Details for: SLC5A2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 11.5722
Cell Significance Index: -1.8000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 7.0276
Cell Significance Index: -1.7800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 1.4842
Cell Significance Index: -1.8300 - Cell Name: proerythroblast (CL0000547)
Fold Change: 1.0666
Cell Significance Index: 15.2900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7325
Cell Significance Index: 15.8700 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.5173
Cell Significance Index: 5.3600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2636
Cell Significance Index: 50.1600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.2560
Cell Significance Index: 5.6100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2375
Cell Significance Index: 6.3700 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.2369
Cell Significance Index: 2.3800 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.2259
Cell Significance Index: 1.9200 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.2230
Cell Significance Index: 1.8800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1784
Cell Significance Index: 3.8000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1710
Cell Significance Index: 16.9200 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.1566
Cell Significance Index: 1.2500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1275
Cell Significance Index: 115.1200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1226
Cell Significance Index: 7.3600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.1176
Cell Significance Index: 2.4400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1019
Cell Significance Index: 11.0900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0819
Cell Significance Index: 13.3200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0689
Cell Significance Index: 1.1800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0651
Cell Significance Index: 2.9500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.0557
Cell Significance Index: 1.1900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0460
Cell Significance Index: 3.1800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0408
Cell Significance Index: 8.1100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0238
Cell Significance Index: 1.4600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0230
Cell Significance Index: 15.8800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.0224
Cell Significance Index: 0.3300 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.0221
Cell Significance Index: 0.3500 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0210
Cell Significance Index: 0.3000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0187
Cell Significance Index: 0.5400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0178
Cell Significance Index: 2.0800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0159
Cell Significance Index: 0.4100 - Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.0125
Cell Significance Index: 0.0100 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.0115
Cell Significance Index: 0.1500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0094
Cell Significance Index: 0.4900 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.0086
Cell Significance Index: 0.1300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0071
Cell Significance Index: 0.2500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0071
Cell Significance Index: 0.4500 - Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.0054
Cell Significance Index: 0.0500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0050
Cell Significance Index: 0.6800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0046
Cell Significance Index: 2.5200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0041
Cell Significance Index: 0.8300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0035
Cell Significance Index: 1.2500 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.0021
Cell Significance Index: 0.0400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0012
Cell Significance Index: 1.8700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0005
Cell Significance Index: 0.8900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0005
Cell Significance Index: 0.9400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0005
Cell Significance Index: 0.2400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0004
Cell Significance Index: -0.5700 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0013
Cell Significance Index: -0.1700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0017
Cell Significance Index: -0.2000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0018
Cell Significance Index: -1.3300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0021
Cell Significance Index: -1.5400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0022
Cell Significance Index: -1.3900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0024
Cell Significance Index: -0.0600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0024
Cell Significance Index: -1.7600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0029
Cell Significance Index: -0.5300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0029
Cell Significance Index: -1.6600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0034
Cell Significance Index: -2.1400 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0035
Cell Significance Index: -0.0500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0039
Cell Significance Index: -1.7600 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0041
Cell Significance Index: -0.1800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0043
Cell Significance Index: -0.6200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0043
Cell Significance Index: -1.2400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0051
Cell Significance Index: -0.2400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0060
Cell Significance Index: -0.3700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0061
Cell Significance Index: -1.0500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0063
Cell Significance Index: -0.6400 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.0065
Cell Significance Index: -0.0500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0080
Cell Significance Index: -0.6300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0097
Cell Significance Index: -2.0400 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: -0.0106
Cell Significance Index: -0.1100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0121
Cell Significance Index: -1.4900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0125
Cell Significance Index: -0.4000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0137
Cell Significance Index: -1.7700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0153
Cell Significance Index: -0.4300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0154
Cell Significance Index: -0.4200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0164
Cell Significance Index: -1.2600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0167
Cell Significance Index: -1.7400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0170
Cell Significance Index: -2.0100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0213
Cell Significance Index: -1.5900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0222
Cell Significance Index: -1.4300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0238
Cell Significance Index: -0.7000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0239
Cell Significance Index: -1.3400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0253
Cell Significance Index: -1.7000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0259
Cell Significance Index: -1.3500 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.0268
Cell Significance Index: -0.4300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0271
Cell Significance Index: -0.6500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0272
Cell Significance Index: -1.2800 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0279
Cell Significance Index: -0.4200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0284
Cell Significance Index: -1.4900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0293
Cell Significance Index: -0.4900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0322
Cell Significance Index: -1.1200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0388
Cell Significance Index: -1.3600 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0388
Cell Significance Index: -0.7900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0411
Cell Significance Index: -0.8600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0418
Cell Significance Index: -1.8500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0423
Cell Significance Index: -1.3900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0430
Cell Significance Index: -0.8400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2937624993
Symbol: SC5A2_HUMAN
Name: Sodium/glucose cotransporter 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1415574
Title: Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter.
