SP1 | ENSG00000185591 | NCBI 6667

Details for: SP1

Gene ID: 6667

Symbol: SP1

Ensembl ID: ENSG00000185591

Description: Sp1 transcription factor

Associated with

Activation of gene expression by srebf (srebp)
(R-HSA-2426168)
Adherens junctions interactions
(R-HSA-418990)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular senescence
(R-HSA-2559583)
Disease
(R-HSA-1643685)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Infectious disease
(R-HSA-5663205)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroids
(R-HSA-8957322)
Nfe2l2 regulating tumorigenic genes
(R-HSA-9818030)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Oncogene induced senescence
(R-HSA-2559585)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of cdh11 expression and function
(R-HSA-9759475)
Regulation of cdh11 gene transcription
(R-HSA-9762293)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-HSA-1655829)
Regulation of expression and function of type ii classical cadherins
(R-HSA-9764260)
Regulation of homotypic cell-cell adhesion
(R-HSA-9759476)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 targets host intracellular signalling and regulatory pathways
(R-HSA-9735871)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov infections
(R-HSA-9679506)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by tgfbr3
(R-HSA-9839373)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
Tgfbr3 expression
(R-HSA-9839394)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Viral infection pathways
(R-HSA-9824446)
Bhlh transcription factor binding
(GO:0043425)
Cellular response to estrogen stimulus
(GO:0071391)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to wortmannin
(GO:1904568)
Cellular response to zinc ion starvation
(GO:0034224)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Euchromatin
(GO:0000791)
Histone acetyltransferase binding
(GO:0035035)
Histone deacetylase binding
(GO:0042826)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Molecular adaptor activity
(GO:0060090)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation by host of viral transcription
(GO:0043923)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of hydrogen sulfide biosynthetic process
(GO:1904828)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of vascular endothelial cell proliferation
(GO:1905564)
Protein-dna complex
(GO:0032993)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to hydroperoxide
(GO:0033194)
Rhythmic process
(GO:0048511)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)
Transcription repressor complex
(GO:0017053)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 176.2831
Cell Significance Index: -27.4200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 111.9879
Cell Significance Index: -28.4100
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 80.0102
Cell Significance Index: -32.9600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 66.4658
Cell Significance Index: -31.3800
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 59.8390
Cell Significance Index: -24.3100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 55.8725
Cell Significance Index: -28.7400
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 25.4728
Cell Significance Index: -24.3200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 24.3399
Cell Significance Index: -30.0100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.2119
Cell Significance Index: -30.0400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.6710
Cell Significance Index: -30.2700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.8126
Cell Significance Index: -14.9100
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 4.0625
Cell Significance Index: 66.9500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.8108
Cell Significance Index: 38.3500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.3710
Cell Significance Index: 149.1200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.3637
Cell Significance Index: 81.8700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1931
Cell Significance Index: 194.0500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.1125
Cell Significance Index: 57.7900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.9611
Cell Significance Index: 26.8600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8843
Cell Significance Index: 175.4900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.8348
Cell Significance Index: 22.2900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7962
Cell Significance Index: 17.2500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7696
Cell Significance Index: 22.1800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7602
Cell Significance Index: 686.3800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7076
Cell Significance Index: 87.0100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6649
Cell Significance Index: 119.8600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.5845
Cell Significance Index: 15.9100
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.4879
Cell Significance Index: 7.4100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4096
Cell Significance Index: 82.1600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4048
Cell Significance Index: 18.3500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3758
Cell Significance Index: 166.1500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3448
Cell Significance Index: 188.3000
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.3440
Cell Significance Index: 8.6000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3302
Cell Significance Index: 45.3400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2969
Cell Significance Index: 16.6600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2944
Cell Significance Index: 56.0300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2760
Cell Significance Index: 7.4000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.2674
Cell Significance Index: 4.9400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2638
Cell Significance Index: 12.3000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2244
Cell Significance Index: 80.5100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2126
Cell Significance Index: 4.5300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1935
Cell Significance Index: 19.1500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.1869
Cell Significance Index: 116.7200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1856
Cell Significance Index: 14.2500
Cell Name: peg cell (CL4033014)
Fold Change: 0.1355
Cell Significance Index: 3.1300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1351
Cell Significance Index: 6.3500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1200
Cell Significance Index: 8.4900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0919
Cell Significance Index: 3.2300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0818
Cell Significance Index: 13.9800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0648
Cell Significance Index: 4.1800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0561
Cell Significance Index: 7.1900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0533
Cell Significance Index: 36.8500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0494
Cell Significance Index: 5.8200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0341
