Details for: ST6GAL1

Gene ID: 6480

Symbol: ST6GAL1

Ensembl ID: ENSG00000073849

Description: ST6 beta-galactoside alpha-2,6-sialyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 224.3078
    Cell Significance Index: -34.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 131.2867
    Cell Significance Index: -33.3000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 87.6568
    Cell Significance Index: -36.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.9556
    Cell Significance Index: -31.6700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 69.3449
    Cell Significance Index: -35.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.2917
    Cell Significance Index: -31.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.4357
    Cell Significance Index: -35.0600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 16.2359
    Cell Significance Index: 100.1700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 14.9560
    Cell Significance Index: 132.7600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.9120
    Cell Significance Index: -42.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.3419
    Cell Significance Index: -29.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.7741
    Cell Significance Index: -34.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.9786
    Cell Significance Index: -35.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 5.5973
    Cell Significance Index: 813.6300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.8964
    Cell Significance Index: 65.6400
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 3.2923
    Cell Significance Index: 34.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.9887
    Cell Significance Index: 229.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5791
    Cell Significance Index: 313.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4803
    Cell Significance Index: 296.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2311
    Cell Significance Index: 145.1900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.1980
    Cell Significance Index: 17.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.1764
    Cell Significance Index: 25.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1358
    Cell Significance Index: 69.8100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.1076
    Cell Significance Index: 23.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8004
    Cell Significance Index: 722.6800
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.7577
    Cell Significance Index: 8.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6731
    Cell Significance Index: 109.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5095
    Cell Significance Index: 30.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3901
    Cell Significance Index: 9.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3672
    Cell Significance Index: 691.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3437
    Cell Significance Index: 23.1100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.3338
    Cell Significance Index: 2.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3316
    Cell Significance Index: 18.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2863
    Cell Significance Index: 102.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2733
    Cell Significance Index: 27.0300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2637
    Cell Significance Index: 2.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2075
    Cell Significance Index: 39.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1912
    Cell Significance Index: 13.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1287
    Cell Significance Index: 1.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1242
    Cell Significance Index: 67.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1188
    Cell Significance Index: 2.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1116
    Cell Significance Index: 5.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1017
    Cell Significance Index: 70.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0939
    Cell Significance Index: 6.0600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0888
    Cell Significance Index: 1.3100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0838
    Cell Significance Index: 1.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0541
    Cell Significance Index: 34.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0298
    Cell Significance Index: 55.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0085
    Cell Significance Index: -13.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0104
    Cell Significance Index: -0.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0162
    Cell Significance Index: -7.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0174
    Cell Significance Index: -0.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0201
    Cell Significance Index: -27.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0208
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0210
    Cell Significance Index: -15.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0225
    Cell Significance Index: -2.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0263
    Cell Significance Index: -19.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0284
    Cell Significance Index: -17.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0309
    Cell Significance Index: -5.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0392
    Cell Significance Index: -28.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0409
    Cell Significance Index: -23.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0482
    Cell Significance Index: -21.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0538
    Cell Significance Index: -3.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0721
    Cell Significance Index: -7.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1039
    Cell Significance Index: -29.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1099
    Cell Significance Index: -23.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1182
    Cell Significance Index: -20.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1705
    Cell Significance Index: -19.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1729
    Cell Significance Index: -8.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1954
    Cell Significance Index: -26.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1961
    Cell Significance Index: -22.8500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2150
    Cell Significance Index: -2.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2489
    Cell Significance Index: -32.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2747
    Cell Significance Index: -28.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2789
    Cell Significance Index: -13.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2923
    Cell Significance Index: -6.4000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2948
    Cell Significance Index: -33.6500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2987
    Cell Significance Index: -3.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3196
    Cell Significance Index: -8.2200
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.3297
    Cell Significance Index: -3.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3465
    Cell Significance Index: -44.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3620
    Cell Significance Index: -7.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3956
    Cell Significance Index: -12.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4181
    Cell Significance Index: -31.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4208
    Cell Significance Index: -11.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4321
    Cell Significance Index: -34.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4486
    Cell Significance Index: -15.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4886
    Cell Significance Index: -25.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4917
    Cell Significance Index: -15.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5309
    Cell Significance Index: -37.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5540
    Cell Significance Index: -20.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5544
    Cell Significance Index: -18.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5969
    Cell Significance Index: -17.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6069
    Cell Significance Index: -12.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6088
    Cell Significance Index: -38.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6093
    Cell Significance Index: -26.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6224
    Cell Significance Index: -17.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6320
    Cell Significance Index: -10.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6568
    Cell Significance Index: -34.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6611
    Cell Significance Index: -34.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme Function:** ST6GAL1 catalyzes the transfer of sialic acid residues to N-glycans, creating complex structures that are essential for protein function, cell signaling, and immune regulation. 2. **Tissue Expression:** ST6GAL1 is widely expressed in various tissues, including the central nervous system, epithelial cells, and immune cells, such as macrophages and microglia. 3. **Cellular Localization:** ST6GAL1 is primarily localized to the Golgi apparatus, where it participates in the biosynthesis of N-glycans. **Pathways and Functions:** 1. **Asparagine N-Linked Glycosylation:** ST6GAL1 is involved in the biosynthesis of N-glycans, which are essential for protein function, cell signaling, and immune regulation. 2. **Humoral Immune Response:** ST6GAL1 plays a crucial role in the humoral immune response by regulating the expression of surface antigens and modulating the function of B cells. 3. **Infectious Disease:** ST6GAL1 has been implicated in the regulation of immune responses to viral infections, including SARS-CoV-1 and SARS-CoV-2. 4. **Disease Mechanisms:** Dysregulation of ST6GAL1 has been linked to various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. 5. **Cell Signaling:** ST6GAL1 modulates cell signaling pathways, including the regulation of chemotaxis, apoptosis, and cell proliferation. **Clinical Significance:** 1. **Infectious Diseases:** ST6GAL1 has been identified as a potential target for the development of therapeutic strategies against SARS-CoV-1 and SARS-CoV-2. 2. **Cancer:** Dysregulation of ST6GAL1 has been linked to cancer progression and metastasis, making it a potential target for cancer therapy. 3. **Neurodegenerative Disorders:** ST6GAL1 has been implicated in the regulation of immune responses to neurodegenerative diseases, such as Alzheimer's and Parkinson's. 4. **Immunotherapy:** ST6GAL1 has been identified as a potential target for immunotherapy, including cancer vaccines and checkpoint inhibitors. In conclusion, ST6GAL1 is a crucial enzyme involved in the regulation of immune responses, disease mechanisms, and cell signaling. Further research is needed to fully elucidate the role of ST6GAL1 in various biological processes and to develop therapeutic strategies targeting this enzyme.

