SNCA | ENSG00000145335 | NCBI 6622

Details for: SNCA

Gene ID: 6622

Symbol: SNCA

Ensembl ID: ENSG00000145335

Description: synuclein alpha

Associated with

Amyloid fiber formation
(R-HSA-977225)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interferon signaling
(R-HSA-913531)
Metabolism of proteins
(R-HSA-392499)
Pkr-mediated signaling
(R-HSA-9833482)
Actin binding
(GO:0003779)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Adult locomotory behavior
(GO:0008344)
Alpha-tubulin binding
(GO:0043014)
Calcium ion binding
(GO:0005509)
Calcium ion homeostasis
(GO:0055074)
Cellular response to oxidative stress
(GO:0034599)
Chemical synaptic transmission
(GO:0007268)
Copper ion binding
(GO:0005507)
Cuprous ion binding
(GO:1903136)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(GO:0043027)
Dopamine biosynthetic process
(GO:0042416)
Dopamine uptake involved in synaptic transmission
(GO:0051583)
Dynein complex binding
(GO:0070840)
Excitatory postsynaptic potential
(GO:0060079)
Fatty acid binding
(GO:0005504)
Fatty acid metabolic process
(GO:0006631)
Ferrous iron binding
(GO:0008198)
Histone binding
(GO:0042393)
Hsp70 protein binding
(GO:0030544)
Identical protein binding
(GO:0042802)
Kinesin binding
(GO:0019894)
Lipid binding
(GO:0008289)
Long-term synaptic potentiation
(GO:0060291)
Magnesium ion binding
(GO:0000287)
Microglial cell activation
(GO:0001774)
Mitochondrial atp synthesis coupled electron transport
(GO:0042775)
Mitochondrial membrane organization
(GO:0007006)
Molecular adaptor activity
(GO:0060090)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043154)
Negative regulation of dopamine uptake involved in synaptic transmission
(GO:0051585)
Negative regulation of exocytosis
(GO:0045920)
Negative regulation of microtubule polymerization
(GO:0031115)
Negative regulation of monooxygenase activity
(GO:0032769)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of norepinephrine uptake
(GO:0051622)
Negative regulation of platelet-derived growth factor receptor signaling pathway
(GO:0010642)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of serotonin uptake
(GO:0051612)
Negative regulation of thrombin-activated receptor signaling pathway
(GO:0070495)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transporter activity
(GO:0032410)
Neuron apoptotic process
(GO:0051402)
Neutral lipid metabolic process
(GO:0006638)
Oxidoreductase activity
(GO:0016491)
Phospholipase d inhibitor activity
(GO:0060961)
Phospholipid binding
(GO:0005543)
Phospholipid metabolic process
(GO:0006644)
Phosphoprotein binding
(GO:0051219)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of endocytosis
(GO:0045807)
Positive regulation of exocytosis
(GO:0045921)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of inositol phosphate biosynthetic process
(GO:0060732)
Positive regulation of neurotransmitter secretion
(GO:0001956)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of receptor recycling
(GO:0001921)
Positive regulation of release of sequestered calcium ion into cytosol
(GO:0051281)
Positive regulation of snare complex assembly
(GO:0035543)
Protein binding
(GO:0005515)
Protein destabilization
(GO:0031648)
Protein kinase inhibitor activity
(GO:0004860)
Protein tetramerization
(GO:0051262)
Receptor internalization
(GO:0031623)
Regulation of acyl-coa biosynthetic process
(GO:0050812)
Regulation of dopamine secretion
(GO:0014059)
Regulation of glutamate secretion
(GO:0014048)
Regulation of locomotion
(GO:0040012)
Regulation of long-term neuronal synaptic plasticity
(GO:0048169)
Regulation of macrophage activation
(GO:0043030)
Regulation of norepinephrine uptake
(GO:0051621)
Regulation of phospholipase activity
(GO:0010517)
Regulation of transmembrane transporter activity
(GO:0022898)
Response to interleukin-1
(GO:0070555)
Response to iron(ii) ion
(GO:0010040)
Response to lipopolysaccharide
(GO:0032496)
Response to magnesium ion
(GO:0032026)
Response to type ii interferon
(GO:0034341)
Response to xenobiotic stimulus
(GO:0009410)
Snare binding
(GO:0000149)
Snare complex assembly
(GO:0035493)
Synapse organization
(GO:0050808)
Synaptic vesicle endocytosis
(GO:0048488)
Synaptic vesicle exocytosis
(GO:0016079)
Synaptic vesicle priming
(GO:0016082)
Synaptic vesicle transport
(GO:0048489)
Tau protein binding
(GO:0048156)
Transcription cis-regulatory region binding
(GO:0000976)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 102.1513
Cell Significance Index: -25.9100
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 75.2280
Cell Significance Index: -30.9900
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 58.9441
Cell Significance Index: -30.3200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.0334
Cell Significance Index: -36.9600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.8012
Cell Significance Index: -34.7300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.0920
Cell Significance Index: -17.7100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 6.3972
Cell Significance Index: 109.6300
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 3.8740
Cell Significance Index: 40.3600
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 3.6554
Cell Significance Index: 22.6200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.4699
Cell Significance Index: 182.1900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 3.1058
Cell Significance Index: 88.6300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.8114