Cell Significance Index: 64.1500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0135
Cell Significance Index: 8.5600
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0111
Cell Significance Index: 20.4100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0003
Cell Significance Index: 0.4600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0033
Cell Significance Index: -1.5200
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0059
Cell Significance Index: -0.1200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0109
Cell Significance Index: -7.9900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0121
Cell Significance Index: -0.3100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0122
Cell Significance Index: -9.0500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0126
Cell Significance Index: -17.1000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0253
Cell Significance Index: -19.1300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0280
Cell Significance Index: -0.5800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0284
Cell Significance Index: -16.0100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0286
Cell Significance Index: -8.2400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0293
Cell Significance Index: -0.8400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0481
Cell Significance Index: -4.9100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0712
Cell Significance Index: -3.7100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0768
Cell Significance Index: -16.1700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0803
Cell Significance Index: -10.3700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0906
Cell Significance Index: -13.1700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0944
Cell Significance Index: -4.7700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1095
Cell Significance Index: -12.5400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1284
Cell Significance Index: -8.0900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1441
Cell Significance Index: -16.7900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1558
Cell Significance Index: -1.4400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1855
Cell Significance Index: -5.9400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1887
Cell Significance Index: -14.0600
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2207
Cell Significance Index: -1.8000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2278
Cell Significance Index: -14.0000
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2422
Cell Significance Index: -4.1500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2558
Cell Significance Index: -29.2100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2589
Cell Significance Index: -26.9600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2647
Cell Significance Index: -4.4300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3025
Cell Significance Index: -23.9600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3047
Cell Significance Index: -20.4900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3706
Cell Significance Index: -22.7200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3754
Cell Significance Index: -9.8700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4424
Cell Significance Index: -19.5700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4462
Cell Significance Index: -11.9400
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.4907
Cell Significance Index: -6.9900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.5140
Cell Significance Index: -17.8600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5264
Cell Significance Index: -27.6400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5499
Cell Significance Index: -20.8300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5602
Cell Significance Index: -16.5000
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.5608
Cell Significance Index: -8.4000
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.5808
Cell Significance Index: -14.1700
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.5956
Cell Significance Index: -10.0300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6080
Cell Significance Index: -22.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** Sp1 is a transcription factor that belongs to the Sp family of proteins. It is characterized by its ability to bind to specific DNA sequences, known as GC-rich motifs, and regulate gene expression. Sp1 has several key characteristics that enable it to perform its functions: 1. **DNA binding**: Sp1 binds to specific DNA sequences, known as GC-rich motifs, through its C-terminal domain. 2. **Transcriptional activation**: Sp1 activates transcription by binding to DNA and recruiting RNA polymerase II and other transcriptional coactivators. 3. **Cell-type specificity**: Sp1 expression is tissue-specific, with varying levels of expression in different cell types. 4. **Regulation of gene expression**: Sp1 regulates the expression of numerous genes involved in cell growth, differentiation, and survival. **Pathways and Functions** Sp1 plays a critical role in various cellular pathways, including: 1. **Cell growth and differentiation**: Sp1 regulates the expression of genes involved in cell growth and differentiation, including cell cycle regulators and growth factor receptors. 2. **Inflammation and immune response**: Sp1 regulates the expression of genes involved in inflammation and immune response, including cytokines and chemokines. 3. **Cardiovascular disease**: Sp1 regulates the expression of genes involved in cardiovascular disease, including lipid metabolism and blood vessel endothelial cell migration. 4. **Cancer**: Sp1 is dysregulated in various cancers, including breast, lung, and colon cancer, and regulates the expression of genes involved in tumor growth and metastasis. **Clinical Significance** Dysregulation of Sp1 has been implicated in various diseases, including: 1. **Cancer**: Sp1 is overexpressed in many types of cancer, including breast, lung, and colon cancer, and contributes to tumor growth and metastasis. 2. **Cardiovascular disease**: Sp1 regulates lipid metabolism and blood vessel endothelial cell migration, and dysregulation contributes to cardiovascular disease. 3. **Inflammatory disorders**: Sp1 regulates the expression of genes involved in inflammation and immune response, and dysregulation contributes to inflammatory disorders, including arthritis and asthma. 4. **Neurological disorders**: Sp1 regulates the expression of genes involved in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, Sp1 is a critical transcription factor that regulates gene expression in various cellular processes, including cell growth, differentiation, and survival. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, and inflammatory disorders. Understanding the mechanisms of Sp1 regulation and its role in disease will be essential for the development of novel therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription factor Sp1

Genular Protein ID: 3124054008

Symbol: SP1_HUMAN

Name: Transcription factor Sp1

UniProtKB Accession Codes:

P08047 E4Z9M7 G5E9M8 Q86TN8 Q9H3Q5 Q9NR51 Q9NY21 Q9NYE7

Database IDs:

Citations:

PubMed ID: 21798247

Title: Identification of a novel Sp1 splice variant as a strong transcriptional activator.