Genular Protein ID: 1329561389

Symbol: SIAT1_HUMAN

Name: Beta-galactoside alpha-2,6-sialyltransferase 1

UniProtKB Accession Codes:

P15907 A8KA14 B2R513 D3DNV3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 12 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2408023

Title: Complete cDNA sequence encoding human beta-galactoside alpha-2,6-sialyltransferase.

PubMed ID: 2408023

DOI: 10.1093/nar/18.3.667

PubMed ID: 2373995

Title: The B cell antigen CD75 is a cell surface sialyltransferase.

PubMed ID: 2373995

DOI: 10.1084/jem.172.2.641

PubMed ID: 1730763

Title: The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase.

PubMed ID: 1730763

DOI: 10.1083/jcb.116.2.423

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2803295

Title: Isolation and characterization of a partial cDNA for a human sialyltransferase.

PubMed ID: 2803295

DOI: 10.1016/0006-291x(89)91706-3

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20378551

Title: Golgi N-glycosyltransferases form both homo- and heterodimeric enzyme complexes in live cells.

PubMed ID: 20378551

DOI: 10.1074/jbc.m110.103184

PubMed ID: 21081508

Title: Universal phosphatase-coupled glycosyltransferase assay.

PubMed ID: 21081508

DOI: 10.1093/glycob/cwq187

PubMed ID: 23999306

Title: The structure of human alpha-2,6-sialyltransferase reveals the binding mode of complex glycans.

PubMed ID: 23999306

DOI: 10.1107/s0907444913015412

Sequence Information:

  • Length: 406
  • Mass: 46605
  • Checksum: AC1E24A3875CF00F
  • Sequence:
    • MIHTNLKKKF SCCVLVFLLF AVICVWKEKK KGSYYDSFKL QTKEFQVLKS LGKLAMGSDS 
QSVSSSSTQD PHRGRQTLGS LRGLAKAKPE ASFQVWNKDS SSKNLIPRLQ KIWKNYLSMN 
KYKVSYKGPG PGIKFSAEAL RCHLRDHVNV SMVEVTDFPF NTSEWEGYLP KESIRTKAGP 
WGRCAVVSSA GSLKSSQLGR EIDDHDAVLR FNGAPTANFQ QDVGTKTTIR LMNSQLVTTE 
KRFLKDSLYN EGILIVWDPS VYHSDIPKWY QNPDYNFFNN YKTYRKLHPN QPFYILKPQM 
PWELWDILQE ISPEEIQPNP PSSGMLGIII MMTLCDQVDI YEFLPSKRKT DVCYYYQKFF 
DSACTMGAYH PLLYEKNLVK HLNQGTDEDI YLLGKATLPG FRTIHC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.