Cell Significance Index: 1008.4100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.8062
Cell Significance Index: 562.9300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.5120
Cell Significance Index: 111.1100
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.4425
Cell Significance Index: 30.3000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.3441
Cell Significance Index: 157.6200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.3069
Cell Significance Index: 87.3600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.3547
Cell Significance Index: 157.8700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.1826
Cell Significance Index: 225.0600
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 1.1522
Cell Significance Index: 15.3700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.0703
Cell Significance Index: 60.0600
Cell Name: melanocyte of skin (CL1000458)
Fold Change: 0.9571
Cell Significance Index: 13.4200
Cell Name: kidney cell (CL1000497)
Fold Change: 0.8166
Cell Significance Index: 6.5200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8033
Cell Significance Index: 79.4600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.8027
Cell Significance Index: 49.3400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7278
Cell Significance Index: 657.1700
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.4991
Cell Significance Index: 12.7500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3738
Cell Significance Index: 60.8000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3724
Cell Significance Index: 701.2200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3364
Cell Significance Index: 9.4000
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.2043
Cell Significance Index: 4.9000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2032
Cell Significance Index: 22.1100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1864
Cell Significance Index: 286.9900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1762
Cell Significance Index: 31.7600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0814
Cell Significance Index: 51.7100
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0798
Cell Significance Index: 147.2200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0568
Cell Significance Index: 6.9800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0519
Cell Significance Index: 70.5500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0383
Cell Significance Index: 16.9300
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0085
Cell Significance Index: 1.0900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0072
Cell Significance Index: 0.1800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0108
Cell Significance Index: -0.3800
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0160
Cell Significance Index: -8.7200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0206
Cell Significance Index: -15.2400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0222
Cell Significance Index: -0.6400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0269
Cell Significance Index: -1.8600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0372
Cell Significance Index: -16.8900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0384
Cell Significance Index: -2.3600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0386
Cell Significance Index: -28.2900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0423
Cell Significance Index: -23.8800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0435
Cell Significance Index: -32.9000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0555
Cell Significance Index: -34.6400
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0556
Cell Significance Index: -11.0400
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0570
Cell Significance Index: -3.6800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0803
Cell Significance Index: -3.6400
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0858
Cell Significance Index: -0.7000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0917
Cell Significance Index: -2.9200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0999
Cell Significance Index: -28.7300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1008
Cell Significance Index: -13.8400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1168
Cell Significance Index: -2.5300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1187
Cell Significance Index: -12.3600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1314
Cell Significance Index: -13.4200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1389
Cell Significance Index: -4.8300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1577
Cell Significance Index: -33.2200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1610
Cell Significance Index: -23.4100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1871
Cell Significance Index: -5.0100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1967
Cell Significance Index: -10.2200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1990
Cell Significance Index: -33.9800
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.2061
Cell Significance Index: -2.5700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.2127
Cell Significance Index: -12.7700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.2290
