Details for: SMARCC2

Gene ID: 6601

Symbol: SMARCC2

Ensembl ID: ENSG00000139613

Description: SWI/SNF related BAF chromatin remodeling complex subunit C2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 222.2826
    Cell Significance Index: -34.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 128.6846
    Cell Significance Index: -32.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 82.6268
    Cell Significance Index: -39.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 74.4092
    Cell Significance Index: -38.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.7513
    Cell Significance Index: -37.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.9794
    Cell Significance Index: -34.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.9265
    Cell Significance Index: -21.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.7908
    Cell Significance Index: -38.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.3897
    Cell Significance Index: -28.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.9391
    Cell Significance Index: 225.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6841
    Cell Significance Index: 273.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3095
    Cell Significance Index: 259.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2872
    Cell Significance Index: 140.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2048
    Cell Significance Index: 32.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1804
    Cell Significance Index: 212.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0603
    Cell Significance Index: 212.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0280
    Cell Significance Index: 126.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9256
    Cell Significance Index: 127.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8321
    Cell Significance Index: 43.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8236
    Cell Significance Index: 43.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7380
    Cell Significance Index: 45.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6614
    Cell Significance Index: 15.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6571
    Cell Significance Index: 42.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6440
    Cell Significance Index: 44.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6397
    Cell Significance Index: 18.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6083
    Cell Significance Index: 13.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5678
    Cell Significance Index: 19.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5345
    Cell Significance Index: 11.5800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5241
    Cell Significance Index: 12.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5234
    Cell Significance Index: 67.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5117
    Cell Significance Index: 462.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5093
    Cell Significance Index: 352.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5087
    Cell Significance Index: 6.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4854
    Cell Significance Index: 174.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4578
    Cell Significance Index: 250.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4347
    Cell Significance Index: 19.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4333
    Cell Significance Index: 27.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4176
    Cell Significance Index: 49.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3459
    Cell Significance Index: 23.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3385
    Cell Significance Index: 149.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3329
    Cell Significance Index: 18.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3163
    Cell Significance Index: 8.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2880
    Cell Significance Index: 13.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1821
    Cell Significance Index: 18.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1805
    Cell Significance Index: 13.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1715
    Cell Significance Index: 4.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1455
    Cell Significance Index: 7.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1318
    Cell Significance Index: 3.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1273
    Cell Significance Index: 9.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1062
    Cell Significance Index: 3.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1040
    Cell Significance Index: 11.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0984
    Cell Significance Index: 4.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0686
    Cell Significance Index: 8.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0508
    Cell Significance Index: 8.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0243
    Cell Significance Index: 4.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0210
    Cell Significance Index: 0.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0098
    Cell Significance Index: 7.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0082
    Cell Significance Index: -15.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0088
    Cell Significance Index: -16.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0126
    Cell Significance Index: -9.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0161
    Cell Significance Index: -24.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0245
    Cell Significance Index: -15.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0278
    Cell Significance Index: -37.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0308
    Cell Significance Index: -17.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0356
    Cell Significance Index: -26.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0459
