Details for: SP2

Gene ID: 6668

Symbol: SP2

Ensembl ID: ENSG00000167182

Description: Sp2 transcription factor

Associated with

  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Histone deacetylase binding
    (GO:0042826)
  • Immune response
    (GO:0006955)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 74.1264
    Cell Significance Index: -11.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.0559
    Cell Significance Index: -12.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 31.6548
    Cell Significance Index: -12.8600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.5639
    Cell Significance Index: -12.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.1277
    Cell Significance Index: -13.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.7931
    Cell Significance Index: -12.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6011
    Cell Significance Index: -14.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.3014
    Cell Significance Index: -10.1400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.0985
    Cell Significance Index: 34.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9887
    Cell Significance Index: 892.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8085
    Cell Significance Index: 48.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7890
    Cell Significance Index: 85.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6751
    Cell Significance Index: 109.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4135
    Cell Significance Index: 28.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4105
    Cell Significance Index: 81.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3911
    Cell Significance Index: 38.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3093
    Cell Significance Index: 62.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2946
    Cell Significance Index: 8.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2766
    Cell Significance Index: 7.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2474
    Cell Significance Index: 5.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2008
    Cell Significance Index: 10.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1898
    Cell Significance Index: 11.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1785
    Cell Significance Index: 21.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1759
    Cell Significance Index: 33.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1732
    Cell Significance Index: 62.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1560
    Cell Significance Index: 28.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1447
    Cell Significance Index: 17.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1341
    Cell Significance Index: 6.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1340
    Cell Significance Index: 92.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1249
    Cell Significance Index: 16.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1196
    Cell Significance Index: 6.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1098
    Cell Significance Index: 59.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1031
    Cell Significance Index: 2.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1025
    Cell Significance Index: 4.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0899
    Cell Significance Index: 12.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0867
    Cell Significance Index: 6.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0833
    Cell Significance Index: 36.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0738
    Cell Significance Index: 4.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0685
    Cell Significance Index: 1.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0650
    Cell Significance Index: 4.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0524
    Cell Significance Index: 1.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0482
    Cell Significance Index: 6.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0341
    Cell Significance Index: 2.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0282
    Cell Significance Index: 0.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0227
    Cell Significance Index: 0.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0120
    Cell Significance Index: 0.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0082
    Cell Significance Index: 15.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0076
    Cell Significance Index: 13.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0037
    Cell Significance Index: 5.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0040
    Cell Significance Index: -0.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0055
    Cell Significance Index: -0.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0087
    Cell Significance Index: -11.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0090
    Cell Significance Index: -6.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0123
    Cell Significance Index: -9.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0134
    Cell Significance Index: -0.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0149
    Cell Significance Index: -6.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0164
    Cell Significance Index: -12.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0240
    Cell Significance Index: -13.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0249
    Cell Significance Index: -15.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0263
    Cell Significance Index: -1.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0283
    Cell Significance Index: -1.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0301
    Cell Significance Index: -3.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0400
    Cell Significance Index: -11.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0423
    Cell Significance Index: -2.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0484
    Cell Significance Index: -1.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0509
    Cell Significance Index: -1.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0527
    Cell Significance Index: -7.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0550
    Cell Significance Index: -1.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0565
    Cell Significance Index: -6.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0703
    Cell Significance Index: -4.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0711
    Cell Significance Index: -8.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0762
    Cell Significance Index: -16.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0819
    Cell Significance Index: -5.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0821
    Cell Significance Index: -4.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0876
    Cell Significance Index: -1.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0904
    Cell Significance Index: -1.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1039
    Cell Significance Index: -2.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1090
    Cell Significance Index: -3.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1223
    Cell Significance Index: -2.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1224
    Cell Significance Index: -1.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1243
    Cell Significance Index: -12.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1331
    Cell Significance Index: -3.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1366
    Cell Significance Index: -3.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1390
    Cell Significance Index: -8.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1569
    Cell Significance Index: -12.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1686
    Cell Significance Index: -3.5300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2046
    Cell Significance Index: -2.9300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2207
    Cell Significance Index: -1.8000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2302
    Cell Significance Index: -1.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2720
    Cell Significance Index: -13.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2812
    Cell Significance Index: -8.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2961
    Cell Significance Index: -3.5300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3064
    Cell Significance Index: -6.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3119
    Cell Significance Index: -7.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3171
    Cell Significance Index: -10.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3174
    Cell Significance Index: -11.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3183
    Cell Significance Index: -11.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3241
    Cell Significance Index: -10.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SP2 is a member of the Sp family of transcription factors, which are known for their role in regulating gene expression in response to various stimuli. SP2 is characterized by its ability to bind to specific DNA sequences, known as cis-regulatory elements, and regulate the transcription of target genes. The protein is highly expressed in various cell types, including cardiac muscle myoblasts, germ cells, and immune cells, such as GABAergic interneurons and intestinal crypt stem cells. **Pathways and Functions:** SP2 is involved in several key pathways, including: 1. **Chromatin regulation**: SP2 interacts with histone deacetylases to regulate chromatin structure and gene expression. 2. **Immune response**: SP2 is involved in the regulation of immune cell development and function, including the differentiation of GABAergic interneurons and the regulation of cytokine production. 3. **Transcriptional regulation**: SP2 regulates the transcription of target genes by binding to specific DNA sequences and recruiting RNA polymerase II. 4. **Metal ion binding**: SP2 has a metal ion binding domain, which is thought to play a role in its ability to regulate gene expression. **Clinical Significance:** Dysregulation of SP2 expression has been implicated in various diseases, including: 1. **Autoimmune disorders**: SP2 has been shown to play a role in the regulation of immune cell function, and dysregulation of SP2 expression may contribute to autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: SP2 has been implicated in the regulation of gene expression in various types of cancer, including leukemia and lymphoma. 3. **Neurological disorders**: SP2 has been shown to play a role in the regulation of gene expression in the brain, and dysregulation of SP2 expression may contribute to neurological disorders such as Parkinson's disease and Alzheimer's disease. In conclusion, SP2 is a critical regulator of gene expression in the immune system, development, and cell differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of SP2 in human health and disease. **Recommendations for Future Research:** 1. **Investigate the role of SP2 in immune cell development and function**: Further research is needed to understand the specific mechanisms by which SP2 regulates immune cell development and function. 2. **Examine the role of SP2 in cancer development and progression**: SP2 has been implicated in the regulation of gene expression in various types of cancer, and further research is needed to understand its role in cancer development and progression. 3. **Explore the therapeutic potential of SP2 in autoimmune disorders**: SP2 has been shown to play a role in the regulation of immune cell function, and targeting SP2 may offer a new therapeutic approach for autoimmune disorders. By continuing to investigate the role of SP2 in human health and disease, we can gain a deeper understanding of its mechanisms of action and identify new therapeutic targets for the treatment of various diseases.

