Details for: SMARCA2

Gene ID: 6595

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SMARCA2

Ensembl ID: ENSG00000080503

Description: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • VIP GABAergic cortical interneuron CL4023016
    CSI 82.67
    rCSI 98.74%
    PRS 10.83
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 71.98
    rCSI 89.55%
    PRS 10.28
  • sst GABAergic cortical interneuron CL4023017
    CSI 68.8
    rCSI 88.7%
    PRS 11.58
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 54.56
    rCSI 91.58%
    PRS 11.04
  • sncg GABAergic cortical interneuron CL4023015
    CSI 52.52
    rCSI 84.47%
    PRS 12
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 50.28
    rCSI 88.8%
    PRS 11.01
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 35.3
    rCSI 85.78%
    PRS 10.84
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 32
    rCSI 69.42%
    PRS 12.58
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 30.02
    rCSI 93.89%
    PRS 12.69
  • astrocyte of the cerebral cortex CL0002605
    CSI 29.73
    rCSI 66.66%
    PRS 11.59
  • cerebral cortex endothelial cell CL1001602
    CSI 29.54
    rCSI 51.09%
    PRS 14.29
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 27.1
    rCSI 64.81%
    PRS 11.77
  • L6b glutamatergic cortical neuron CL4023038
    CSI 26.42
    rCSI 82.57%
    PRS 11.79
  • neuron CL0000540
    CSI 23.44
    rCSI 62.42%
    PRS 15.62
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 22.42
    rCSI 80.68%
    PRS 10.39
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 18.75
    rCSI 70.87%
    PRS 11.35
  • kidney connecting tubule epithelial cell CL1000768
    CSI 15.37
    rCSI 38.98%
    PRS 14.2
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 14.78
    rCSI 87.02%
    PRS 11.57
  • adipocyte CL0000136
    CSI 13.12
    rCSI 16.84%
    PRS 18.23
  • transit amplifying cell CL0009010
    CSI 12.4
    rCSI 18.97%
    PRS 30.28
  • stromal cell of ovary CL0002132
    CSI 11.99
    rCSI 32.95%
    PRS 30.78
  • central nervous system neuron CL2000029
    CSI 11.87
    rCSI 87.26%
    PRS 10.74
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 11.45
    rCSI 10.34%
    PRS 16.84
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 10.82
    rCSI 35.55%
    PRS 11.41
  • myoepithelial cell CL0000185
    CSI 10.79
    rCSI 27.31%
    PRS 23.22
  • keratocyte CL0002363
    CSI 10.54
    rCSI 25.35%
    PRS 27.7
  • hematopoietic stem cell CL0000037
    CSI 10.31
    rCSI 6.85%
    PRS 22.5
  • glycinergic amacrine cell CL4030028
    CSI 9.86
    rCSI 25.68%
    PRS 18.61
  • enteroendocrine cell of small intestine CL0009006
    CSI 9.33
    rCSI 20.53%
    PRS 28.49
  • GABAergic amacrine cell CL4030027
    CSI 9.15
    rCSI 31.34%
    PRS 16.2
  • inhibitory interneuron CL0000498
    CSI 9.07
    rCSI 20.94%
    PRS 15.13
  • endothelial cell of vascular tree CL0002139
    CSI 8.25
    rCSI 45.12%
    PRS 29.71
  • invaginating midget bipolar cell CL4033034
    CSI 7.92
    rCSI 46.75%
    PRS 19.97
  • vascular associated smooth muscle cell CL0000359
    CSI 7.79
    rCSI 25.27%
    PRS 22.62
  • CD4-positive helper T cell CL0000492
    CSI 7.7
    rCSI 5.83%
    PRS 25.7
  • pancreatic A cell CL0000171
    CSI 7.35
    rCSI 7.7%
    PRS 19.99
  • placental villous trophoblast CL2000060
    CSI 6.76
    rCSI 10.45%
    PRS 17.55
  • type L enteroendocrine cell CL0002279
    CSI 6.58
    rCSI 12.35%
    PRS 36.58
  • glutamatergic neuron CL0000679
    CSI 6.36
    rCSI 13.08%
    PRS 18.61
  • melanocyte CL0000148
    CSI 6.31
    rCSI 4.67%
    PRS 16.34
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 6.08
    rCSI 23.66%
    PRS 30.8
  • mesodermal cell CL0000222
    CSI 6.07
    rCSI 7.28%
    PRS 18.35
  • naive B cell CL0000788
    CSI 6.04
    rCSI 5.18%
    PRS 30.77
  • unswitched memory B cell CL0000970
    CSI 5.74
    rCSI 4.83%
    PRS 29.7
  • vascular leptomeningeal cell CL4023051
    CSI 5.33
    rCSI 9.34%
    PRS 14.13
  • P/D1 enteroendocrine cell CL0002268
    CSI 4.82
    rCSI 26.22%
    PRS 43.55
  • GABAergic neuron CL0000617
    CSI 4.52
    rCSI 15.15%
    PRS 13.22
  • blood vessel endothelial cell CL0000071
    CSI 4.46
    rCSI 9.25%
    PRS 18.7
  • multi-ciliated epithelial cell CL0005012
    CSI 4.32
    rCSI 4.31%
    PRS 15.99
  • diffuse bipolar 3a cell CL4033029
    CSI 4.24
    rCSI 28.84%
    PRS 19.53
  • ependymal cell CL0000065
    CSI 4.21
    rCSI 8.55%
    PRS 9.28
  • mesangial cell CL0000650
    CSI 4.17
    rCSI 16.99%
    PRS 26.29
  • duct epithelial cell CL0000068
    CSI 4.09
    rCSI 5.98%
    PRS 19.84
  • Bergmann glial cell CL0000644
    CSI 4.08
    rCSI 5.58%
    PRS 18.64
  • podocyte CL0000653
    CSI 4.04
    rCSI 17.96%
    PRS 18.33
  • pancreatic PP cell CL0002275
    CSI 3.97
