Details for: SCN4B

Gene ID: 6330

Symbol: SCN4B

Ensembl ID: ENSG00000177098

Description: sodium voltage-gated channel beta subunit 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.1559
    Cell Significance Index: 95.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.7334
    Cell Significance Index: 65.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.0326
    Cell Significance Index: -2.2600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.7691
    Cell Significance Index: 6.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3780
    Cell Significance Index: 75.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2996
    Cell Significance Index: 6.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2032
    Cell Significance Index: 36.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1504
    Cell Significance Index: 53.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0928
    Cell Significance Index: 1.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0809
    Cell Significance Index: 2.3100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.0789
    Cell Significance Index: 0.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0782
    Cell Significance Index: 34.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0726
    Cell Significance Index: 0.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0635
    Cell Significance Index: 4.2700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0377
    Cell Significance Index: 0.4700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0322
    Cell Significance Index: 0.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0252
    Cell Significance Index: 1.3100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0217
    Cell Significance Index: 0.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0156
    Cell Significance Index: 1.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0053
    Cell Significance Index: 3.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0027
    Cell Significance Index: 1.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0005
    Cell Significance Index: 0.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0029
    Cell Significance Index: -5.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0033
    Cell Significance Index: -5.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0040
    Cell Significance Index: -5.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0076
    Cell Significance Index: -5.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0077
    Cell Significance Index: -5.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0097
    Cell Significance Index: -5.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.8800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0115
    Cell Significance Index: -0.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0122
    Cell Significance Index: -3.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0129
    Cell Significance Index: -0.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0143
    Cell Significance Index: -0.4000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0157
    Cell Significance Index: -0.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0217
    Cell Significance Index: -4.3000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0255
    Cell Significance Index: -0.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0256
    Cell Significance Index: -0.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0264
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0265
    Cell Significance Index: -5.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0319
    Cell Significance Index: -5.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0330
    Cell Significance Index: -4.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0335
    Cell Significance Index: -4.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0349
    Cell Significance Index: -4.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0366
    Cell Significance Index: -2.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0371
    Cell Significance Index: -4.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0398
    Cell Significance Index: -4.0700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0406
    Cell Significance Index: -0.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0419
    Cell Significance Index: -0.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0438
    Cell Significance Index: -5.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0450
    Cell Significance Index: -5.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0458
    Cell Significance Index: -2.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0496
    Cell Significance Index: -5.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0596
    Cell Significance Index: -1.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0605
    Cell Significance Index: -2.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0647
    Cell Significance Index: -4.8200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0659
    Cell Significance Index: -0.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0740
    Cell Significance Index: -1.5700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0764
    Cell Significance Index: -0.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0772
    Cell Significance Index: -1.5500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0778
    Cell Significance Index: -1.9400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0817
    Cell Significance Index: -0.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0829
    Cell Significance Index: -3.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0839
    Cell Significance Index: -4.7100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0849
    Cell Significance Index: -1.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0915
    Cell Significance Index: -5.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1092
    Cell Significance Index: -5.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1155
    Cell Significance Index: -4.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1205
    Cell Significance Index: -3.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1207
    Cell Significance Index: -3.4600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1222
    Cell Significance Index: -2.9300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1234
    Cell Significance Index: -2.9900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1242
    Cell Significance Index: -2.6600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1268
    Cell Significance Index: -2.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1276
    Cell Significance Index: -1.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1371
    Cell Significance Index: -2.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1375
    Cell Significance Index: -4.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1514
    Cell Significance Index: -5.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1534
    Cell Significance Index: -4.4200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1600
    Cell Significance Index: -3.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1604
    Cell Significance Index: -2.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1613
    Cell Significance Index: -4.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1613
    Cell Significance Index: -8.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1616
    Cell Significance Index: -3.1800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1644
    Cell Significance Index: -2.3400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1657
    Cell Significance Index: -1.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1677
    Cell Significance Index: -4.3100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1695
    Cell Significance Index: -5.3600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1754
    Cell Significance Index: -4.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1757
    Cell Significance Index: -4.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1759
    Cell Significance Index: -5.1800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1809
    Cell Significance Index: -2.1100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1815
    Cell Significance Index: -3.6200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1816
    Cell Significance Index: -3.7900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1825
    Cell Significance Index: -2.3900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1850
    Cell Significance Index: -2.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1866
    Cell Significance Index: -7.6400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1917
    Cell Significance Index: -3.9000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1930
    Cell Significance Index: -4.8200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1935
    Cell Significance Index: -3.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of Voltage-Gated Sodium Channel:** SCN4B is a beta subunit of the voltage-gated sodium channel, which is composed of alpha, beta, and gamma subunits. The beta subunit plays a crucial role in regulating the channel's activity and localization. 2. **Expression in Immune Cells:** SCN4B is expressed in various immune cells, including granulocytes, monocytes, and T lineage precursors, suggesting its involvement in immune response. 3. **Cardiac Conduction:** SCN4B is also expressed in cardiac muscle cells and plays a crucial role in regulating cardiac conduction and heart rate. 4. **Regulation of Sodium Ion Transport:** SCN4B regulates the activity of sodium ion transporters, which is essential for maintaining proper ion balance and cellular function. **Pathways and Functions:** 1. **Cardiac Conduction:** SCN4B is involved in regulating cardiac conduction by modulating the activity of voltage-gated sodium channels in cardiac muscle cells. 2. **Immune Response:** SCN4B is expressed in immune cells and plays a role in regulating immune response by modulating the activity of sodium ion transporters. 3. **Neuronal Action Potential:** SCN4B is also expressed in neurons and plays a role in regulating neuronal action potentials. 4. **Sensory Perception:** SCN4B is involved in regulating sensory perception, particularly in the detection of sweet, bitter, and umami tastes. **Clinical Significance:** 1. **Cardiovascular Disorders:** Dysregulation of SCN4B has been implicated in various cardiovascular disorders, including arrhythmias and cardiac conduction defects. 2. **Immune-Related Conditions:** SCN4B dysregulation has also been linked to immune-related conditions, including autoimmune diseases and inflammatory disorders. 3. **Taste Disorders:** SCN4B mutations have been associated with taste disorders, including impaired taste perception and taste hallucinations. 4. **Neurological Disorders:** SCN4B dysregulation has also been implicated in neurological disorders, including epilepsy and migraines. In conclusion, the SCN4B gene plays a crucial role in regulating cardiac conduction, immune response, and sensory perception. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining proper cellular function and overall health. Further research is needed to fully understand the role of SCN4B in human disease and to develop effective therapeutic strategies for its dysregulation.