Genular Protein ID: 1701775535

Symbol: SP2_HUMAN

Name: Transcription factor Sp2

UniProtKB Accession Codes:

Q02086 A6NK74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1341900

Title: Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.

PubMed ID: 1341900

DOI: 10.1128/mcb.12.10.4251-4261.1992

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

Sequence Information:

  • Length: 613
  • Mass: 64900
  • Checksum: DEE6BFCAE3405793
  • Sequence:
    • MSDPQTSMAA TAAVSPSDYL QPAASTTQDS QPSPLALLAA TCSKIGPPAV EAAVTPPAPP 
QPTPRKLVPI KPAPLPLSPG KNSFGILSSK GNILQIQGSQ LSASYPGGQL VFAIQNPTMI 
NKGTRSNANI QYQAVPQIQA SNSQTIQVQP NLTNQIQIIP GTNQAIITPS PSSHKPVPIK 
PAPIQKSSTT TTPVQSGANV VKLTGGGGNV TLTLPVNNLV NASDTGAPTQ LLTESPPTPL 
SKTNKKARKK SLPASQPPVA VAEQVETVLI ETTADNIIQA GNNLLIVQSP GGGQPAVVQQ 
VQVVPPKAEQ QQVVQIPQQA LRVVQAASAT LPTVPQKPSQ NFQIQAAEPT PTQVYIRTPS 
GEVQTVLVQD SPPATAAATS NTTCSSPASR APHLSGTSKK HSAAILRKER PLPKIAPAGS 
IISLNAAQLA AAAQAMQTIN INGVQVQGVP VTITNTGGQQ QLTVQNVSGN NLTISGLSPT 
QIQLQMEQAL AGETQPGEKR RRMACTCPNC KDGEKRSGEQ GKKKHVCHIP DCGKTFRKTS 
LLRAHVRLHT GERPFVCNWF FCGKRFTRSD ELQRHARTHT GDKRFECAQC QKRFMRSDHL 
TKHYKTHLVT KNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.