Details for: SP1

Gene ID: 6667

Symbol: SP1

Ensembl ID: ENSG00000185591

Description: Sp1 transcription factor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167948
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.39
    Marker Score: 2052
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.35
    Marker Score: 921
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.33
    Marker Score: 415
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.29
    Marker Score: 1362
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.28
    Marker Score: 3005
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.27
    Marker Score: 408
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.25
    Marker Score: 838
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.18
    Marker Score: 18454
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.18
    Marker Score: 2056
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.17
    Marker Score: 706
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.17
    Marker Score: 1287
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.09
    Marker Score: 2225
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.07
    Marker Score: 982
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.06
    Marker Score: 1128
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.01
    Marker Score: 290
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71692
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47916
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30390
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.98
    Marker Score: 1736
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.98
    Marker Score: 1126
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.97
    Marker Score: 4057
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.95
    Marker Score: 819
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.94
    Marker Score: 2153
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.94
    Marker Score: 52745
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2396
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.94
    Marker Score: 2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.92
    Marker Score: 5877
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2698
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9
    Marker Score: 1020
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.9
    Marker Score: 207
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.9
    Marker Score: 5402
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1448
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.88
    Marker Score: 1131
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.87
    Marker Score: 215
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.87
    Marker Score: 2155
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.85
    Marker Score: 879
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.84
    Marker Score: 804
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.84
    Marker Score: 906
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.84
    Marker Score: 467
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4758
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.83
    Marker Score: 403
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.83
    Marker Score: 17710
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.82
    Marker Score: 385
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.81
    Marker Score: 982
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.81
    Marker Score: 387
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.8
    Marker Score: 30515
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.8
    Marker Score: 1537.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 604
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.79
    Marker Score: 6751
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.78
    Marker Score: 2773
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.78
    Marker Score: 454
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 312
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.77
    Marker Score: 223
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.77
    Marker Score: 7322
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.77
    Marker Score: 2065
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.77
    Marker Score: 47347
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.77
    Marker Score: 189
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.76
    Marker Score: 26027
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.76
    Marker Score: 1082
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.76
    Marker Score: 2823
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.76
    Marker Score: 281
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.76
    Marker Score: 264
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.75
    Marker Score: 510
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.75
    Marker Score: 744
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.75
    Marker Score: 758
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.74
    Marker Score: 443
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.74
    Marker Score: 149
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.73
    Marker Score: 5428
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.73
    Marker Score: 175
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.73
    Marker Score: 3487
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.72
    Marker Score: 1818
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.72
    Marker Score: 449
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.72
    Marker Score: 507
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.72
    Marker Score: 6185
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.71
    Marker Score: 2966.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.71
    Marker Score: 1421
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.71
    Marker Score: 4189
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.71
    Marker Score: 183
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.69
    Marker Score: 2388
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.69
    Marker Score: 1568
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.68
    Marker Score: 1498.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.68
    Marker Score: 735
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.68
    Marker Score: 278
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.68
    Marker Score: 719
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 448
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 617
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.68
    Marker Score: 3321
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.68
    Marker Score: 461
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.67
    Marker Score: 23234
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.66
    Marker Score: 269
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.66
    Marker Score: 1401
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.66
    Marker Score: 1023

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Other Information

**Key Characteristics** Sp1 is a transcription factor that belongs to the Sp family of proteins. It is characterized by its ability to bind to specific DNA sequences, known as GC-rich motifs, and regulate gene expression. Sp1 has several key characteristics that enable it to perform its functions: 1. **DNA binding**: Sp1 binds to specific DNA sequences, known as GC-rich motifs, through its C-terminal domain. 2. **Transcriptional activation**: Sp1 activates transcription by binding to DNA and recruiting RNA polymerase II and other transcriptional coactivators. 3. **Cell-type specificity**: Sp1 expression is tissue-specific, with varying levels of expression in different cell types. 4. **Regulation of gene expression**: Sp1 regulates the expression of numerous genes involved in cell growth, differentiation, and survival. **Pathways and Functions** Sp1 plays a critical role in various cellular pathways, including: 1. **Cell growth and differentiation**: Sp1 regulates the expression of genes involved in cell growth and differentiation, including cell cycle regulators and growth factor receptors. 2. **Inflammation and immune response**: Sp1 regulates the expression of genes involved in inflammation and immune response, including cytokines and chemokines. 3. **Cardiovascular disease**: Sp1 regulates the expression of genes involved in cardiovascular disease, including lipid metabolism and blood vessel endothelial cell migration. 4. **Cancer**: Sp1 is dysregulated in various cancers, including breast, lung, and colon cancer, and regulates the expression of genes involved in tumor growth and metastasis. **Clinical Significance** Dysregulation of Sp1 has been implicated in various diseases, including: 1. **Cancer**: Sp1 is overexpressed in many types of cancer, including breast, lung, and colon cancer, and contributes to tumor growth and metastasis. 2. **Cardiovascular disease**: Sp1 regulates lipid metabolism and blood vessel endothelial cell migration, and dysregulation contributes to cardiovascular disease. 3. **Inflammatory disorders**: Sp1 regulates the expression of genes involved in inflammation and immune response, and dysregulation contributes to inflammatory disorders, including arthritis and asthma. 4. **Neurological disorders**: Sp1 regulates the expression of genes involved in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, Sp1 is a critical transcription factor that regulates gene expression in various cellular processes, including cell growth, differentiation, and survival. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, and inflammatory disorders. Understanding the mechanisms of Sp1 regulation and its role in disease will be essential for the development of novel therapeutic strategies.