Cell Significance Index: -29.5800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2467
Cell Significance Index: -18.9300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2483
Cell Significance Index: -8.1300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2641
Cell Significance Index: -31.1400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2731
Cell Significance Index: -4.5700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2889
Cell Significance Index: -33.1000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3105
Cell Significance Index: -21.9600
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.3194
Cell Significance Index: -3.4800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3247
Cell Significance Index: -10.4000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3609
Cell Significance Index: -28.5800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.4114
Cell Significance Index: -30.6600
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.4191
Cell Significance Index: -5.2900
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.4296
Cell Significance Index: -18.6800
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.4337
Cell Significance Index: -8.5800
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.4761
Cell Significance Index: -4.5300
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.4775
Cell Significance Index: -11.9100
Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: -0.4863
Cell Significance Index: -5.3700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4934
Cell Significance Index: -25.7000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.5110
Cell Significance Index: -10.6000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.5220
Cell Significance Index: -24.5400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5260
Cell Significance Index: -33.1500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.5334
Cell Significance Index: -14.5200
Cell Name: theca cell (CL0000503)
Fold Change: -0.5668
Cell Significance Index: -3.3300
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.5768
Cell Significance Index: -11.5800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5886
Cell Significance Index: -12.5400
Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.5922
Cell Significance Index: -18.7300
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.5955
Cell Significance Index: -13.0400
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.5982
Cell Significance Index: -7.4000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6077
Cell Significance Index: -17.9000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6117
Cell Significance Index: -21.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** Alpha-synuclein is characterized by its: 1. Small size: Alpha-synuclein is a 140-amino acid protein, making it one of the smallest proteins in the human genome. 2. Membrane-associated nature: Alpha-synuclein is primarily expressed in neurons and is associated with the plasma membrane, where it interacts with various signaling molecules. 3. High sequence homology: Alpha-synuclein shares high sequence homology with other synuclein proteins, including beta-synuclein and gamma-synuclein. 4. Ability to form oligomers and fibrils: Alpha-synuclein can form oligomers and fibrils, which are thought to be involved in its pathogenic effects. **Pathways and Functions** Alpha-synuclein is involved in various cellular pathways, including: 1. **Synaptic transmission**: Alpha-synuclein regulates the release of neurotransmitters, such as dopamine, glutamate, and GABA, and interacts with synaptic proteins, including synaptophysin and SNAP-25. 2. **Dopamine biosynthesis**: Alpha-synuclein is involved in the regulation of dopamine biosynthesis and uptake, which is critical for the regulation of movement and cognition. 3. **Immune responses**: Alpha-synuclein interacts with immune cells, such as microglia and macrophages, and regulates their activation and function. 4. **Oxidative stress**: Alpha-synuclein can induce oxidative stress by interacting with redox-sensitive proteins and generating reactive oxygen species. 5. **Calcium homeostasis**: Alpha-synuclein regulates calcium homeostasis in neurons by interacting with calcium channels and pumps. **Clinical Significance** Dysregulation of alpha-synuclein has been implicated in several neurodegenerative diseases, including: 1. **Parkinson's disease**: Alpha-synuclein aggregation is a hallmark of Parkinson's disease, and its dysregulation is thought to contribute to the development of the disease. 2. **Alzheimer's disease**: Alpha-synuclein has been implicated in the pathogenesis of Alzheimer's disease, and its dysregulation is thought to contribute to the development of the disease. 3. **Amyloid-related disorders**: Alpha-synuclein aggregation has been linked to the development of amyloid-related disorders, including Alzheimer's disease and frontotemporal dementia. In conclusion, alpha-synuclein is a multifunctional protein that plays a critical role in various cellular processes, including synaptic transmission, dopamine biosynthesis, and immune responses. Dysregulation of alpha-synuclein has been implicated in several neurodegenerative diseases, highlighting the importance of further research into the role of alpha-synuclein in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Alpha-synuclein
H6UYS5_HUMAN

