Details for: CLEC11A

Gene ID: 6320

Symbol: CLEC11A

Ensembl ID: ENSG00000105472

Description: C-type lectin domain containing 11A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 146.3240
    Cell Significance Index: -22.7600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 57.6772
    Cell Significance Index: -23.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.8699
    Cell Significance Index: -20.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 49.8176
    Cell Significance Index: -23.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.4432
    Cell Significance Index: -11.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.9189
    Cell Significance Index: -23.6200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.2989
    Cell Significance Index: -20.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.7274
    Cell Significance Index: -23.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 9.4062
    Cell Significance Index: 251.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.9105
    Cell Significance Index: -23.8700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 6.4170
    Cell Significance Index: 37.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.0111
    Cell Significance Index: -23.7200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 5.3609
    Cell Significance Index: 68.6600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 5.2381
    Cell Significance Index: 34.7500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.0269
    Cell Significance Index: 32.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.4796
    Cell Significance Index: 289.0000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 4.2171
    Cell Significance Index: 26.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.9471
    Cell Significance Index: -6.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.6259
    Cell Significance Index: 336.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3359
    Cell Significance Index: 320.7800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.9708
    Cell Significance Index: 15.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.5846
    Cell Significance Index: 36.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2727
    Cell Significance Index: 26.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9967
    Cell Significance Index: 28.5700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.7977
    Cell Significance Index: 4.7100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.7136
    Cell Significance Index: 11.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7043
    Cell Significance Index: 19.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6731
    Cell Significance Index: 607.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6597
    Cell Significance Index: 14.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6157
    Cell Significance Index: 8.4000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5750
    Cell Significance Index: 4.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5221
    Cell Significance Index: 13.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4903
    Cell Significance Index: 30.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4771
    Cell Significance Index: 25.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4665
    Cell Significance Index: 75.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3962
    Cell Significance Index: 216.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3545
    Cell Significance Index: 26.4200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3251
    Cell Significance Index: 2.0200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3057
    Cell Significance Index: 4.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2952
    Cell Significance Index: 4.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2176
    Cell Significance Index: 41.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1993
    Cell Significance Index: 5.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1989
    Cell Significance Index: 5.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1910
    Cell Significance Index: 38.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1898
    Cell Significance Index: 18.7800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1881
    Cell Significance Index: 2.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1791
    Cell Significance Index: 12.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1615
    Cell Significance Index: 71.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1581
    Cell Significance Index: 20.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1115
    Cell Significance Index: 5.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1013
    Cell Significance Index: 5.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0937
    Cell Significance Index: 3.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0777
    Cell Significance Index: 3.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0680
    Cell Significance Index: 24.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0583
    Cell Significance Index: 6.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0503
    Cell Significance Index: 3.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0457
    Cell Significance Index: 8.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0231
    Cell Significance Index: 16.9100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.0170
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0081
    Cell Significance Index: 15.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0066
    Cell Significance Index: 0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0030
    Cell Significance Index: -4.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0037
    Cell Significance Index: -2.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0101
    Cell Significance Index: -7.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0102
    Cell Significance Index: -0.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0106
    Cell Significance Index: -0.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0109
    Cell Significance Index: -6.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0109
    Cell Significance Index: -0.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0145
    Cell Significance Index: -1.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0197
    Cell Significance Index: -2.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0222
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0242
    Cell Significance Index: -17.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0331
    Cell Significance Index: -15.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0336
    Cell Significance Index: -18.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0368
    Cell Significance Index: -3.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0422
    Cell Significance Index: -26.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0442
    Cell Significance Index: -12.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0573
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0576
    Cell Significance Index: -9.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0624
    Cell Significance Index: -12.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0688
    Cell Significance Index: -0.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0702
    Cell Significance Index: -3.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0790
    Cell Significance Index: -11.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1208
    Cell Significance Index: -25.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1286
    Cell Significance Index: -14.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1576
    Cell Significance Index: -2.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1753
    Cell Significance Index: -13.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2149
    Cell Significance Index: -22.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2556
    Cell Significance Index: -15.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2631
    Cell Significance Index: -17.6900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2651
    Cell Significance Index: -1.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2857
    Cell Significance Index: -16.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2984
    Cell Significance Index: -22.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3490
    Cell Significance Index: -18.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3868
    Cell Significance Index: -12.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4030
    Cell Significance Index: -10.3600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.4081
    Cell Significance Index: -0.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4139
    Cell Significance Index: -12.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **C-type lectin domain**: The CLEC11A protein contains a C-type lectin domain, which is a carbohydrate-binding domain that allows the protein to interact with carbohydrate molecules. 2. **Significant expression in immune cells**: CLEC11A is expressed in early pro-B cells, which are precursor cells to B lymphocytes, suggesting that it may play a role in the development and function of the immune system. 3. **Widespread expression in fibroblasts**: CLEC11A is also expressed in fibroblasts, which are cells that produce collagen and other extracellular matrix components, suggesting that it may play a role in tissue development and remodeling. 4. **Involvement in cell signaling and proliferation**: The CLEC11A protein is involved in signaling pathways that regulate cell proliferation and growth, which suggests that it may play a role in tissue development and homeostasis. **Pathways and Functions:** 1. **Carbohydrate binding**: The CLEC11A protein binds to carbohydrates, which triggers signaling pathways that regulate immune responses, cell proliferation, and tissue development. 2. **Signal transduction**: The CLEC11A protein is involved in signaling pathways that regulate cell proliferation, growth, and differentiation, including the PI3K/AKT and MAPK/ERK pathways. 3. **Immune response regulation**: CLEC11A is expressed in immune cells, suggesting that it may play a role in regulating immune responses, including the activation and proliferation of immune cells. 4. **Tissue development and remodeling**: The CLEC11A protein is involved in signaling pathways that regulate tissue development and remodeling, including the ossification of bone and the development of connective tissue. **Clinical Significance:** 1. **Immune system disorders**: Mutations in the CLEC11A gene have been associated with immune system disorders, including autoimmune diseases and immunodeficiency syndromes. 2. **Cancer**: The CLEC11A protein has been implicated in the development and progression of cancer, including leukemia and lymphoma. 3. **Inflammatory diseases**: CLEC11A is involved in signaling pathways that regulate inflammation, which suggests that it may play a role in the development of inflammatory diseases, including arthritis and asthma. 4. **Regenerative medicine**: The CLEC11A protein has been shown to promote tissue regeneration and repair, which suggests that it may be a useful target for regenerative medicine therapies. In conclusion, the CLEC11A gene is a critical component of the immune system and plays a role in regulating immune responses, tissue development, and cell proliferation. Further research is needed to fully understand the functions and clinical significance of this gene, but it has already provided valuable insights into the mechanisms of immune system regulation and tissue development.