Genular Protein ID: 3124054008

Symbol: SP1_HUMAN

Name: Transcription factor Sp1

UniProtKB Accession Codes:

P08047 E4Z9M7 G5E9M8 Q86TN8 Q9H3Q5 Q9NR51 Q9NY21 Q9NYE7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 11 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 11 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 21798247

Title: Identification of a novel Sp1 splice variant as a strong transcriptional activator.

PubMed ID: 21798247

DOI: 10.1016/j.bbrc.2011.07.047

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10973950

Title: Heterogeneous Sp1 mRNAs in human HepG2 cells include a product of homotypic trans-splicing.

PubMed ID: 10973950

DOI: 10.1074/jbc.m002010200

PubMed ID: 3319186

Title: Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain.

PubMed ID: 3319186

DOI: 10.1016/0092-8674(87)90594-0

PubMed ID: 3139301

Title: O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation.

PubMed ID: 3139301

DOI: 10.1016/0092-8674(88)90015-3

PubMed ID: 3142690

Title: Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif.

PubMed ID: 3142690

DOI: 10.1016/0092-8674(88)90144-4

PubMed ID: 7592727

Title: Interaction of virion protein Vpr of human immunodeficiency virus type 1 with cellular transcription factor Sp1 and trans-activation of viral long terminal repeat.

PubMed ID: 7592727

DOI: 10.1074/jbc.270.43.25564

PubMed ID: 8626793

Title: The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1.

PubMed ID: 8626793

DOI: 10.1074/jbc.271.8.4417

PubMed ID: 9343410

Title: O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions.

PubMed ID: 9343410

DOI: 10.1128/mcb.17.11.6472

PubMed ID: 9466902

Title: The SV40 capsid protein VP3 cooperates with the cellular transcription factor Sp1 in DNA-binding and in regulating viral promoter activity.

PubMed ID: 9466902

DOI: 10.1006/jmbi.1997.1461

PubMed ID: 10391891

Title: Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene.

PubMed ID: 10391891

DOI: 10.1074/jbc.274.28.19573

PubMed ID: 10976766

Title: A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.

PubMed ID: 10976766

DOI: 10.1023/a:1007177623283

PubMed ID: 11371615

Title: O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability.

PubMed ID: 11371615

DOI: 10.1073/pnas.111099998

PubMed ID: 11904305

Title: Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription.

PubMed ID: 11904305

DOI: 10.1074/jbc.m201753200

PubMed ID: 12004059

Title: POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.

PubMed ID: 12004059

DOI: 10.1074/jbc.m202078200

PubMed ID: 12021324

Title: Cellular transcription factor Sp1 recruits simian virus 40 capsid proteins to the viral packaging signal, ses.

PubMed ID: 12021324

DOI: 10.1128/jvi.76.12.5915-5924.2002

PubMed ID: 12847090

Title: Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter.

PubMed ID: 12847090

DOI: 10.1074/jbc.m306694200

PubMed ID: 12855699

Title: Interaction between the varicella zoster virus IE62 major transactivator and cellular transcription factor Sp1.

PubMed ID: 12855699

DOI: 10.1074/jbc.m302259200

PubMed ID: 14593115

Title: Fibroblast growth factor-2 represses platelet-derived growth factor receptor-alpha (PDGFR-alpha) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter.

PubMed ID: 14593115

DOI: 10.1074/jbc.m308254200

PubMed ID: 15691849

Title: Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins.

PubMed ID: 15691849

DOI: 10.1074/jbc.m413654200

PubMed ID: 16818630

Title: DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor.

PubMed ID: 16818630

DOI: 10.1158/0008-5472.can-05-2415

PubMed ID: 16332679

Title: Insulin dynamically regulates calmodulin gene expression by sequential O-glycosylation and phosphorylation of SP1 and its subcellular compartmentalization in liver cells.

PubMed ID: 16332679

DOI: 10.1074/jbc.m511223200

PubMed ID: 16377629

Title: HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion.

PubMed ID: 16377629

DOI: 10.1074/jbc.m510937200

PubMed ID: 16407261

Title: Sumoylation inhibits cleavage of Sp1 N-terminal negative regulatory domain and inhibits Sp1-dependent transcription.

PubMed ID: 16407261

DOI: 10.1074/jbc.m600035200

PubMed ID: 17049555

Title: Increased chromatin association of Sp1 in interphase cells by PP2A-mediated dephosphorylations.

PubMed ID: 17049555

DOI: 10.1016/j.jmb.2006.09.036

PubMed ID: 16478997

Title: Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription.

PubMed ID: 16478997

DOI: 10.1128/mcb.26.5.1770-1785.2006

PubMed ID: 16943418

Title: Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression of transcription of the luteinizing hormone receptor gene.