PubMed ID: 21798247

DOI: 10.1016/j.bbrc.2011.07.047

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10973950

Title: Heterogeneous Sp1 mRNAs in human HepG2 cells include a product of homotypic trans-splicing.

PubMed ID: 10973950

DOI: 10.1074/jbc.m002010200

PubMed ID: 3319186

Title: Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain.

PubMed ID: 3319186

DOI: 10.1016/0092-8674(87)90594-0

PubMed ID: 3139301

Title: O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation.

PubMed ID: 3139301

DOI: 10.1016/0092-8674(88)90015-3

PubMed ID: 3142690

Title: Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif.

PubMed ID: 3142690

DOI: 10.1016/0092-8674(88)90144-4

PubMed ID: 7592727

Title: Interaction of virion protein Vpr of human immunodeficiency virus type 1 with cellular transcription factor Sp1 and trans-activation of viral long terminal repeat.

PubMed ID: 7592727

DOI: 10.1074/jbc.270.43.25564

PubMed ID: 8626793

Title: The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1.

PubMed ID: 8626793

DOI: 10.1074/jbc.271.8.4417

PubMed ID: 9343410

Title: O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions.

PubMed ID: 9343410

DOI: 10.1128/mcb.17.11.6472

PubMed ID: 9466902

Title: The SV40 capsid protein VP3 cooperates with the cellular transcription factor Sp1 in DNA-binding and in regulating viral promoter activity.

PubMed ID: 9466902

DOI: 10.1006/jmbi.1997.1461

PubMed ID: 10391891

Title: Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene.

PubMed ID: 10391891

DOI: 10.1074/jbc.274.28.19573

PubMed ID: 10976766

Title: A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.

PubMed ID: 10976766

DOI: 10.1023/a:1007177623283

PubMed ID: 11371615

Title: O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability.

PubMed ID: 11371615

DOI: 10.1073/pnas.111099998

PubMed ID: 11904305

Title: Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription.

PubMed ID: 11904305

DOI: 10.1074/jbc.m201753200

PubMed ID: 12004059

Title: POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.

PubMed ID: 12004059

DOI: 10.1074/jbc.m202078200

PubMed ID: 12021324

Title: Cellular transcription factor Sp1 recruits simian virus 40 capsid proteins to the viral packaging signal, ses.

PubMed ID: 12021324

DOI: 10.1128/jvi.76.12.5915-5924.2002

PubMed ID: 12847090

Title: Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter.

PubMed ID: 12847090

DOI: 10.1074/jbc.m306694200

PubMed ID: 12855699

Title: Interaction between the varicella zoster virus IE62 major transactivator and cellular transcription factor Sp1.

PubMed ID: 12855699

DOI: 10.1074/jbc.m302259200

PubMed ID: 14593115

Title: Fibroblast growth factor-2 represses platelet-derived growth factor receptor-alpha (PDGFR-alpha) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter.

PubMed ID: 14593115

DOI: 10.1074/jbc.m308254200

PubMed ID: 15691849

Title: Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins.

PubMed ID: 15691849

DOI: 10.1074/jbc.m413654200

PubMed ID: 16818630

Title: DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor.

PubMed ID: 16818630

DOI: 10.1158/0008-5472.can-05-2415

PubMed ID: 16332679

Title: Insulin dynamically regulates calmodulin gene expression by sequential O-glycosylation and phosphorylation of SP1 and its subcellular compartmentalization in liver cells.

PubMed ID: 16332679

DOI: 10.1074/jbc.m511223200

PubMed ID: 16377629

Title: HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion.

PubMed ID: 16377629

DOI: 10.1074/jbc.m510937200

PubMed ID: 16407261

Title: Sumoylation inhibits cleavage of Sp1 N-terminal negative regulatory domain and inhibits Sp1-dependent transcription.

PubMed ID: 16407261

DOI: 10.1074/jbc.m600035200

PubMed ID: 17049555

Title: Increased chromatin association of Sp1 in interphase cells by PP2A-mediated dephosphorylations.

