S100A8 | ENSG00000143546 | NCBI 6279

Details for: S100A8

Gene ID: 6279

Symbol: S100A8

Ensembl ID: ENSG00000143546

Description: S100 calcium binding protein A8

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Antimicrobial peptides
(R-HSA-6803157)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Disease
(R-HSA-1643685)
Diseases associated with the tlr signaling cascade
(R-HSA-5602358)
Diseases of immune system
(R-HSA-5260271)
Er-phagosome pathway
(R-HSA-1236974)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Irak4 deficiency (tlr2/4)
(R-HSA-5603041)
Metal sequestration by antimicrobial proteins
(R-HSA-6799990)
Myd88 deficiency (tlr2/4)
(R-HSA-5602498)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Neutrophil degranulation
(R-HSA-6798695)
Regulation of tlr by endogenous ligand
(R-HSA-5686938)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate nadph oxidases
(R-HSA-5668599)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Apoptotic process
(GO:0006915)
Arachidonate binding
(GO:0050544)
Astrocyte development
(GO:0014002)
Autocrine signaling
(GO:0035425)
Autophagy
(GO:0006914)
Calcium-dependent protein binding
(GO:0048306)
Calcium ion binding
(GO:0005509)
Calprotectin complex
(GO:1990660)
Chronic inflammatory response
(GO:0002544)
Collagen-containing extracellular matrix
(GO:0062023)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Defense response to bacterium
(GO:0042742)
Defense response to fungus
(GO:0050832)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Intermediate filament cytoskeleton
(GO:0045111)
Leukocyte migration involved in inflammatory response
(GO:0002523)
Microtubule binding
(GO:0008017)
Neutrophil aggregation
(GO:0070488)
Neutrophil chemotaxis
(GO:0030593)
Nucleus
(GO:0005634)
Peptide secretion
(GO:0002790)
Peptidyl-cysteine s-nitrosylation
(GO:0018119)
Plasma membrane
(GO:0005886)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of intrinsic apoptotic signaling pathway
(GO:2001244)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of peptide secretion
(GO:0002793)
Protein binding
(GO:0005515)
Rage receptor binding
(GO:0050786)
Regulation of cytoskeleton organization
(GO:0051493)
Regulation of toll-like receptor signaling pathway
(GO:0034121)
Response to ethanol
(GO:0045471)
Response to lipopolysaccharide
(GO:0032496)
Response to zinc ion
(GO:0010043)
Secretory granule lumen
(GO:0034774)
Sequestering of zinc ion
(GO:0032119)
Toll-like receptor 4 binding
(GO:0035662)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 100.9488
Cell Significance Index: -25.6100
Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 100.6781
Cell Significance Index: -15.6600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 70.2634
Cell Significance Index: -28.5500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 64.6441
Cell Significance Index: -26.6300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 57.5250
Cell Significance Index: -29.5900
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 44.7097
Cell Significance Index: 384.1900
Cell Name: liver dendritic cell (CL2000055)
Fold Change: 33.8407
Cell Significance Index: 89.2700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 32.6452
Cell Significance Index: 603.3700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 30.5161
Cell Significance Index: -29.1400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 10.4383
Cell Significance Index: -12.8700
Cell Name: late promyelocyte (CL0002151)
Fold Change: 7.2624
Cell Significance Index: 48.1800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.6522
Cell Significance Index: -26.2500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 3.5990
Cell Significance Index: 100.5800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 2.5608
Cell Significance Index: 157.0000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.2553
Cell Significance Index: 65.3900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.8941
Cell Significance Index: 395.3200
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.8732
Cell Significance Index: 13.5100
Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
Fold Change: 0.7536
Cell Significance Index: 7.2500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6593
Cell Significance Index: 125.4700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.6560
Cell Significance Index: 8.9500
Cell Name: blood cell (CL0000081)
Fold Change: 0.4400
Cell Significance Index: 3.7500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3251
Cell Significance Index: 293.5300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.3107
Cell Significance Index: 3.5300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.3001
Cell Significance Index: 63.2100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2740
Cell Significance Index: 7.3300
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.2545
Cell Significance Index: 2.3700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2448
Cell Significance Index: 24.2200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1351
Cell Significance Index: 21.9800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0883
Cell Significance Index: 66.8200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0687
Cell Significance Index: 7.4700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0384
Cell Significance Index: 11.0400
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0308
Cell Significance Index: 3.9900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0301
Cell Significance Index: 18.8100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0137
Cell Significance Index: -25.7400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0142
Cell Significance Index: -10.5400
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0199
Cell Significance Index: -0.3900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0222
Cell Significance Index: -12.5100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0327
Cell Significance Index: -1.1500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0388
Cell Significance Index: -1.5900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0394
Cell Significance Index: -4.8500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0437
Cell Significance Index: -27.7400
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0466
Cell Significance Index: -25.4400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0506
Cell Significance Index: -9.1300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0623
Cell Significance Index: -28.2700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0763
Cell Significance Index: -27.3800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0764
Cell Significance Index: -2.2000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0866
Cell Significance Index: -8.8500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0940
Cell Significance Index: -2.3500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0959
Cell Significance Index: -16.3700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0969
Cell Significance Index: -4.3900
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1189
