Details for: STAT4

Gene ID: 6775

Symbol: STAT4

Ensembl ID: ENSG00000138378

Description: signal transducer and activator of transcription 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 91.0989
    Cell Significance Index: -14.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 54.5254
    Cell Significance Index: -13.8300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.4455
    Cell Significance Index: -16.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.5170
    Cell Significance Index: -14.2000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 5.9577
    Cell Significance Index: 15.9600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.8083
    Cell Significance Index: -17.8400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1008
    Cell Significance Index: -8.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.9774
    Cell Significance Index: -10.6600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.0166
    Cell Significance Index: 49.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1629
    Cell Significance Index: 233.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.8912
    Cell Significance Index: 19.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.7210
    Cell Significance Index: 104.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6638
    Cell Significance Index: 126.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6514
    Cell Significance Index: 19.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4728
    Cell Significance Index: 46.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4038
    Cell Significance Index: 364.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3977
    Cell Significance Index: 142.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3156
    Cell Significance Index: 11.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2802
    Cell Significance Index: 381.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2684
    Cell Significance Index: 11.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2267
    Cell Significance Index: 36.8700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.2247
    Cell Significance Index: 2.3300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2036
    Cell Significance Index: 2.5300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1990
    Cell Significance Index: 5.6800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.1456
    Cell Significance Index: 1.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1186
    Cell Significance Index: 12.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1178
    Cell Significance Index: 23.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0890
    Cell Significance Index: 5.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0765
    Cell Significance Index: 117.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0604
    Cell Significance Index: 1.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0515
    Cell Significance Index: 96.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0451
    Cell Significance Index: 31.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0392
    Cell Significance Index: 0.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0362
    Cell Significance Index: 66.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0301
    Cell Significance Index: 2.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0135
    Cell Significance Index: 0.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0113
    Cell Significance Index: 0.6900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0069
    Cell Significance Index: 0.0500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0077
    Cell Significance Index: -0.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0088
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0152
    Cell Significance Index: -9.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0170
    Cell Significance Index: -12.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0191
    Cell Significance Index: -3.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0229
    Cell Significance Index: -12.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0236
    Cell Significance Index: -13.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0239
    Cell Significance Index: -17.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0243
    Cell Significance Index: -15.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0275
    Cell Significance Index: -12.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0350
    Cell Significance Index: -15.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0409
    Cell Significance Index: -11.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0435
    Cell Significance Index: -1.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0535
    Cell Significance Index: -1.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0613
    Cell Significance Index: -1.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0623
    Cell Significance Index: -1.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0675
    Cell Significance Index: -8.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0699
    Cell Significance Index: -14.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0726
    Cell Significance Index: -12.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0859
    Cell Significance Index: -11.8000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0879
    Cell Significance Index: -1.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0912
    Cell Significance Index: -10.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0936
    Cell Significance Index: -5.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1039
    Cell Significance Index: -2.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1068
    Cell Significance Index: -1.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1119
    Cell Significance Index: -13.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1153
    Cell Significance Index: -2.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1158
    Cell Significance Index: -13.2700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1175
    Cell Significance Index: -2.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1255
    Cell Significance Index: -7.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1277
    Cell Significance Index: -16.5000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1305
    Cell Significance Index: -2.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1310
    Cell Significance Index: -13.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1356
    Cell Significance Index: -4.3200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1364
    Cell Significance Index: -1.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1417
    Cell Significance Index: -14.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1479
    Cell Significance Index: -18.9600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1490
    Cell Significance Index: -1.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1649
    Cell Significance Index: -5.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1736
    Cell Significance Index: -8.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1906
    Cell Significance Index: -4.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1983
    Cell Significance Index: -10.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2055
    Cell Significance Index: -13.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2082
    Cell Significance Index: -15.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2162
    Cell Significance Index: -11.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2182
    Cell Significance Index: -13.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2211
    Cell Significance Index: -7.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2223
    Cell Significance Index: -15.7200
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.2289
    Cell Significance Index: -2.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2301
    Cell Significance Index: -8.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2449
    Cell Significance Index: -4.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2474
    Cell Significance Index: -6.9200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2512
    Cell Significance Index: -1.3700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2727
    Cell Significance Index: -3.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2744
    Cell Significance Index: -17.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2748
    Cell Significance Index: -9.5500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2788
    Cell Significance Index: -4.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2919
    Cell Significance Index: -13.6100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2947
    Cell Significance Index: -6.1500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3024
    Cell Significance Index: -4.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STAT4 is a member of the STAT family of transcription factors, which are characterized by their ability to bind to specific DNA sequences and regulate gene expression. Unlike other STAT family members, STAT4 is primarily involved in the signaling pathways of the interleukin-12 (IL-12) and IL-23 cytokines, which are critical for the differentiation and function of Th1 cells. STAT4 is also involved in the regulation of immune cell proliferation, apoptosis, and the production of pro-inflammatory cytokines. **Pathways and Functions:** STAT4 is a key mediator of the JAK/STAT signaling pathway, which is activated by the binding of cytokines to their respective receptors. Upon activation, STAT4 is phosphorylated and translocated to the nucleus, where it regulates the expression of target genes involved in immune responses. The primary functions of STAT4 include: 1. **Th1 cell differentiation and function**: STAT4 is essential for the differentiation and function of Th1 cells, which play a critical role in cell-mediated immunity. 2. **Immune cell proliferation**: STAT4 regulates the proliferation of immune cells, including T cells, B cells, and natural killer cells. 3. **Cytokine production**: STAT4 promotes the production of pro-inflammatory cytokines, such as IL-2, IL-12, and IL-23. 4. **Apoptosis regulation**: STAT4 regulates the expression of genes involved in apoptosis, including the promotion of programmed cell death in infected cells. **Clinical Significance:** Dysregulation of STAT4 has been implicated in various immune-mediated diseases, including: 1. **Autoimmune disorders**: STAT4 has been associated with multiple sclerosis, rheumatoid arthritis, and type 1 diabetes, where it plays a critical role in the regulation of immune cell responses. 2. **Infectious diseases**: STAT4 has been implicated in the regulation of immune responses to infections, including tuberculosis and HIV. 3. **Cancer**: STAT4 has been shown to promote the proliferation and survival of cancer cells, making it a potential target for cancer therapy. In conclusion, STAT4 is a critical transcription factor that plays a vital role in the regulation of immune responses. Its dysregulation has been implicated in various immune-mediated diseases, highlighting the importance of understanding its molecular mechanisms and clinical implications. Further research is needed to fully elucidate the role of STAT4 in immune regulation and its potential as a therapeutic target for immune-mediated diseases.

