SKP2 | ENSG00000145604 | NCBI 6502

Details for: SKP2

Gene ID: 6502

Symbol: SKP2

Ensembl ID: ENSG00000145604

Description: S-phase kinase associated protein 2

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic exit in cancer due to rb1 defects
(R-HSA-9687136)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Deubiquitination
(R-HSA-5688426)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna replication
(R-HSA-69306)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Metabolism of proteins
(R-HSA-392499)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Neddylation
(R-HSA-8951664)
Orc1 removal from chromatin
(R-HSA-68949)
Post-translational protein modification
(R-HSA-597592)
Regulation of bach1 activity
(R-HSA-9708530)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of runx2 expression and activity
(R-HSA-8939902)
Rna polymerase ii transcription
(R-HSA-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Transcriptional regulation by runx2
(R-HSA-8878166)
Ub-specific processing proteases
(R-HSA-5689880)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
G1/s transition of mitotic cell cycle
(GO:0000082)
G2/m transition of mitotic cell cycle
(GO:0000086)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of double-strand break repair via homologous recombination
(GO:1905168)
Positive regulation of intracellular estrogen receptor signaling pathway
(GO:0033148)
Positive regulation of protein polyubiquitination
(GO:1902916)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein k48-linked ubiquitination
(GO:0070936)
Protein k63-linked ubiquitination
(GO:0070534)
Regulation of apoptotic process
(GO:0042981)
Regulation of cell cycle
(GO:0051726)
Scf-dependent proteasomal ubiquitin-dependent protein catabolic process
(GO:0031146)
Scf ubiquitin ligase complex
(GO:0019005)
Ubiquitin-like ligase-substrate adaptor activity
(GO:1990756)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 77.3408
Cell Significance Index: -12.0300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 46.0883
Cell Significance Index: -11.6900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 31.5564
Cell Significance Index: -12.8200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 13.4801
Cell Significance Index: -12.8700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 11.3305
Cell Significance Index: -13.9700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.3586
Cell Significance Index: -14.3600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.2374
Cell Significance Index: -13.0200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.6391
Cell Significance Index: -14.3600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 3.1781
Cell Significance Index: 84.8600
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.6004
Cell Significance Index: 28.2700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.0882
Cell Significance Index: 75.2600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.9323
Cell Significance Index: 55.9700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8783
Cell Significance Index: 176.1800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7550
Cell Significance Index: 122.7900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6233
Cell Significance Index: 123.7000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.5847
Cell Significance Index: 68.1400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5141
Cell Significance Index: 50.8600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.4245
Cell Significance Index: 11.3800
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.3718
Cell Significance Index: 2.3100
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.3717
Cell Significance Index: 7.7800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3611
Cell Significance Index: 9.6600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3261
Cell Significance Index: 294.4800
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.2948
Cell Significance Index: 7.5300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2662
Cell Significance Index: 16.7800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2656
Cell Significance Index: 183.7100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2488
Cell Significance Index: 5.3900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2322
Cell Significance Index: 83.2900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2322
Cell Significance Index: 13.0300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.2095
Cell Significance Index: 7.2800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1970
Cell Significance Index: 23.2300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1837
Cell Significance Index: 100.3100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1584
Cell Significance Index: 4.5700
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.1567
Cell Significance Index: 3.2500
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1567
Cell Significance Index: 4.1200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1379
Cell Significance Index: 3.8600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1275
Cell Significance Index: 24.2600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1267
Cell Significance Index: 7.7900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1218
Cell Significance Index: 21.9500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1168
Cell Significance Index: 51.6200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1056
Cell Significance Index: 2.6400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1041
Cell Significance Index: 5.4100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0776
Cell Significance Index: 5.4900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0753
Cell Significance Index: 10.3400
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.0539
Cell Significance Index: 0.6900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0470
Cell Significance Index: 1.7800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0286
Cell Significance Index: 1.2700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0264
Cell Significance Index: 1.7100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0236
Cell Significance Index: 0.8300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0146
Cell Significance Index: 0.6600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0101
Cell Significance Index: 1.4700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0082
Cell Significance Index: 0.1800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0018
Cell Significance Index: 3.2400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0007
Cell Significance Index: 1.4000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0001
Cell Significance Index: 0.2200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0092
Cell Significance Index: -1.1300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0093
Cell Significance Index: -5.8900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0097
Cell Significance Index: -0.6500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0102