    rCSI 15.81%
    PRS 32.22
  • conjunctival epithelial cell CL1000432
    CSI 3.92
    rCSI 5.99%
    PRS 18.87
  • myelocyte CL0002193
    CSI 3.81
    rCSI 25.03%
    PRS 54.8
  • myeloid dendritic cell CL0000782
    CSI 3.79
    rCSI 5.5%
    PRS 28.14
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 3.79
    rCSI 32.76%
    PRS 29.71
  • secretory cell CL0000151
    CSI 3.75
    rCSI 3.92%
    PRS 19.22
  • Langerhans cell CL0000453
    CSI 3.67
    rCSI 5.61%
    PRS 32.9
  • medium spiny neuron CL1001474
    CSI 3.61
    rCSI 31.14%
    PRS 8.92
  • direct pathway medium spiny neuron CL4023026
    CSI 3.61
    rCSI 86.46%
    PRS 9.38
  • group 3 innate lymphoid cell CL0001071
    CSI 3.59
    rCSI 2.69%
    PRS 19.85
  • indirect pathway medium spiny neuron CL4023029
    CSI 3.57
    rCSI 86.17%
    PRS 10.32
  • neural cell CL0002319
    CSI 3.55
    rCSI 13.39%
    PRS 25.57
  • rod bipolar cell CL0000751
    CSI 3.51
    rCSI 6.3%
    PRS 15.54
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 3.5
    rCSI 2.63%
    PRS 50.65
  • nasal mucosa goblet cell CL0002480
    CSI 3.35
    rCSI 3.89%
    PRS 27.26
  • retinal bipolar neuron CL0000748
    CSI 3.28
    rCSI 6.14%
    PRS 13.47
  • brush cell of tracheobronchial tree CL0002075
    CSI 3.27
    rCSI 9.69%
    PRS 26.41
  • neural progenitor cell CL0011020
    CSI 3.26
    rCSI 14.33%
    PRS 17.74
  • myofibroblast cell CL0000186
    CSI 3.21
    rCSI 4.45%
    PRS 26.51
  • flat midget bipolar cell CL4033033
    CSI 3.19
    rCSI 22.84%
    PRS 19.5
  • mononuclear phagocyte CL0000113
    CSI 3.19
    rCSI 7.03%
    PRS 21.15
  • kidney collecting duct principal cell CL1001431
    CSI 3.17
    rCSI 15.96%
    PRS 42.7
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 3.03
    rCSI 2.13%
    PRS 44.13
  • innate lymphoid cell CL0001065
    CSI 2.92
    rCSI 6.03%
    PRS 28.05
  • acinar cell of salivary gland CL0002623
    CSI 2.9
    rCSI 67.48%
    PRS 34.85
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 2.88
    rCSI 2.19%
    PRS 24.76
  • S cone cell CL0003050
    CSI 2.83
    rCSI 12.44%
    PRS 16.26
  • mucosal invariant T cell CL0000940
    CSI 2.81
    rCSI 2.27%
    PRS 29.39
  • ciliated epithelial cell CL0000067
    CSI 2.71
    rCSI 2.38%
    PRS 13.62
  • central nervous system macrophage CL0000878
    CSI 2.67
    rCSI 8.86%
    PRS 21.79
  • ON midget ganglion cell CL4033046
    CSI 2.65
    rCSI 54.01%
    PRS 14.88
  • lung ciliated cell CL1000271
    CSI 2.61
    rCSI 3.02%
    PRS 13.77
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 2.58
    rCSI 27.28%
    PRS 24.59
  • perivascular cell CL4033054
    CSI 2.55
    rCSI 3.48%
    PRS 21.23
  • OFF midget ganglion cell CL4033047
    CSI 2.53
    rCSI 51.45%
    PRS 15.92
  • Mueller cell CL0000636
    CSI 2.52
    rCSI 5.75%
    PRS 16.11
  • ON parasol ganglion cell CL4033052
    CSI 2.51
    rCSI 35.67%
    PRS 14
  • dendritic cell, human CL0001056
    CSI 2.41
    rCSI 3.7%
    PRS 22.36
  • alveolar macrophage CL0000583
    CSI 2.4
    rCSI 3.96%
    PRS 22.15
  • renal interstitial pericyte CL1001318
    CSI 2.3
    rCSI 6.35%
    PRS 17.37
  • cerebellar granule cell CL0001031
    CSI 2.3
    rCSI 3.38%
    PRS 17.2
  • double negative thymocyte CL0002489
    CSI 2.28
    rCSI 1.58%
    PRS 22.4
  • Schwann cell CL0002573
    CSI 2.23
    rCSI 6.34%
    PRS 21.62
  • fallopian tube secretory epithelial cell CL4030006
    CSI 2.15
    rCSI 2.07%
    PRS 19.4
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.14
    rCSI 1.49%
    PRS 19.93
  • group 2 innate lymphoid cell CL0001069
    CSI -0.9
    rCSI -5.1%
    PRS 58.0%
  • pulmonary capillary endothelial cell CL4028001
    CSI -0.9
    rCSI -1.7%
    PRS 29.7%
  • double-positive, alpha-beta thymocyte CL0000809
    CSI -0.8
    rCSI -0.8%
    PRS 26.9%
  • alternatively activated macrophage CL0000890
    CSI -0.6
    rCSI -0.7%
    PRS 28.9%
  • microcirculation associated smooth muscle cell CL0008035
    CSI -0.5
    rCSI -1.3%
    PRS 21.2%
  • lung pericyte CL0009089
    CSI -0.4
    rCSI -1.2%
    PRS 22.4%
  • interstitial cell of Cajal CL0002088
    CSI -0.4
    rCSI -0.6%
    PRS 21.8%
  • luminal cell of prostate epithelium CL0002340
    CSI -0.4
    rCSI -2.3%
    PRS 33.2%
  • cerebral cortex pyramidal neuron CL4023111
    CSI -0.3
    rCSI -2.0%
    PRS 46.4%
  • erythroid progenitor cell CL0000038
    CSI -0.1
    rCSI -0.8%
    PRS 28.3%
  • exhausted T cell CL0011025
    CSI -0.1
    rCSI -1.3%
    PRS 60.5%
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.0
    rCSI 0.2%
    PRS 36.2%
  • respiratory goblet cell CL0002370
    CSI 0.0
    rCSI 0.4%
    PRS 35.7%
  • cytotoxic T cell CL0000910
    CSI 0.1
    rCSI 0.4%
    PRS 27.5%
  • mesenchymal stem cell CL0000134
    CSI 0.1
