -56.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.7937
    Cell Significance Index: -54.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8196
    Cell Significance Index: -93.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0939
    Cell Significance Index: -68.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1895
    Cell Significance Index: -73.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.4121
    Cell Significance Index: -205.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.4842
    Cell Significance Index: -43.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.5392
    Cell Significance Index: -25.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.5868
    Cell Significance Index: -71.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.6530
    Cell Significance Index: -41.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.1315
    Cell Significance Index: -221.9400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.2510
    Cell Significance Index: -13.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -2.3272
    Cell Significance Index: -66.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.3933
    Cell Significance Index: -51.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.6815
    Cell Significance Index: -205.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.9006
    Cell Significance Index: -39.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.9481
    Cell Significance Index: -198.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -3.0560
    Cell Significance Index: -59.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.1548
    Cell Significance Index: -193.4200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.5438
    Cell Significance Index: -53.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.9566
    Cell Significance Index: -116.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -4.3052
    Cell Significance Index: -190.4300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -4.3778
    Cell Significance Index: -56.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -4.3865
    Cell Significance Index: -52.2900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -4.8652
    Cell Significance Index: -30.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -5.0152
    Cell Significance Index: -184.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -5.4288
    Cell Significance Index: -145.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -5.4514
    Cell Significance Index: -206.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -5.6739
    Cell Significance Index: -117.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -5.7083
    Cell Significance Index: -146.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -5.8412
    Cell Significance Index: -191.2400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -6.1120
    Cell Significance Index: -51.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -6.1715
    Cell Significance Index: -216.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPS20 is a small, acidic protein located on the 40S ribosomal subunit, which is one of the two subunits that make up the ribosome. It is essential for the initiation of protein synthesis, specifically for the binding of mRNA to the ribosome. RPS20 interacts with other ribosomal proteins and can form complexes with other proteins, such as eukaryotic translation initiation factors (eIFs). This protein is highly conserved across species, suggesting its critical role in ribosomal function. **Pathways and Functions:** RPS20 is involved in multiple cellular pathways, including: 1. **Activation of mRNA upon binding of the cap-binding complex and eIFs**: RPS20 plays a crucial role in the recognition of the 5' cap of mRNA by the cap-binding complex, facilitating the binding of eIFs and the initiation of translation. 2. **Axon guidance**: RPS20 is involved in the regulation of axon growth and guidance during neuronal development. 3. **Cap-dependent translation initiation**: RPS20 participates in the initiation of translation by interacting with eIFs and the mRNA. 4. **Cellular responses to stimuli**: RPS20 is involved in the regulation of protein synthesis in response to various cellular stimuli, such as stress and starvation. 5. **Cytoplasmic translation**: RPS20 is essential for the translation of mRNAs in the cytoplasm. **Clinical Significance:** RPS20 has been implicated in various diseases, including: 1. **Influenza infection**: RPS20 has been shown to play a crucial role in the translation of viral RNA, facilitating the replication of the virus. 2. **SARS-CoV-1 and SARS-CoV-2 infections**: RPS20 has been implicated in the modulation of host translation machinery by these viruses, leading to the disruption of normal cellular functions. 3. **Cancer**: RPS20 has been shown to be overexpressed in certain types of cancer, suggesting its potential role in cancer development and progression. 4. **Neurological disorders**: RPS20 has been implicated in the regulation of protein synthesis in neurons, and its dysregulation may contribute to the development of neurological disorders, such as Alzheimer's disease. In conclusion, RPS20 is a critical component of the eukaryotic ribosome, essential for the translation of mRNAs into proteins. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its functions and mechanisms of action. Further research is needed to elucidate the role of RPS20 in human disease and to develop therapeutic strategies targeting this protein.

Genular Protein ID: 751194119

Symbol: RS20_HUMAN

Name: 40S ribosomal protein S20

UniProtKB Accession Codes:

P60866 B2R4F4 B4DW28 P17075 Q5M8S9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 67 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 83 PDBsum 83 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 18 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8479924

Title: Human ribosomal protein S20 cDNA sequence.

PubMed ID: 8479924

DOI: 10.1093/nar/21.7.1672

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28065601

Title: Initiation of quality control during poly(A) translation requires site-specific ribosome ubiquitination.

PubMed ID: 28065601

DOI: 10.1016/j.molcel.2016.11.039

PubMed ID: 28132843

Title: ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation.

PubMed ID: 28132843

DOI: 10.1016/j.molcel.2016.12.026

PubMed ID: 28685749

Title: The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

PubMed ID: 28685749

DOI: 10.1038/ncomms16056

PubMed ID: 32011234

Title: Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized.

PubMed ID: 32011234

DOI: 10.7554/elife.54023

PubMed ID: 36302773

Title: A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

PubMed ID: 36302773

DOI: 10.1038/s41467-022-34097-9

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 119
  • Mass: 13373
  • Checksum: 8802DF7894ADDF94
  • Sequence:
    • MAFKDTGKTP VEPEVAIHRI RITLTSRNVK SLEKVCADLI RGAKEKNLKV KGPVRMPTKT 
LRITTRKTPC GEGSKTWDRF QMRIHKRLID LHSPSEIVKQ ITSISIEPGV EVEVTIADA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.