PubMed ID: 17049555

DOI: 10.1016/j.jmb.2006.09.036

PubMed ID: 16478997

Title: Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription.

PubMed ID: 16478997

DOI: 10.1128/mcb.26.5.1770-1785.2006

PubMed ID: 16943418

Title: Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression of transcription of the luteinizing hormone receptor gene.

PubMed ID: 16943418

DOI: 10.1128/mcb.00560-06

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18171990

Title: Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase.

PubMed ID: 18171990

DOI: 10.1158/1541-7786.mcr-07-0374

PubMed ID: 18513490

Title: Activation of PPARgamma negatively regulates O-GlcNAcylation of Sp1.

PubMed ID: 18513490

DOI: 10.1016/j.bbrc.2008.05.096

PubMed ID: 18239466

Title: Phosphorylation mediates Sp1 coupled activities of proteolytic processing, desumoylation and degradation.

PubMed ID: 18239466

DOI: 10.4161/cc.7.5.5402

PubMed ID: 18619531

Title: Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites.

PubMed ID: 18619531

DOI: 10.1016/j.cellsig.2008.06.007

PubMed ID: 18258854

Title: Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1.

PubMed ID: 18258854

DOI: 10.1161/circresaha.107.167395

PubMed ID: 18199680

Title: Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis.

PubMed ID: 18199680

DOI: 10.1091/mbc.e07-09-0881

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19285002

Title: O-GlcNAc inhibits interaction between Sp1 and Elf-1 transcription factors.

PubMed ID: 19285002

DOI: 10.1016/j.bbrc.2009.01.121

PubMed ID: 19302979

Title: O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y.

PubMed ID: 19302979

DOI: 10.1016/j.bbrc.2009.03.075

PubMed ID: 19106100

Title: MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.

PubMed ID: 19106100

DOI: 10.1074/jbc.m807098200

PubMed ID: 19193796

Title: O-linked N-acetylglucosaminylation of Sp1 inhibits the human immunodeficiency virus type 1 promoter.

PubMed ID: 19193796

DOI: 10.1128/jvi.01384-08

PubMed ID: 19666599

Title: Human BAHD1 promotes heterochromatic gene silencing.

PubMed ID: 19666599

DOI: 10.1073/pnas.0901259106

PubMed ID: 20121949

Title: Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b.

PubMed ID: 20121949

DOI: 10.1111/j.1742-4658.2009.07553.x

PubMed ID: 20091743

Title: Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1.

PubMed ID: 20091743

DOI: 10.1002/jcb.22457

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20953893

Title: Transforming growth factor-beta-inducible early response gene 1 is a novel substrate for atypical protein kinase Cs.

PubMed ID: 20953893

DOI: 10.1007/s00018-010-0541-1

PubMed ID: 21746878

Title: Cooperative transcriptional activation by Klf4, Meis2, and Pbx1.

PubMed ID: 21746878

DOI: 10.1128/mcb.01456-10

PubMed ID: 21046154

Title: Mithramycin A suppresses expression of the human melanoma-associated gene ABCB8.

PubMed ID: 21046154

DOI: 10.1007/s00438-010-0586-8

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

PubMed ID: 9065444

Title: Structures of zinc finger domains from transcription factor Sp1. Insights into sequence-specific protein-DNA recognition.

PubMed ID: 9065444

DOI: 10.1074/jbc.272.12.7801

Sequence Information:

Length: 785
Mass: 80693
Checksum: 43893DBF6518B9EA
Sequence:

MSDQDHSMDE MTAVVKIEKG VGGNNGGNGN GGGAFSQARS SSTGSSSSTG GGGQESQPSP 
LALLAATCSR IESPNENSNN SQGPSQSGGT GELDLTATQL SQGANGWQII SSSSGATPTS 
KEQSGSSTNG SNGSESSKNR TVSGGQYVVA AAPNLQNQQV LTGLPGVMPN IQYQVIPQFQ 
TVDGQQLQFA ATGAQVQQDG SGQIQIIPGA NQQIITNRGS GGNIIAAMPN LLQQAVPLQG 
LANNVLSGQT QYVTNVPVAL NGNITLLPVN SVSAATLTPS SQAVTISSSG SQESGSQPVT 
SGTTISSASL VSSQASSSSF FTNANSYSTT TTTSNMGIMN FTTSGSSGTN SQGQTPQRVS 
GLQGSDALNI QQNQTSGGSL QAGQQKEGEQ NQQTQQQQIL IQPQLVQGGQ ALQALQAAPL 
SGQTFTTQAI SQETLQNLQL QAVPNSGPII IRTPTVGPNG QVSWQTLQLQ NLQVQNPQAQ 
TITLAPMQGV SLGQTSSSNT TLTPIASAAS IPAGTVTVNA AQLSSMPGLQ TINLSALGTS 
GIQVHPIQGL PLAIANAPGD HGAQLGLHGA GGDGIHDDTA GGEEGENSPD AQPQAGRRTR 
REACTCPYCK DSEGRGSGDP GKKKQHICHI QGCGKVYGKT SHLRAHLRWH TGERPFMCTW 
SYCGKRFTRS DELQRHKRTH TGEKKFACPE CPKRFMRSDH LSKHIKTHQN KKGGPGVALS 
VGTLPLDSGA GSEGSGTATP SALITTNMVA MEAICPEGIA RLANSGINVM QVADLQSINI 
SGNGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SP1