    rCSI 0.9%
    PRS 33.4%
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.1
    rCSI 0.9%
    PRS 14.6%
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 0.2
    rCSI 0.5%
    PRS 24.3%
  • cerebellar neuron CL1001611
    CSI 0.2
    rCSI 1.5%
    PRS 12.2%
  • eosinophil CL0000771
    CSI 0.2
    rCSI 1.2%
    PRS 46.8%
  • mucus secreting cell CL0000319
    CSI 0.2
    rCSI 0.3%
    PRS 24.1%
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 0.2
    rCSI 0.3%
    PRS 36.6%
  • fraction A pre-pro B cell CL0002045
    CSI 0.2
    rCSI 0.2%
    PRS 37.9%
  • mature alpha-beta T cell CL0000791
    CSI 0.2
    rCSI 0.7%
    PRS 32.1%
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 0.2
    rCSI 0.3%
    PRS 23.4%
  • transit amplifying cell of small intestine CL0009012
    CSI 0.2
    rCSI 0.9%
    PRS 34.6%
  • pancreatic stellate cell CL0002410
    CSI 0.2
    rCSI 1.3%
    PRS 27.9%
  • intestinal tuft cell CL0019032
    CSI 0.2
    rCSI 0.4%
    PRS 21.5%
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 0.2
    rCSI 1.4%
    PRS 41.4%
  • retina horizontal cell CL0000745
    CSI 0.2
    rCSI 0.4%
    PRS 17.4%
  • deuterosomal cell CL4033044
    CSI 0.2
    rCSI 0.8%
    PRS 30.1%
  • CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074
    CSI 0.3
    rCSI 2.9%
    PRS 62.7%
  • type EC enteroendocrine cell CL0000577
    CSI 0.3
    rCSI 0.9%
    PRS 30.4%
  • intestinal crypt stem cell of colon CL0009043
    CSI 0.3
    rCSI 2.0%
    PRS 34.1%
  • tracheobronchial smooth muscle cell CL0019019
    CSI 0.3
    rCSI 0.5%
    PRS 24.7%
  • tracheobronchial serous cell CL0019001
    CSI 0.3
    rCSI 1.3%
    PRS 34.5%
  • tracheal goblet cell CL1000329
    CSI 0.3
    rCSI 0.6%
    PRS 36.5%
  • neuroendocrine cell CL0000165
    CSI 0.3
    rCSI 1.2%
    PRS 37.0%
  • basal cell of epithelium of trachea CL1000348
    CSI 0.3
    rCSI 2.2%
    PRS 51.5%
  • retinal pigment epithelial cell CL0002586
    CSI 0.3
    rCSI 0.6%
    PRS 19.8%
  • elicited macrophage CL0000861
    CSI 0.3
    rCSI 0.3%
    PRS 21.9%
  • erythroblast CL0000765
    CSI 0.3
    rCSI 0.9%
    PRS 30.0%
  • mesenchymal cell CL0008019
    CSI 0.4
    rCSI 0.9%
    PRS 18.9%
  • IgG plasma cell CL0000985
    CSI 0.4
    rCSI 0.5%
    PRS 32.4%
  • macroglial cell CL0000126
    CSI 0.4
    rCSI 1.0%
    PRS 24.6%
  • endothelial cell of placenta CL0009092
    CSI 0.4
    rCSI 2.1%
    PRS 25.4%
  • endothelial cell of uterus CL0009095
    CSI 0.5
    rCSI 3.3%
    PRS 48.8%
  • large pre-B-II cell CL0000957
    CSI 0.5
    rCSI 1.3%
    PRS 31.9%
  • lung neuroendocrine cell CL1000223
    CSI 0.5
    rCSI 0.7%
    PRS 21.4%
  • fibroblast of breast CL4006000
    CSI 0.5
    rCSI 2.0%
    PRS 45.3%
  • lung microvascular endothelial cell CL2000016
    CSI 0.5
    rCSI 9.2%
    PRS 52.1%
  • serotonergic neuron CL0000850
    CSI 0.5
    rCSI 2.1%
    PRS 11.1%
  • diffuse bipolar 1 cell CL4033027
    CSI 0.5
    rCSI 3.7%
    PRS 18.9%
  • pancreatic acinar cell CL0002064
    CSI 0.5
    rCSI 0.7%
    PRS 20.6%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 0.5
    rCSI 1.2%
    PRS 19.3%
  • bronchial goblet cell CL1000312
    CSI 0.5
    rCSI 2.0%
    PRS 39.5%
  • luminal epithelial cell of mammary gland CL0002326
    CSI 0.5
    rCSI 0.9%
    PRS 28.6%
  • syncytiotrophoblast cell CL0000525
    CSI 0.5
    rCSI 1.5%
    PRS 35.0%
  • alveolar adventitial fibroblast CL4028006
    CSI 0.5
    rCSI 0.8%
    PRS 18.9%
  • myeloid dendritic cell, human CL0001057
    CSI 0.5
    rCSI 3.0%
    PRS 54.8%
  • centrilobular region hepatocyte CL0019029
    CSI 0.5
    rCSI 1.4%
    PRS 28.7%
  • type B pancreatic cell CL0000169
    CSI 0.5
    rCSI 1.2%
    PRS 17.3%
  • glandular epithelial cell CL0000150
    CSI 0.6
    rCSI 1.5%
    PRS 36.3%
  • platelet CL0000233
    CSI 0.6
    rCSI 2.3%
    PRS 34.5%
  • squamous epithelial cell CL0000076
    CSI 0.6
    rCSI 1.4%
    PRS 23.2%
  • OFF-bipolar cell CL0000750
    CSI 0.6
    rCSI 0.8%
    PRS 29.5%
  • lung secretory cell CL1000272
    CSI 0.6
    rCSI 1.5%
    PRS 17.3%
  • H2 horizontal cell CL0004218
    CSI 0.6
    rCSI 3.0%
    PRS 20.2%
  • enteroendocrine cell of colon CL0009042
    CSI 0.6
    rCSI 2.8%
    PRS 46.5%
  • pancreatic ductal cell CL0002079
    CSI 0.6
    rCSI 1.2%
    PRS 19.2%
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 0.6
    rCSI 1.5%
    PRS 29.7%
  • common lymphoid progenitor CL0000051
    CSI 0.6
    rCSI 0.8%
    PRS 35.6%
  • lung macrophage CL1001603
    CSI 0.6
    rCSI 1.4%
    PRS 21.7%
  • mature B cell CL0000785
    CSI 0.6
    rCSI 0.5%
    PRS 23.5%
  • class switched memory B cell CL0000972
    CSI 0.6
    rCSI 0.5%
    PRS 31.4%
  • regular atrial cardiac myocyte CL0002129
    CSI 0.6
    rCSI 2.0%
    PRS 19.7%
  • T-helper 17 cell CL0000899