    Cell Significance Index: -4.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0496
    Cell Significance Index: -31.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0598
    Cell Significance Index: -1.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0744
    Cell Significance Index: -33.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0773
    Cell Significance Index: -5.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0939
    Cell Significance Index: -19.7700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1012
    Cell Significance Index: -0.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1145
    Cell Significance Index: -32.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1363
    Cell Significance Index: -1.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1863
    Cell Significance Index: -3.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1916
    Cell Significance Index: -3.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2071
    Cell Significance Index: -5.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2084
    Cell Significance Index: -23.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2356
    Cell Significance Index: -34.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2360
    Cell Significance Index: -7.5600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2561
    Cell Significance Index: -5.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2569
    Cell Significance Index: -7.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3630
    Cell Significance Index: -37.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4071
    Cell Significance Index: -32.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4337
    Cell Significance Index: -11.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4566
    Cell Significance Index: -12.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4607
    Cell Significance Index: -11.7700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4972
    Cell Significance Index: -6.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5141
    Cell Significance Index: -5.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5173
    Cell Significance Index: -14.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5235
    Cell Significance Index: -11.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5331
    Cell Significance Index: -9.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5678
    Cell Significance Index: -34.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6417
    Cell Significance Index: -16.0400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6523
    Cell Significance Index: -9.6300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.6575
    Cell Significance Index: -8.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6694
    Cell Significance Index: -7.9800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6783
    Cell Significance Index: -9.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7043
    Cell Significance Index: -22.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7172
    Cell Significance Index: -23.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Chromatin Remodeling:** SMARCC2 is a key component of the SWI/SNF complex, which is a highly conserved family of chromatin remodeling enzymes. These enzymes play a crucial role in regulating gene expression by altering chromatin structure and accessibility to transcription factors. 2. **Transcription Regulation:** SMARCC2 is involved in the regulation of transcription by interacting with transcription factors and co-activators. It also plays a role in the regulation of RNA polymerase II-dependent transcription. 3. **Cell Differentiation:** SMARCC2 is required for the proper differentiation of various cell types, including myeloid dendritic cells, Purkinje cells, and skeletal muscle satellite stem cells. 4. **DNA Repair:** SMARCC2 is involved in the regulation of DNA repair pathways, including non-homologous end joining (NHEJ) and homologous recombination (HR). 5. **Cancer Association:** SMARCC2 has been implicated in several types of cancer, including breast, lung, and colon cancer, where it is often found to be mutated or deleted. **Pathways and Functions:** 1. **Brahma Complex:** SMARCC2 is a subunit of the Brahma complex, which is a chromatin remodeling enzyme that plays a critical role in the regulation of gene expression and cell cycle progression. 2. **Chromatin Organization:** SMARCC2 is involved in the organization of chromatin structure and the regulation of chromatin remodeling enzymes. 3. **Gene Expression (Transcription):** SMARCC2 is required for the regulation of gene expression by interacting with transcription factors and co-activators. 4. **Histone Binding:** SMARCC2 binds to histones and regulates their turnover and modification. 5. **Kinetochore Function:** SMARCC2 is required for the proper formation and function of the kinetochore, a protein structure that plays a critical role in chromosome segregation during mitosis. **Clinical Significance:** 1. **Cancer Therapy:** SMARCC2 is a potential therapeutic target for the treatment of cancer, as its dysregulation has been implicated in several types of cancer. 2. **Neurological Disorders:** SMARCC2 has been implicated in several neurological disorders, including autism, schizophrenia, and Alzheimer's disease. 3. **Autoimmune Conditions:** SMARCC2 has been implicated in several autoimmune conditions, including multiple sclerosis and rheumatoid arthritis. 4. **Genetic Disorders:** SMARCC2 mutations have been identified in several genetic disorders, including Fanconi anemia and Bloom syndrome. In conclusion, SMARCC2 is a critical gene that plays a key role in various cellular processes, including chromatin remodeling, transcription regulation, and cell differentiation. Its dysregulation has been implicated in several diseases, including cancer, neurological disorders, and autoimmune conditions. Further research is needed to fully understand the function and clinical significance of SMARCC2.