PubMed ID: 16943418

DOI: 10.1128/mcb.00560-06

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18171990

Title: Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase.

PubMed ID: 18171990

DOI: 10.1158/1541-7786.mcr-07-0374

PubMed ID: 18513490

Title: Activation of PPARgamma negatively regulates O-GlcNAcylation of Sp1.

PubMed ID: 18513490

DOI: 10.1016/j.bbrc.2008.05.096

PubMed ID: 18239466

Title: Phosphorylation mediates Sp1 coupled activities of proteolytic processing, desumoylation and degradation.

PubMed ID: 18239466

DOI: 10.4161/cc.7.5.5402

PubMed ID: 18619531

Title: Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites.

PubMed ID: 18619531

DOI: 10.1016/j.cellsig.2008.06.007

PubMed ID: 18258854

Title: Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1.

PubMed ID: 18258854

DOI: 10.1161/circresaha.107.167395

PubMed ID: 18199680

Title: Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis.

PubMed ID: 18199680

DOI: 10.1091/mbc.e07-09-0881

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19285002

Title: O-GlcNAc inhibits interaction between Sp1 and Elf-1 transcription factors.

PubMed ID: 19285002

DOI: 10.1016/j.bbrc.2009.01.121

PubMed ID: 19302979

Title: O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y.

PubMed ID: 19302979

DOI: 10.1016/j.bbrc.2009.03.075

PubMed ID: 19106100

Title: MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.

PubMed ID: 19106100

DOI: 10.1074/jbc.m807098200

PubMed ID: 19193796

Title: O-linked N-acetylglucosaminylation of Sp1 inhibits the human immunodeficiency virus type 1 promoter.

PubMed ID: 19193796

DOI: 10.1128/jvi.01384-08

PubMed ID: 19666599

Title: Human BAHD1 promotes heterochromatic gene silencing.

PubMed ID: 19666599

DOI: 10.1073/pnas.0901259106

PubMed ID: 20121949

Title: Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b.

PubMed ID: 20121949

DOI: 10.1111/j.1742-4658.2009.07553.x

PubMed ID: 20091743

Title: Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1.

PubMed ID: 20091743

DOI: 10.1002/jcb.22457

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20953893

Title: Transforming growth factor-beta-inducible early response gene 1 is a novel substrate for atypical protein kinase Cs.

PubMed ID: 20953893

DOI: 10.1007/s00018-010-0541-1

PubMed ID: 21746878

Title: Cooperative transcriptional activation by Klf4, Meis2, and Pbx1.

PubMed ID: 21746878

DOI: 10.1128/mcb.01456-10

PubMed ID: 21046154

Title: Mithramycin A suppresses expression of the human melanoma-associated gene ABCB8.

PubMed ID: 21046154

DOI: 10.1007/s00438-010-0586-8

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

PubMed ID: 9065444

Title: Structures of zinc finger domains from transcription factor Sp1. Insights into sequence-specific protein-DNA recognition.

PubMed ID: 9065444

DOI: 10.1074/jbc.272.12.7801

Sequence Information:

  • Length: 785
  • Mass: 80693
  • Checksum: 43893DBF6518B9EA
  • Sequence:
    • MSDQDHSMDE MTAVVKIEKG VGGNNGGNGN GGGAFSQARS SSTGSSSSTG GGGQESQPSP 
LALLAATCSR IESPNENSNN SQGPSQSGGT GELDLTATQL SQGANGWQII SSSSGATPTS 
KEQSGSSTNG SNGSESSKNR TVSGGQYVVA AAPNLQNQQV LTGLPGVMPN IQYQVIPQFQ 
TVDGQQLQFA ATGAQVQQDG SGQIQIIPGA NQQIITNRGS GGNIIAAMPN LLQQAVPLQG 
LANNVLSGQT QYVTNVPVAL NGNITLLPVN SVSAATLTPS SQAVTISSSG SQESGSQPVT 
SGTTISSASL VSSQASSSSF FTNANSYSTT TTTSNMGIMN FTTSGSSGTN SQGQTPQRVS 
GLQGSDALNI QQNQTSGGSL QAGQQKEGEQ NQQTQQQQIL IQPQLVQGGQ ALQALQAAPL 
SGQTFTTQAI SQETLQNLQL QAVPNSGPII IRTPTVGPNG QVSWQTLQLQ NLQVQNPQAQ 
TITLAPMQGV SLGQTSSSNT TLTPIASAAS IPAGTVTVNA AQLSSMPGLQ TINLSALGTS 
GIQVHPIQGL PLAIANAPGD HGAQLGLHGA GGDGIHDDTA GGEEGENSPD AQPQAGRRTR 
REACTCPYCK DSEGRGSGDP GKKKQHICHI QGCGKVYGKT SHLRAHLRWH TGERPFMCTW 
SYCGKRFTRS DELQRHKRTH TGEKKFACPE CPKRFMRSDH LSKHIKTHQN KKGGPGVALS 
VGTLPLDSGA GSEGSGTATP SALITTNMVA MEAICPEGIA RLANSGINVM QVADLQSINI 
SGNGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.