Details for: SLC5A1

Gene ID: 6523

Symbol: SLC5A1

Ensembl ID: ENSG00000100170

Description: solute carrier family 5 member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor cell (CL0011115)
    Fold Change: 17.2761
    Cell Significance Index: 131.0100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.5070
    Cell Significance Index: 25.2900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 2.4640
    Cell Significance Index: 9.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8894
    Cell Significance Index: 113.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.7111
    Cell Significance Index: 35.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6545
    Cell Significance Index: 126.9600
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 1.6108
    Cell Significance Index: 16.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4544
    Cell Significance Index: 1313.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8391
    Cell Significance Index: 58.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7877
    Cell Significance Index: 77.9200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.7278
    Cell Significance Index: 4.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.6786
    Cell Significance Index: 7.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6353
    Cell Significance Index: 69.1000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.5400
    Cell Significance Index: 5.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4838
    Cell Significance Index: 21.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4415
    Cell Significance Index: 51.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4324
    Cell Significance Index: 20.1600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4062
    Cell Significance Index: 9.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3296
    Cell Significance Index: 15.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2829
    Cell Significance Index: 9.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2683
    Cell Significance Index: 4.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2634
    Cell Significance Index: 5.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2168
    Cell Significance Index: 3.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2135
    Cell Significance Index: 27.5900
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: 0.2129
    Cell Significance Index: 1.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1834
    Cell Significance Index: 34.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1542
    Cell Significance Index: 25.0800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.1515
    Cell Significance Index: 1.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1252
    Cell Significance Index: 4.0100
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.0479
    Cell Significance Index: 0.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0173
    Cell Significance Index: 3.1200
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0081
    Cell Significance Index: 0.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0065
    Cell Significance Index: 4.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0010
    Cell Significance Index: 0.4300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0019
    Cell Significance Index: -0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0047
    Cell Significance Index: -8.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0056
    Cell Significance Index: -7.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0059
    Cell Significance Index: -9.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0091
    Cell Significance Index: -6.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0105
    Cell Significance Index: -7.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0123
    Cell Significance Index: -2.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0134
    Cell Significance Index: -10.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0143
    Cell Significance Index: -0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0151
    Cell Significance Index: -8.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0159
    Cell Significance Index: -10.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0167
    Cell Significance Index: -10.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0173
    Cell Significance Index: -9.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0177
    Cell Significance Index: -6.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0232
    Cell Significance Index: -0.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0233
    Cell Significance Index: -10.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0331
    Cell Significance Index: -9.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0399
    Cell Significance Index: -7.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0434
    Cell Significance Index: -4.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0512
    Cell Significance Index: -10.7800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0531
    Cell Significance Index: -0.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0542
    Cell Significance Index: -3.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0567
    Cell Significance Index: -7.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0580
    Cell Significance Index: -7.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0587
    Cell Significance Index: -10.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0638
    Cell Significance Index: -9.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0664
    Cell Significance Index: -7.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0696
    Cell Significance Index: -3.5200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0714
    Cell Significance Index: -2.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0726
    Cell Significance Index: -0.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0928
    Cell Significance Index: -5.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0954
    Cell Significance Index: -9.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0977
    Cell Significance Index: -2.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1126
    Cell Significance Index: -3.1500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1150
    Cell Significance Index: -1.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1167
    Cell Significance Index: -3.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1175
    Cell Significance Index: -8.7600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1201
    Cell Significance Index: -1.5400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1209
    Cell Significance Index: -0.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1330
    Cell Significance Index: -10.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1404
    Cell Significance Index: -9.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1550
    Cell Significance Index: -2.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1550
    Cell Significance Index: -3.9600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1619
    Cell Significance Index: -7.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1793
    Cell Significance Index: -11.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1798
    Cell Significance Index: -3.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1849
    Cell Significance Index: -3.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1897
    Cell Significance Index: -9.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1998
    Cell Significance Index: -11.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2008
    Cell Significance Index: -7.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2162
    Cell Significance Index: -11.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2225
    Cell Significance Index: -9.8400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2282
    Cell Significance Index: -5.7000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2380
    Cell Significance Index: -1.7300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2381
    Cell Significance Index: -3.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2392
    Cell Significance Index: -8.3800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2416
    Cell Significance Index: -4.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2622
    Cell Significance Index: -9.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2709
    Cell Significance Index: -7.9800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2747
    Cell Significance Index: -6.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2753
    Cell Significance Index: -6.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2783
    Cell Significance Index: -9.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2854
    Cell Significance Index: -9.0900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.2878
    Cell Significance Index: -0.6500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2913
    Cell Significance Index: -4.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: SLC5A1 is a transmembrane protein with 12 transmembrane domains, which confer its ability to transport glucose and galactose across the plasma membrane. 2. **Function**: SGLT1 mediates the cotransport of glucose and sodium ions across the apical plasma membrane of enterocytes, facilitating glucose absorption in the small intestine. 3. **Substrate specificity**: SGLT1 has a high affinity for glucose and galactose, but its specificity for galactose is lower compared to glucose. 4. **Regulation**: SLC5A1 is regulated by various factors, including glucose levels, pH, and signaling pathways. **Pathways and Functions** 1. **Glucose homeostasis**: SGLT1 plays a critical role in maintaining glucose homeostasis by facilitating glucose absorption in the small intestine. 2. **Galactose metabolism**: SLC5A1 is involved in the transport of galactose across the intestinal epithelium, which is essential for galactose metabolism. 3. **Sodium ion transport**: SGLT1 mediates the cotransport of glucose and sodium ions, which is essential for maintaining sodium ion homeostasis. 4. **Transport across blood-brain barrier**: SLC5A1 is involved in the transport of glucose across the blood-brain barrier, which is essential for maintaining glucose homeostasis in the brain. **Clinical Significance** 1. **Congenital glucose/galactose malabsorption (GGM)**: Mutations in the SLC5A1 gene lead to GGM, a disorder characterized by impaired glucose and galactose absorption in the small intestine. 2. **Diabetes**: Abnormalities in SGLT1 function have been linked to diabetes, as impaired glucose absorption can lead to hyperglycemia. 3. **Gastrointestinal disorders**: SLC5A1 dysfunction has been implicated in various gastrointestinal disorders, including celiac disease and Crohn's disease. 4. **Neurological disorders**: Abnormalities in SGLT1 function have been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, SLC5A1 plays a critical role in maintaining glucose homeostasis and galactose metabolism, and its dysfunction can lead to various clinical disorders. Further research is needed to fully understand the mechanisms of SLC5A1 function and its clinical significance.