Cell Significance Index: -23.6000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1280
Cell Significance Index: -4.1000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1299
Cell Significance Index: -6.1100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1344
Cell Significance Index: -26.9600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1458
Cell Significance Index: -10.0800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1625
Cell Significance Index: -3.5200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1807
Cell Significance Index: -10.8500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1848
Cell Significance Index: -25.3800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1876
Cell Significance Index: -27.2700
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2073
Cell Significance Index: -4.3000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2074
Cell Significance Index: -23.6800
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: -0.2130
Cell Significance Index: -1.7400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2189
Cell Significance Index: -25.8100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2499
Cell Significance Index: -26.0200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2547
Cell Significance Index: -6.8000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2614
Cell Significance Index: -29.9500
Cell Name: odontoblast (CL0000060)
Fold Change: -0.3045
Cell Significance Index: -39.0400
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.3164
Cell Significance Index: -2.1000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3427
Cell Significance Index: -24.2400
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3458
Cell Significance Index: -2.8200
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3471
Cell Significance Index: -22.3900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3554
Cell Significance Index: -27.2700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3569
Cell Significance Index: -26.6000
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.3728
Cell Significance Index: -9.0300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3905
Cell Significance Index: -24.0100
Cell Name: elicited macrophage (CL0000861)
Fold Change: -0.4118
Cell Significance Index: -3.6000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4166
Cell Significance Index: -21.6400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4439
Cell Significance Index: -29.8500
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.4778
Cell Significance Index: -7.2000
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.4875
Cell Significance Index: -7.1300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.4932
Cell Significance Index: -2.9800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5592
Cell Significance Index: -29.3600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.5753
Cell Significance Index: -21.1200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5898
Cell Significance Index: -12.5600
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.6048
Cell Significance Index: -26.3000
Cell Name: mononuclear cell (CL0000842)
Fold Change: -0.6199
Cell Significance Index: -2.5800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.6809
Cell Significance Index: -6.2700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.6926
Cell Significance Index: -32.2900
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.6957
Cell Significance Index: -6.1300
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.7187
Cell Significance Index: -9.5500
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: -0.7568
Cell Significance Index: -7.3900
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.7591
Cell Significance Index: -18.9600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.7860
Cell Significance Index: -29.7700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.7921
Cell Significance Index: -27.7500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.7924
Cell Significance Index: -23.3400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.8072
Cell Significance Index: -20.7500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.8318
Cell Significance Index: -28.9100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.8329
Cell Significance Index: -27.2700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.8565
Cell Significance Index: -27.2800
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.8679
Cell Significance Index: -12.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Calcium-binding protein:** S100A8 binds to calcium ions, which regulates its interactions with other proteins and modulates its biological activities. 2. **Multifaceted expression:** S100A8 is expressed in various cell types, including neutrophils, monocytes, epithelial cells, and keratinocytes. 3. **Inflammatory mediator:** S100A8 is released in response to inflammatory stimuli and acts as a pro-inflammatory mediator by regulating the activity of immune cells. 4. **Antimicrobial properties:** S100A8 has antimicrobial properties, which help to protect against bacterial and fungal infections. 5. **Cytoskeletal regulation:** S100A8 regulates cytoskeletal organization and dynamics, which is essential for cell migration, adhesion, and signaling. **Pathways and Functions:** 1. **Inflammatory response:** S100A8 is involved in the regulation of inflammatory responses by modulating the activity of immune cells, such as neutrophils and monocytes. 2. **Antigen processing and presentation:** S100A8 plays a role in antigen processing and presentation by regulating the activity of antigen-presenting cells. 3. **Apoptosis:** S100A8 regulates apoptosis by modulating the activity of pro-apoptotic and anti-apoptotic proteins. 4. **Cytoskeletal regulation:** S100A8 regulates cytoskeletal organization and dynamics, which is essential for cell migration, adhesion, and signaling. 5. **Cell survival:** S100A8 regulates cell survival by modulating the activity of anti-apoptotic proteins. **Clinical Significance:** 1. **Inflammatory disorders:** Dysregulation of S100A8 has been implicated in various inflammatory disorders, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. 2. **Autoimmune diseases:** S100A8 is involved in the pathogenesis of autoimmune diseases, such as lupus and multiple sclerosis. 3. **Cancer:** S100A8 has been implicated in cancer progression and metastasis, particularly in breast, lung, and colon cancers. 4. **Neurological disorders:** S100A8 is involved in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 5. **Infectious diseases:** S100A8 plays a role in the regulation of immune responses to bacterial and fungal infections. In conclusion, S100A8 is a multifaceted protein that plays a crucial role in regulating various cellular processes, including inflammation, immune response, and cell survival. Its dysregulation has been implicated in various diseases, highlighting the importance of S100A8 in maintaining immune homeostasis and preventing disease pathogenesis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Calgranulin-A