Genular Protein ID: 1474762581

Symbol: SYUA_HUMAN

Name: Alpha-synuclein

UniProtKB Accession Codes:

P37840 A8K2A4 Q13701 Q4JHI3 Q6IAU6

Database IDs:

Citations:

PubMed ID: 8248242

Title: Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

PubMed ID: 8248242

DOI: 10.1073/pnas.90.23.11282

PubMed ID: 7601450

Title: The NACP/synuclein gene: chromosomal assignment and screening for alterations in Alzheimer disease.

PubMed ID: 7601450

DOI: 10.1016/0888-7543(95)80208-4

PubMed ID: 7802671

Title: Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-A beta component of Alzheimer's disease amyloid.

PubMed ID: 7802671

DOI: 10.1006/bbrc.1994.2816

PubMed ID: 11156617

Title: Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element.

PubMed ID: 11156617

DOI: 10.1101/gr.165801

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8194594

Title: Identification of two distinct synucleins from human brain.

PubMed ID: 8194594

DOI: 10.1016/0014-5793(94)00395-5

PubMed ID: 10617630

Title: Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein.

PubMed ID: 10617630

DOI: 10.1074/jbc.275.1.390

PubMed ID: 10852916

Title: Synucleins are a novel class of substrates for G protein-coupled receptor kinases.

PubMed ID: 10852916

DOI: 10.1074/jbc.m003542200

PubMed ID: 11162638

Title: Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.

PubMed ID: 11162638

DOI: 10.1006/bbrc.2000.4253

PubMed ID: 11821392

Title: Alpha-synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells.

PubMed ID: 11821392

DOI: 10.1074/jbc.m110414200

PubMed ID: 11813001

Title: alpha-Synuclein is phosphorylated in synucleinopathy lesions.

PubMed ID: 11813001

DOI: 10.1038/ncb748

PubMed ID: 12859192

Title: Nuclear localization of alpha-synuclein and its interaction with histones.

PubMed ID: 12859192

DOI: 10.1021/bi0341152

PubMed ID: 12859200

Title: Role of alpha-synuclein carboxy-terminus on fibril formation in vitro.

PubMed ID: 12859200

DOI: 10.1021/bi027363r

PubMed ID: 12558071

Title: Recent advances on alpha-synuclein cell biology: functions and dysfunctions.

PubMed ID: 12558071

DOI: 10.2174/1566524033361690

PubMed ID: 12893833

Title: Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation.

PubMed ID: 12893833

DOI: 10.1074/jbc.m213217200

PubMed ID: 15207266

Title: Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.

PubMed ID: 15207266

DOI: 10.1016/j.nbd.2004.01.001

PubMed ID: 15282274

Title: Lipid rafts mediate the synaptic localization of alpha-synuclein.

PubMed ID: 15282274

DOI: 10.1523/jneurosci.1594-04.2004

PubMed ID: 19722699

Title: Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization.

PubMed ID: 19722699

DOI: 10.1021/bi900539p

PubMed ID: 20798282

Title: Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.

PubMed ID: 20798282

DOI: 10.1126/science.1195227

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21319811

Title: Coordination features and affinity of the Cu(2)+ site in the alpha-synuclein protein of Parkinson's disease.

PubMed ID: 21319811

DOI: 10.1021/bi101912q

PubMed ID: 21841800

Title: alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation.

PubMed ID: 21841800

DOI: 10.1038/nature10324

PubMed ID: 22854022

Title: SERF protein is a direct modifier of amyloid fiber assembly.

