Details for: SMARCD2

Gene ID: 6603

Symbol: SMARCD2

Ensembl ID: ENSG00000108604

Description: SWI/SNF related BAF chromatin remodeling complex subunit D2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 134.9768
    Cell Significance Index: -21.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 77.1556
    Cell Significance Index: -19.5700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 53.7690
    Cell Significance Index: -22.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 41.1170
    Cell Significance Index: -21.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.5919
    Cell Significance Index: -21.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5965
    Cell Significance Index: -20.3500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 6.1788
    Cell Significance Index: 13.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.7252
    Cell Significance Index: -12.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.5701
    Cell Significance Index: -21.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.8680
    Cell Significance Index: 39.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.7262
    Cell Significance Index: 188.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4932
    Cell Significance Index: 162.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0132
    Cell Significance Index: 47.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0081
    Cell Significance Index: 71.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9279
    Cell Significance Index: 59.8700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7998
    Cell Significance Index: 7.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7910
    Cell Significance Index: 21.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7327
    Cell Significance Index: 119.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7123
    Cell Significance Index: 19.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6857
    Cell Significance Index: 303.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6774
    Cell Significance Index: 18.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6578
    Cell Significance Index: 34.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6422
    Cell Significance Index: 115.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6326
    Cell Significance Index: 571.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5554
    Cell Significance Index: 76.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5381
    Cell Significance Index: 66.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4985
    Cell Significance Index: 10.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4822
    Cell Significance Index: 95.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4803
    Cell Significance Index: 262.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4645
    Cell Significance Index: 11.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4236
    Cell Significance Index: 54.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4163
    Cell Significance Index: 11.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4027
    Cell Significance Index: 76.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3857
    Cell Significance Index: 8.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3683
    Cell Significance Index: 17.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3533
    Cell Significance Index: 10.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3310
    Cell Significance Index: 66.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2162
    Cell Significance Index: 21.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1888
    Cell Significance Index: 22.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1525
    Cell Significance Index: 54.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1519
    Cell Significance Index: 7.6800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1265
    Cell Significance Index: 0.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0763
    Cell Significance Index: 13.0300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0635
    Cell Significance Index: 1.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0469
    Cell Significance Index: 1.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0459
    Cell Significance Index: 3.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0459
    Cell Significance Index: 3.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0349
    Cell Significance Index: 2.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0205
    Cell Significance Index: 38.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0139
    Cell Significance Index: 21.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0124
    Cell Significance Index: 16.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0113
    Cell Significance Index: 20.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0091
    Cell Significance Index: 0.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0001
    Cell Significance Index: 0.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0008
    Cell Significance Index: -0.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0142
    Cell Significance Index: -10.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0252
    Cell Significance Index: -18.6900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0259
    Cell Significance Index: -0.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0265
    Cell Significance Index: -12.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0289
    Cell Significance Index: -3.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0291
    Cell Significance Index: -0.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0352
    Cell Significance Index: -5.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0368
    Cell Significance Index: -22.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0374
    Cell Significance Index: -21.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0580
    Cell Significance Index: -0.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0595
    Cell Significance Index: -1.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0607
    Cell Significance Index: -6.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0628
    Cell Significance Index: -18.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0665
    Cell Significance Index: -7.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0843
    Cell Significance Index: -2.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0927
    Cell Significance Index: -4.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0971
    Cell Significance Index: -11.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1128
    Cell Significance Index: -23.7700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1304
    Cell Significance Index: -1.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1396
    Cell Significance Index: -2.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1533
    Cell Significance Index: -10.3100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1835
    Cell Significance Index: -1.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1902
    Cell Significance Index: -19.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2169
    Cell Significance Index: -13.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2184
    Cell Significance Index: -5.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2288
    Cell Significance Index: -18.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2299
    Cell Significance Index: -12.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2443
    Cell Significance Index: -8.4900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2474
    Cell Significance Index: -3.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2486
    Cell Significance Index: -3.7300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2496
    Cell Significance Index: -3.9600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2641
    Cell Significance Index: -3.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2762
    Cell Significance Index: -14.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2990
    Cell Significance Index: -18.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3235
    Cell Significance Index: -16.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3649
    Cell Significance Index: -10.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3711
    Cell Significance Index: -9.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3738
    Cell Significance Index: -11.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3751
    Cell Significance Index: -16.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3832
    Cell Significance Index: -8.0200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3886
    Cell Significance Index: -5.5800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3980
    Cell Significance Index: -3.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4270
    Cell Significance Index: -12.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4389
    Cell Significance Index: -16.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4497
    Cell Significance Index: -17.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SMARCD2 is a member of the SWI/SNF family of proteins, which are characterized by their ability to remodel chromatin structure and regulate gene expression. The SMARCD2 protein has a unique structure, containing actin-binding domains and a histone-binding domain, which allows it to interact with chromatin and regulate transcription. SMARCD2 has been shown to interact with various transcription factors and co-regulators, including Runx1, and plays a role in regulating cell differentiation, DNA repair, and transcriptional regulation. **Pathways and Functions** SMARCD2 is involved in several cellular pathways, including: 1. **Chromatin Remodeling**: SMARCD2 regulates chromatin structure by interacting with histones and other chromatin-associated proteins, allowing for changes in gene expression and transcriptional regulation. 2. **Transcription Regulation**: SMARCD2 interacts with transcription factors and co-regulators, such as Runx1, to regulate gene expression and transcriptional regulation. 3. **DNA Repair**: SMARCD2 plays a role in regulating DNA repair pathways, including double-strand break repair and nucleotide-excision repair. 4. **Cell Differentiation**: SMARCD2 is involved in regulating cell differentiation, including myoblast differentiation and T-cell differentiation. 5. **Mitotic Cell Cycle Regulation**: SMARCD2 regulates the mitotic cell cycle, including the G0 to G1 transition, G1/S transition, and mitotic metaphase/anaphase transition. **Clinical Significance** SMARCD2 has been implicated in various diseases, including: 1. **Cancer**: SMARCD2 has been shown to be overexpressed in various types of cancer, including leukemia, lymphoma, and breast cancer, suggesting its potential role in tumorigenesis. 2. **Neurological Disorders**: SMARCD2 has been implicated in neurological disorders, including autism spectrum disorder and schizophrenia, suggesting its potential role in regulating gene expression and brain development. 3. **Immunological Disorders**: SMARCD2 has been shown to play a role in regulating immune responses, including T-cell differentiation and activation, suggesting its potential role in immunological disorders, such as autoimmune diseases. In conclusion, SMARCD2 is a critical gene involved in chromatin remodeling, transcription regulation, and DNA repair. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target for the treatment of cancer, neurological disorders, and immunological disorders. Further studies are needed to fully elucidate the role of SMARCD2 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 135418669