Genular Protein ID: 1220871660

Symbol: SMRC2_HUMAN

Name: SWI/SNF complex subunit SMARCC2

UniProtKB Accession Codes:

Q8TAQ2 F8VTJ5 Q59GV3 Q92923 Q96E12 Q96GY4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 30 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 3 Ensembl 3 ExpressionAtlas 1 GO 27 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8804307

Title: Diversity and specialization of mammalian SWI/SNF complexes.

PubMed ID: 8804307

DOI: 10.1101/gad.10.17.2117

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10078207

Title: Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.

PubMed ID: 10078207

DOI: 10.1016/s1097-2765(00)80315-9

PubMed ID: 11018012

Title: Functional selectivity of recombinant mammalian SWI/SNF subunits.

PubMed ID: 11018012

DOI: 10.1101/gad.828000

PubMed ID: 11238380

Title: Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes.

PubMed ID: 11238380

DOI: 10.1101/gad.872801

PubMed ID: 12192000

Title: REST repression of neuronal genes requires components of the hSWI.SNF complex.

PubMed ID: 12192000

DOI: 10.1074/jbc.m205691200

PubMed ID: 12917342

Title: BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.

PubMed ID: 12917342

DOI: 10.1128/mcb.23.17.6210-6220.2003

PubMed ID: 18765789

Title: Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.

PubMed ID: 18765789

DOI: 10.1101/gad.471408

PubMed ID: 22952240

Title: SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions.

PubMed ID: 22952240

DOI: 10.1074/jbc.r111.309302

PubMed ID: 24874740

Title: The cockayne syndrome B protein is essential for neuronal differentiation and neuritogenesis.

PubMed ID: 24874740

DOI: 10.1038/cddis.2014.228

PubMed ID: 26601204

Title: Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.

PubMed ID: 26601204

DOI: 10.1126/sciadv.1500447

PubMed ID: 28533407

Title: Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.

PubMed ID: 28533407

DOI: 10.1073/pnas.1700328114

PubMed ID: 30580808

Title: Expanding the Spectrum of BAF-Related Disorders: De Novo Variants in SMARCC2 Cause a Syndrome with Intellectual Disability and Developmental Delay.

PubMed ID: 30580808

DOI: 10.1016/j.ajhg.2018.11.007

Sequence Information:

  • Length: 1214
  • Mass: 132879
  • Checksum: EEFC1042A9296320
  • Sequence:
    • MAVRKKDGGP NVKYYEAADT VTQFDNVRLW LGKNYKKYIQ AEPPTNKSLS SLVVQLLQFQ 
EEVFGKHVSN APLTKLPIKC FLDFKAGGSL CHILAAAYKF KSDQGWRRYD FQNPSRMDRN 
VEMFMTIEKS LVQNNCLSRP NIFLCPEIEP KLLGKLKDII KRHQGTVTED KNNASHVVYP 
VPGNLEEEEW VRPVMKRDKQ VLLHWGYYPD SYDTWIPASE IEASVEDAPT PEKPRKVHAK 
WILDTDTFNE WMNEEDYEVN DDKNPVSRRK KISAKTLTDE VNSPDSDRRD KKGGNYKKRK 
RSPSPSPTPE AKKKNAKKGP STPYTKSKRG HREEEQEDLT KDMDEPSPVP NVEEVTLPKT 
VNTKKDSESA PVKGGTMTDL DEQEDESMET TGKDEDENST GNKGEQTKNP DLHEDNVTEQ 
THHIIIPSYA AWFDYNSVHA IERRALPEFF NGKNKSKTPE IYLAYRNFMI DTYRLNPQEY 
LTSTACRRNL AGDVCAIMRV HAFLEQWGLI NYQVDAESRP TPMGPPPTSH FHVLADTPSG 
LVPLQPKTPQ QTSASQQMLN FPDKGKEKPT DMQNFGLRTD MYTKKNVPSK SKAAASATRE 
WTEQETLLLL EALEMYKDDW NKVSEHVGSR TQDECILHFL RLPIEDPYLE DSEASLGPLA 
YQPIPFSQSG NPVMSTVAFL ASVVDPRVAS AAAKSALEEF SKMKEEVPTA LVEAHVRKVE 
EAAKVTGKAD PAFGLESSGI AGTTSDEPER IEESGNDEAR VEGQATDEKK EPKEPREGGG 
AIEEEAKEKT SEAPKKDEEK GKEGDSEKES EKSDGDPIVD PEKEKEPKEG QEEVLKEVVE 
SEGERKTKVE RDIGEGNLST AAAAALAAAA VKAKHLAAVE ERKIKSLVAL LVETQMKKLE 
IKLRHFEELE TIMDREREAL EYQRQQLLAD RQAFHMEQLK YAEMRARQQH FQQMHQQQQQ 
PPPALPPGSQ PIPPTGAAGP PAVHGLAVAP ASVVPAPAGS GAPPGSLGPS EQIGQAGSTA 
GPQQQQPAGA PQPGAVPPGV PPPGPHGPSP FPNQQTPPSM MPGAVPGSGH PGVAGNAPLG 
LPFGMPPPPP PPAPSIIPFG SLADSISINL PAPPNLHGHH HHLPFAPGTL PPPNLPVSMA 
NPLHPNLPAT TTMPSSLPLG PGLGSAAAQS PAIVAAVQGN LLPSASPLPD PGTPLPPDPT 
APSPGTVTPV PPPQ