Genular Protein ID: 1366023673

Symbol: CLC11_HUMAN

Name: C-type lectin domain family 11 member A

UniProtKB Accession Codes:

Q9Y240 B2RAD4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9442024

Title: Molecular cloning of a new secreted sulfated mucin-like protein with a C-type lectin domain that is expressed in lymphoblastic cells.

PubMed ID: 9442024

DOI: 10.1074/jbc.273.4.1911

PubMed ID: 9705843

Title: Isolation and characterization of a cDNA for human, mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily.

PubMed ID: 9705843

DOI: 10.1006/bbrc.1998.9073

PubMed ID: 10198175

Title: Cloning, mapping, and genomic organization of the LSLCL gene, encoding a new lymphocytic secreted mucin-like protein with a C-type lectin domain: a new model of exon shuffling.

PubMed ID: 10198175

DOI: 10.1006/geno.1999.5762

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11920266

Title: Stem cell growth factor: in situ hybridization analysis on the gene expression, molecular characterization and in vitro proliferative activity of a recombinant preparation on primitive hematopoietic progenitor cells.

PubMed ID: 11920266

DOI: 10.1038/sj.thj.6200118

PubMed ID: 11803813

Title: Expression of LSLCL, a new C-type lectin, is closely restricted, in bone marrow, to immature neutrophils.

PubMed ID: 11803813

DOI: 10.1016/s0764-4469(01)01392-0

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27976999

Title: Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton.

PubMed ID: 27976999

DOI: 10.7554/elife.18782

Sequence Information:

  • Length: 323
  • Mass: 35695
  • Checksum: D13604CDAF087427
  • Sequence:
    • MQAAWLLGAL VVPQLLGFGH GARGAEREWE GGWGGAQEEE REREALMLKH LQEALGLPAG 
RGDENPAGTV EGKEDWEMEE DQGEEEEEEA TPTPSSGPSP SPTPEDIVTY ILGRLAGLDA 
GLHQLHVRLH ALDTRVVELT QGLRQLRNAA GDTRDAVQAL QEAQGRAERE HGRLEGCLKG 
LRLGHKCFLL SRDFEAQAAA QARCTARGGS LAQPADRQQM EALTRYLRAA LAPYNWPVWL 
GVHDRRAEGL YLFENGQRVS FFAWHRSPRP ELGAQPSASP HPLSPDQPNG GTLENCVAQA 
SDDGSWWDHD CQRRLYYVCE FPF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.