Details for: RTKN

Gene ID: 6242

Symbol: RTKN

Ensembl ID: ENSG00000114993

Description: rhotekin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 89.9738
    Cell Significance Index: -14.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.8194
    Cell Significance Index: -12.8900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 35.4171
    Cell Significance Index: -14.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.9710
    Cell Significance Index: -14.1500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 21.1766
    Cell Significance Index: -14.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.3792
    Cell Significance Index: -14.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5555
    Cell Significance Index: -14.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.7573
    Cell Significance Index: 66.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7525
    Cell Significance Index: 23.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7129
    Cell Significance Index: 37.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6955
    Cell Significance Index: 76.8500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4422
    Cell Significance Index: 21.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3895
    Cell Significance Index: 37.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1797
    Cell Significance Index: 234.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0864
    Cell Significance Index: 126.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0138
    Cell Significance Index: 164.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8496
    Cell Significance Index: 24.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5345
    Cell Significance Index: 36.9600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5116
    Cell Significance Index: 4.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5010
    Cell Significance Index: 10.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4703
    Cell Significance Index: 16.5300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4473
    Cell Significance Index: 7.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4216
    Cell Significance Index: 54.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3173
    Cell Significance Index: 219.4600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.2942
    Cell Significance Index: 1.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2784
    Cell Significance Index: 7.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2748
    Cell Significance Index: 150.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2713
    Cell Significance Index: 20.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2439
    Cell Significance Index: 11.4700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.2347
    Cell Significance Index: 2.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2321
    Cell Significance Index: 22.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2246
    Cell Significance Index: 10.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2018
    Cell Significance Index: 89.2100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.1354
    Cell Significance Index: 1.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1271
    Cell Significance Index: 6.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1193
    Cell Significance Index: 8.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1141
    Cell Significance Index: 16.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0836
    Cell Significance Index: 15.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0620
    Cell Significance Index: 7.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0557
    Cell Significance Index: 1.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0361
    Cell Significance Index: 4.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0324
    Cell Significance Index: 2.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0305
    Cell Significance Index: 5.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0293
    Cell Significance Index: 1.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0273
    Cell Significance Index: 0.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0273
    Cell Significance Index: 0.6300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0188
    Cell Significance Index: 0.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0119
    Cell Significance Index: 21.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0117
    Cell Significance Index: 22.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0114
    Cell Significance Index: 17.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0100
    Cell Significance Index: 6.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0054
    Cell Significance Index: 0.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0038
    Cell Significance Index: 0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0004
    Cell Significance Index: 0.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0056
    Cell Significance Index: -4.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0073
    Cell Significance Index: -5.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0126
    Cell Significance Index: -9.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0139
    Cell Significance Index: -4.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0221
    Cell Significance Index: -12.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0242
    Cell Significance Index: -10.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0251
    Cell Significance Index: -15.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0294
    Cell Significance Index: -3.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0305
    Cell Significance Index: -6.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0382
    Cell Significance Index: -11.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0416
    Cell Significance Index: -4.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0460
    Cell Significance Index: -0.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0491
    Cell Significance Index: -6.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0755
    Cell Significance Index: -15.9000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0809
    Cell Significance Index: -1.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0834
    Cell Significance Index: -5.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0838
    Cell Significance Index: -2.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1009
    Cell Significance Index: -11.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1032
    Cell Significance Index: -2.1600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1213
    Cell Significance Index: -1.7900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1270
    Cell Significance Index: -2.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1293
    Cell Significance Index: -13.4600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1372
    Cell Significance Index: -1.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1391
    Cell Significance Index: -8.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1529
    Cell Significance Index: -12.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1530
    Cell Significance Index: -4.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1550
    Cell Significance Index: -8.7000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1874
    Cell Significance Index: -2.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1928
    Cell Significance Index: -11.8200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1931
    Cell Significance Index: -2.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1976
    Cell Significance Index: -12.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2036
    Cell Significance Index: -13.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2066
    Cell Significance Index: -8.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2235
    Cell Significance Index: -5.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2282
    Cell Significance Index: -5.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2684
    Cell Significance Index: -14.0900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2721
    Cell Significance Index: -3.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2815
    Cell Significance Index: -8.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3129
    Cell Significance Index: -8.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3212
    Cell Significance Index: -9.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3224
    Cell Significance Index: -14.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3307
    Cell Significance Index: -12.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3408
    Cell Significance Index: -8.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3437
    Cell Significance Index: -12.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3574
    Cell Significance Index: -4.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RTKN is a member of the Rhotekin family of proteins, which are characterized by their ability to bind to Rho GTPases and regulate their activity. RTKN is a GTPase inhibitor, meaning that it inhibits the GTPase activity of Rho GTPases, thereby prolonging their GTP-bound state and activating downstream signaling pathways. RTKN also exhibits a high affinity for actin, which suggests its involvement in cytoskeletal organization and cell migration. **Pathways and Functions** RTKN regulates various signaling pathways, including: 1. **Actomyosin contractile ring formation**: RTKN interacts with Rho GTPases to regulate the formation of actomyosin contractile rings, which are essential for cell migration, wound healing, and tissue development. 2. **Apoptotic process**: RTKN regulates the activity of Rho GTPases to modulate apoptosis, or programmed cell death. 3. **Cytoskeleton organization**: RTKN interacts with actin to regulate cytoskeletal organization and cell migration. 4. **Rho protein signal transduction**: RTKN regulates the activity of Rho GTPases to modulate signal transduction pathways involved in cell proliferation, differentiation, and survival. **Clinical Significance** Dysregulation of RTKN has been implicated in several diseases, including: 1. **Cancer**: RTKN overexpression has been observed in various types of cancer, including breast, lung, and colon cancer, where it may contribute to tumorigenesis and metastasis. 2. **Neurodegenerative disorders**: RTKN has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation may contribute to neuronal dysfunction and death. 3. **Cardiovascular disease**: RTKN has been implicated in cardiovascular disease, where its dysregulation may contribute to vascular smooth muscle cell migration and proliferation. In conclusion, RTKN is a critical regulator of cellular processes, including cytoskeletal organization, cell migration, and apoptosis. Its dysregulation has been implicated in several diseases, and further research is needed to fully understand its role in human disease.

