Details for: ATXN2

Gene ID: 6311

Symbol: ATXN2

Ensembl ID: ENSG00000204842

Description: ataxin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 553.6653
    Cell Significance Index: -86.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 327.9407
    Cell Significance Index: -83.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 187.6419
    Cell Significance Index: -88.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 168.6124
    Cell Significance Index: -68.5000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 156.9641
    Cell Significance Index: -80.7400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 132.1119
    Cell Significance Index: -88.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 71.8728
    Cell Significance Index: -68.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 71.3245
    Cell Significance Index: -87.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.9792
    Cell Significance Index: -80.3100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.5054
    Cell Significance Index: -81.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.5086
    Cell Significance Index: -88.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.3210
    Cell Significance Index: -35.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.3293
    Cell Significance Index: 660.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6658
    Cell Significance Index: 534.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.6158
    Cell Significance Index: 938.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.4518
    Cell Significance Index: 188.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.3243
    Cell Significance Index: 130.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.7302
    Cell Significance Index: 1196.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4878
    Cell Significance Index: 91.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4145
    Cell Significance Index: 39.5300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.3151
    Cell Significance Index: 28.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2657
    Cell Significance Index: 33.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1963
    Cell Significance Index: 30.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9637
    Cell Significance Index: 173.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9091
    Cell Significance Index: 40.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.8798
    Cell Significance Index: 21.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8654
    Cell Significance Index: 16.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8340
    Cell Significance Index: 31.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8309
    Cell Significance Index: 102.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7500
    Cell Significance Index: 21.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7436
    Cell Significance Index: 102.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7290
    Cell Significance Index: 49.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.6986
    Cell Significance Index: 317.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6973
    Cell Significance Index: 113.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6572
    Cell Significance Index: 71.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6553
    Cell Significance Index: 1233.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6077
    Cell Significance Index: 27.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5490
    Cell Significance Index: 299.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4765
    Cell Significance Index: 733.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4549
    Cell Significance Index: 838.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4429
    Cell Significance Index: 399.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4342
    Cell Significance Index: 275.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3194
    Cell Significance Index: 31.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3081
    Cell Significance Index: 418.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2906
    Cell Significance Index: 55.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2434
    Cell Significance Index: 12.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2071
    Cell Significance Index: 91.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0996
    Cell Significance Index: 3.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0881
    Cell Significance Index: 11.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0788
    Cell Significance Index: 1.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0452
    Cell Significance Index: 1.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0266
    Cell Significance Index: -1.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0434
    Cell Significance Index: -31.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0462
    Cell Significance Index: -2.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0500
    Cell Significance Index: -37.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0621
    Cell Significance Index: -38.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0860
    Cell Significance Index: -2.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0886
    Cell Significance Index: -49.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0903
    Cell Significance Index: -68.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1126
    Cell Significance Index: -19.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1703
    Cell Significance Index: -10.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2260
    Cell Significance Index: -10.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2291
    Cell Significance Index: -48.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2328
    Cell Significance Index: -24.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2385
    Cell Significance Index: -34.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2558
    Cell Significance Index: -73.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2819
    Cell Significance Index: -28.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2873
    Cell Significance Index: -33.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3011
    Cell Significance Index: -38.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3138
    Cell Significance Index: -37.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3277
    Cell Significance Index: -15.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3716
    Cell Significance Index: -6.2600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3935
    Cell Significance Index: -5.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4408
    Cell Significance Index: -32.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4569
    Cell Significance Index: -23.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4977
    Cell Significance Index: -12.4400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4999
    Cell Significance Index: -57.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5163
    Cell Significance Index: -11.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5754
    Cell Significance Index: -65.9200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5861
    Cell Significance Index: -8.4300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6525
    Cell Significance Index: -9.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7396
    Cell Significance Index: -20.1300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7409
    Cell Significance Index: -5.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7914
    Cell Significance Index: -55.9700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8052
    Cell Significance Index: -4.8700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.8860
    Cell Significance Index: -18.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9173
    Cell Significance Index: -72.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9997
    Cell Significance Index: -32.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0131
    Cell Significance Index: -16.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0214
    Cell Significance Index: -62.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0515
    Cell Significance Index: -27.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.0671
    Cell Significance Index: -15.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0713
    Cell Significance Index: -12.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.1712
    Cell Significance Index: -15.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1980
    Cell Significance Index: -34.3400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.2182
    Cell Significance Index: -15.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.2700
    Cell Significance Index: -27.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.2845
    Cell Significance Index: -44.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.3429
    Cell Significance Index: -28.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.3992
    Cell Significance Index: -12.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Ataxin-2 is a 375-amino acid protein, which, when mutated, can lead to the expansion of CAG repeats, resulting in the formation of an abnormal polyglutamine tract. This expansion causes protein aggregation, leading to cellular toxicity and the development of neurodegenerative diseases. ATXN2 is primarily localized to the cytosol, where it interacts with various RNA-binding proteins and participates in RNA metabolic processes, including translation regulation and stress granule assembly. **Pathways and Functions:** ATXN2 is involved in multiple cellular pathways, including: 1. **RNA Metabolism:** ATXN2 regulates translation, RNA binding, and RNA transport, playing a crucial role in the processing and storage of RNA molecules. 2. **Protein Binding:** ATXN2 interacts with various proteins, including RNA-binding proteins, cytoskeletal proteins, and signaling molecules, influencing cellular signaling and protein homeostasis. 3. **Stress Granule Assembly:** ATXN2 is a key component of stress granules, which are cytoplasmic structures that regulate mRNA translation in response to stress. 4. **Regulation of Translation:** ATXN2 modulates translation initiation and elongation, influencing protein synthesis and cell growth. **Clinical Significance:** The ATXN2 gene has been associated with several neurological disorders, including: 1. **Spinocerebellar Ataxia Type 2 (SCA2):** A autosomal dominant disorder characterized by progressive ataxia, dysarthria, and eye movement abnormalities. 2. **Spinocerebellar Ataxia Type 6 (SCA6):** A autosomal dominant disorder characterized by ataxia, dysarthria, and eye movement abnormalities. 3. **Other Neurodegenerative Diseases:** ATXN2 has been implicated in other neurodegenerative disorders, including Machado-Joseph disease, dentatorubral-pallidoluysian atrophy, and spinocerebellar ataxia type 3. In conclusion, ATXN2 is a complex protein involved in various cellular processes, including RNA metabolism, protein binding, and cytoskeletal dynamics. Its dysregulation has been linked to several neurological disorders, highlighting the importance of this gene in understanding the molecular mechanisms underlying neurodegenerative diseases. Further research is needed to elucidate the functional significance of ATXN2 and to develop therapeutic strategies for treating these diseases.

