Details for: STAT5A

Gene ID: 6776

Symbol: STAT5A

Ensembl ID: ENSG00000126561

Description: signal transducer and activator of transcription 5A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 81.7769
    Cell Significance Index: -12.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.3040
    Cell Significance Index: -13.5300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 31.5172
    Cell Significance Index: -14.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.0067
    Cell Significance Index: -15.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 29.3325
    Cell Significance Index: -7.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.4123
    Cell Significance Index: -13.7600
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 12.6551
    Cell Significance Index: 55.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.9899
    Cell Significance Index: -13.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.3190
    Cell Significance Index: -11.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5479
    Cell Significance Index: -14.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0796
    Cell Significance Index: -6.7400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 2.6628
    Cell Significance Index: 33.5300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.9064
    Cell Significance Index: 12.1700
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 1.3647
    Cell Significance Index: 9.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1137
    Cell Significance Index: 211.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7708
    Cell Significance Index: 16.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7589
    Cell Significance Index: 123.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7211
    Cell Significance Index: 20.6700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7109
    Cell Significance Index: 13.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6746
    Cell Significance Index: 66.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5973
    Cell Significance Index: 28.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5762
    Cell Significance Index: 520.2700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4625
    Cell Significance Index: 7.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4090
    Cell Significance Index: 44.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4004
    Cell Significance Index: 11.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3226
    Cell Significance Index: 19.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2976
    Cell Significance Index: 7.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2964
    Cell Significance Index: 19.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2933
    Cell Significance Index: 37.9000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.2295
    Cell Significance Index: 7.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2152
    Cell Significance Index: 16.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2059
    Cell Significance Index: 24.2800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1692
    Cell Significance Index: 1.3800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1592
    Cell Significance Index: 0.9800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1357
    Cell Significance Index: 0.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1220
    Cell Significance Index: 5.6900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1047
    Cell Significance Index: 1.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0896
    Cell Significance Index: 39.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0854
    Cell Significance Index: 2.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0847
    Cell Significance Index: 16.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0833
    Cell Significance Index: 57.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0831
    Cell Significance Index: 9.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0795
    Cell Significance Index: 2.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0660
    Cell Significance Index: 1.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0640
    Cell Significance Index: 1.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0610
    Cell Significance Index: 8.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0527
    Cell Significance Index: 2.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0220
    Cell Significance Index: 0.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0185
    Cell Significance Index: 2.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0177
    Cell Significance Index: 6.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0154
    Cell Significance Index: 2.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0137
    Cell Significance Index: 1.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0076
    Cell Significance Index: 14.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0074
    Cell Significance Index: 4.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0044
    Cell Significance Index: 8.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0034
    Cell Significance Index: -2.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0036
    Cell Significance Index: -5.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -3.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0066
    Cell Significance Index: -9.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0075
    Cell Significance Index: -3.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0115
    Cell Significance Index: -1.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0168
    Cell Significance Index: -0.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0171
    Cell Significance Index: -12.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0196
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0206
    Cell Significance Index: -15.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0234
    Cell Significance Index: -1.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0238
    Cell Significance Index: -2.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0255
    Cell Significance Index: -3.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0262
    Cell Significance Index: -16.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0269
    Cell Significance Index: -15.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0339
    Cell Significance Index: -9.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0527
    Cell Significance Index: -3.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0539
    Cell Significance Index: -10.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0600
    Cell Significance Index: -3.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0615
    Cell Significance Index: -3.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0776
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0781
    Cell Significance Index: -16.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0843
    Cell Significance Index: -4.2600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0856
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0916
    Cell Significance Index: -10.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0971
    Cell Significance Index: -7.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1021
    Cell Significance Index: -2.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1061
    Cell Significance Index: -1.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1150
    Cell Significance Index: -11.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1218
    Cell Significance Index: -3.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1331
    Cell Significance Index: -8.1600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1406
    Cell Significance Index: -1.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1523
    Cell Significance Index: -4.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1561
    Cell Significance Index: -12.3600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1566
    Cell Significance Index: -2.7000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1917
    Cell Significance Index: -1.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2186
    Cell Significance Index: -13.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2246
    Cell Significance Index: -15.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2452
    Cell Significance Index: -15.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2454
    Cell Significance Index: -5.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2735
    Cell Significance Index: -15.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2766
    Cell Significance Index: -7.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2790
    Cell Significance Index: -12.1300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2812
    Cell Significance Index: -4.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2987
    Cell Significance Index: -6.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STAT5A is a member of the STAT family of transcription factors, which are characterized by their ability to dimerize and bind to specific DNA sequences. STAT5A is specifically activated by a wide range of cytokines and growth factors, including erythropoietin, interleukins, and leukemia inhibitory factor (LIF). Once activated, STAT5A translocates to the nucleus, where it regulates gene expression by binding to target genes and influencing transcriptional activity. **Pathways and Functions:** STAT5A is involved in multiple signaling pathways, including: 1. **Cytokine-mediated signaling pathway:** STAT5A is activated by various cytokines, such as interleukin-2 (IL-2), interleukin-3 (IL-3), and interleukin-5 (IL-5), which regulate immune responses, cell growth, and differentiation. 2. **Growth hormone receptor signaling:** STAT5A is activated by growth hormone (GH), which regulates cell growth, differentiation, and metabolism. 3. **Flt3 signaling:** STAT5A is activated by the Flt3 tyrosine kinase receptor, which is involved in hematopoiesis and immune responses. 4. **Interleukin-15 signaling:** STAT5A is activated by interleukin-15 (IL-15), which regulates T cell development and function. STAT5A plays a crucial role in various cellular processes, including: 1. **Cell proliferation and differentiation:** STAT5A regulates cell growth and differentiation by influencing transcriptional activity. 2. **Immune response:** STAT5A is involved in the regulation of immune responses, including T cell development, function, and differentiation. 3. **Hematopoiesis:** STAT5A regulates hematopoiesis by influencing the proliferation and differentiation of hematopoietic stem cells. 4. **Metabolic regulation:** STAT5A regulates metabolic processes, including glucose and lipid metabolism. **Clinical Significance:** Dysregulation of STAT5A has been implicated in various diseases, including: 1. **Hematological malignancies:** Mutations in STAT5A have been associated with hematological malignancies, such as acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). 2. **Autoimmune diseases:** Dysregulation of STAT5A has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Metabolic disorders:** STAT5A regulates metabolic processes, and dysregulation of STAT5A has been associated with metabolic disorders, such as obesity and diabetes. In conclusion, STAT5A is a multifunctional transcription factor that plays a crucial role in various cellular processes, including immune response, cell growth, and differentiation. Understanding the complex signaling pathways and clinical significance of STAT5A is essential for the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 870958936

