Details for: MAPK12

Gene ID: 6300

Symbol: MAPK12

Ensembl ID: ENSG00000188130

Description: mitogen-activated protein kinase 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 56.2859
    Cell Significance Index: -8.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 29.9633
    Cell Significance Index: -7.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.0988
    Cell Significance Index: -8.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.9639
    Cell Significance Index: -7.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.2275
    Cell Significance Index: -8.7900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.9635
    Cell Significance Index: 23.5100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.9272
    Cell Significance Index: 14.9600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7866
    Cell Significance Index: 12.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5964
    Cell Significance Index: 12.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4126
    Cell Significance Index: 82.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3644
    Cell Significance Index: 4.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2503
    Cell Significance Index: 34.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2402
    Cell Significance Index: 6.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1745
    Cell Significance Index: 9.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1243
    Cell Significance Index: 44.5800
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.1205
    Cell Significance Index: 1.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1019
    Cell Significance Index: 70.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0967
    Cell Significance Index: 9.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0728
    Cell Significance Index: 13.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0699
    Cell Significance Index: 8.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0681
    Cell Significance Index: 13.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0490
    Cell Significance Index: 2.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0347
    Cell Significance Index: 1.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0327
    Cell Significance Index: 0.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0278
    Cell Significance Index: 4.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0184
    Cell Significance Index: 1.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0122
    Cell Significance Index: 1.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0070
    Cell Significance Index: 0.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0025
    Cell Significance Index: 4.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0005
    Cell Significance Index: -0.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0028
    Cell Significance Index: -1.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0047
    Cell Significance Index: -7.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0064
    Cell Significance Index: -8.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0077
    Cell Significance Index: -4.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0079
    Cell Significance Index: -3.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0109
    Cell Significance Index: -8.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0113
    Cell Significance Index: -6.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0124
    Cell Significance Index: -9.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0148
    Cell Significance Index: -9.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0171
    Cell Significance Index: -7.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0223
    Cell Significance Index: -4.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0226
    Cell Significance Index: -6.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0283
    Cell Significance Index: -4.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0308
    Cell Significance Index: -1.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0339
    Cell Significance Index: -4.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0419
    Cell Significance Index: -1.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0428
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0430
    Cell Significance Index: -9.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0440
    Cell Significance Index: -1.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0459
    Cell Significance Index: -5.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0464
    Cell Significance Index: -7.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0469
    Cell Significance Index: -5.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0478
    Cell Significance Index: -0.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0509
    Cell Significance Index: -3.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0537
    Cell Significance Index: -5.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0538
    Cell Significance Index: -0.7700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0542
    Cell Significance Index: -0.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0556
    Cell Significance Index: -2.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0661
    Cell Significance Index: -4.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0757
    Cell Significance Index: -1.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0762
    Cell Significance Index: -7.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0772
    Cell Significance Index: -8.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0822
    Cell Significance Index: -5.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0859
    Cell Significance Index: -5.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0998
    Cell Significance Index: -7.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1015