Genular Protein ID: 3274670810

Symbol: ATX2_HUMAN

Name: Ataxin-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8896555

Title: Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.

PubMed ID: 8896555

DOI: 10.1038/ng1196-269

PubMed ID: 8896556

Title: Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT.

PubMed ID: 8896556

DOI: 10.1038/ng1196-277

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8896557

Title: Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats.

PubMed ID: 8896557

DOI: 10.1038/ng1196-285

PubMed ID: 9480749

Title: Genomic structure of the human gene for spinocerebellar ataxia type 2 (SCA2) on chromosome 12q24.1.

PubMed ID: 9480749

DOI: 10.1006/geno.1997.5131

PubMed ID: 10814712

Title: A novel protein with RNA-binding motifs interacts with ataxin-2.

PubMed ID: 10814712

DOI: 10.1093/hmg/9.9.1303

PubMed ID: 16835262

Title: Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes.

PubMed ID: 16835262

DOI: 10.1093/hmg/ddl173

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18602463

Title: Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.

PubMed ID: 18602463

DOI: 10.1016/j.cellsig.2008.05.018

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20740007

Title: Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.

PubMed ID: 20740007

DOI: 10.1038/nature09320

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23209657

Title: Ataxin-2-like is a regulator of stress granules and processing bodies.

PubMed ID: 23209657

DOI: 10.1371/journal.pone.0050134

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1313
  • Mass: 140283
  • Checksum: 40A2883FF9D5D118
  • Sequence:
  • MRSAAAAPRS PAVATESRRF AAARWPGWRS LQRPARRSGR GGGGAAPGPY PSAAPPPPGP 
    GPPPSRQSSP PSASDCFGSN GNGGGAFRPG SRRLLGLGGP PRPFVVLLLP LASPGAPPAA 
    PTRASPLGAR ASPPRSGVSL ARPAPGCPRP ACEPVYGPLT MSLKPQQQQQ QQQQQQQQQQ 
    QQQQQQQQPP PAAANVRKPG GSGLLASPAA APSPSSSSVS SSSATAPSSV VAATSGGGRP 
    GLGRGRNSNK GLPQSTISFD GIYANMRMVH ILTSVVGSKC EVQVKNGGIY EGVFKTYSPK 
    CDLVLDAAHE KSTESSSGPK REEIMESILF KCSDFVVVQF KDMDSSYAKR DAFTDSAISA 
    KVNGEHKEKD LEPWDAGELT ANEELEALEN DVSNGWDPND MFRYNEENYG VVSTYDSSLS 
    SYTVPLERDN SEEFLKREAR ANQLAEEIES SAQYKARVAL ENDDRSEEEK YTAVQRNSSE 
    REGHSINTRE NKYIPPGQRN REVISWGSGR QNSPRMGQPG SGSMPSRSTS HTSDFNPNSG 
