Details for: SLC5A2

Gene ID: 6524

Symbol: SLC5A2

Ensembl ID: ENSG00000140675

Description: solute carrier family 5 member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 11.5722
    Cell Significance Index: -1.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 7.0276
    Cell Significance Index: -1.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.4842
    Cell Significance Index: -1.8300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.0666
    Cell Significance Index: 15.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7325
    Cell Significance Index: 15.8700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.5173
    Cell Significance Index: 5.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2636
    Cell Significance Index: 50.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2560
    Cell Significance Index: 5.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2375
    Cell Significance Index: 6.3700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.2369
    Cell Significance Index: 2.3800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.2259
    Cell Significance Index: 1.9200
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.2230
    Cell Significance Index: 1.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1784
    Cell Significance Index: 3.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1710
    Cell Significance Index: 16.9200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1566
    Cell Significance Index: 1.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1275
    Cell Significance Index: 115.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1226
    Cell Significance Index: 7.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1176
    Cell Significance Index: 2.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1019
    Cell Significance Index: 11.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0819
    Cell Significance Index: 13.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0689
    Cell Significance Index: 1.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0651
    Cell Significance Index: 2.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0557
    Cell Significance Index: 1.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0460
    Cell Significance Index: 3.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0408
    Cell Significance Index: 8.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0238
    Cell Significance Index: 1.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0230
    Cell Significance Index: 15.8800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0224
    Cell Significance Index: 0.3300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0221
    Cell Significance Index: 0.3500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0210
    Cell Significance Index: 0.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0187
    Cell Significance Index: 0.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0178
    Cell Significance Index: 2.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0159
    Cell Significance Index: 0.4100
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.0125
    Cell Significance Index: 0.0100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0115
    Cell Significance Index: 0.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0094
    Cell Significance Index: 0.4900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0086
    Cell Significance Index: 0.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0071
    Cell Significance Index: 0.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0071
    Cell Significance Index: 0.4500
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.0054
    Cell Significance Index: 0.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0050
    Cell Significance Index: 0.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0046
    Cell Significance Index: 2.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0041
    Cell Significance Index: 0.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0035
    Cell Significance Index: 1.2500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0021
    Cell Significance Index: 0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0012
    Cell Significance Index: 1.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 0.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0005
    Cell Significance Index: 0.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0005
    Cell Significance Index: 0.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0013
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0017
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0018
    Cell Significance Index: -1.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0021
    Cell Significance Index: -1.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0022
    Cell Significance Index: -1.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0024
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0029
    Cell Significance Index: -0.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0029
    Cell Significance Index: -1.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0034
    Cell Significance Index: -2.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0035
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0039
    Cell Significance Index: -1.7600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0041
    Cell Significance Index: -0.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0043
    Cell Significance Index: -0.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0043
    Cell Significance Index: -1.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0051
    Cell Significance Index: -0.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0060
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0061
    Cell Significance Index: -1.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0063
    Cell Significance Index: -0.6400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0065
    Cell Significance Index: -0.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0080
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0097
    Cell Significance Index: -2.0400
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.0106
    Cell Significance Index: -0.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0121
    Cell Significance Index: -1.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0125
    Cell Significance Index: -0.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0137
    Cell Significance Index: -1.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0153
    Cell Significance Index: -0.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0154
    Cell Significance Index: -0.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0164
    Cell Significance Index: -1.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0167
    Cell Significance Index: -1.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0170
    Cell Significance Index: -2.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0213
    Cell Significance Index: -1.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0222
    Cell Significance Index: -1.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0238
    Cell Significance Index: -0.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0239
    Cell Significance Index: -1.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0253
    Cell Significance Index: -1.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0259
    Cell Significance Index: -1.3500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0268
    Cell Significance Index: -0.4300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0271
    Cell Significance Index: -0.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0272
    Cell Significance Index: -1.2800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0279
    Cell Significance Index: -0.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0284
    Cell Significance Index: -1.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0293
    Cell Significance Index: -0.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0322
    Cell Significance Index: -1.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0388
    Cell Significance Index: -1.3600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0388
    Cell Significance Index: -0.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0411
    Cell Significance Index: -0.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0418
    Cell Significance Index: -1.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0423
    Cell Significance Index: -1.3900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0430
    Cell Significance Index: -0.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Function**: SGLT2 is a high-affinity glucose transporter that mediates glucose reabsorption in the kidneys, with a high capacity for glucose uptake and low affinity for sodium. 2. **Expression**: SGLT2 is highly expressed in the proximal tubules of the kidneys, as well as in other tissues such as the small intestine, colon, and brain. 3. **Regulation**: SGLT2 is regulated by various factors, including insulin, glucagon, and glucose levels. 4. **Transport Mechanism**: SGLT2 uses a Na+/glucose cotransporter mechanism, where one sodium ion is transported across the membrane for every glucose molecule. **Pathways and Functions** 1. **Glucose Homeostasis**: SGLT2 plays a critical role in maintaining glucose homeostasis by facilitating glucose reabsorption in the kidneys. 2. **Renal Function**: SGLT2 is essential for the reabsorption of glucose in the proximal tubules, preventing excessive glucose loss in the urine. 3. **Sodium Homeostasis**: SGLT2 also regulates sodium homeostasis by transporting sodium ions across the apical plasma membrane. 4. **Energy Metabolism**: SGLT2 is involved in the regulation of energy metabolism by influencing glucose and insulin levels. **Clinical Significance** 1. **Renal Glucosuria**: Mutations in the SLC5A2 gene have been associated with renal glucosuria, a rare disorder characterized by excessive glucose excretion in the urine. 2. **Hyperglycemia**: Impaired SGLT2 function has been linked to hyperglycemia, a hallmark of diabetes mellitus. 3. **Hyperuricemia**: Elevated uric acid levels have been observed in patients with SLC5A2 mutations, which may contribute to the development of kidney stones. 4. **Therapeutic Potential**: SGLT2 inhibitors, a class of medications, have been developed to treat type 2 diabetes by reducing glucose reabsorption in the kidneys, thereby lowering blood glucose levels. In conclusion, the SLC5A2 gene plays a vital role in maintaining glucose homeostasis and renal function, and its dysfunction can lead to various clinical disorders. Further research is needed to fully understand the mechanisms of SGLT2 and its clinical significance.