Genular Protein ID: 1175955061

Symbol: S10A8_HUMAN

Name: Calgranulin-A

UniProtKB Accession Codes:

P05109 A8K5L3 D3DV37 Q5SY70 Q9UC84 Q9UC92 Q9UCJ0 Q9UCM6

Database IDs:

Citations:

PubMed ID: 3561500

Title: A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene.

PubMed ID: 3561500

DOI: 10.1038/326614a0

PubMed ID: 3313057

Title: Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis.

PubMed ID: 3313057

DOI: 10.1038/330080a0

PubMed ID: 3405210

Title: Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation.

PubMed ID: 3405210

DOI: 10.1128/mcb.8.6.2402-2410.1988

PubMed ID: 2039599

Title: The calcium-binding protein MRP-8 is produced by human pulmonary tumor cells.

PubMed ID: 2039599

DOI: 10.1515/bchm3.1991.372.1.1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8619876

Title: Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin.

PubMed ID: 8619876

DOI: 10.1006/bbrc.1996.0616

PubMed ID: 8423249

Title: In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena.

PubMed ID: 8423249

DOI: 10.1177/00220345930720020801

PubMed ID: 1326551

Title: Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation.

PubMed ID: 1326551

DOI: 10.1016/s0021-9258(18)41786-3

PubMed ID: 7849642

Title: Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone.

PubMed ID: 7849642

PubMed ID: 7695842

Title: Isolation of an ascitic oncodevelopmental protein exhibiting high sequence homology with calcium-binding protein MRP8.

PubMed ID: 7695842

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 9083090

Title: Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway.

PubMed ID: 9083090

DOI: 10.1074/jbc.272.14.9496

PubMed ID: 11708798

Title: The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes.

