Details for: ST3GAL3

Gene ID: 6487

Symbol: ST3GAL3

Ensembl ID: ENSG00000126091

Description: ST3 beta-galactoside alpha-2,3-sialyltransferase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 163.5537
    Cell Significance Index: -25.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 99.8646
    Cell Significance Index: -25.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.6606
    Cell Significance Index: -21.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 51.5761
    Cell Significance Index: -26.5300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.8648
    Cell Significance Index: -21.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.3309
    Cell Significance Index: -26.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.0565
    Cell Significance Index: -26.9400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.1827
    Cell Significance Index: -15.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7181
    Cell Significance Index: -26.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.9600
    Cell Significance Index: 106.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.4190
    Cell Significance Index: 135.7400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.3099
    Cell Significance Index: 28.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1684
    Cell Significance Index: 434.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.1265
    Cell Significance Index: 94.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.0495
    Cell Significance Index: 77.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8455
    Cell Significance Index: 661.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.7788
    Cell Significance Index: 136.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.5270
    Cell Significance Index: 96.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3341
    Cell Significance Index: 922.6900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.3306
    Cell Significance Index: 25.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.2117
    Cell Significance Index: 29.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0801
    Cell Significance Index: 23.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0406
    Cell Significance Index: 63.9600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8260
    Cell Significance Index: 11.8800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7417
    Cell Significance Index: 15.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7210
    Cell Significance Index: 20.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5162
    Cell Significance Index: 51.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4861
    Cell Significance Index: 8.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4698
    Cell Significance Index: 5.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3788
    Cell Significance Index: 9.4700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.3673
    Cell Significance Index: 3.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2940
    Cell Significance Index: 265.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2662
    Cell Significance Index: 43.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2661
    Cell Significance Index: 47.9700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.1933
    Cell Significance Index: 1.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1591
    Cell Significance Index: 19.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1424
    Cell Significance Index: 15.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0819
    Cell Significance Index: 2.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0667
    Cell Significance Index: 1.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0648
    Cell Significance Index: 12.3400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0337
    Cell Significance Index: 0.4200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0178
    Cell Significance Index: 0.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0067
    Cell Significance Index: 0.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0047
    Cell Significance Index: 0.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0059
    Cell Significance Index: -2.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0114
    Cell Significance Index: -21.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0143
    Cell Significance Index: -26.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0160
    Cell Significance Index: -0.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0178
    Cell Significance Index: -27.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0204
    Cell Significance Index: -27.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0253
    Cell Significance Index: -13.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0264
    Cell Significance Index: -19.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0288
    Cell Significance Index: -1.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0297
    Cell Significance Index: -21.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0328
    Cell Significance Index: -24.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0362
    Cell Significance Index: -22.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0412
    Cell Significance Index: -23.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0413
    Cell Significance Index: -2.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0472
    Cell Significance Index: -1.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0480
    Cell Significance Index: -29.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0512
    Cell Significance Index: -23.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0628
    Cell Significance Index: -4.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0738
    Cell Significance Index: -12.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0778
    Cell Significance Index: -22.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0795
    Cell Significance Index: -9.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0848
    Cell Significance Index: -5.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0871
    Cell Significance Index: -11.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0897
    Cell Significance Index: -4.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1101
    Cell Significance Index: -2.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1108
    Cell Significance Index: -7.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1199
    Cell Significance Index: -23.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1274
    Cell Significance Index: -2.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1334
    Cell Significance Index: -28.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1428
    Cell Significance Index: -14.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1523
    Cell Significance Index: -3.3000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1533
    Cell Significance Index: -1.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1552
    Cell Significance Index: -22.5600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1585
    Cell Significance Index: -2.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1618
    Cell Significance Index: -20.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1654
    Cell Significance Index: -18.9500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1711
    Cell Significance Index: -2.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1911
    Cell Significance Index: -22.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2089
    Cell Significance Index: -6.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2163
    Cell Significance Index: -6.8900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2325
    Cell Significance Index: -1.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2570
    Cell Significance Index: -26.7600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2724
    Cell Significance Index: -4.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2768
    Cell Significance Index: -20.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2842
    Cell Significance Index: -13.2500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3027
    Cell Significance Index: -6.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3053
    Cell Significance Index: -21.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3063
    Cell Significance Index: -9.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3081
    Cell Significance Index: -14.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3100
    Cell Significance Index: -24.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3207
    Cell Significance Index: -11.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3442
    Cell Significance Index: -9.0500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3856
    Cell Significance Index: -2.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3864
    Cell Significance Index: -25.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3903
    Cell Significance Index: -20.3300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3907
    Cell Significance Index: -3.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ST3GAL3 gene encodes a type II transmembrane glycosyltransferase that catalyzes the transfer of sialic acid residues to the terminal galactose of glycoproteins and glycolipids. This enzyme is involved in the synthesis of various sialylated molecules, including Lewis blood group antigens, gangliosides, and keratan sulfate. The ST3GAL3 enzyme is also involved in the regulation of cell adhesion, cell signaling, and immune responses. **Pathways and Functions** The ST3GAL3 gene is involved in several cellular pathways, including: 1. **Asparagine N-linked Glycosylation**: ST3GAL3 is required for the synthesis of N-linked glycoproteins, which play crucial roles in protein folding, stability, and function. 2. **Beta-galactoside (cmp) alpha-2,3-sialyltransferase activity**: ST3GAL3 catalyzes the transfer of sialic acid residues to the terminal galactose of glycoproteins and glycolipids. 3. **Biosynthesis of the n-glycan precursor (dolichol lipid-linked oligosaccharide, llo)**: ST3GAL3 is involved in the synthesis of the llo precursor, which is then modified and attached to a nascent protein. 4. **Glycosaminoglycan metabolism**: ST3GAL3 is involved in the synthesis of keratan sulfate, a glycosaminoglycan that plays roles in cell adhesion and signaling. 5. **Glycosphingolipid biosynthesis**: ST3GAL3 is involved in the synthesis of gangliosides, which play crucial roles in cell-to-cell communication and immune responses. **Clinical Significance** Mutations in the ST3GAL3 gene have been linked to several neurological and metabolic disorders, including: 1. **MCT12**: a rare genetic disorder characterized by developmental delays, intellectual disability, and seizures. 2. **EIEE15**: a rare genetic disorder characterized by developmental delays, intellectual disability, and epilepsy. 3. **Glycosylation disorders**: ST3GAL3 mutations can lead to glycosylation disorders, which affect the synthesis of sialylated glycoproteins and glycolipids. 4. **Neurological disorders**: ST3GAL3 mutations have been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In summary, the ST3GAL3 gene plays a crucial role in the biosynthesis of sialylated glycoproteins and glycolipids, which are involved in various cellular processes. Mutations in this gene can lead to neurological and metabolic disorders, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 3118443544