    Cell Significance Index: -1.7400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1041
    Cell Significance Index: -1.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1057
    Cell Significance Index: -3.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1060
    Cell Significance Index: -3.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1086
    Cell Significance Index: -5.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1091
    Cell Significance Index: -3.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1104
    Cell Significance Index: -5.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1135
    Cell Significance Index: -6.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1155
    Cell Significance Index: -8.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1195
    Cell Significance Index: -3.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1218
    Cell Significance Index: -6.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1290
    Cell Significance Index: -7.9100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1296
    Cell Significance Index: -2.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1313
    Cell Significance Index: -6.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1375
    Cell Significance Index: -3.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1409
    Cell Significance Index: -2.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1422
    Cell Significance Index: -3.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1425
    Cell Significance Index: -3.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1432
    Cell Significance Index: -3.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1539
    Cell Significance Index: -4.9000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1605
    Cell Significance Index: -2.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1608
    Cell Significance Index: -5.2700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1658
    Cell Significance Index: -2.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1698
    Cell Significance Index: -5.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1723
    Cell Significance Index: -4.9400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1763
    Cell Significance Index: -3.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1962
    Cell Significance Index: -5.7800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1970
    Cell Significance Index: -2.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2032
    Cell Significance Index: -4.3900
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2112
    Cell Significance Index: -1.6000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2159
    Cell Significance Index: -4.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2192
    Cell Significance Index: -5.7700
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.2218
    Cell Significance Index: -2.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAPK12 is a serine/threonine kinase that belongs to the MAPK cascade, which is a complex signaling pathway involved in the regulation of cellular responses to external stimuli. MAPK12 is specifically activated by mitogens, such as growth factors and cytokines, and is characterized by its ability to phosphorylate and activate downstream targets. The protein is highly expressed in various cell types, including immune cells, epithelial cells, and neuronal cells. **Pathways and Functions:** MAPK12 is involved in multiple signaling pathways, including: 1. **Activation of PGC-1α**: MAPK12 phosphorylates and activates PGC-1α, a transcriptional coactivator involved in the regulation of energy metabolism and mitochondrial biogenesis. 2. **Mitochondrial Biogenesis**: MAPK12 regulates mitochondrial biogenesis and function by interacting with PGC-1α and other mitochondrial proteins. 3. **Immune System**: MAPK12 plays a crucial role in the regulation of immune responses, including the activation of T-helper 17 cells and the regulation of innate immune responses. 4. **Cell Cycle Regulation**: MAPK12 regulates cell cycle progression by phosphorylating and activating cell cycle regulators, such as p21 and p27. 5. **Neurodevelopment**: MAPK12 is involved in the regulation of neuronal development and function, including the regulation of axon guidance and neuronal differentiation. **Clinical Significance:** Dysregulation of MAPK12 has been implicated in various diseases, including: 1. **Cancer**: MAPK12 is often upregulated in cancer cells, contributing to their proliferation and survival. 2. **Neurodegenerative Diseases**: MAPK12 has been implicated in the regulation of neuronal function and survival, and its dysregulation has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Immune Disorders**: MAPK12 plays a crucial role in the regulation of immune responses, and its dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, MAPK12 is a multifunctional protein that plays a crucial role in various cellular processes, including signal transduction, cell cycle regulation, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of MAPK12 regulation and its potential therapeutic applications. **Recommendations:** Further research is needed to fully understand the mechanisms of MAPK12 regulation and its role in various diseases. Potential therapeutic strategies include: 1. **Targeting MAPK12**: Developing inhibitors or activators of MAPK12 to modulate its activity in various diseases. 2. **Modulating PGC-1α**: Targeting PGC-1α to modulate mitochondrial biogenesis and function in diseases such as cancer and neurodegenerative diseases. 3. **Regulating immune responses**: Modulating MAPK12 to regulate immune responses in autoimmune diseases. By elucidating the mechanisms of MAPK12 regulation and its role in various diseases, researchers can develop novel therapeutic strategies to target this protein and improve human health.