PubMed ID: 11708798

DOI: 10.1006/bbrc.2001.5955

PubMed ID: 12626582

Title: Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion.

PubMed ID: 12626582

DOI: 10.4049/jimmunol.170.6.3233

PubMed ID: 15331440

Title: MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes.

PubMed ID: 15331440

DOI: 10.1182/blood-2004-02-0446

PubMed ID: 15598812

Title: Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells.

PubMed ID: 15598812

DOI: 10.1182/blood-2004-07-2520

PubMed ID: 15642721

Title: The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2.

PubMed ID: 15642721

DOI: 10.1096/fj.04-2377fje

PubMed ID: 16258195

Title: Regulation of S100A8/A9 (calprotectin) binding to tumor cells by zinc ion and its implication for apoptosis-inducing activity.

PubMed ID: 16258195

DOI: 10.1155/mi.2005.280

PubMed ID: 18786929

Title: Interaction between S100A8/A9 and annexin A6 is involved in the calcium-induced cell surface exposition of S100A8/A9.

PubMed ID: 18786929

DOI: 10.1074/jbc.m803908200

PubMed ID: 18832721

Title: S-nitrosylated S100A8: novel anti-inflammatory properties.

PubMed ID: 18832721

DOI: 10.4049/jimmunol.181.8.5627

PubMed ID: 20523765

Title: Anti-infective protective properties of S100 calgranulins.

PubMed ID: 20523765

DOI: 10.2174/187152309789838975

PubMed ID: 19835859

Title: S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis.

PubMed ID: 19835859

DOI: 10.1016/j.ejphar.2009.08.044

PubMed ID: 19087201

Title: Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation.

PubMed ID: 19087201

DOI: 10.1111/j.1574-695x.2008.00498.x

PubMed ID: 19122197

Title: Calprotectin S100A9 calcium-binding loops I and II are essential for keratinocyte resistance to bacterial invasion.

PubMed ID: 19122197

DOI: 10.1074/jbc.m806605200

PubMed ID: 19451397

Title: The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer.

PubMed ID: 19451397

DOI: 10.1189/jlb.1008647

PubMed ID: 19935772

Title: S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3.

PubMed ID: 19935772

DOI: 10.1038/cr.2009.129

PubMed ID: 19935766

Title: S100 Calgranulins in inflammatory arthritis.

PubMed ID: 19935766

DOI: 10.1038/icb.2009.88

PubMed ID: 20213444

Title: Inflammation-associated S100 proteins: new mechanisms that regulate function.

PubMed ID: 20213444

DOI: 10.1007/s00726-010-0528-0

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22095980

Title: S100A8 and S100A9 in cardiovascular biology and disease.

PubMed ID: 22095980

DOI: 10.1161/atvbaha.111.236927

PubMed ID: 21487906

Title: Dynamic mobility of immunological cells expressing S100A8 and S100A9 in vivo: a variety of functional roles of the two proteins as regulators in acute inflammatory reaction.

PubMed ID: 21487906

DOI: 10.1007/s10753-011-9330-8

PubMed ID: 22489132

Title: Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes.

PubMed ID: 22489132

DOI: 10.3390/ijms13032893

PubMed ID: 21912088

Title: S100A8 and S100A9: new insights into their roles in malignancy.

PubMed ID: 21912088

DOI: 10.1159/000330095

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22808130

Title: Molecular interface of S100A8 with cytochrome b and NADPH oxidase activation.

PubMed ID: 22808130

DOI: 10.1371/journal.pone.0040277

PubMed ID: 22363402

Title: Constitutive neutrophil apoptosis: regulation by cell concentration via S100 A8/9 and the MEK-ERK pathway.

PubMed ID: 22363402

DOI: 10.1371/journal.pone.0029333

PubMed ID: 25417112

Title: Target-selective protein S-nitrosylation by sequence motif recognition.