Symbol: SIAT6_HUMAN

Name: CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

UniProtKB Accession Codes:

Q11203 A9Z1W2 D3DPX8 Q5T4W9 Q5T4X0 Q5T4X7 Q5T4X8 Q5T4X9 Q5T4Y0 Q5T4Y2 Q5T4Y3 Q5T4Y4 Q86UR6 Q86UR7 Q86UR8 Q86UR9 Q86US0 Q86US1 Q86US2 Q8IX41 Q8IX42 Q8IX43 Q8IX44 Q8IX45 Q8IX46 Q8IX47 Q8IX48 Q8IX49 Q8IX50 Q8IX51 Q8IX52 Q8IX53 Q8IX54 Q8IX55 Q8IX56 Q8IX57 Q8IX58

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 18 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 33 Ensembl 35 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 12 RNAct 1 Reactome 10 RefSeq 19 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8333853

Title: Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase.

PubMed ID: 8333853

DOI: 10.1006/bbrc.1993.1830

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21907012

Title: ST3GAL3 mutations impair the development of higher cognitive functions.

PubMed ID: 21907012

DOI: 10.1016/j.ajhg.2011.08.008

PubMed ID: 23252400

Title: West syndrome caused by ST3Gal-III deficiency.

PubMed ID: 23252400

DOI: 10.1111/epi.12050

Sequence Information:

  • Length: 375
  • Mass: 42171
  • Checksum: C9B7B61AD580EC2E
  • Sequence:
    • MGLLVFVRNL LLALCLFLVL GFLYYSAWKL HLLQWEEDSN SVVLSFDSAG QTLGSEYDRL 
GFLLNLDSKL PAELATKYAN FSEGACKPGY ASALMTAIFP RFSKPAPMFL DDSFRKWARI 
REFVPPFGIK GQDNLIKAIL SVTKEYRLTP ALDSLRCRRC IIVGNGGVLA NKSLGSRIDD 
YDIVVRLNSA PVKGFEKDVG SKTTLRITYP EGAMQRPEQY ERDSLFVLAG FKWQDFKWLK 
YIVYKERVSA SDGFWKSVAT RVPKEPPEIR ILNPYFIQEA AFTLIGLPFN NGLMGRGNIP 
TLGSVAVTMA LHGCDEVAVA GFGYDMSTPN APLHYYETVR MAAIKESWTH NIQREKEFLR 
KLVKARVITD LSSGI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.