Details for: RPS20

Gene ID: 6224

Symbol: RPS20

Ensembl ID: ENSG00000008988

Description: ribosomal protein S20

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 6.13
    Marker Score: 3452.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.56
    Marker Score: 4352.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.15
    Marker Score: 3738
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.09
    Marker Score: 7836
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 5.06
    Marker Score: 3819
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.05
    Marker Score: 2595
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.95
    Marker Score: 3188
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 4.88
    Marker Score: 2521
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.87
    Marker Score: 1797
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.83
    Marker Score: 47851
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.72
    Marker Score: 3383.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.71
    Marker Score: 6133
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.56
    Marker Score: 23943
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.52
    Marker Score: 13199
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 4.45
    Marker Score: 3389
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.44
    Marker Score: 3963
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.39
    Marker Score: 1426
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.37
    Marker Score: 9161
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.33
    Marker Score: 2633
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.29
    Marker Score: 1845
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.28
    Marker Score: 57534
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 4.26
    Marker Score: 1918
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.23
    Marker Score: 11678
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.19
    Marker Score: 3568
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.18
    Marker Score: 10208.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.14
    Marker Score: 9442
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.11
    Marker Score: 982
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 4.08
    Marker Score: 2881
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.07
    Marker Score: 4528
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.06
    Marker Score: 2378
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.04
    Marker Score: 213745
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.04
    Marker Score: 6932
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.04
    Marker Score: 2153
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.04
    Marker Score: 16827
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.02
    Marker Score: 4288
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4
    Marker Score: 3411
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.95
    Marker Score: 3886
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.94
    Marker Score: 51945
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.92
    Marker Score: 23822.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.84
    Marker Score: 25054
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.82
    Marker Score: 7185
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.82
    Marker Score: 10713.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.8
    Marker Score: 11977
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.69
    Marker Score: 15806
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.68
    Marker Score: 856
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.66
    Marker Score: 1334
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.65
    Marker Score: 2013
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.65
    Marker Score: 42395
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.65
    Marker Score: 3252.5
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.64
    Marker Score: 1199
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.63
    Marker Score: 5767
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.59
    Marker Score: 2027.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.57
    Marker Score: 5186
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.56
    Marker Score: 817
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 3.56
    Marker Score: 1484
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.55
    Marker Score: 8056
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.5
    Marker Score: 3655.5
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.5
    Marker Score: 1664
  • Cell Name: club cell (CL0000158)
    Fold Change: 3.5
    Marker Score: 4087
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.5
    Marker Score: 921
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.5
    Marker Score: 993
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.49
    Marker Score: 1565
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.48
    Marker Score: 2729
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 3.47
    Marker Score: 1587
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.47
    Marker Score: 1799
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 3.47
    Marker Score: 922
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.47
    Marker Score: 977
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.47
    Marker Score: 3730
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.46
    Marker Score: 9049
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.44
    Marker Score: 1480
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.44
    Marker Score: 4140
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.42
    Marker Score: 2877
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.42
    Marker Score: 905
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 3.41
    Marker Score: 689
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.39
    Marker Score: 1169
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.38
    Marker Score: 6760
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 3.38
    Marker Score: 820
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.38
    Marker Score: 26377.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.37
    Marker Score: 962
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.37
    Marker Score: 3155
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.36
    Marker Score: 1080
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.36
    Marker Score: 5694
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.36
    Marker Score: 8378
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.36
    Marker Score: 116433
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.36
    Marker Score: 2211
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 3.36
    Marker Score: 917
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.35
    Marker Score: 3235.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.34
    Marker Score: 4598
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.34
    Marker Score: 21309
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.34
    Marker Score: 2871
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.33
    Marker Score: 12854
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.33
    Marker Score: 1387.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.32
    Marker Score: 6052
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 3.32
    Marker Score: 980
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.31
    Marker Score: 1321
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 3.3
    Marker Score: 820
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 3.3
    Marker Score: 991
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.29
    Marker Score: 2492
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.29
    Marker Score: 1644
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.29
    Marker Score: 3179

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Other Information

**Key characteristics:** * Gene name: RPS20 * Ensembl ID: ENSG00000008988 * Protein: RS20_HUMAN (40S ribosomal protein S20) * Cellular expression: Epithelial cell of exocrine pancreas, thyroid follicular cell, activated CD8-positive, alpha-beta T cell, mesenchymal stem cell, cord blood hematopoietic stem cell, natural T-regulatory cell, naive T cell, professional antigen presenting cell, radial glial cell, mature T cell **Pathways and functions:** * Axon guidance: The protein is involved in axon guidance by interacting with microtubules and influencing the direction of cell migration. * Cellular responses to stimuli: It plays a role in cellular responses to various stimuli, including those related to inflammation, injury, and tissue repair. * Cellular responses to stress: RS20 is crucial for cellular responses to stress, such as those caused by heat, cold, or oxidative stress. * Developmental biology: The protein is expressed in early-stage embryos and is involved in developmental processes, such as organogenesis and tissue specification. * Disease: Mutations in RPS20 have been linked to several human diseases, including cancer and neurodegenerative disorders. * Metabolism: RS20 is involved in the metabolism of amino acids, proteins, and nucleic acids. * Metabolism of rna: It is involved in the processing and translation of RNA molecules. * Nervous system development: The protein is expressed in neurons and plays a role in neuronal development and function. * Nonsense-mediated decay (nmd): RS20 is a target for nonsense-mediated decay, a process that removes premature stop codons from mRNA, leading to early termination of translation. * Rrna processing: It is involved in the processing and maturation of RNA molecules. * Selenoamino acid metabolism: The protein is involved in the metabolism of selenoamino acids, a group of amino acids that are important for various cellular processes. **Clinical significance:** * Mutations in RPS20 have been implicated in several human diseases, including cancer, neurodegenerative disorders, and metabolic diseases. * Targeting the RPS20 gene has been investigated as a therapeutic strategy for these diseases.

Genular Protein ID: 751194119

Symbol: RS20_HUMAN

Name: 40S ribosomal protein S20

UniProtKB Accession Codes:

P60866 B2R4F4 B4DW28 P17075 Q5M8S9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 53 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 69 PDBsum 68 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 18 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8479924

Title: Human ribosomal protein S20 cDNA sequence.

PubMed ID: 8479924

DOI: 10.1093/nar/21.7.1672

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28065601

Title: Initiation of quality control during poly(A) translation requires site-specific ribosome ubiquitination.

PubMed ID: 28065601

DOI: 10.1016/j.molcel.2016.11.039

PubMed ID: 28132843

Title: ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation.

PubMed ID: 28132843

DOI: 10.1016/j.molcel.2016.12.026

PubMed ID: 28685749

Title: The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

PubMed ID: 28685749

DOI: 10.1038/ncomms16056

PubMed ID: 32011234

Title: Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized.

PubMed ID: 32011234

DOI: 10.7554/elife.54023

PubMed ID: 36302773

Title: A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

PubMed ID: 36302773

DOI: 10.1038/s41467-022-34097-9

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 119
  • Mass: 13373
  • Checksum: 8802DF7894ADDF94
  • Sequence:
    • MAFKDTGKTP VEPEVAIHRI RITLTSRNVK SLEKVCADLI RGAKEKNLKV KGPVRMPTKT 
LRITTRKTPC GEGSKTWDRF QMRIHKRLID LHSPSEIVKQ ITSISIEPGV EVEVTIADA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.