Genular Protein ID: 2989945706

Symbol: SCN4B_HUMAN

Name: Sodium channel subunit beta-4

UniProtKB Accession Codes:

Q8IWT1 E9PPT5 Q6PIG5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 ComplexPortal 20 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EMBL 3 EMDB 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 4 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12930796

Title: Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.

PubMed ID: 12930796

DOI: 10.1523/jneurosci.23-20-07577.2003

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24297919

Title: Crystallographic insights into sodium-channel modulation by the beta4 subunit.

PubMed ID: 24297919

DOI: 10.1073/pnas.1314557110

PubMed ID: 17592081

Title: SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome.

PubMed ID: 17592081

DOI: 10.1161/circulationaha.106.659086

PubMed ID: 21051419

Title: Mutations in sodium channel beta-subunit SCN3B are associated with early-onset lone atrial fibrillation.

PubMed ID: 21051419

DOI: 10.1093/cvr/cvq348

PubMed ID: 23604097

Title: Mutations of the SCN4B-encoded sodium channel beta4 subunit in familial atrial fibrillation.

PubMed ID: 23604097

DOI: 10.3892/ijmm.2013.1355

Sequence Information:

  • Length: 228
  • Mass: 24969
  • Checksum: 2F17E1210E8EFEF8
  • Sequence:
    • MPGAGDGGKA PARWLGTGLL GLFLLPVTLS LEVSVGKATD IYAVNGTEIL LPCTFSSCFG 
FEDLHFRWTY NSSDAFKILI EGTVKNEKSD PKVTLKDDDR ITLVGSTKEK MNNISIVLRD 
LEFSDTGKYT CHVKNPKENN LQHHATIFLQ VVDRLEEVDN TVTLIILAVV GGVIGLLILI 
LLIKKLIIFI LKKTREKKKE CLVSSSGNDN TENGLPGSKA EEKPPSKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.