Genular Protein ID: 2937624993

Symbol: SC5A2_HUMAN

Name: Sodium/glucose cotransporter 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1415574

Title: Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter.

PubMed ID: 1415574

DOI: 10.1152/ajprenal.1992.263.3.f459

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28592437

Title: Characterization of the transport activity of SGLT2/MAP17, the renal low-affinity Na+-glucose cotransporter.

PubMed ID: 28592437

DOI: 10.1152/ajprenal.00628.2016

PubMed ID: 20980548

Title: Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2.

PubMed ID: 20980548

DOI: 10.1152/ajpcell.00388.2010

PubMed ID: 34880493

Title: Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter.

PubMed ID: 34880493

DOI: 10.1038/s41586-021-04212-9

PubMed ID: 14614622

Title: Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria.

PubMed ID: 14614622

DOI: 10.1007/s00439-003-1054-x

Sequence Information:

  • Length: 672
  • Mass: 72897
  • Checksum: 233C65F1601B0337
  • Sequence:
  • MEEHTEAGSA PEMGAQKALI DNPADILVIA AYFLLVIGVG LWSMCRTNRG TVGGYFLAGR 
    SMVWWPVGAS LFASNIGSGH FVGLAGTGAA SGLAVAGFEW NALFVVLLLG WLFAPVYLTA 
    GVITMPQYLR KRFGGRRIRL YLSVLSLFLY IFTKISVDMF SGAVFIQQAL GWNIYASVIA 
    LLGITMIYTV TGGLAALMYT DTVQTFVILG GACILMGYAF HEVGGYSGLF DKYLGAATSL 
    TVSEDPAVGN ISSFCYRPRP DSYHLLRHPV TGDLPWPALL LGLTIVSGWY WCSDQVIVQR 
    CLAGKSLTHI KAGCILCGYL KLTPMFLMVM PGMISRILYP DEVACVVPEV CRRVCGTEVG 
    CSNIAYPRLV VKLMPNGLRG LMLAVMLAAL MSSLASIFNS SSTLFTMDIY TRLRPRAGDR 
    ELLLVGRLWV VFIVVVSVAW LPVVQAAQGG QLFDYIQAVS SYLAPPVSAV FVLALFVPRV 
    NEQGAFWGLI GGLLMGLARL IPEFSFGSGS CVQPSACPAF LCGVHYLYFA IVLFFCSGLL 
    TLTVSLCTAP IPRKHLHRLV FSLRHSKEER EDLDADEQQG SSLPVQNGCP ESAMEMNEPQ 
    APAPSLFRQC LLWFCGMSRG GVGSPPPLTQ EEAAAAARRL EDISEDPSWA RVVNLNALLM 
    MAVAVFLWGF YA

Genular Protein ID: 3695781949

Symbol: Q8WY15_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 698
  • Mass: 75695
  • Checksum: 89A4A1CE9C897CA2
  • Sequence:
  • MEEHTEAGSA PEMGAQKALI DNPADILVIA AYFLLVIGVG LWSMCRTNRG TVGGYFLAGR 
    SMVWWPVGAS LFASNIGSGH FVGLAGTGAA SGLAVAGFEW NALFVVLLLG WLFAPVYLTA 
    GVITMPQYLR KRFGGRRIRL YLSVLSLFLY IFTKISVDMF SGAVFIQQAL GWNIYASVIA 
    LLGITMIYTV TGGLAALMYT DTVQTFVILG GACILMGYAF HEVGGYSGLF DKYLGAATSL 
    TVSEDPAVGN ISSFCYRPRP DSYHLLRHPV TGDLPWPALL LGLTIVSGWY WCSDQVIVQR 
    CLAGKSLTHI KAGCILCGYL KLTPMFLMVM PGMISRILYP DEVACVVPEV CRRVCGTEVG 
    CSNIAYPRLV VKLMPNGLRG LMLAVMLAAL MSSLASIFNS SSTLFTMDIY TRLRPRAGDR 
    ELLLVGRLWV VFIVVVSVAW LPVVQAAQGG QLFDYIQAVS SYLAPPVSAV FVLALFVPRV 
    NEQGAFWGLI GGLLMGLARL IPEFSFGSGS CVQPSACPAF LCGVHYLYFA IVLFFCSGLL 
    TLTVSLCTAP IPRKHLHRLV FSLRHSKEER EDLDADEQQG SSLPVQNGCP ESAMEMNGRA 
    PCWEVGLEEL SSRKLTAGPQ FPSEPQAPAP SLFRQCLLWF CGMSRGGVGS PPPLTQEEAA 
    AAARRLEDIS EDPSWARVVN LNALLMMAVA VFLWGFYA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.