Genular Protein ID: 3562728418

Symbol: STAT4_HUMAN

Name: Signal transducer and activator of transcription 4

UniProtKB Accession Codes:

Q14765 Q96NZ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7638186

Title: Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

PubMed ID: 7638186

DOI: 10.1073/pnas.92.16.7307

PubMed ID: 8943379

Title: Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation.

PubMed ID: 8943379

PubMed ID: 10415122

Title: Direct interaction of STAT4 with the IL-12 receptor.

PubMed ID: 10415122

DOI: 10.1006/abbi.1999.1302

PubMed ID: 9890938

Title: Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling.

PubMed ID: 9890938

DOI: 10.1074/jbc.274.4.1875

PubMed ID: 10961885

Title: Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.

PubMed ID: 10961885

PubMed ID: 11114383

Title: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

PubMed ID: 11114383

DOI: 10.1016/s1074-7613(00)00070-4

PubMed ID: 12213961

Title: STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation.

PubMed ID: 12213961

DOI: 10.1073/pnas.182618999

PubMed ID: 19109131

Title: Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.

PubMed ID: 19109131

DOI: 10.4049/jimmunol.182.1.34

PubMed ID: 26990433

Title: STAT4-mediated transcriptional repression of the IL5 gene in human memory Th2 cells.

PubMed ID: 26990433

DOI: 10.1002/eji.201546050

PubMed ID: 34508746

Title: Interleukin-35 inhibits lipopolysaccharide-induced endothelial cell activation by downregulating inflammation and apoptosis.

PubMed ID: 34508746

DOI: 10.1016/j.yexcr.2021.112784

PubMed ID: 35614130

Title: Acetylation licenses Th1 cell polarization to constrain Listeria monocytogenes infection.

PubMed ID: 35614130

DOI: 10.1038/s41418-022-01017-9

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17804842

Title: STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.

PubMed ID: 17804842

DOI: 10.1056/nejmoa073003

PubMed ID: 37256972

Title: Variant STAT4 and Response to Ruxolitinib in an Autoinflammatory Syndrome.

PubMed ID: 37256972

DOI: 10.1056/nejmoa2202318

Sequence Information:

  • Length: 748
  • Mass: 85941
  • Checksum: 11E43803A9AF4FFA
  • Sequence:
    • MSQWNQVQQL EIKFLEQVDQ FYDDNFPMEI RHLLAQWIEN QDWEAASNNE TMATILLQNL 
LIQLDEQLGR VSKEKNLLLI HNLKRIRKVL QGKFHGNPMH VAVVISNCLR EERRILAAAN 
MPVQGPLEKS LQSSSVSERQ RNVEHKVAAI KNSVQMTEQD TKYLEDLQDE FDYRYKTIQT 
MDQSDKNSAM VNQEVLTLQE MLNSLDFKRK EALSKMTQII HETDLLMNTM LIEELQDWKR 
RQQIACIGGP LHNGLDQLQN CFTLLAESLF QLRRQLEKLE EQSTKMTYEG DPIPMQRTHM 
LERVTFLIYN LFKNSFVVER QPCMPTHPQR PLVLKTLIQF TVKLRLLIKL PELNYQVKVK 
ASIDKNVSTL SNRRFVLCGT NVKAMSIEES SNGSLSVEFR HLQPKEMKSS AGGKGNEGCH 
MVTEELHSIT FETQICLYGL TIDLETSSLP VVMISNVSQL PNAWASIIWY NVSTNDSQNL 
VFFNNPPPAT LSQLLEVMSW QFSSYVGRGL NSDQLHMLAE KLTVQSSYSD GHLTWAKFCK 
EHLPGKSFTF WTWLEAILDL IKKHILPLWI DGYVMGFVSK EKERLLLKDK MPGTFLLRFS 
ESHLGGITFT WVDHSESGEV RFHSVEPYNK GRLSALPFAD ILRDYKVIMA ENIPENPLKY 
LYPDIPKDKA FGKHYSSQPC EVSRPTERGD KGYVPSVFIP ISTIRSDSTE PHSPSDLLPM 
SPSVYAVLRE NLSPTTIETA MKSPYSAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.