Cell Significance Index: -13.8100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0116
Cell Significance Index: -5.2900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0167
Cell Significance Index: -12.2100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0169
Cell Significance Index: -12.7700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0192
Cell Significance Index: -14.2100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0257
Cell Significance Index: -14.4900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0270
Cell Significance Index: -16.8300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0308
Cell Significance Index: -2.3600
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0398
Cell Significance Index: -0.5700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0402
Cell Significance Index: -11.5800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0434
Cell Significance Index: -2.6600
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0434
Cell Significance Index: -5.5700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0442
Cell Significance Index: -0.7400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0525
Cell Significance Index: -8.9600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0551
Cell Significance Index: -2.8700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0567
Cell Significance Index: -5.7900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0698
Cell Significance Index: -3.2600
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0736
Cell Significance Index: -0.6000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0791
Cell Significance Index: -16.6600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0877
Cell Significance Index: -2.8100
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0925
Cell Significance Index: -2.6400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1029
Cell Significance Index: -11.7900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1048
Cell Significance Index: -13.5400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1237
Cell Significance Index: -2.1200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1329
Cell Significance Index: -13.8400
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1407
Cell Significance Index: -3.0800
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1443
Cell Significance Index: -3.4600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1761
Cell Significance Index: -13.9500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1814
Cell Significance Index: -8.5300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1835
Cell Significance Index: -5.3900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1849
Cell Significance Index: -13.7800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2006
Cell Significance Index: -6.3900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2030
Cell Significance Index: -10.6600
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2158
Cell Significance Index: -4.5800
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2269
Cell Significance Index: -3.4200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2320
Cell Significance Index: -11.7300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2465
Cell Significance Index: -8.0700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2766
Cell Significance Index: -9.6900
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2835
Cell Significance Index: -2.9400
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: -0.2874
Cell Significance Index: -1.3800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3061
Cell Significance Index: -9.0200
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.3196
Cell Significance Index: -4.5800
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.3211
Cell Significance Index: -3.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** SKP2 is a protein that belongs to the F-box family of proteins, which are characterized by their ability to bind to specific substrates and regulate their degradation. SKP2 is specifically known for its ability to bind to and degrade the cyclin-dependent kinase inhibitors p27 and p21, which are essential for the inhibition of cyclin-dependent kinases and the regulation of the cell cycle. SKP2's activity is tightly regulated by its binding to the SCF complex, which is composed of SKP1, CUL1, and F-box proteins. The SCF complex is involved in the ubiquitination and degradation of target proteins, and SKP2's activity is dependent on its binding to the SCF complex. SKP2 has been shown to be highly expressed in various cell types, including placental villous trophoblast, germ cells, and neural crest cells. Its expression is also regulated by various transcription factors, including Runx2, which is a key regulator of cell proliferation and differentiation. **Pathways and Functions** SKP2's primary function is to regulate the cell cycle by degrading cyclin-dependent kinase inhibitors, such as p27 and p21. This process is essential for the progression from the G1 phase to the S phase, where DNA replication occurs. SKP2's activity is also involved in the regulation of cell proliferation, differentiation, and survival. SKP2's involvement in various cellular processes has been described in the following pathways: 1. **Apoptosis**: SKP2's activity has been shown to regulate the degradation of pro-apoptotic proteins, such as Bax and Bak, which are essential for the induction of apoptosis. 2. **Cell cycle regulation**: SKP2's activity is essential for the regulation of the cell cycle, particularly in the transition from the G1 phase to the S phase. 3. **DNA replication**: SKP2's activity is involved in the regulation of DNA replication, particularly in the transition from the G1 phase to the S phase. 4. **Immune system**: SKP2's activity has been shown to regulate the degradation of immune-related proteins, such as MHC class I molecules, which are essential for the presentation of antigens to T cells. **Clinical Significance** SKP2's dysregulation has been implicated in various diseases, including: 1. **Cancer**: SKP2's overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. Its overexpression is associated with increased cell proliferation and tumor progression. 2. **Neurodegenerative diseases**: SKP2's dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Autoimmune diseases**: SKP2's dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. SKP2 has been identified as a potential therapeutic target in various diseases, including cancer and neurodegenerative diseases. Its inhibition has been shown to reduce cell proliferation and tumor progression in preclinical studies. However, further research is needed to fully understand its role in disease and to develop effective therapeutic strategies. In conclusion, SKP2 is a key regulator of the cell cycle, particularly in the transition from the G1 phase to the S phase. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Its inhibition has been shown to reduce cell proliferation and tumor progression in preclinical studies, highlighting its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

