Details for: RYK

Gene ID: 6259

Symbol: RYK

Ensembl ID: ENSG00000163785

Description: receptor like tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 333.1507
    Cell Significance Index: -51.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 201.6611
    Cell Significance Index: -51.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 111.4541
    Cell Significance Index: -52.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 105.9181
    Cell Significance Index: -43.0300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 96.1342
    Cell Significance Index: -49.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.0697
    Cell Significance Index: -43.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.6293
    Cell Significance Index: -52.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.7057
    Cell Significance Index: -50.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.2017
    Cell Significance Index: -43.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.3703
    Cell Significance Index: -52.7600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.8283
    Cell Significance Index: -21.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.5719
    Cell Significance Index: 35.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.0648
    Cell Significance Index: 240.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.0545
    Cell Significance Index: 115.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0037
    Cell Significance Index: 401.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6496
    Cell Significance Index: 591.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5821
    Cell Significance Index: 313.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3783
    Cell Significance Index: 38.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9675
    Cell Significance Index: 174.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9526
    Cell Significance Index: 73.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8391
    Cell Significance Index: 103.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7826
    Cell Significance Index: 52.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7807
    Cell Significance Index: 539.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7305
    Cell Significance Index: 44.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6696
    Cell Significance Index: 91.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6142
    Cell Significance Index: 554.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5788
    Cell Significance Index: 25.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5782
    Cell Significance Index: 315.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5656
    Cell Significance Index: 250.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5493
    Cell Significance Index: 13.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5222
    Cell Significance Index: 19.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4910
    Cell Significance Index: 12.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4556
    Cell Significance Index: 21.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4441
    Cell Significance Index: 23.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4365
    Cell Significance Index: 43.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3631
    Cell Significance Index: 7.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3228
    Cell Significance Index: 8.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2992
    Cell Significance Index: 13.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2836
    Cell Significance Index: 13.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2605
    Cell Significance Index: 401.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2545
    Cell Significance Index: 32.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2543
    Cell Significance Index: 17.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2406
    Cell Significance Index: 12.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2267
    Cell Significance Index: 43.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1914
    Cell Significance Index: 353.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1732
    Cell Significance Index: 326.0700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1614
    Cell Significance Index: 3.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1333
    Cell Significance Index: 84.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0670
    Cell Significance Index: 91.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0633
    Cell Significance Index: 1.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0535
    Cell Significance Index: 24.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0529
    Cell Significance Index: 1.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0045
    Cell Significance Index: -0.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0236
    Cell Significance Index: -3.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0342
    Cell Significance Index: -25.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0342
    Cell Significance Index: -5.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0505
    Cell Significance Index: -38.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0584
    Cell Significance Index: -43.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0904
    Cell Significance Index: -56.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0965
    Cell Significance Index: -2.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0969
    Cell Significance Index: -54.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1102
    Cell Significance Index: -3.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1175
    Cell Significance Index: -3.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1357
    Cell Significance Index: -4.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1488
    Cell Significance Index: -19.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1591
    Cell Significance Index: -45.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2696
    Cell Significance Index: -27.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2865
    Cell Significance Index: -4.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2898
    Cell Significance Index: -61.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3178
    Cell Significance Index: -8.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3254
    Cell Significance Index: -20.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3412
    Cell Significance Index: -25.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3432
    Cell Significance Index: -7.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3441
    Cell Significance Index: -7.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3595
    Cell Significance Index: -41.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3748
    Cell Significance Index: -39.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3784
    Cell Significance Index: -44.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3900
    Cell Significance Index: -12.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5381
    Cell Significance Index: -7.9500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5465
    Cell Significance Index: -7.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5734
    Cell Significance Index: -45.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6026
    Cell Significance Index: -10.0900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6727
    Cell Significance Index: -9.6600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6844
    Cell Significance Index: -14.6300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6869
    Cell Significance Index: -4.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6904
    Cell Significance Index: -42.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7527
    Cell Significance Index: -48.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7981
    Cell Significance Index: -27.7400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8443
    Cell Significance Index: -7.7800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8644
    Cell Significance Index: -14.5600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9214
    Cell Significance Index: -13.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9222
    Cell Significance Index: -46.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9452
    Cell Significance Index: -49.6300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9519
    Cell Significance Index: -19.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9611
    Cell Significance Index: -30.6100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9892
    Cell Significance Index: -21.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0165
    Cell Significance Index: -33.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0295
    Cell Significance Index: -23.7900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -1.1806
    Cell Significance Index: -10.4800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.1844
    Cell Significance Index: -23.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RYK is a receptor-like tyrosine kinase with a unique structure, featuring a transmembrane domain and an intracellular tyrosine kinase domain. Its extracellular domain contains a frizzled-binding motif, allowing it to interact with Wnt proteins. RYK has been shown to regulate various cellular processes, including: 1. **Axon guidance**: RYK is involved in axon extension and guidance, particularly in the development of the nervous system. 2. **Neuron differentiation**: RYK plays a role in the differentiation of GABAergic cortical interneurons and L2/3-6 intratelencephalic projecting glutamatergic neurons. 3. **Cell proliferation**: RYK is involved in the regulation of cell proliferation in the midbrain, particularly in the development of dopaminergic neurons. 4. **Signaling by Wnt**: RYK interacts with Wnt proteins, modulating their signaling pathways. **Pathways and Functions** RYK's signaling pathways are complex and interconnected with various cellular processes. The key pathways involved in RYK's functions include: 1. **Wnt signaling pathway**: RYK interacts with Wnt proteins, modulating their signaling pathways, which are involved in cell fate determination, cell migration, and cell proliferation. 2. **Planar cell polarity pathway**: RYK is involved in the regulation of planar cell polarity, which is crucial for the development of the nervous system and other tissues. 3. **MAPK cascade**: RYK activates the MAPK cascade, a signaling pathway involved in cell proliferation, differentiation, and survival. 4. **Axonogenesis**: RYK is involved in the development of axons, particularly in the guidance of dopaminergic neuron axons. 5. **Neurogenesis**: RYK plays a role in the regulation of neurogenesis, particularly in the development of GABAergic cortical interneurons. **Clinical Significance** RYK's dysregulation has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders**: RYK's dysregulation has been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Neurodegenerative diseases**: RYK's dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: RYK's dysregulation has been linked to cancer, particularly in the development of glioblastoma. In conclusion, RYK is a complex gene that plays a crucial role in various cellular processes, including axon guidance, neuron differentiation, and cell proliferation. Its dysregulation has been implicated in various neurological disorders and cancer. Further research is needed to fully understand the mechanisms of RYK's functions and its clinical significance.