    CSI 0.6
    rCSI 0.5%
    PRS 33.2%
  • T follicular helper cell CL0002038
    CSI 0.6
    rCSI 0.5%
    PRS 29.8%
  • brain vascular cell CL4023072
    CSI 0.7
    rCSI 6.9%
    PRS 21.7%
  • dopaminergic neuron CL0000700
    CSI 0.7
    rCSI 3.8%
    PRS 9.9%
  • stromal cell CL0000499
    CSI 0.7
    rCSI 1.9%
    PRS 25.4%
  • H1 horizontal cell CL0004217
    CSI 0.7
    rCSI 2.8%
    PRS 25.6%
  • basophil CL0000767
    CSI 0.7
    rCSI 1.5%
    PRS 37.5%
  • enterocyte of epithelium of large intestine CL0002071
    CSI 0.7
    rCSI 3.9%
    PRS 32.2%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 0.7
    rCSI 1.1%
    PRS 17.4%
  • respiratory suprabasal cell CL4033048
    CSI 0.8
    rCSI 1.0%
    PRS 21.7%
  • club cell CL0000158
    CSI 0.8
    rCSI 1.1%
    PRS 21.6%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 0.8
    rCSI 2.2%
    PRS 27.8%
  • intestine goblet cell CL0019031
    CSI 0.8
    rCSI 0.7%
    PRS 18.9%
  • transitional stage B cell CL0000818
    CSI 0.8
    rCSI 2.5%
    PRS 48.7%
  • extravillous trophoblast CL0008036
    CSI 0.8
    rCSI 0.9%
    PRS 16.4%
  • granulocyte monocyte progenitor cell CL0000557
    CSI 0.8
    rCSI 0.7%
    PRS 21.1%
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 0.8
    rCSI 0.9%
    PRS 22.5%
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 0.8
    rCSI 1.0%
    PRS 26.7%
  • colon epithelial cell CL0011108
    CSI 0.8
    rCSI 0.9%
    PRS 17.5%
  • epithelial cell of lung CL0000082
    CSI 0.8
    rCSI 0.7%
    PRS 17.7%
  • endothelial cell of periportal hepatic sinusoid CL0019021
    CSI 0.8
    rCSI 3.8%
    PRS 44.7%
  • epicardial adipocyte CL1000309
    CSI 0.8
    rCSI 2.7%
    PRS 22.8%
  • erythroid lineage cell CL0000764
    CSI 0.8
    rCSI 5.3%
    PRS 41.3%
  • CD14-positive monocyte CL0001054
    CSI 0.8
    rCSI 1.0%
    PRS 26.5%
  • promonocyte CL0000559
    CSI 0.8
    rCSI 1.4%
    PRS 25.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [SMARCA2](/details-gene/6595), also known as SNF2L2 or BRM, is a protein-coding gene located on chromosome 9p24.3. It encodes a core catalytic subunit of the SWI/SNF family of chromatin remodeling complexes, which utilize the energy of ATP hydrolysis to alter nucleosome structure and regulate gene expression. Functionally, [SMARCA2](/details-gene/6595) acts as a transcriptional co-activator or co-repressor and is fundamentally involved in processes such as cell cycle control, DNA repair, and differentiation [Link](https://doi.org/10.1101/gad.1180204). **Overall**, expression data reveals that [SMARCA2](/details-gene/6595) is a highly significant gene in the central nervous system, showing prominent expression in numerous subtypes of cortical neurons, particularly GABAergic interneurons like [VIP GABAergic cortical interneuron](/details-cell/CL4023016) and [pvalb GABAergic cortical interneuron](/details-cell/CL4023018), suggesting a crucial role in maintaining neuronal identity and function. ## Cellular Roles and Expression Landscape The expression profile of [SMARCA2](/details-gene/6595) underscores its central role in the cerebral cortex. **Overall**, the gene exhibits its highest significance scores across a wide array of neuronal subtypes. It is a particularly strong marker for inhibitory GABAergic cortical interneurons, including [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 82.67), [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 71.98), [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 68.80), and [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 54.56). Its high significance extends to excitatory glutamatergic neurons, such as [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040), as well as non-neuronal cells like [astrocyte of the cerebral cortex](/details-cell/CL0002605). This broad but high expression within the brain suggests that [SMARCA2](/details-gene/6595)-mediated chromatin remodeling is a fundamental mechanism for establishing and maintaining the complex transcriptional landscapes that define diverse neural cell types. In stark contrast, [SMARCA2](/details-gene/6595) shows minimal to negative significance in various hematopoietic and endothelial lineages. For example, its expression is negligible in [group 2 innate lymphoid cell](/details-cell/CL0001069) (CSI: -0.94), [double-positive, alpha-beta thymocyte](/details-cell/CL0000809) (CSI: -0.77), and [alternatively activated macrophage](/details-cell/CL0000890) (CSI: -0.56). This lack of expression outside the nervous system and a few other tissues highlights its specialized function and suggests that other SWI/SNF ATPase paralogs, such as SMARCA4, may perform analogous roles in these other cell types. ## Pathways and Molecular Function As the enzymatic core of multiple SWI/SNF