    SDQRVVNGGV PWPSPCPSPS SRPPSRYQSG PNSLPPRAAT PTRPPSRPPS RPSRPPSHPS 
    AHGSPAPVST MPKRMSSEGP PRMSPKAQRH PRNHRVSAGR GSISSGLEFV SHNPPSEAAT 
    PPVARTSPSG GTWSSVVSGV PRLSPKTHRP RSPRQNSIGN TPSGPVLASP QAGIIPTEAV 
    AMPIPAASPT PASPASNRAV TPSSEAKDSR LQDQRQNSPA GNKENIKPNE TSPSFSKAEN 
    KGISPVVSEH RKQIDDLKKF KNDFRLQPSS TSESMDQLLN KNREGEKSRD LIKDKIEPSA 
    KDSFIENSSS NCTSGSSKPN SPSISPSILS NTEHKRGPEV TSQGVQTSSP ACKQEKDDKE 
    EKKDAAEQVR KSTLNPNAKE FNPRSFSQPK PSTTPTSPRP QAQPSPSMVG HQQPTPVYTQ 
    PVCFAPNMMY PVPVSPGVQP LYPIPMTPMP VNQAKTYRAV PNMPQQRQDQ HHQSAMMHPA 
    SAAGPPIAAT PPAYSTQYVA YSPQQFPNQP LVQHVPHYQS QHPHVYSPVI QGNARMMAPP 
    THAQPGLVSS SATQYGAHEQ THAMYACPKL PYNKETSPSF YFAISTGSLA QQYAHPNATL 
    HPHTPHPQPS ATPTGQQQSQ HGGSHPAPSP VQHHQHQAAQ ALHLASPQQQ SAIYHAGLAP 
    TPPSMTPASN TQSPQNSFPA AQQTVFTIHP SHVQPAYTNP PHMAHVPQAH VQSGMVPSHP 
    TAHAPMMLMT TQPPGGPQAA LAQSALQPIP VSTTAHFPYM THPSVQAHHQ QQL

Genular Protein ID: 2878210373

Symbol: F8VQP2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1073
  • Mass: 116514
  • Checksum: 1A6B3159AEC51C45
  • Sequence:
  • MRMVHILTSV VGSKCEVQVK NGGIYEGVFK TYSPKCDLVL DAAHEKSTES SSGPKREEIM 
    ESILFKCSDF VVVQFKDMDS SYAKRDAFTD SAISAKVNGE HKEKDLEPWD AGELTANEEL 
    EALENDVSNG WDPNDMFRYN EENYGVVSTY DSSLSSYTVP LERDNSEEFL KREARANQLA 
    EEIESSAQYK ARVALENDDR SEEEKYTAVQ RNSSEREGHS INTRENKYIP PGQRNREVIS 
    WGSGRQNSPR MGQPGSGSMP SRSTSHTSDF NPNSGSDQRV VNGGVPWPSP CPSPSSRPPS 
    RYQSGPNSLP PRAATPTRPP SRPPSRPSRP PSHPSAHGSP APVSTMPKRM SSEGPPRMSP 
    KAQRHPRNHR VSAGRGSISS GLEFVSHNPP SEAATPPVAR TSPSGGTWSS VVSGVPRLSP 
    KTHRPRSPRQ NSIGNTPSGP VLASPQAGII PTEAVAMPIP AASPTPASPA SNRAVTPSSE 
    AKDSRLQDQR QNSPAGNKEN IKPNETSPSF SKAENKGISP VVSEHRKQID DLKKFKNDFR 
    LQPSSTSESM DQLLNKNREG EKSRDLIKDK IEPSAKDSFI ENSSSNCTSG SSKPNSPSIS 
    PSILSNTEHK RGPEVTSQGV QTSSPACKQE KDDKEEKKDA AEQVRKSTLN PNAKEFNPRS 
    FSQPKPSTTP TSPRPQAQPS PSMVGHQQPT PVYTQPVCFA PNMMYPVPVS PGVQPLYPIP 
    MTPMPVNQAK TYRAVPNMPQ QRQDQHHQSA MMHPASAAGP PIAATPPAYS TQYVAYSPQQ 
    FPNQPLVQHV PHYQSQHPHV YSPVIQGNAR MMAPPTHAQP GLVSSSATQY GAHEQTHAMY 
    ACPKLPYNKE TSPSFYFAIS TGSLAQQYAH PNATLHPHTP HPQPSATPTG QQQSQHGGSH 
    PAPSPVQHHQ HQAAQALHLA SPQQQSAIYH AGLAPTPPSM TPASNTQSPQ NSFPAAQQTV 
    FTIHPSHVQP AYTNPPHMAH VPQCASEALA RCGLEMRLSW IYLSEGYLAH VQSGMVPSHP 
    TAHAPMMLMT TQPPGGPQAA LAQSALQPIP VSTTAHFPYM THPSVQAHHQ QQL

