Details for: SP2

Gene ID: 6668

Symbol: SP2

Ensembl ID: ENSG00000167182

Description: Sp2 transcription factor

Associated with

  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Histone deacetylase binding
    (GO:0042826)
  • Immune response
    (GO:0006955)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.14
    Marker Score: 17767
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.04
    Marker Score: 1820
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1
    Marker Score: 922
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71742
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47966
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.97
    Marker Score: 303
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.94
    Marker Score: 749
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.92
    Marker Score: 2174
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.92
    Marker Score: 297
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2714
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4924
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.84
    Marker Score: 502
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.81
    Marker Score: 1640
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.79
    Marker Score: 4736
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1253
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 558
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.67
    Marker Score: 321
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 607
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.62
    Marker Score: 1697
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.6
    Marker Score: 592
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.57
    Marker Score: 147
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.54
    Marker Score: 838
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.54
    Marker Score: 1134
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 426
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.53
    Marker Score: 353
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.52
    Marker Score: 6015
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.51
    Marker Score: 740
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.51
    Marker Score: 679
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.51
    Marker Score: 178
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.5
    Marker Score: 312
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.49
    Marker Score: 216
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.48
    Marker Score: 327
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.48
    Marker Score: 933
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.47
    Marker Score: 4889
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.47
    Marker Score: 339
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.47
    Marker Score: 115
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.46
    Marker Score: 957
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.45
    Marker Score: 183
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.45
    Marker Score: 95
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.45
    Marker Score: 27453
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.45
    Marker Score: 253
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.44
    Marker Score: 446
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.44
    Marker Score: 332
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.44
    Marker Score: 423
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.44
    Marker Score: 476
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.44
    Marker Score: 211
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.44
    Marker Score: 1294
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.43
    Marker Score: 523
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.43
    Marker Score: 1658
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.42
    Marker Score: 1191
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.42
    Marker Score: 1041
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.42
    Marker Score: 128
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.42
    Marker Score: 205
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.42
    Marker Score: 444
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.42
    Marker Score: 103
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.42
    Marker Score: 230
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.42
    Marker Score: 22070
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.41
    Marker Score: 431
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.41
    Marker Score: 3547
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.41
    Marker Score: 108
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.41
    Marker Score: 152
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.41
    Marker Score: 90
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.41
    Marker Score: 130
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.41
    Marker Score: 403
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.41
    Marker Score: 440
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.41
    Marker Score: 408
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.4
    Marker Score: 390
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.4
    Marker Score: 106
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.4
    Marker Score: 3799
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.4
    Marker Score: 15095
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.39
    Marker Score: 354
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.39
    Marker Score: 1606
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.39
    Marker Score: 289
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.39
    Marker Score: 94
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.39
    Marker Score: 171
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.39
    Marker Score: 1240
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.39
    Marker Score: 578
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.39
    Marker Score: 492
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.39
    Marker Score: 190
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.39
    Marker Score: 88
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.38
    Marker Score: 159
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.38
    Marker Score: 105
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.38
    Marker Score: 725.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.38
    Marker Score: 259
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.38
    Marker Score: 85
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.38
    Marker Score: 93
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.38
    Marker Score: 98
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.38
    Marker Score: 96
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.37
    Marker Score: 185
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.37
    Marker Score: 600

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Other Information

**Key Characteristics:** SP2 is a member of the Sp family of transcription factors, which are known for their role in regulating gene expression in response to various stimuli. SP2 is characterized by its ability to bind to specific DNA sequences, known as cis-regulatory elements, and regulate the transcription of target genes. The protein is highly expressed in various cell types, including cardiac muscle myoblasts, germ cells, and immune cells, such as GABAergic interneurons and intestinal crypt stem cells. **Pathways and Functions:** SP2 is involved in several key pathways, including: 1. **Chromatin regulation**: SP2 interacts with histone deacetylases to regulate chromatin structure and gene expression. 2. **Immune response**: SP2 is involved in the regulation of immune cell development and function, including the differentiation of GABAergic interneurons and the regulation of cytokine production. 3. **Transcriptional regulation**: SP2 regulates the transcription of target genes by binding to specific DNA sequences and recruiting RNA polymerase II. 4. **Metal ion binding**: SP2 has a metal ion binding domain, which is thought to play a role in its ability to regulate gene expression. **Clinical Significance:** Dysregulation of SP2 expression has been implicated in various diseases, including: 1. **Autoimmune disorders**: SP2 has been shown to play a role in the regulation of immune cell function, and dysregulation of SP2 expression may contribute to autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: SP2 has been implicated in the regulation of gene expression in various types of cancer, including leukemia and lymphoma. 3. **Neurological disorders**: SP2 has been shown to play a role in the regulation of gene expression in the brain, and dysregulation of SP2 expression may contribute to neurological disorders such as Parkinson's disease and Alzheimer's disease. In conclusion, SP2 is a critical regulator of gene expression in the immune system, development, and cell differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of SP2 in human health and disease. **Recommendations for Future Research:** 1. **Investigate the role of SP2 in immune cell development and function**: Further research is needed to understand the specific mechanisms by which SP2 regulates immune cell development and function. 2. **Examine the role of SP2 in cancer development and progression**: SP2 has been implicated in the regulation of gene expression in various types of cancer, and further research is needed to understand its role in cancer development and progression. 3. **Explore the therapeutic potential of SP2 in autoimmune disorders**: SP2 has been shown to play a role in the regulation of immune cell function, and targeting SP2 may offer a new therapeutic approach for autoimmune disorders. By continuing to investigate the role of SP2 in human health and disease, we can gain a deeper understanding of its mechanisms of action and identify new therapeutic targets for the treatment of various diseases.

Genular Protein ID: 1701775535

Symbol: SP2_HUMAN

Name: Transcription factor Sp2

UniProtKB Accession Codes:

Q02086 A6NK74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1341900

Title: Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.

PubMed ID: 1341900

DOI: 10.1128/mcb.12.10.4251-4261.1992

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

Sequence Information:

  • Length: 613
  • Mass: 64900
  • Checksum: DEE6BFCAE3405793
  • Sequence:
    • MSDPQTSMAA TAAVSPSDYL QPAASTTQDS QPSPLALLAA TCSKIGPPAV EAAVTPPAPP 
QPTPRKLVPI KPAPLPLSPG KNSFGILSSK GNILQIQGSQ LSASYPGGQL VFAIQNPTMI 
NKGTRSNANI QYQAVPQIQA SNSQTIQVQP NLTNQIQIIP GTNQAIITPS PSSHKPVPIK 
PAPIQKSSTT TTPVQSGANV VKLTGGGGNV TLTLPVNNLV NASDTGAPTQ LLTESPPTPL 
SKTNKKARKK SLPASQPPVA VAEQVETVLI ETTADNIIQA GNNLLIVQSP GGGQPAVVQQ 
VQVVPPKAEQ QQVVQIPQQA LRVVQAASAT LPTVPQKPSQ NFQIQAAEPT PTQVYIRTPS 
GEVQTVLVQD SPPATAAATS NTTCSSPASR APHLSGTSKK HSAAILRKER PLPKIAPAGS 
IISLNAAQLA AAAQAMQTIN INGVQVQGVP VTITNTGGQQ QLTVQNVSGN NLTISGLSPT 
QIQLQMEQAL AGETQPGEKR RRMACTCPNC KDGEKRSGEQ GKKKHVCHIP DCGKTFRKTS 
LLRAHVRLHT GERPFVCNWF FCGKRFTRSD ELQRHARTHT GDKRFECAQC QKRFMRSDHL 
TKHYKTHLVT KNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.