complexes (including BAF, PBAF, and GBAF), the primary molecular function of [SMARCA2](/details-gene/6595) is [ATP-dependent chromatin remodeler activity](/details-go/GO:0140658), which involves [chromatin binding](/details-go/GO:0003682) and [helicase activity](/details-go/GO:0004386). This function is critical for the biological process of [Chromatin remodeling](/details-go/GO:0006338), a key step in [Gene expression (transcription)](/details-reactome/R-HSA-74160). The gene product is a component of several distinct complexes, including the [Brahma complex](/details-go/GO:0035060) and the canonical [SWI/SNF complex](/details-go/GO:0016514), and is predominantly localized to the [nucleus](/details-go/GO:0005634) and specifically the [nucleoplasm](/details-go/GO:0005654). Its involvement in both [Positive regulation of dna-templated transcription](/details-go/GO:0045893) and [Negative regulation of dna-templated transcription](/details-go/GO:0045892) underscores its contextual role as a transcriptional switch. This dual capacity is reflected in its diverse annotated functions, which range from promoting [Nervous system development](/details-go/GO:0007399) and [Positive regulation of t cell differentiation](/details-go/GO:0045582) to suppressing cell proliferation ([Negative regulation of cell population proliferation](/details-go/GO:0008285)). The high expression of [SMARCA2](/details-gene/6595) in post-mitotic neurons is consistent with its role in regulating terminal differentiation and maintaining cellular identity, potentially by controlling access to lineage-specific genes while repressing cell cycle-related transcripts. ## Research Directions The data firmly establishes [SMARCA2](/details-gene/6595) as a key epigenetic regulator in the central nervous system. Its involvement in chromatin remodeling makes it a critical node for integrating developmental and environmental signals to shape the neuronal transcriptome. Previous research has implicated dysregulation of the SWI/SNF complex, including [SMARCA2](/details-gene/6595), in neurological disorders such as schizophrenia [Link](https://doi.org/10.1093/hmg/ddp166). This connection, coupled with its highly specific expression pattern, opens several avenues for future investigation. **Testable Hypotheses:** 1. The high significance of [SMARCA2](/details-gene/6595) across distinct subtypes of cortical interneurons suggests it is essential for establishing and/or maintaining their unique transcriptional identities. We hypothesize that loss of [SMARCA2](/details-gene/6595) function in cortical interneuron progenitors would disrupt subtype specification, leading to an imbalance in excitatory/inhibitory circuits and contributing to network hyperexcitability. 2. Given its roles in both cell cycle regulation ([Regulation of g1/s transition of mitotic cell cycle](/details-go/GO:2000045)) and neuronal function, we hypothesize that [SMARCA2](/details-gene/6595) undergoes a functional switch during neurodevelopment. In neural progenitors, it primarily regulates proliferation, while in mature, post-mitotic neurons, it is repurposed to control the expression of genes critical for synaptic plasticity, neurotransmission, and long-term cellular homeostasis. **Proposed Experiment:** To test the first hypothesis regarding interneuron identity, a conditional knockout mouse model could be generated. By crossing a floxed-[SMARCA2](/details-gene/6595) allele mouse with a mouse line expressing Cre recombinase under an interneuron-specific promoter (e.g., Dlx5/6-Cre), [SMARCA2](/details-gene/6595) can be selectively deleted in cortical GABAergic neurons. Single-cell RNA sequencing (scRNA-seq) of the adult cortex from these knockout animals would allow for a direct assessment of interneuron subtype composition and transcriptional integrity compared to wild-type controls. This could be complemented with electrophysiological recordings (e.g., patch-clamp) to measure functional deficits in inhibitory neurotransmission. **Therapeutic Potential:** As an ATPase and a core component of a major chromatin-modifying complex, [SMARCA2](/details-gene/6595) is a druggable epigenetic target. However, its broad importance in nearly all neuronal types within the cortex presents a significant challenge for therapeutic intervention, as systemic inhibition would likely cause severe neurological side effects. A more promising strategy would be the development of small molecule modulators that could selectively correct for hypo- or hyper-activity associated with specific disease states, rather than simple inhibition. Such compounds could potentially restore transcriptional balance in disorders linked to [SMARCA2](/details-gene/6595) dysfunction, representing a targeted epigenetic therapy for complex neurological conditions.