Genular Protein ID: 1145307661

Symbol: RTKN_HUMAN

Name: Rhotekin

UniProtKB Accession Codes:

Q9BST9 H7BXD4 Q8WVN1 Q96PT6 Q9HB05

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10873388

Title: Molecular cloning, expression characterization, and mapping of a novel putative inhibitor of rho GTPase activity, RTKN, to D2S145-D2S286.

PubMed ID: 10873388

DOI: 10.1006/geno.2000.6212

PubMed ID: 10940294

Title: The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element.

PubMed ID: 10940294

DOI: 10.1074/jbc.m000465200

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15480428

Title: Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis.

PubMed ID: 15480428

DOI: 10.1038/sj.onc.1208106

PubMed ID: 16007136

Title: Possible role of Rho/Rhotekin signaling in mammalian septin organization.

PubMed ID: 16007136

DOI: 10.1038/sj.onc.1208862

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 563
  • Mass: 62667
  • Checksum: B3C64CB737E88501
  • Sequence:
    • MFSRNHRSRV TVARGSALEM EFKRGRFRLS LFSDLPEDTE LQRKLDHEIR MREGACKLLA 
ACSQREQALE ATKSLLVCNS RILSYMGELQ RRKEAQVLGK TSRRPSDSGP PAERSPCRGR 
VCISDLRIPL MWKDTEYFKN KGDLHRWAVF LLLQLGEHIQ DTEMILVDRT LTDISFQSNV 
LFAEAGPDFE LRLELYGACV EEEGALTGGP KRLATKLSSS LGRSSGRRVR ASLDSAGGSG 
SSPILLPTPV VGGPRYHLLA HTTLTLAAVQ DGFRTHDLTL ASHEENPAWL PLYGSVCCRL 
AAQPLCMTQP TASGTLRVQQ AGEMQNWAQV HGVLKGTNLF CYRQPEDADT GEEPLLTIAV 
NKETRVRAGE LDQALGRPFT LSISNQYGDD EVTHTLQTES REALQSWMEA LWQLFFDMSQ 
WKQCCDEIMK IETPAPRKPP QALAKQGSLY HEMAIEPLDD IAAVTDILTQ REGARLETPP 
PWLAMFTDQP ALPNPCSPAS VAPAPDWTHP LPWGRPRTFS LDAVPPDHSP RARSVAPLPP 
QRSPRTRGLC SKGQPRTWLQ SPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.