S-phase kinase-associated protein 2

Genular Protein ID: 4174062576

Symbol: SKP2_HUMAN

Name: S-phase kinase-associated protein 2

UniProtKB Accession Codes:

Q13309 A8K5E0 B4DJT4 Q8TDZ0 Q8TDZ1 Q9BV69

Database IDs:

Citations:

PubMed ID: 7553852

Title: p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase.

PubMed ID: 7553852

DOI: 10.1016/0092-8674(95)90271-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12435635

Title: The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).

PubMed ID: 12435635

DOI: 10.1101/gad.1011202

PubMed ID: 11931757

Title: Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.

PubMed ID: 11931757

DOI: 10.1016/s1097-2765(02)00467-7

PubMed ID: 12840033

Title: The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation.

PubMed ID: 12840033

DOI: 10.1074/jbc.c300251200

PubMed ID: 12769844

Title: The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription.

PubMed ID: 12769844

DOI: 10.1016/s1097-2765(03)00193-x

PubMed ID: 15342634

Title: The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase.

PubMed ID: 15342634

DOI: 10.1074/jbc.m403189200

PubMed ID: 16262255

Title: Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection.

PubMed ID: 16262255

DOI: 10.1021/bi051071j

PubMed ID: 15949444

Title: Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle.

PubMed ID: 15949444

DOI: 10.1016/j.molcel.2005.05.011

PubMed ID: 16103164

Title: Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation.

PubMed ID: 16103164

DOI: 10.1128/jvi.79.17.11135-11141.2005

PubMed ID: 15668399

Title: Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

PubMed ID: 15668399

DOI: 10.1073/pnas.0406789102

PubMed ID: 16951159

Title: Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination.

PubMed ID: 16951159

DOI: 10.1158/0008-5472.can-06-1603

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16581786

Title: The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2.

PubMed ID: 16581786

DOI: 10.1128/mcb.26.8.3114-3123.2006

PubMed ID: 16880511

Title: Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein.

PubMed ID: 16880511

DOI: 10.1128/mcb.01630-05

PubMed ID: 17908926

Title: Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions.

PubMed ID: 17908926

DOI: 10.1101/gad.1574507

PubMed ID: 17962192

Title: Ubiquitination and degradation of Tal1/SCL are induced by Notch signaling and depend on Skp2 and CHIP.

PubMed ID: 17962192

DOI: 10.1074/jbc.m704981200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21119685

Title: Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.

PubMed ID: 21119685

DOI: 10.1038/cr.2010.165

PubMed ID: 21571647

Title: Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.

PubMed ID: 21571647

DOI: 10.1073/pnas.1100028108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22770219

Title: Acetylation-dependent regulation of Skp2 function.

PubMed ID: 22770219

DOI: 10.1016/j.cell.2012.05.038

PubMed ID: 22464731

Title: Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1.

PubMed ID: 22464731

DOI: 10.1016/j.molcel.2012.02.018

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27194766

Title: ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway.

PubMed ID: 27194766

DOI: 10.1128/jvi.00352-16

PubMed ID: 32267835

Title: YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators.

PubMed ID: 32267835

DOI: 10.1371/journal.pbio.3000664

PubMed ID: 11099048

Title: Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.

PubMed ID: 11099048

DOI: 10.1038/35042620

PubMed ID: 11961546

Title: Structure of the Cul1-Rbx1-Skp1-F box Skp2 SCF ubiquitin ligase complex.

PubMed ID: 11961546

DOI: 10.1038/416703a

Sequence Information:

Length: 424
Mass: 47761
Checksum: F29B7C338A7A37E9
Sequence:

MHRKHLQEIP DLSSNVATSF TWGWDSSKTS ELLSGMGVSA LEKEEPDSEN IPQELLSNLG 
HPESPPRKRL KSKGSDKDFV IVRRPKLNRE NFPGVSWDSL PDELLLGIFS CLCLPELLKV 
SGVCKRWYRL ASDESLWQTL DLTGKNLHPD VTGRLLSQGV IAFRCPRSFM DQPLAEHFSP 
FRVQHMDLSN SVIEVSTLHG ILSQCSKLQN LSLEGLRLSD PIVNTLAKNS NLVRLNLSGC 
SGFSEFALQT LLSSCSRLDE LNLSWCFDFT EKHVQVAVAH VSETITQLNL SGYRKNLQKS 
DLSTLVRRCP NLVHLDLSDS VMLKNDCFQE FFQLNYLQHL SLSRCYDIIP ETLLELGEIP 
TLKTLQVFGI VPDGTLQLLK EALPHLQINC SHFTTIARPT IGNKKNQEIW GIKCRLTLQK 
PSCL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SKP2

Associated with

Cells (max top 100)

Other Information

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. PubMed ID: 7553852

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2). PubMed ID: 12435635

Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. PubMed ID: 11931757

The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. PubMed ID: 12840033

The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. PubMed ID: 12769844

The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase. PubMed ID: 15342634

Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection. PubMed ID: 16262255

Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle. PubMed ID: 15949444

Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation. PubMed ID: 16103164

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. PubMed ID: 15668399

Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination. PubMed ID: 16951159

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2. PubMed ID: 16581786

Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. PubMed ID: 16880511

Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions. PubMed ID: 17908926

Ubiquitination and degradation of Tal1/SCL are induced by Notch signaling and depend on Skp2 and CHIP. PubMed ID: 17962192

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. PubMed ID: 21119685

Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. PubMed ID: 21571647

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Acetylation-dependent regulation of Skp2 function. PubMed ID: 22770219

Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. PubMed ID: 22464731

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway. PubMed ID: 27194766

YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators. PubMed ID: 32267835

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. PubMed ID: 11099048

Structure of the Cul1-Rbx1-Skp1-F box Skp2 SCF ubiquitin ligase complex. PubMed ID: 11961546