Genular Protein ID: 812409638

Symbol: SMCA2_HUMAN

Name: Probable global transcription activator SNF2L2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8223438

Title: A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor.

PubMed ID: 8223438

DOI: 10.1002/j.1460-2075.1993.tb06112.x

PubMed ID: 8208605

Title: Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.

PubMed ID: 8208605

DOI: 10.1093/nar/22.10.1815

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 11259672

Title: The human brm protein is cleaved during apoptosis: the role of cathepsin G.

PubMed ID: 11259672

DOI: 10.1073/pnas.071057398

PubMed ID: 15075294

Title: TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.

PubMed ID: 15075294

DOI: 10.1101/gad.1180204

PubMed ID: 15107404

Title: Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.

PubMed ID: 15107404

DOI: 10.1101/gad.1183304

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18765789

Title: Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.

PubMed ID: 18765789

DOI: 10.1101/gad.471408

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19363039

Title: Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia.

PubMed ID: 19363039

DOI: 10.1093/hmg/ddp166

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20111005

Title: Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code.

PubMed ID: 20111005

DOI: 10.1038/emboj.2010.3

PubMed ID: 20460684

Title: Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.

PubMed ID: 20460684

DOI: 10.1074/jbc.m109.087783

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22952240

Title: SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions.

PubMed ID: 22952240

DOI: 10.1074/jbc.r111.309302

PubMed ID: 22426308

Title: Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome.

PubMed ID: 22426308

DOI: 10.1038/ng.2219

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 26601204

Title: Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.

PubMed ID: 26601204

DOI: 10.1126/sciadv.1500447

PubMed ID: 23906836

Title: A comprehensive molecular study on Coffin-Siris and Nicolaides-Baraitser syndromes identifies a broad molecular and clinical spectrum converging on altered chromatin remodeling.

PubMed ID: 23906836

DOI: 10.1093/hmg/ddt366

PubMed ID: 22366787

Title: Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome.

PubMed ID: 22366787

DOI: 10.1038/ng.1105

PubMed ID: 27665729

Title: New SMARCA2 mutation in a patient with Nicolaides-Baraitser syndrome and myoclonic astatic epilepsy.

PubMed ID: 27665729

DOI: 10.1002/ajmg.a.37935

PubMed ID: 32694869

Title: De novo SMARCA2 variants clustered outside the helicase domain cause a new recognizable syndrome with intellectual disability and blepharophimosis distinct from Nicolaides-Baraitser syndrome.

PubMed ID: 32694869

DOI: 10.1038/s41436-020-0898-y

Sequence Information:

  • Length: 1590
  • Mass: 181279
  • Checksum: CE69BBB287D35AB5
  • Sequence:
  • MSTPTDPGAM PHPGPSPGPG PSPGPILGPS PGPGPSPGSV HSMMGPSPGP PSVSHPMPTM 
    GSTDFPQEGM HQMHKPIDGI HDKGIVEDIH CGSMKGTGMR PPHPGMGPPQ SPMDQHSQGY 
    MSPHPSPLGA PEHVSSPMSG GGPTPPQMPP SQPGALIPGD PQAMSQPNRG PSPFSPVQLH 
    QLRAQILAYK MLARGQPLPE TLQLAVQGKR TLPGLQQQQQ QQQQQQQQQQ QQQQQQQQPQ 
    QQPPQPQTQQ QQQPALVNYN RPSGPGPELS GPSTPQKLPV PAPGGRPSPA PPAAAQPPAA 
    AVPGPSVPQP APGQPSPVLQ LQQKQSRISP IQKPQGLDPV EILQEREYRL QARIAHRIQE 
    LENLPGSLPP DLRTKATVEL KALRLLNFQR QLRQEVVACM RRDTTLETAL NSKAYKRSKR 
    QTLREARMTE KLEKQQKIEQ ERKRRQKHQE YLNSILQHAK DFKEYHRSVA GKIQKLSKAV 
    ATWHANTERE QKKETERIEK ERMRRLMAED EEGYRKLIDQ KKDRRLAYLL QQTDEYVANL 
    TNLVWEHKQA QAAKEKKKRR RRKKKAEENA EGGESALGPD GEPIDESSQM SDLPVKVTHT 
    ETGKVLFGPE APKASQLDAW LEMNPGYEVA PRSDSEESDS DYEEEDEEEE SSRQETEEKI 
    LLDPNSEEVS EKDAKQIIET AKQDVDDEYS MQYSARGSQS YYTVAHAISE RVEKQSALLI 
    NGTLKHYQLQ GLEWMVSLYN NNLNGILADE MGLGKTIQTI ALITYLMEHK RLNGPYLIIV 
    PLSTLSNWTY EFDKWAPSVV KISYKGTPAM RRSLVPQLRS GKFNVLLTTY EYIIKDKHIL 
    AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH YVAPRRILLT GTPLQNKLPE LWALLNFLLP 
    TIFKSCSTFE QWFNAPFAMT GERVDLNEEE TILIIRRLHK VLRPFLLRRL KKEVESQLPE 
    KVEYVIKCDM SALQKILYRH MQAKGILLTD GSEKDKKGKG GAKTLMNTIM QLRKICNHPY 
    MFQHIEESFA EHLGYSNGVI NGAELYRASG KFELLDRILP KLRATNHRVL LFCQMTSLMT 
    IMEDYFAFRN FLYLRLDGTT KSEDRAALLK KFNEPGSQYF IFLLSTRAGG LGLNLQAADT 
    VVIFDSDWNP HQDLQAQDRA HRIGQQNEVR VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ 
    AGMFDQKSSS HERRAFLQAI LEHEEENEEE DEVPDDETLN QMIARREEEF DLFMRMDMDR 
    RREDARNPKR KPRLMEEDEL PSWIIKDDAE VERLTCEEEE EKIFGRGSRQ RRDVDYSDAL 
    TEKQWLRAIE DGNLEEMEEE VRLKKRKRRR NVDKDPAKED VEKAKKRRGR PPAEKLSPNP 
    PKLTKQMNAI IDTVINYKDR CNVEKVPSNS QLEIEGNSSG RQLSEVFIQL PSRKELPEYY 
    ELIRKPVDFK KIKERIRNHK YRSLGDLEKD VMLLCHNAQT FNLEGSQIYE DSIVLQSVFK 
    SARQKIAKEE ESEDESNEEE EEEDEEESES EAKSVKVKIK LNKKDDKGRD KGKGKKRPNR 
    GKAKPVVSDF DSDEEQDERE QSEGSGTDDE