PubMed ID: 25417112

DOI: 10.1016/j.cell.2014.09.032

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26296369

Title: Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation.

PubMed ID: 26296369

DOI: 10.1096/fj.15-273987

PubMed ID: 33388094

Title: Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.

PubMed ID: 33388094

DOI: 10.1016/j.chom.2020.12.016

PubMed ID: 10771424

Title: The structure of human MRP8, a member of the S100 calcium-binding protein family, by MAD phasing at 1.9 A resolution.

PubMed ID: 10771424

DOI: 10.1107/s0907444900002833

PubMed ID: 17553524

Title: The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins.

PubMed ID: 17553524

DOI: 10.1016/j.jmb.2007.04.065

Sequence Information:

Length: 93
Mass: 10835
Checksum: 78F589140B9CE166
Sequence:

MLTELEKALN SIIDVYHKYS LIKGNFHAVY RDDLKKLLET ECPQYIRKKG ADVWFKELDI 
NTDGAVNFQE FLILVIKMGV AAHKKSHEES HKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: S100A8

Associated with

Cells (max top 100)

Other Information

A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene. PubMed ID: 3561500

Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis. PubMed ID: 3313057

Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation. PubMed ID: 3405210

The calcium-binding protein MRP-8 is produced by human pulmonary tumor cells. PubMed ID: 2039599

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin. PubMed ID: 8619876

In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena. PubMed ID: 8423249

Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation. PubMed ID: 1326551

Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone. PubMed ID: 7849642

Isolation of an ascitic oncodevelopmental protein exhibiting high sequence homology with calcium-binding protein MRP8. PubMed ID: 7695842

Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. PubMed ID: 1286667

Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. PubMed ID: 9083090

The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes. PubMed ID: 11708798

Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion. PubMed ID: 12626582

MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes. PubMed ID: 15331440

Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells. PubMed ID: 15598812

The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2. PubMed ID: 15642721

Regulation of S100A8/A9 (calprotectin) binding to tumor cells by zinc ion and its implication for apoptosis-inducing activity. PubMed ID: 16258195

Interaction between S100A8/A9 and annexin A6 is involved in the calcium-induced cell surface exposition of S100A8/A9. PubMed ID: 18786929

S-nitrosylated S100A8: novel anti-inflammatory properties. PubMed ID: 18832721

Anti-infective protective properties of S100 calgranulins. PubMed ID: 20523765

S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis. PubMed ID: 19835859

Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation. PubMed ID: 19087201

Calprotectin S100A9 calcium-binding loops I and II are essential for keratinocyte resistance to bacterial invasion. PubMed ID: 19122197

The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. PubMed ID: 19451397

S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3. PubMed ID: 19935772

S100 Calgranulins in inflammatory arthritis. PubMed ID: 19935766

Inflammation-associated S100 proteins: new mechanisms that regulate function. PubMed ID: 20213444

Initial characterization of the human central proteome. PubMed ID: 21269460

S100A8 and S100A9 in cardiovascular biology and disease. PubMed ID: 22095980

Dynamic mobility of immunological cells expressing S100A8 and S100A9 in vivo: a variety of functional roles of the two proteins as regulators in acute inflammatory reaction. PubMed ID: 21487906

Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes. PubMed ID: 22489132

S100A8 and S100A9: new insights into their roles in malignancy. PubMed ID: 21912088

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Molecular interface of S100A8 with cytochrome b and NADPH oxidase activation. PubMed ID: 22808130

Constitutive neutrophil apoptosis: regulation by cell concentration via S100 A8/9 and the MEK-ERK pathway. PubMed ID: 22363402

Target-selective protein S-nitrosylation by sequence motif recognition. PubMed ID: 25417112

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation. PubMed ID: 26296369

Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. PubMed ID: 33388094

The structure of human MRP8, a member of the S100 calcium-binding protein family, by MAD phasing at 1.9 A resolution. PubMed ID: 10771424

The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins. PubMed ID: 17553524