Symbol: SMRD2_HUMAN

Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

UniProtKB Accession Codes:

Q92925 A5PLL5 A6NNQ7 B4DV56 B4E1R6 Q7L2I6 Q9UHZ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 22 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8804307

Title: Diversity and specialization of mammalian SWI/SNF complexes.

PubMed ID: 8804307

DOI: 10.1101/gad.10.17.2117

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20148946

Title: The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt.

PubMed ID: 20148946

DOI: 10.1111/j.1742-4658.2010.07575.x

PubMed ID: 18765789

Title: Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.

PubMed ID: 18765789

DOI: 10.1101/gad.471408

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 22952240

Title: SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions.

PubMed ID: 22952240

DOI: 10.1074/jbc.r111.309302

PubMed ID: 26601204

Title: Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.

PubMed ID: 26601204

DOI: 10.1126/sciadv.1500447

PubMed ID: 28369036

Title: Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes.

PubMed ID: 28369036

DOI: 10.1038/ng.3833

Sequence Information:

  • Length: 531
  • Mass: 58921
  • Checksum: 8C92168AE7782814
  • Sequence:
    • MSGRGAGGFP LPPLSPGGGA VAAALGAPPP PAGPGMLPGP ALRGPGPAGG VGGPGAAAFR 
PMGPAGPAAQ YQRPGMSPGN RMPMAGLQVG PPAGSPFGAA APLRPGMPPT MMDPFRKRLL 
VPQAQPPMPA QRRGLKRRKM ADKVLPQRIR ELVPESQAYM DLLAFERKLD QTIARKRMEI 
QEAIKKPLTQ KRKLRIYISN TFSPSKAEGD SAGTAGTPGG TPAGDKVASW ELRVEGKLLD 
DPSKQKRKFS SFFKSLVIEL DKELYGPDNH LVEWHRMPTT QETDGFQVKR PGDLNVKCTL 
LLMLDHQPPQ YKLDPRLARL LGVHTQTRAA IMQALWLYIK HNQLQDGHER EYINCNRYFR 
QIFSCGRLRF SEIPMKLAGL LQHPDPIVIN HVISVDPNDQ KKTACYDIDV EVDDPLKAQM 
SNFLASTTNQ QEIASLDVKI HETIESINQL KTQRDFMLSF STDPQDFIQE WLRSQRRDLK 
IITDVIGNPE EERRAAFYHQ PWAQEAVGRH IFAKVQQRRQ ELEQVLGIRL T

Genular Protein ID: 183195268

Symbol: J3KMX2_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KMX2

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 456
  • Mass: 52238
  • Checksum: 8C2885A1EAC8CA10
  • Sequence:
    • MSPGNRMPMA GLQVGPPAGS PFGAAAPLRP GMPPTMMDPF RKRLLVPQAQ PPMPAQRRGL 
KRRKMADKVL PQRIRELVPE SQAYMDLLAF ERKLDQTIAR KRMEIQEAIK KPLTQKRKLR 
IYISNTFSPS KAEGDSAGTA GTPGGTPAGD KVASWELRVE GKLLDDPSKQ KRKFSSFFKS 
LVIELDKELY GPDNHLVEWH RMPTTQETDG FQVKRPGDLN VKCTLLLMLD HQPPQYKLDP 
RLARLLGVHT QTRAAIMQAL WLYIKHNQLQ DGHEREYINC NRYFRQIFSC GRLRFSEIPM 
KLAGLLQHPD PIVINHVISV DPNDQKKTAC YDIDVEVDDP LKAQMSNFLA STTNQQEIAS 
LDVKIHETIE SINQLKTQRD FMLSFSTDPQ DFIQEWLRSQ RRDLKIITDV IGNPEEERRA 
AFYHQPWAQE AVGRHIFAKV QQRRQELEQV LGIRLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.