Genular Protein ID: 1263460578

Symbol: F6T8Q0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 248
  • Mass: 28895
  • Checksum: 19A66DF2CA2CB948
  • Sequence:
  • MWLAIEDGNL EEMEEEVRLK KRKRRRNVDK DPAKEDVEKA KKRRGRPPAE KLSPNPPKLT 
    KQMNAIIDTV INYKDSSGRQ LSEVFIQLPS RKELPEYYEL IRKPVDFKKI KERIRNHKYR 
    SLGDLEKDVM LLCHNAQTFN LEGSQIYEDS IVLQSVFKSA RQKIAKEEES EDESNEEEEE 
    EDEEESESEA KSVKVKIKLN KKDDKGRDKG KGKKRPNRGK AKPVVSDFDS DEEQDEREQS 
    EGSGTDDE

Genular Protein ID: 4008992530

Symbol: B1ALF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 278
  • Mass: 31979
  • Checksum: 5766E7798DBF003B
  • Sequence:
  • MLMKRLAARC FAGLLILSPL TVISDSRPAD SGKAIEDGNL EEMEEEVRLK KRKRRRNVDK 
    DPAKEDVEKA KKRRGRPPAE KLSPNPPKLT KQMNAIIDTV INYKDSSGRQ LSEVFIQLPS 
    RKELPEYYEL IRKPVDFKKI KERIRNHKYR SLGDLEKDVM LLCHNAQTFN LEGSQIYEDS 
    IVLQSVFKSA RQKIAKEEES EDESNEEEEE EDEEESESEA KSVKVKIKLN KKDDKGRDKG 
    KGKKRPNRGK AKPVVSDFDS DEEQDEREQS EGSGTDDE

Genular Protein ID: 2713643219

Symbol: Q56A76_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 298
  • Mass: 31141
  • Checksum: 61E0203031C27DF5
  • Sequence:
  • MSTPTDPGAM PHPGPSPGPG PSPGPILGPS PGPGPSPGSV HSMMGPSPGP PSVSHPMPTM 
    GSTDFPQEGM HQMHKPIDGI HDKGIVEDIH CGSMKGTGMR PPHPGMGPPQ SPMDQHSQGY 
    MSPHPSPLGA PEHVSSPMSG GGPTPPQMPP SQPGALIPGD PQAMSQPNRG PSPFSPVQLH 
    QLRAQILAYK MLARGQPLPE TLQLAVQGKR TLPGLQQQQQ QQQQQQQQQQ QQQQQQQQPQ 
    QQPPQPQTQQ QQQPALVNYN RPSGPGPELS GPSTPQKLPV PAPGGRPSPA PPAAAQPP

