Details for: SDF2

Gene ID: 6388

Symbol: SDF2

Ensembl ID: ENSG00000132581

Description: stromal cell derived factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 222.3148
    Cell Significance Index: -34.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 123.5199
    Cell Significance Index: -31.3300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 90.1571
    Cell Significance Index: -37.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 81.1018
    Cell Significance Index: -38.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 71.1918
    Cell Significance Index: -36.6200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 57.1516
    Cell Significance Index: -38.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.0416
    Cell Significance Index: -37.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6198
    Cell Significance Index: -37.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4331
    Cell Significance Index: -25.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.3190
    Cell Significance Index: -22.4800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.3048
    Cell Significance Index: -11.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.3099
    Cell Significance Index: 269.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2493
    Cell Significance Index: 60.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.6404
    Cell Significance Index: 43.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3350
    Cell Significance Index: 217.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2542
    Cell Significance Index: 65.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2324
    Cell Significance Index: 33.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1047
    Cell Significance Index: 151.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0941
    Cell Significance Index: 51.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0716
    Cell Significance Index: 22.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0010
    Cell Significance Index: 123.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9085
    Cell Significance Index: 163.7700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.9048
    Cell Significance Index: 7.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8822
    Cell Significance Index: 481.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8634
    Cell Significance Index: 59.7100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7699
    Cell Significance Index: 7.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7008
    Cell Significance Index: 89.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6800
    Cell Significance Index: 31.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6423
    Cell Significance Index: 16.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6361
    Cell Significance Index: 47.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6286
    Cell Significance Index: 18.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5529
    Cell Significance Index: 35.6700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5431
    Cell Significance Index: 6.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5230
    Cell Significance Index: 51.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5156
    Cell Significance Index: 23.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5128
    Cell Significance Index: 11.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4994
    Cell Significance Index: 220.8000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4860
    Cell Significance Index: 3.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4440
    Cell Significance Index: 15.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3735
    Cell Significance Index: 10.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3694
    Cell Significance Index: 10.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3421
    Cell Significance Index: 67.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3178
    Cell Significance Index: 20.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2966
    Cell Significance Index: 38.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2954
    Cell Significance Index: 20.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2858
    Cell Significance Index: 57.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2776
    Cell Significance Index: 52.8300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2686
    Cell Significance Index: 3.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1919
    Cell Significance Index: 22.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1814
    Cell Significance Index: 4.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1716
    Cell Significance Index: 29.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1663
    Cell Significance Index: 150.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1047
    Cell Significance Index: 37.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0844
    Cell Significance Index: 2.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0354
    Cell Significance Index: 1.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0263
    Cell Significance Index: 0.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0220
    Cell Significance Index: 0.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0110
    Cell Significance Index: 7.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0092
    Cell Significance Index: 0.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0083
    Cell Significance Index: 6.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0017
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -1.9800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0056
    Cell Significance Index: -10.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0129
    Cell Significance Index: -0.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0211
    Cell Significance Index: -38.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0222
    Cell Significance Index: -13.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0237
    Cell Significance Index: -36.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0261
    Cell Significance Index: -35.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0282
    Cell Significance Index: -15.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0325
    Cell Significance Index: -20.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0362
    Cell Significance Index: -3.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0607
    Cell Significance Index: -27.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0654
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0685
    Cell Significance Index: -7.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0690
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0752
    Cell Significance Index: -15.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1079
    Cell Significance Index: -31.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1843
    Cell Significance Index: -26.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1917
    Cell Significance Index: -10.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2182
    Cell Significance Index: -13.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2294
    Cell Significance Index: -5.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2678
    Cell Significance Index: -4.9500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2803
    Cell Significance Index: -32.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2936
    Cell Significance Index: -22.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2976
    Cell Significance Index: -4.0600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3407
    Cell Significance Index: -3.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3481
    Cell Significance Index: -4.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3618
    Cell Significance Index: -37.6800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3658
    Cell Significance Index: -2.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3746
    Cell Significance Index: -9.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4044
    Cell Significance Index: -32.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4067
    Cell Significance Index: -10.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4210
    Cell Significance Index: -28.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5724
    Cell Significance Index: -9.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5818
    Cell Significance Index: -12.3900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5918
    Cell Significance Index: -4.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6081
    Cell Significance Index: -15.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6131
    Cell Significance Index: -37.5900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.6431
    Cell Significance Index: -3.9600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6712
    Cell Significance Index: -9.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SDF2 is a small, secreted protein that belongs to the chemokine family. It is produced by various cell types, including placental villous trophoblast, bladder urothelial cell, preosteoblast, mural cell, fibroblast of mammary gland, Leydig cell, and kidney cell. SDF2 is characterized by its ability to bind to its receptor, CXCR4, which is expressed on the surface of various immune cells, including T cells, B cells, and natural killer cells. This interaction triggers a signaling cascade that regulates immune cell migration, proliferation, and differentiation. **Pathways and Functions:** SDF2 is involved in several key pathways that regulate immune cell function, including: 1. **Immune cell trafficking:** SDF2 acts as a chemoattractant, guiding immune cells to sites of inflammation and tissue damage. 2. **Protein folding and chaperone-mediated protein refolding:** SDF2 interacts with chaperone proteins, such as Hsp90, to regulate protein folding and refolding, which is essential for immune cell function. 3. **Endoplasmic reticulum (ER) stress response:** SDF2 is involved in the regulation of ER stress response, which is critical for maintaining immune cell homeostasis. 4. **Misfolded protein binding:** SDF2 binds to misfolded proteins, such as those associated with neurodegenerative diseases, to regulate protein aggregation and clearance. **Clinical Significance:** SDF2 has significant implications in various immunological disorders, including: 1. **Autoimmune diseases:** SDF2 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where immune cell trafficking and differentiation are dysregulated. 2. **Cancer:** SDF2 has been shown to promote cancer progression by regulating immune cell infiltration and tumor growth. 3. **Infectious diseases:** SDF2 plays a critical role in the regulation of immune cell responses to infections, such as HIV and tuberculosis. 4. **Neurological disorders:** SDF2 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where protein folding and chaperone-mediated protein refolding are dysregulated. In conclusion, SDF2 is a multifunctional chemokine that plays a critical role in regulating immune cell trafficking, differentiation, and survival. Its dysregulation has significant implications in various immunological disorders, highlighting the need for further research into the mechanisms of SDF2-mediated immune responses.

Genular Protein ID: 438341786

Symbol: SDF2_HUMAN

Name: Stromal cell-derived factor 2

UniProtKB Accession Codes:

Q99470 Q9BQ79

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8918255

Title: Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method.

PubMed ID: 8918255

DOI: 10.1016/0378-1119(96)00251-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 211
  • Mass: 23026
  • Checksum: 5EFC91C62E7B61E9
  • Sequence:
    • MAVVPLLLLG GLWSAVGASS LGVVTCGSVV KLLNTRHNVR LHSHDVRYGS GSGQQSVTGV 
TSVDDSNSYW RIRGKSATVC ERGTPIKCGQ PIRLTHVNTG RNLHSHHFTS PLSGNQEVSA 
FGEEGEGDYL DDWTVLCNGP YWVRDGEVRF KHSSTEVLLS VTGEQYGRPI SGQKEVHGMA 
QPSQNNYWKA MEGIFMKPSE LLKAEAHHAE L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.