Genular Protein ID: 2694093366

Symbol: MK12_HUMAN

Name: Mitogen-activated protein kinase 12

UniProtKB Accession Codes:

P53778 Q14260 Q6IC53 Q99588 Q99672

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 4 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 2 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8633070

Title: ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation.

PubMed ID: 8633070

DOI: 10.1073/pnas.93.9.4355

PubMed ID: 9169156

Title: Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization.

PubMed ID: 9169156

DOI: 10.1006/geno.1997.4633

PubMed ID: 8920915

Title: The primary structure of p38 gamma: a new member of p38 group of MAP kinases.

PubMed ID: 8920915

DOI: 10.1006/bbrc.1996.1662

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9430721

Title: Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.

PubMed ID: 9430721

DOI: 10.1074/jbc.273.3.1741

PubMed ID: 10212242

Title: Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition.

PubMed ID: 10212242

DOI: 10.1074/jbc.274.18.12626

PubMed ID: 11010976

Title: Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength.

PubMed ID: 11010976

DOI: 10.1074/jbc.m007835200

PubMed ID: 10848581

Title: Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest.

PubMed ID: 10848581

DOI: 10.1128/mcb.20.13.4543-4552.2000

PubMed ID: 11991731

Title: Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3).

PubMed ID: 11991731

DOI: 10.1006/jmcc.2001.1523

PubMed ID: 12167088

Title: A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria.

PubMed ID: 12167088

DOI: 10.1042/bj20020553

PubMed ID: 14592936

Title: p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle.

PubMed ID: 14592936

DOI: 10.1152/ajpregu.00563.2003

PubMed ID: 15284239

Title: Active mutants of the human p38alpha mitogen-activated protein kinase.

PubMed ID: 15284239

DOI: 10.1074/jbc.m404595200

PubMed ID: 17724032

Title: p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response.

PubMed ID: 17724032

DOI: 10.1074/jbc.m703857200

PubMed ID: 20605917

Title: p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock.

PubMed ID: 20605917

DOI: 10.1242/jcs.066514

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21172807

Title: Loss of p38gamma MAPK induces pleiotropic mitotic defects and massive cell death.

PubMed ID: 21172807

DOI: 10.1242/jcs.068254

PubMed ID: 21532888

Title: p38gamma mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer.

PubMed ID: 21532888

DOI: 10.1593/neo.101748

PubMed ID: 20626350

Title: Mechanisms and functions of p38 MAPK signalling.

PubMed ID: 20626350

DOI: 10.1042/bj20100323

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27246854

Title: Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38gamma.

PubMed ID: 27246854

DOI: 10.1074/jbc.m115.707208

PubMed ID: 10508788

Title: The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation.

PubMed ID: 10508788

DOI: 10.1016/s0969-2126(99)80173-7

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 367
  • Mass: 41940
  • Checksum: EF680401D8E40610
  • Sequence:
    • MSSPPPARSG FYRQEVTKTA WEVRAVYRDL QPVGSGAYGA VCSAVDGRTG AKVAIKKLYR 
PFQSELFAKR AYRELRLLKH MRHENVIGLL DVFTPDETLD DFTDFYLVMP FMGTDLGKLM 
KHEKLGEDRI QFLVYQMLKG LRYIHAAGII HRDLKPGNLA VNEDCELKIL DFGLARQADS 
EMTGYVVTRW YRAPEVILNW MRYTQTVDIW SVGCIMAEMI TGKTLFKGSD HLDQLKEIMK 
VTGTPPAEFV QRLQSDEAKN YMKGLPELEK KDFASILTNA SPLAVNLLEK MLVLDAEQRV 
TAGEALAHPY FESLHDTEDE PQVQKYDDSF DDVDRTLDEW KRVTYKEVLS FKPPRQLGAR 
VSKETPL

Genular Protein ID: 2854174154

Symbol: Q6N076_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6N076

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 319
  • Mass: 36674
  • Checksum: FB884744C0141BA4
  • Sequence:
    • PPRSSAVDGR TGAKVAIKKL YRPFQSELFA KRAYRELRLL KHMRHENVIG LLDVFTPDET 
LDDFTDFYLV MPFMGTDLGK LMKHEKLGED RIQFLVYQML KGLRDLKPGN LAVNEDCELK 
ILDFGLARQA DSEMTGYVVT RWYRAPEVIL NWMRYTQTVD IWSVGCIMAE MITGKTLFKG 
SDHLDQLKEI MKVTGTPPAE FVQRLQSDEA KNYMKGLPEL EKKDFASILT NASPLAVNLL 
EKMLVLDAEQ RVTAGEALAH PYFESLHDTE DEPQVQKYDD SFDDVDRTLD EWKRVTYKEV 
LSFKPPRQLG ARVSKETPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.