Genular Protein ID: 2176804596

Symbol: RYK_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8386829

Title: Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases (RYK).

PubMed ID: 8386829

PubMed ID: 8390040

Title: The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain.

PubMed ID: 8390040

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 8726462

Title: H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer.

PubMed ID: 8726462

DOI: 10.1007/bf03401616

PubMed ID: 10454588

Title: Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family.

PubMed ID: 10454588

DOI: 10.1128/mcb.19.9.6427

PubMed ID: 15454084

Title: Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.

PubMed ID: 15454084

DOI: 10.1016/j.cell.2004.09.019

PubMed ID: 16116452

Title: Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract.

PubMed ID: 16116452

DOI: 10.1038/nn1520

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 607
  • Mass: 67815
  • Checksum: 3AFAE21A2680F400
  • Sequence:
  • MRGAARLGRP GRSCLPGARG LRAPPPPPLL LLLALLPLLP APGAAAAPAP RPPELQSASA 
    GPSVSLYLSE DEVRRLIGLD AELYYVRNDL ISHYALSFSL LVPSETNFLH FTWHAKSKVE 
    YKLGFQVDNV LAMDMPQVNI SVQGEVPRTL SVFRVELSCT GKVDSEVMIL MQLNLTVNSS 
    KNFTVLNFKR RKMCYKKLEE VKTSALDKNT SRTIYDPVHA APTTSTRVFY ISVGVCCAVI 
    FLVAIILAVL HLHSMKRIEL DDSISASSSS QGLSQPSTQT TQYLRADTPN NATPITSYPT 
    LRIEKNDLRS VTLLEAKGKV KDIAISRERI TLKDVLQEGT FGRIFHGILI DEKDPNKEKQ 
    AFVKTVKDQA SEIQVTMMLT ESCKLRGLHH RNLLPITHVC IEEGEKPMVI LPYMNWGNLK 
    LFLRQCKLVE ANNPQAISQQ DLVHMAIQIA CGMSYLARRE VIHKDLAARN CVIDDTLQVK 
    ITDNALSRDL FPMDYHCLGD NENRPVRWMA LESLVNNEFS SASDVWAFGV TLWELMTLGQ 
    TPYVDIDPFE MAAYLKDGYR IAQPINCPDE LFAVMACCWA LDPEERPKFQ QLVQCLTEFH 
    AALGAYV

Genular Protein ID: 2881397041

Symbol: Q8WTZ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 395
  • Mass: 44354
  • Checksum: 6A8E7F6B95C6623B
  • Sequence:
  • DPVHAAPTTS TRVFYISVGV CCAVIFLVAI ILAVLHLHSM KRIELDDSIS ASSSSQGLSQ 
    PSTQTTQYLR ADTPNNATPI TSSLGYPTLR IEKNDLRSVT LLEAKGKVKD IAISRERITL 
    KDVLQEGTFG RIFHGILIDE KDPNKEKQAF VKTVKDQASE IQVTMMLTES CKLRGLHHRN 
    LLPITHVCIE EGEKPMVILP YMNWGNLKLF LRQCKLVEAN NPQAISQQDL VHMAIQIACG 
    MSYLARREVI HKDLAARNCV IDDTLQVKIT DNALSRDLFP MDYHCLGDNE NRPVRWMALE 
    SLVNNEFSSA SDVWAFGVTL WELMTLGQTP YVDIDPFEMA AYLKDGYRIA QPINCPDELF 
    AVMACCWALD PEERPKFQQL VQCLTEFHAA LGAYV

Genular Protein ID: 578336624

Symbol: Q59FQ5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 232
  • Mass: 26555
  • Checksum: CDB46823CD9A02EC
  • Sequence:
  • HFGFLCLSPN FLLFYRNLLP ITHVCIEEGE KPMVILPYMN WGNLKLFLRQ CKLVEANNPQ 
    AISQQDLVHM AIQIACGMSY LARREVIHKD LAARNCVIDD TLQVKITDNA LSRDLFPMDY 
    HCLGDNENRP VRWMALESLV NNEFSSASDV WAFGVTLWEL MTLGQTPYVD IDPFEMAAYL 
    KDGYRIAQPI NCPDELFAVM ACCWALDPEE RPKFQQLVQC LTEFHAALGA YV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.