PubMed ID: 1415574
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 28592437
Title: Characterization of the transport activity of SGLT2/MAP17, the renal low-affinity Na+-glucose cotransporter.
PubMed ID: 28592437
PubMed ID: 20980548
Title: Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2.
PubMed ID: 20980548
PubMed ID: 34880493
Title: Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter.
PubMed ID: 34880493
PubMed ID: 14614622
Title: Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria.
PubMed ID: 14614622
Sequence Information:
- Length: 672
- Mass: 72897
- Checksum: 233C65F1601B0337
- Sequence:
MEEHTEAGSA PEMGAQKALI DNPADILVIA AYFLLVIGVG LWSMCRTNRG TVGGYFLAGR SMVWWPVGAS LFASNIGSGH FVGLAGTGAA SGLAVAGFEW NALFVVLLLG WLFAPVYLTA GVITMPQYLR KRFGGRRIRL YLSVLSLFLY IFTKISVDMF SGAVFIQQAL GWNIYASVIA LLGITMIYTV TGGLAALMYT DTVQTFVILG GACILMGYAF HEVGGYSGLF DKYLGAATSL TVSEDPAVGN ISSFCYRPRP DSYHLLRHPV TGDLPWPALL LGLTIVSGWY WCSDQVIVQR CLAGKSLTHI KAGCILCGYL KLTPMFLMVM PGMISRILYP DEVACVVPEV CRRVCGTEVG CSNIAYPRLV VKLMPNGLRG LMLAVMLAAL MSSLASIFNS SSTLFTMDIY TRLRPRAGDR ELLLVGRLWV VFIVVVSVAW LPVVQAAQGG QLFDYIQAVS SYLAPPVSAV FVLALFVPRV NEQGAFWGLI GGLLMGLARL IPEFSFGSGS CVQPSACPAF LCGVHYLYFA IVLFFCSGLL TLTVSLCTAP IPRKHLHRLV FSLRHSKEER EDLDADEQQG SSLPVQNGCP ESAMEMNEPQ APAPSLFRQC LLWFCGMSRG GVGSPPPLTQ EEAAAAARRL EDISEDPSWA RVVNLNALLM MAVAVFLWGF YA
Genular Protein ID: 3695781949
Symbol: Q8WY15_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
Sequence Information:
- Length: 698
- Mass: 75695
- Checksum: 89A4A1CE9C897CA2
- Sequence:
MEEHTEAGSA PEMGAQKALI DNPADILVIA AYFLLVIGVG LWSMCRTNRG TVGGYFLAGR SMVWWPVGAS LFASNIGSGH FVGLAGTGAA SGLAVAGFEW NALFVVLLLG WLFAPVYLTA GVITMPQYLR KRFGGRRIRL YLSVLSLFLY IFTKISVDMF SGAVFIQQAL GWNIYASVIA LLGITMIYTV TGGLAALMYT DTVQTFVILG GACILMGYAF HEVGGYSGLF DKYLGAATSL TVSEDPAVGN ISSFCYRPRP DSYHLLRHPV TGDLPWPALL LGLTIVSGWY WCSDQVIVQR CLAGKSLTHI KAGCILCGYL KLTPMFLMVM PGMISRILYP DEVACVVPEV CRRVCGTEVG CSNIAYPRLV VKLMPNGLRG LMLAVMLAAL MSSLASIFNS SSTLFTMDIY TRLRPRAGDR ELLLVGRLWV VFIVVVSVAW LPVVQAAQGG QLFDYIQAVS SYLAPPVSAV FVLALFVPRV NEQGAFWGLI GGLLMGLARL IPEFSFGSGS CVQPSACPAF LCGVHYLYFA IVLFFCSGLL TLTVSLCTAP IPRKHLHRLV FSLRHSKEER EDLDADEQQG SSLPVQNGCP ESAMEMNGRA PCWEVGLEEL SSRKLTAGPQ FPSEPQAPAP SLFRQCLLWF CGMSRGGVGS PPPLTQEEAA AAARRLEDIS EDPSWARVVN LNALLMMAVA VFLWGFYA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.