PubMed ID: 22854022

DOI: 10.1016/j.celrep.2012.06.012

PubMed ID: 22407793

Title: N-Terminal acetylation is critical for forming alpha-helical oligomer of alpha-synuclein.

PubMed ID: 22407793

DOI: 10.1002/pro.2056

PubMed ID: 26442590

Title: Dopamine Transporter Activity Is Modulated by alpha-Synuclein.

PubMed ID: 26442590

DOI: 10.1074/jbc.m115.691592

PubMed ID: 27597756

Title: Munc18-1 is a molecular chaperone for alpha-synuclein, controlling its self-replicating aggregation.

PubMed ID: 27597756

DOI: 10.1083/jcb.201512016

PubMed ID: 28288128

Title: alpha-Synuclein promotes dilation of the exocytotic fusion pore.

PubMed ID: 28288128

DOI: 10.1038/nn.4529

PubMed ID: 30404828

Title: Soluble alpha-synuclein facilitates priming and fusion by releasing Ca2+ from the thapsigargin-sensitive Ca2+ pool in PC12 cells.

PubMed ID: 30404828

DOI: 10.1242/jcs.213017

PubMed ID: 31034892

Title: Increased Aggregation Tendency of Alpha-Synuclein in a Fully Disordered Protein Complex.

PubMed ID: 31034892

DOI: 10.1016/j.jmb.2019.04.031

PubMed ID: 15615727

Title: Structure and dynamics of micelle-bound human alpha-synuclein.

PubMed ID: 15615727

DOI: 10.1074/jbc.m411805200

PubMed ID: 19762560

Title: Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication.

PubMed ID: 19762560

DOI: 10.1096/fj.09-133082

PubMed ID: 21462277

Title: Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation.

PubMed ID: 21462277

DOI: 10.1002/pro.630

PubMed ID: 23607618

Title: NMR structure of calmodulin complexed to an N-terminally acetylated alpha-synuclein peptide.

PubMed ID: 23607618

DOI: 10.1021/bi400199p

PubMed ID: 26352473

Title: Structure of the toxic core of alpha-synuclein from invisible crystals.

PubMed ID: 26352473

DOI: 10.1038/nature15368

PubMed ID: 27018801

Title: Solid-state NMR structure of a pathogenic fibril of full-length human alpha-synuclein.

PubMed ID: 27018801

DOI: 10.1038/nsmb.3194

PubMed ID: 30190461

Title: Cryo-EM of full-length alpha-synuclein reveals fibril polymorphs with a common structural kernel.

PubMed ID: 30190461

DOI: 10.1038/s41467-018-05971-2

PubMed ID: 9197268

Title: Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.

PubMed ID: 9197268

DOI: 10.1126/science.276.5321.2045

PubMed ID: 9462735

Title: Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.

PubMed ID: 9462735

DOI: 10.1038/ng0298-106

PubMed ID: 14755719

Title: The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia.

PubMed ID: 14755719

DOI: 10.1002/ana.10795

PubMed ID: 15498564

Title: Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein.

PubMed ID: 15498564

DOI: 10.1016/j.febslet.2004.09.038

PubMed ID: 23457019

Title: Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.

PubMed ID: 23457019

DOI: 10.1002/mds.25421

PubMed ID: 23427326

Title: A novel alpha-synuclein missense mutation in Parkinson disease.

PubMed ID: 23427326

DOI: 10.1212/wnl.0b013e31828727ba

PubMed ID: 24936070

Title: The H50Q mutation enhances alpha-synuclein aggregation, secretion, and toxicity.

PubMed ID: 24936070

DOI: 10.1074/jbc.m114.553297

PubMed ID: 25561023

Title: Molecular determinants of alpha-synuclein mutants' oligomerization and membrane interactions.