Genular Protein ID: 2895219963

Symbol: F8VXC8_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8VXC8

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneTree 1 HGNC 1 IntAct 1 InterPro 11 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 5 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1245
  • Mass: 136184
  • Checksum: FEEF5643D15E712C
  • Sequence:
    • MAVRKKDGGP NVKYYEAADT VTQFDNVRLW LGKNYKKYIQ AEPPTNKSLS SLVVQLLQFQ 
EEVFGKHVSN APLTKLPIKC FLDFKAGGSL CHILAAAYKF KSDQGWRRYD FQNPSRMDRN 
VEMFMTIEKS LVQNNCLSRP NIFLCPEIEP KLLGKLKDII KRHQGTVTED KNNASHVVYP 
VPGNLEEEEW VRPVMKRDKQ VLLHWGYYPD SYDTWIPASE IEASVEDAPT PEKPRKVHAK 
WILDTDTFNE WMNEEDYEVN DDKNPVSRRK KISAKTLTDE VNSPDSDRRD KKGGNYKKRK 
RSPSPSPTPE AKKKNAKKGP STPYTKSKRG HREEEQEDLT KDMDEPSPVP NVEEVTLPKT 
VNTKKDSESA PVKGGTMTDL DEQEDESMET TGKDEDENST GNKGEQTKNP DLHEDNVTEQ 
THHIIIPSYA AWFDYNSVHA IERRALPEFF NGKNKSKTPE IYLAYRNFMI DTYRLNPQEY 
LTSTACRRNL AGDVCAIMRV HAFLEQWGLI NYQVDAESRP TPMGPPPTSH FHVLADTPSG 
LVPLQPKTPQ GRQVDADTKA GRKGKELDDL VPETAKGKPE LQTSASQQML NFPDKGKEKP 
TDMQNFGLRT DMYTKKNVPS KSKAAASATR EWTEQETLLL LEALEMYKDD WNKVSEHVGS 
RTQDECILHF LRLPIEDPYL EDSEASLGPL AYQPIPFSQS GNPVMSTVAF LASVVDPRVA 
SAAAKSALEE FSKMKEEVPT ALVEAHVRKV EEAAKVTGKA DPAFGLESSG IAGTTSDEPE 
RIEESGNDEA RVEGQATDEK KEPKEPREGG GAIEEEAKEK TSEAPKKDEE KGKEGDSEKE 
SEKSDGDPIV DPEKEKEPKE GQEEVLKEVV ESEGERKTKV ERDIGEGNLS TAAAAALAAA 
AVKAKHLAAV EERKIKSLVA LLVETQMKKL EIKLRHFEEL ETIMDREREA LEYQRQQLLA 
DRQAFHMEQL KYAEMRARQQ HFQQMHQQQQ QPPPALPPGS QPIPPTGAAG PPAVHGLAVA 
PASVVPAPAG SGAPPGSLGP SEQIGQAGST AGPQQQQPAG APQPGAVPPG VPPPGPHGPS 
PFPNQQTPPS MMPGAVPGSG HPGVAGNAPL GLPFGMPPPP PPPAPSIIPF GSLADSISIN 
LPAPPNLHGH HHHLPFAPGT LPPPNLPVSM ANPLHPNLPA TTTMPSSLPL GPGLGSAAAQ 
SPAIVAAVQG NLLPSASPLP DPGTPLPPDP TAPSPGTVTP VPPPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.