Associated with

Cells (max top 100)

Other Information

Identification of a novel Sp1 splice variant as a strong transcriptional activator. PubMed ID: 21798247

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Heterogeneous Sp1 mRNAs in human HepG2 cells include a product of homotypic trans-splicing. PubMed ID: 10973950

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. PubMed ID: 3319186

O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation. PubMed ID: 3139301

Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. PubMed ID: 3142690

Interaction of virion protein Vpr of human immunodeficiency virus type 1 with cellular transcription factor Sp1 and trans-activation of viral long terminal repeat. PubMed ID: 7592727

The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. PubMed ID: 8626793

O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions. PubMed ID: 9343410

The SV40 capsid protein VP3 cooperates with the cellular transcription factor Sp1 in DNA-binding and in regulating viral promoter activity. PubMed ID: 9466902

Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene. PubMed ID: 10391891

A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. PubMed ID: 10976766

O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability. PubMed ID: 11371615

Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription. PubMed ID: 11904305

POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1. PubMed ID: 12004059

Cellular transcription factor Sp1 recruits simian virus 40 capsid proteins to the viral packaging signal, ses. PubMed ID: 12021324

Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter. PubMed ID: 12847090

Interaction between the varicella zoster virus IE62 major transactivator and cellular transcription factor Sp1. PubMed ID: 12855699

Fibroblast growth factor-2 represses platelet-derived growth factor receptor-alpha (PDGFR-alpha) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter. PubMed ID: 14593115

Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins. PubMed ID: 15691849

DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor. PubMed ID: 16818630

Insulin dynamically regulates calmodulin gene expression by sequential O-glycosylation and phosphorylation of SP1 and its subcellular compartmentalization in liver cells. PubMed ID: 16332679

HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. PubMed ID: 16377629

Sumoylation inhibits cleavage of Sp1 N-terminal negative regulatory domain and inhibits Sp1-dependent transcription. PubMed ID: 16407261

Increased chromatin association of Sp1 in interphase cells by PP2A-mediated dephosphorylations. PubMed ID: 17049555

Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription. PubMed ID: 16478997

Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression of transcription of the luteinizing hormone receptor gene. PubMed ID: 16943418

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase. PubMed ID: 18171990

Activation of PPARgamma negatively regulates O-GlcNAcylation of Sp1. PubMed ID: 18513490

Phosphorylation mediates Sp1 coupled activities of proteolytic processing, desumoylation and degradation. PubMed ID: 18239466

Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites. PubMed ID: 18619531

Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1. PubMed ID: 18258854

Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis. PubMed ID: 18199680

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

O-GlcNAc inhibits interaction between Sp1 and Elf-1 transcription factors. PubMed ID: 19285002

O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y. PubMed ID: 19302979

MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. PubMed ID: 19106100

O-linked N-acetylglucosaminylation of Sp1 inhibits the human immunodeficiency virus type 1 promoter. PubMed ID: 19193796

Human BAHD1 promotes heterochromatic gene silencing. PubMed ID: 19666599

Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. PubMed ID: 20121949

Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1. PubMed ID: 20091743

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Transforming growth factor-beta-inducible early response gene 1 is a novel substrate for atypical protein kinase Cs. PubMed ID: 20953893

Cooperative transcriptional activation by Klf4, Meis2, and Pbx1. PubMed ID: 21746878

Mithramycin A suppresses expression of the human melanoma-associated gene ABCB8. PubMed ID: 21046154

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs. PubMed ID: 31375868

Structures of zinc finger domains from transcription factor Sp1. Insights into sequence-specific protein-DNA recognition. PubMed ID: 9065444