PubMed ID: 25561023

DOI: 10.1021/cn500332w

Sequence Information:

Length: 140
Mass: 14460
Checksum: 6BB2F12128931663
Sequence:

MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK 
EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP 
DNEAYEMPSE EGYQDYEPEA

Genular Protein ID: 2184757065

Symbol: H6UYS5_HUMAN

Name: N/A

UniProtKB Accession Codes:

H6UYS5

Database IDs:

Sequence Information:

Length: 112
Mass: 11372
Checksum: 16EA234777EFA89E
Sequence:

MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK 
EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKEGYQDYEP EA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SNCA

Associated with

Cells (max top 100)

Other Information

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. PubMed ID: 8248242

The NACP/synuclein gene: chromosomal assignment and screening for alterations in Alzheimer disease. PubMed ID: 7601450

Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-A beta component of Alzheimer's disease amyloid. PubMed ID: 7802671

Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element. PubMed ID: 11156617

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of two distinct synucleins from human brain. PubMed ID: 8194594

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. PubMed ID: 10617630

Synucleins are a novel class of substrates for G protein-coupled receptor kinases. PubMed ID: 10852916

Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125. PubMed ID: 11162638

Alpha-synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells. PubMed ID: 11821392

alpha-Synuclein is phosphorylated in synucleinopathy lesions. PubMed ID: 11813001

Nuclear localization of alpha-synuclein and its interaction with histones. PubMed ID: 12859192

Role of alpha-synuclein carboxy-terminus on fibril formation in vitro. PubMed ID: 12859200

Recent advances on alpha-synuclein cell biology: functions and dysfunctions. PubMed ID: 12558071

Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation. PubMed ID: 12893833

Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease. PubMed ID: 15207266

Lipid rafts mediate the synaptic localization of alpha-synuclein. PubMed ID: 15282274

Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization. PubMed ID: 19722699

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. PubMed ID: 20798282

Initial characterization of the human central proteome. PubMed ID: 21269460

Coordination features and affinity of the Cu(2)+ site in the alpha-synuclein protein of Parkinson's disease. PubMed ID: 21319811

alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. PubMed ID: 21841800

SERF protein is a direct modifier of amyloid fiber assembly. PubMed ID: 22854022

N-Terminal acetylation is critical for forming alpha-helical oligomer of alpha-synuclein. PubMed ID: 22407793

Dopamine Transporter Activity Is Modulated by alpha-Synuclein. PubMed ID: 26442590

Munc18-1 is a molecular chaperone for alpha-synuclein, controlling its self-replicating aggregation. PubMed ID: 27597756

alpha-Synuclein promotes dilation of the exocytotic fusion pore. PubMed ID: 28288128

Soluble alpha-synuclein facilitates priming and fusion by releasing Ca2+ from the thapsigargin-sensitive Ca2+ pool in PC12 cells. PubMed ID: 30404828

Increased Aggregation Tendency of Alpha-Synuclein in a Fully Disordered Protein Complex. PubMed ID: 31034892

Structure and dynamics of micelle-bound human alpha-synuclein. PubMed ID: 15615727

Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication. PubMed ID: 19762560

Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation. PubMed ID: 21462277

NMR structure of calmodulin complexed to an N-terminally acetylated alpha-synuclein peptide. PubMed ID: 23607618

Structure of the toxic core of alpha-synuclein from invisible crystals. PubMed ID: 26352473

Solid-state NMR structure of a pathogenic fibril of full-length human alpha-synuclein. PubMed ID: 27018801

Cryo-EM of full-length alpha-synuclein reveals fibril polymorphs with a common structural kernel. PubMed ID: 30190461

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. PubMed ID: 9197268

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. PubMed ID: 9462735

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. PubMed ID: 14755719

Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein. PubMed ID: 15498564

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease. PubMed ID: 23457019

A novel alpha-synuclein missense mutation in Parkinson disease. PubMed ID: 23427326

The H50Q mutation enhances alpha-synuclein aggregation, secretion, and toxicity. PubMed ID: 24936070

Molecular determinants of alpha-synuclein mutants' oligomerization and membrane interactions. PubMed ID: 25561023