Genular Protein ID: 2685627276

Symbol: Q2M2R5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1127
  • Mass: 122181
  • Checksum: 0ADB2888EFD2C33E
  • Sequence:
  • PRKQPSAPPA PHVSLPAPGP PHVLLPSDPS DFRGRNSNKG LPQSTISFDG IYANMRMVHI 
    LTSVVGSKCE VQVKNGGIYE GVFKTYSPKC DLVLDAAHEK STESSSGPKR EEIMESILFK 
    CSDFVVVQFK DMDSSYAKRD AFTDSAISAK VNGEHKEKDL EPWDAGELTA NEELEALEND 
    VSNGWDPNDM FRYNEENYGV VSTYDSSLSS YTVPLERDNS EEFLKREARA NQLAEEIESS 
    AQYKARVALE NDDRSEEEKY TAVQRNSSER EGHSINTREN KYIPPGQRNR EVISWGSGRQ 
    NSPRMGQPGS GSMPSRSTSH TSDFNPNSGS DQRVVNGGVP WPSPCPSPSS RPPSRYQSGP 
    NSLPPRAATP TRPPSRPPSR PSRPPSHPSA HGSPAPVSTM PKRMSSEGPP RMSPKAQRHP 
    RNHRVSAGRG SISSGLEFVS HNPPSEAATP PVARTSPSGG TWSSVVSGVP RLSPKTHRPR 
    SPRQNSIGNT PSGPVLASPQ AGIIPTEAVA MPIPAASPTP ASPASNRAVT PSSEAKDSRL 
    QDQRQNSPAG NKENIKPNET SPSFSKAENK GISPVVSEHR KQIDDLKKFK NDFRLQPSST 
    SESMDQLLNK NREGEKSRDL IKDKIEPSAK DSFIENSSSN CTSGSSKPNS PSISPSILSN 
    TEHKRGPEVT SQGVQTSSPA CKQEKDDKEE KKDAAEQVRK STLNPNAKEF NPRSFSQPKP 
    STTPTSPRPQ AQPSPSMVGH QQPTPVYTQP VCFAPNMMYP VPVSPGVQPL YPIPMTPMPV 
    NQAKTYRAVP NMPQQRQDQH HQSAMMHPAS AAGPPIAATP PAYSTQYVAY SPQQFPNQPL 
    VQHVPHYQSQ HPHVYSPVIQ GNARMMAPPT HAQPGLVSSS ATQYGAHEQT HAMYACPKLP 
    YNKETSPSFY FAISTGSLAQ QYAHPNATLH PHTPHPQPSA TPTGQQQSQH GGSHPAPSPV 
    QHHQHQAAQA LHLASPQQQS AIYHAGLAPT PPSMTPASNT QSPQNSFPAA QQTVFTIHPS 
    HVQPAYTNPP HMAHVPQCAS EALARCGLEM RLSWIYLSEG YLAHVQSGMV PSHPTAHAPM 
    MLMTTQPPGG PQAALAQSAL QPIPVSTTAH FPYMTHPSVQ AHHQQQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.