Genular Protein ID: 814879460

Symbol: F6VDE0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1514
  • Mass: 172592
  • Checksum: 77255AC165E51BE0
  • Sequence:
  • MSTPTDPGAM PHPGPSPGPG PSPGPILGPS PGPGPSPGSV HSMMGPSPGP PSVSHPMPTM 
    GSTDFPQEGM HQMHKPIDGI HDKGIVEDIH CGSMKGTGMR PPHPGMGPPQ SPMDQHSQGY 
    MSPHPSPLGA PEHVSSPMSG GGPTPPQMPP SQPGALIPGD PQAMSQPNRG PSPFSPVQLH 
    QLRAQILAYK MLARGQPLPE TLQLAVQGKR TLPGLQQQQQ QQQQQQQQQQ QQQQQQQQPQ 
    QQPPQPQTQQ QQQPALVNYN RPSGPGPELS GPSTPQKLPV PAPGGRPSPA PPAAAQPPAA 
    AVPGPSVPQP APGQPSPVLQ LQQKQSRISP IQKPQGLDPV EILQEREYRL QARIAHRIQE 
    LENLPGSLPP DLRTKATVEL KALRLLNFQR QLRQEVVACM RRDTTLETAL NSKAYKRSKR 
    QTLREARMTE KLEKQQKIEQ ERKRRQKHQE YLNSILQHAK DFKEYHRSVA GKIQKLSKAV 
    ATWHANTERE QKKETERIEK ERMRRLMAED EEGYRKLIDQ KKDRRLAYLL QQTDEYVANL 
    TNLVWEHKQA QAAKEKKKRR RRKKKAEENA EGGESALGPD GEPIDESSQM SDLPVKVTHT 
    ETGKVLFGPE APKASQLDAW LEMNPGYEVA PRSDSEESDS DYEEEDEEEE SSRQETEEKI 
    LLDPNSEEVS EKDAKQIIET AKQDVDDEYS MQYSARGSQS YYTVAHAISE RVEKQSALLI 
    NGTLKHYQLQ GLEWMVSLYN NNLNGILADE MGLGKTIQTI ALITYLMEHK RLNGPYLIIV 
    PLSTLSNWTY EFDKWAPSVV KISYKGTPAM RRSLVPQLRS GKFNVLLTTY EYIIKDKHIL 
    AKIRWKYMIV DEGHRMKNHH CKLTQVDLNE EETILIIRRL HKVLRPFLLR RLKKEVESQL 
    PEKVEYVIKC DMSALQKILY RHMQAKGILL TDGSEKDKKG KGGAKTLMNT IMQLRKICNH 
    PYMFQHIEES FAEHLGYSNG VINGAELYRA SGKFELLDRI LPKLRATNHR VLLFCQMTSL 
    MTIMEDYFAF RNFLYLRLDG TTKSEDRAAL LKKFNEPGSQ YFIFLLSTRA GGLGLNLQAA 
    DTVVIFDSDW NPHQDLQAQD RAHRIGQQNE VRVLRLCTVN SVEEKILAAA KYKLNVDQKV 
    IQAGMFDQKS SSHERRAFLQ AILEHEEENE EEDEVPDDET LNQMIARREE EFDLFMRMDM 
    DRRREDARNP KRKPRLMEED ELPSWIIKDD AEVERLTCEE EEEKIFGRGS RQRRDVDYSD 
    ALTEKQWLRA IEDGNLEEME EEVRLKKRKR RRNVDKDPAK EDVEKAKKRR GRPPAEKLSP 
    NPPKLTKQMN AIIDTVINYK DSSGRQLSEV FIQLPSRKEL PEYYELIRKP VDFKKIKERI 
    RNHKYRSLGD LEKDVMLLCH NAQTFNLEGS QIYEDSIVLQ SVFKSARQKI AKEEESEDES 
    NEEEEEEDEE ESESEAKSVK VKIKLNKKDD KGRDKGKGKK RPNRGKAKPV VSDFDSDEEQ 
    DEREQSEGSG TDDE

Genular Protein ID: 1705852360

Symbol: B4DNT1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 276
  • Mass: 31735
  • Checksum: E7B935AD63F97B42
  • Sequence:
  • MKRLAARCFA GLLILSPLTV ISDSRPADSG KAIEDGNLEE MEEEVRLKKR KRRRNVDKDP 
    AKEDVEKAKK RRGRPPAEKL SPNPPKLTKQ MNAIIDTVIN YKDSSGRQLS EVFIQLPSRK 
    ELPEYYELIR KPVDFKKIKE RIRNHKYRSL GDLEKDVMLL CHNAQTFNLE GSQIYEDSIV 
    LQSVFKSARQ KIAKEEESED ESNEEEEEED EEESESEAKS VKVKIKLNKK DDKGRDKGKG 
    KKRPNRGKAK PVVSDFDSDE EQDEREQSEG SGTDDE

Genular Protein ID: 1422371905

Symbol: Q8N9Q1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 278
  • Mass: 31993
  • Checksum: A7BD8AC0C9789669
  • Sequence:
  • MLMKRLAARC FAGLLILSPL TVISDSRPAD SGKAIEDGDL EEMEEEVRLK KRKRRRNVDK 
    DPAKEDVEKA KKRRGRPPAE KLSPNPPKLT KQMNAIIDTV INYKDSSGRQ LSEVFIQLPS 
    RKELPEYYEL IRKPVDFKKI KERIRNHKYR SLGDLEKDVM LLCHNAQTFN LEGSQIYEDS 
    IVLQSVFKSA RQKIAKEEES EDESNEEEEE KDEEESESEA KSVKVKIKLN KKDEKGRDKG 
    KGKKRPNRGK AKPVVSDFDS DEEQDEREQS EGSGTDDE

Genular Protein ID: 1214930230

Symbol: B4DSC8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 715
  • Mass: 83454
  • Checksum: 164EFED89D0591D8
  • Sequence:
  • MVSLYNNNLN GILADEMGLG KTIQTIALIT YLMEHKRLNG PYLIIVPLST LSNWTYEFDK 
    WAPSVVKISY KGTPAMRRSL VPQLRSGKFN VLLTTYEYII KDKHILAKIR WKYMIVDEGH 
    RMKNHHCKLT QVLNTHYVAP RRILLTGTPL QNKLPELWAL LNFLLPTIFK SCSTFEQWFN 
    APFAMTGERV DLNEEETILI IRRLHKVLRP FLLRRLKKEV ESQLPEKVEY VIKCDMSALQ 
    KILYRHMQAK GILLTDGSEK DKKGKGGAKT LMNTIMQLRK ICNHPYMFQH IEESFAEHLG 
    YSNGVINGAE LYRASGKFEL LDRILPKLRA TNHRVLLFCQ MTSLMTIMED YFAFRNFLYL 
    RLDGTTKSED RAALLKKFNE PGSQYFIFLL STRAGGLGLN LQAADTVVIF DSDWNPHQDL 
    QAQDRAHRIG QQNEVRVLRL CTVNSVEEKI LAAAKYKLNV DQKVIQAGMF DQKSSSHERR 
    AFLQAILEHE EENEEEDEVP DDETLNQMIA RREEEFDLFM RMDMDRRRED ARNPKRKPRL 
    MEEDELPSWI IKDDAEVGRL TCEEEEEKIF GRGSRQRRDV DYSDALTEKQ WLRAIEDGNL 
    EEMEEEVRLK KRKRRRNVDK DPAKEDVEKA KKRRGRPPAE KLSPNPPKLT KQMNAIIDTV 
    INYKDRCNVE KVPSNSQLEI EGNSSGRQLS EVFIQLPSRK ELPEYYELIR KPVDF