Genular Protein ID: 1355133729

Symbol: SC5A1_HUMAN

Name: Sodium/glucose cotransporter 1

UniProtKB Accession Codes:

P13866 B2R7E2 B7Z4Q9 B7ZA69

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 23 EMDB 4 Ensembl 2 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2490366

Title: Homology of the human intestinal Na+/glucose and Escherichia coli Na+/proline cotransporters.

PubMed ID: 2490366

DOI: 10.1073/pnas.86.15.5748

PubMed ID: 8195156

Title: Structure of the human Na+/glucose cotransporter gene SGLT1.

PubMed ID: 8195156

DOI: 10.1016/s0021-9258(17)36592-4

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 8567640

Title: Membrane topology of the human Na+/glucose cotransporter SGLT1.

PubMed ID: 8567640

DOI: 10.1074/jbc.271.4.1925

PubMed ID: 14695256

Title: Glucose accumulation can account for the initial water flux triggered by Na+/glucose cotransport.

PubMed ID: 14695256

DOI: 10.1016/s0006-3495(04)74090-4

PubMed ID: 20980548

Title: Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2.

PubMed ID: 20980548

DOI: 10.1152/ajpcell.00388.2010

PubMed ID: 26945065

Title: The Sodium Glucose Cotransporter SGLT1 Is an Extremely Efficient Facilitator of Passive Water Transport.

PubMed ID: 26945065

DOI: 10.1074/jbc.m115.706986

PubMed ID: 28974690

Title: Loss of Endometrial Sodium Glucose Cotransporter SGLT1 is Detrimental to Embryo Survival and Fetal Growth in Pregnancy.

PubMed ID: 28974690

DOI: 10.1038/s41598-017-11674-3

PubMed ID: 35077764

Title: Structural basis of the selective sugar transport in sodium-glucose cotransporters.

PubMed ID: 35077764

DOI: 10.1016/j.jmb.2022.167464

PubMed ID: 34880492

Title: Structure and mechanism of the SGLT family of glucose transporters.

PubMed ID: 34880492

DOI: 10.1038/s41586-021-04211-w

PubMed ID: 2008213

Title: Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter.

PubMed ID: 2008213

DOI: 10.1038/350354a0

PubMed ID: 8563765

Title: Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption.

PubMed ID: 8563765

DOI: 10.1038/ng0296-216

PubMed ID: 10036327

Title: Missense mutations in SGLT1 cause glucose-galactose malabsorption by trafficking defects.

PubMed ID: 10036327

DOI: 10.1016/s0925-4439(98)00109-4

PubMed ID: 11406349

Title: A missense mutation in the Na(+)/glucose cotransporter gene SGLT1 in a patient with congenital glucose-galactose malabsorption: normal trafficking but inactivation of the mutant protein.

PubMed ID: 11406349

DOI: 10.1016/s0925-4439(01)00043-6

Sequence Information:

  • Length: 664
  • Mass: 73498
  • Checksum: 2B403376595EAB74
  • Sequence:
    • MDSSTWSPKT TAVTRPVETH ELIRNAADIS IIVIYFVVVM AVGLWAMFST NRGTVGGFFL 
AGRSMVWWPI GASLFASNIG SGHFVGLAGT GAASGIAIGG FEWNALVLVV VLGWLFVPIY 
IKAGVVTMPE YLRKRFGGQR IQVYLSLLSL LLYIFTKISA DIFSGAIFIN LALGLNLYLA 
IFLLLAITAL YTITGGLAAV IYTDTLQTVI MLVGSLILTG FAFHEVGGYD AFMEKYMKAI 
PTIVSDGNTT FQEKCYTPRA DSFHIFRDPL TGDLPWPGFI FGMSILTLWY WCTDQVIVQR 
CLSAKNMSHV KGGCILCGYL KLMPMFIMVM PGMISRILYT EKIACVVPSE CEKYCGTKVG 
CTNIAYPTLV VELMPNGLRG LMLSVMLASL MSSLTSIFNS ASTLFTMDIY AKVRKRASEK 
ELMIAGRLFI LVLIGISIAW VPIVQSAQSG QLFDYIQSIT SYLGPPIAAV FLLAIFWKRV 
NEPGAFWGLI LGLLIGISRM ITEFAYGTGS CMEPSNCPTI ICGVHYLYFA IILFAISFIT 
IVVISLLTKP IPDVHLYRLC WSLRNSKEER IDLDAEEENI QEGPKETIEI ETQVPEKKKG 
IFRRAYDLFC GLEQHGAPKM TEEEEKAMKM KMTDTSEKPL WRTVLNVNGI ILVTVAVFCH 
AYFA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.