Symbol: STA5A_HUMAN

Name: Signal transducer and activator of transcription 5A

UniProtKB Accession Codes:

P42229 Q1KLZ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 3 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 7 Ensembl 5 ExpressionAtlas 1 GO 33 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 22 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7719937

Title: Identification and purification of human Stat proteins activated in response to interleukin-2.

PubMed ID: 7719937

DOI: 10.1016/1074-7613(95)90140-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11773439

Title: A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus.

PubMed ID: 11773439

DOI: 10.1210/mend.16.1.0761

PubMed ID: 24319783

Title: Retraction.

PubMed ID: 24319783

DOI: 10.1210/me.2013-1264

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 12954634

Title: NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain.

PubMed ID: 12954634

DOI: 10.1074/jbc.m303644200

PubMed ID: 12529425

Title: STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA.

PubMed ID: 12529425

DOI: 10.1091/mbc.e02-08-0454

PubMed ID: 14504097

Title: FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.

PubMed ID: 14504097

DOI: 10.1182/blood-2003-02-0418

PubMed ID: 15526160

Title: Signal transduction via the stem cell factor receptor/c-Kit.

PubMed ID: 15526160

DOI: 10.1007/s00018-004-4189-6

PubMed ID: 15534001

Title: The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone.

PubMed ID: 15534001

DOI: 10.1083/jcb.200403155

PubMed ID: 15677474

Title: Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.

PubMed ID: 15677474

DOI: 10.1074/jbc.m411596200

PubMed ID: 21135090

Title: Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells.

PubMed ID: 21135090

DOI: 10.1074/jbc.m110.182642

PubMed ID: 35939714

Title: Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells.

PubMed ID: 35939714

DOI: 10.1073/pnas.2208522119

Sequence Information:

  • Length: 794
  • Mass: 90647
  • Checksum: C64237295F88CFBE
  • Sequence:
    • MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRAQATQL 
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQKTYDR CPLELVRCIR HILYNEQRLV 
REANNCSSPA GILVDAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL 
RIQAQFAQLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL 
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL 
NVHMNPPQVK ATIISEQQAK SLLKNENTRN ECSGEILNNC CVMEYHQATG TLSAHFRNMS 
LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK TLSLPVVVIV HGSQDHNATA 
TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN 
SSSHLEDYSG LSVSWSQFNR ENLPGWNYTF WQWFDGVMEV LKKHHKPHWN DGAILGFVNK 
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSPERNL WNLKPFTTRD FSIRSLADRL 
GDLSYLIYVF PDRPKDEVFS KYYTPVLAKA VDGYVKPQIK QVVPEFVNAS ADAGGSSATY 
MDQAPSPAVC PQAPYNMYPQ NPDHVLDQDG EFDLDETMDV ARHVEELLRR PMDSLDSRLS 
PPAGLFTSAR GSLS

Genular Protein ID: 1898510509

Symbol: K7EK35_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7EK35

Database IDs:

