Details for: SH3BP2

Gene ID: 6452

Symbol: SH3BP2

Ensembl ID: ENSG00000087266

Description: SH3 domain binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 123.6939
    Cell Significance Index: -19.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.7793
    Cell Significance Index: -18.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.0792
    Cell Significance Index: -18.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 42.2771
    Cell Significance Index: -19.9600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 39.3868
    Cell Significance Index: -20.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.7645
    Cell Significance Index: -18.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.6534
    Cell Significance Index: -19.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.4953
    Cell Significance Index: -17.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.0427
    Cell Significance Index: -18.5600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9264
    Cell Significance Index: -19.4400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.3727
    Cell Significance Index: -9.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.1392
    Cell Significance Index: 58.0200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.1577
    Cell Significance Index: 9.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0575
    Cell Significance Index: 172.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9496
    Cell Significance Index: 110.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9014
    Cell Significance Index: 813.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8397
    Cell Significance Index: 50.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7002
    Cell Significance Index: 76.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6998
    Cell Significance Index: 45.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6044
    Cell Significance Index: 31.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5511
    Cell Significance Index: 25.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3692
    Cell Significance Index: 25.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3386
    Cell Significance Index: 9.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3382
    Cell Significance Index: 60.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3354
    Cell Significance Index: 66.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3113
    Cell Significance Index: 14.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3099
    Cell Significance Index: 169.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2714
    Cell Significance Index: 33.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2631
    Cell Significance Index: 5.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2344
    Cell Significance Index: 12.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2131
    Cell Significance Index: 5.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1990
    Cell Significance Index: 5.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1827
    Cell Significance Index: 4.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1798
    Cell Significance Index: 79.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1450
    Cell Significance Index: 14.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1208
    Cell Significance Index: 3.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1171
    Cell Significance Index: 7.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1058
    Cell Significance Index: 20.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0937
    Cell Significance Index: 12.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0635
    Cell Significance Index: 4.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0585
    Cell Significance Index: 21.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0447
    Cell Significance Index: 3.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0364
    Cell Significance Index: 1.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0347
    Cell Significance Index: 4.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0088
    Cell Significance Index: 6.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0085
    Cell Significance Index: 16.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0078
    Cell Significance Index: 0.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0019
    Cell Significance Index: 0.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0057
    Cell Significance Index: -0.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0074
    Cell Significance Index: -11.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0090
    Cell Significance Index: -0.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0094
    Cell Significance Index: -0.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0115
    Cell Significance Index: -1.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0144
    Cell Significance Index: -19.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0172
    Cell Significance Index: -0.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0182
    Cell Significance Index: -13.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0246
    Cell Significance Index: -15.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0249
    Cell Significance Index: -18.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0257
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0259
    Cell Significance Index: -19.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0336
    Cell Significance Index: -15.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0353
    Cell Significance Index: -19.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0378
    Cell Significance Index: -10.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0709
    Cell Significance Index: -14.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0782
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1006
    Cell Significance Index: -21.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1188
    Cell Significance Index: -17.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1259
    Cell Significance Index: -14.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1331
    Cell Significance Index: -8.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1555
    Cell Significance Index: -4.9800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1739
    Cell Significance Index: -2.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1812
    Cell Significance Index: -18.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1818
    Cell Significance Index: -2.4800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1903
    Cell Significance Index: -1.1500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2045
    Cell Significance Index: -2.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2076
    Cell Significance Index: -11.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2226
    Cell Significance Index: -1.8700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2229
    Cell Significance Index: -3.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2345
    Cell Significance Index: -18.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2409
    Cell Significance Index: -6.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2411
    Cell Significance Index: -17.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2469
    Cell Significance Index: -3.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2539
    Cell Significance Index: -4.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2869
    Cell Significance Index: -17.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2964
    Cell Significance Index: -19.9300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3359
    Cell Significance Index: -5.6500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3407
    Cell Significance Index: -5.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3418
    Cell Significance Index: -4.9000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.3460
    Cell Significance Index: -0.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3596
    Cell Significance Index: -12.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3610
    Cell Significance Index: -8.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3680
    Cell Significance Index: -19.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4190
    Cell Significance Index: -12.0100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4199
    Cell Significance Index: -10.0700
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.4225
    Cell Significance Index: -3.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4333
    Cell Significance Index: -11.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4461
    Cell Significance Index: -19.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4536
    Cell Significance Index: -16.6500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4592
    Cell Significance Index: -11.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** SH3BP2 is expressed in a wide range of cell types, including CD14-positive and CD16-positive classical monocytes, non-classical monocytes, kidney proximal straight tubule epithelial cells, and lung macrophages. This widespread expression suggests a critical role in maintaining cellular homeostasis and immune function. 2. **Protein Structure:** The SH3BP2 protein contains a unique combination of SH3 and proline-rich sequence domains, which are involved in protein-protein interactions and signal transduction. 3. **Signaling Pathways:** SH3BP2 is implicated in various signaling pathways, including phosphotyrosine residue binding, protein binding, and Sh3 domain binding. These pathways are essential for regulating cellular responses to stimuli, including immune responses and cellular growth. **Pathways and Functions:** 1. **Phosphotyrosine Residue Binding:** SH3BP2 interacts with phosphotyrosine residues, which are key regulators of signal transduction. This interaction is essential for transmitting signals from the cell surface to the cytoskeleton and regulating cellular responses. 2. **Protein Binding:** SH3BP2 binds to various proteins, including those involved in immune responses, such as CD14 and CD16. This binding is crucial for regulating the function of these proteins and maintaining cellular homeostasis. 3. **Sh3 Domain Binding:** The SH3 domain of SH3BP2 interacts with other proteins containing SH3 domains, which are involved in signaling and cellular homeostasis. This interaction is essential for regulating the function of these proteins and maintaining cellular homeostasis. **Clinical Significance:** 1. **Monocyte Function:** SH3BP2 plays a critical role in regulating monocyte function, including their ability to phagocytose pathogens and produce cytokines. Dysregulation of SH3BP2 has been implicated in various immune-related disorders, including lupus and rheumatoid arthritis. 2. **Cancer:** SH3BP2 has been implicated in cancer development and progression, particularly in myeloid malignancies. Its expression and function are often dysregulated in cancer cells, leading to enhanced tumor growth and metastasis. 3. **Inflammatory Diseases:** SH3BP2 has been implicated in various inflammatory diseases, including atherosclerosis and chronic obstructive pulmonary disease (COPD). Its expression and function are often dysregulated in these diseases, leading to enhanced inflammation and tissue damage. In conclusion, SH3BP2 is a multifaceted gene involved in regulating cellular functions, particularly in immune responses and cellular homeostasis. Its dysregulation has been implicated in various immune-related disorders, cancer, and inflammatory diseases. Further research is necessary to fully understand the mechanisms by which SH3BP2 regulates cellular functions and to explore its therapeutic potential in various diseases.