ARBA 13 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 4 GeneTree 1 HGNC 1 InterPro 12 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 5 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 4 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 763
  • Mass: 87362
  • Checksum: C7B1D8A7DDFFE969
  • Sequence:
    • MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRAQATQL 
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQKTYDR CPLELVRCIR HILYNEQRLV 
REANNCSSPA GILVDAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL 
RIQAQFAQLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL 
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL 
NVHMNPPQVK ATIISEQQAK SLLKNENTRN ECSGEILNNC CVMEYHQATG TLSAHFRNMS 
LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK GRVPFAVPDK VLWPQLCEAL 
NMKFKAEVQS NRGLTKENLV FLAQKLFNNS SSHLEDYSGL SVSWSQFNRE NLPGWNYTFW 
QWFDGVMEVL KKHHKPHWND GAILGFVNKQ QAHDLLINKP DGTFLLRFSD SEIGGITIAW 
KFDSPERNLW NLKPFTTRDF SIRSLADRLG DLSYLIYVFP DRPKDEVFSK YYTPVLAKAV 
DGYVKPQIKQ VVPEFVNASA DAGGSSATYM DQAPSPAVCP QAPYNMYPQN PDHVLDQDGE 
FDLDETMDVA RHVEELLRRP MDSLDSRLSP PAGLFTSARG SLS

Genular Protein ID: 940485263

Symbol: Q59GY7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GY7

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 10 Gene3D 4 InterPro 12 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 ProteomicsDB 1 RefSeq 4 RuleBase 1 SAM 1 SMART 2 SUPFAM 4

Sequence Information:

  • Length: 765
  • Mass: 87535
  • Checksum: 9C1359E4174275E0
  • Sequence:
    • TAMAGWIQAQ QLQGDALRQM QVLYGQHFPI EVRHYLAQWI ESQPWDAIDL DNPQDRAQAT 
QLLEGLVQEL QKKAEHQVGE DGFLLKIKLG HYATQLQKTY DRCPLELVRC IRHILYNEQR 
LVREANNCSS PAGILVDAMS QKHLQINQTF EELRLVTQDT ENELKKLQQT QEYFIIQYQE 
SLRIQAQFAQ LAQLSPQERL SRETALQQKQ VSLEAWLQRE AQTLQQYRVE LAEKHQKTLQ 
LLRKQQTIIL DDELIQWKRR QQLAGNGGPP EGSLDVLQSW CEKLAEIIWQ NRQQIRRAEH 
LCQQLPIPGP VEEMLAEVNA TITDIISALV TSTFIIEKQP PQVLKTQTKF AATVRLLVGG 
KLNVHMNPPQ VKATIISEQQ AKSLLKNENT RNECSGEILN NCCVMEYHQA TGTLSAHFRN 
MSLKRIKRAD RRGAESVTEE KFTVLFESQF SVGSNELVFQ VKGRVPFAVP DKVLWPQLCE 
ALNMKFKAEV QSNRGLTKEN LVFLAQKLFN NSSSHLEDYS GLSVSWSQFN RENLPGWNYT 
FWQWFDGVME VLKKHHKPHW NDGAILGFVN KQQAHDLLIN KPDGTFLLRF SDSEIGGITI 
AWKFDSPERN LWNLKPFTTR DFSIRSLADR LGDLSYLIYV FPDRPKDEVF SKYYTPVLAK 
AVDGYVKPQI KQVVPEFVNA SADAGGSSAT YMDQAPSPAV CPQAPYNMYP QNPDHVLDQD 
GEFDLDETMD VARHVEELLR RPMDSLDSRL SPPAGLFTSA RGSLS

Genular Protein ID: 992641356

Symbol: A8K6I5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K6I5

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 10 Gene3D 5 InterPro 13 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 5 PharmGKB 1 RefSeq 4 RuleBase 1 SAM 1 SMART 2 SUPFAM 4

Sequence Information:

  • Length: 794
  • Mass: 90646
  • Checksum: B17B6BB224AC312C
  • Sequence:
    • MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRAQATQL 
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQKTYDR CPLELVRCIR HILYNEQRLV 
REANNCSSPA GILVDAMSQK HLQINQTFEE LRLVTQDTEN ELKELQQTQE YFIIQYQESL 
RIQAQFAQLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL 
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL 
NVHMNPPQVK ATIISEQQAK SLLKNENTRN ECSGEILNNC CVMEYHQATG TLSAHFRNMS 
LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK TLSLPVVVIV HGSQDHNATA 
TVLWDNAFAE PGRVPFAVPD KMLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN 
SSSHLEDYSG LSVSWSQFNR ENLPGWNYTF WQWFDGVMEV LKKHHKPHWN DGAILGFVNK 
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKLDSPERNL WNLKPFTTRD FSIRSLADRL 
GDLSYLIYVF PDRPKDEVFS KYYTPVLAKA VDGYVKPQIK QVVPEFVNAS ADAGGSSATY 
MDQAPSPAVC PQAPYNMYPQ NPDHVLDQDG EFDLDETMDV ARHVEELLRR PMDSLDSRLS 
PPAGLFTSAR GSLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.