Genular Protein ID: 1574093332

Symbol: 3BP2_HUMAN

Name: SH3 domain-binding protein 2

UniProtKB Accession Codes:

P78314 A6NNC2 B2R5R6 B4DT04 D3DVR0 D6R919 O00500 O15373 P78315

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 3 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9299232

Title: Identification and characterization of the human homologue of SH3BP2, an SH3 binding domain protein within a common region of deletion at 4p16.3 involved in bladder cancer.

PubMed ID: 9299232

DOI: 10.1006/geno.1997.4849

PubMed ID: 9734812

Title: The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3.

PubMed ID: 9734812

DOI: 10.1093/dnares/5.3.177

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11381256

Title: Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism.

PubMed ID: 11381256

DOI: 10.1038/88832

PubMed ID: 12900899

Title: Novel mutation in the gene encoding c-Abl-binding protein SH3BP2 causes cherubism.

PubMed ID: 12900899

DOI: 10.1002/ajmg.a.20226

PubMed ID: 14577811

Title: A missense mutation in the SH3BP2 gene on chromosome 4p16.3 found in a case of nonfamilial cherubism.

PubMed ID: 14577811

DOI: 10.1597/1545-1569_2003_040_0632_ammits_2.0.co_2

Sequence Information:

  • Length: 561
  • Mass: 62244
  • Checksum: 69E6846A4F6D8F15
  • Sequence:
    • MAAEEMHWPV PMKAIGAQNL LTMPGGVAKA GYLHKKGGTQ LQLLKWPLRF VIIHKRCVYY 
FKSSTSASPQ GAFSLSGYNR VMRAAEETTS NNVFPFKIIH ISKKHRTWFF SASSEEERKS 
WMALLRREIG HFHEKKDLPL DTSDSSSDTD SFYGAVERPV DISLSPYPTD NEDYEHDDED 
DSYLEPDSPE PGRLEDALMH PPAYPPPPVP TPRKPAFSDM PRAHSFTSKG PGPLLPPPPP 
KHGLPDVGLA AEDSKRDPLC PRRAEPCPRV PATPRRMSDP PLSTMPTAPG LRKPPCFRES 
ASPSPEPWTP GHGACSTSSA AIMATATSRN CDKLKSFHLS PRGPPTSEPP PVPANKPKFL 
KIAEEDPPRE AAMPGLFVPP VAPRPPALKL PVPEAMARPA VLPRPEKPQL PHLQRSPPDG 
QSFRSFSFEK PRQPSQADTG GDDSDEDYEK VPLPNSVFVN TTESCEVERL FKATSPRGEP 
QDGLYCIRNS STKSGKVLVV WDETSNKVRN YRIFEKDSKF YLEGEVLFVS VGSMVEHYHT 
HVLPSHQSLL LRHPYGYTGP R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.