Details for: STAT5A

Gene ID: 6776

Symbol: STAT5A

Ensembl ID: ENSG00000126561

Description: signal transducer and activator of transcription 5A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.61
    Marker Score: 955
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.38
    Marker Score: 773
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.29
    Marker Score: 413
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.16
    Marker Score: 784
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.08
    Marker Score: 4428
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.08
    Marker Score: 1528
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.06
    Marker Score: 770
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.05
    Marker Score: 368
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71728
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47952
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.94
    Marker Score: 455
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2711
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.88
    Marker Score: 29986
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.88
    Marker Score: 2071
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5244
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4898
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.85
    Marker Score: 47665
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.81
    Marker Score: 512
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.79
    Marker Score: 207
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.78
    Marker Score: 12276
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.77
    Marker Score: 1378
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.76
    Marker Score: 182
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.75
    Marker Score: 243
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1219
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.75
    Marker Score: 39676
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.74
    Marker Score: 2752
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.74
    Marker Score: 368
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.72
    Marker Score: 18519
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 550
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.72
    Marker Score: 1396
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.71
    Marker Score: 1441
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.7
    Marker Score: 522
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.69
    Marker Score: 184
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.69
    Marker Score: 469.5
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.69
    Marker Score: 339
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.68
    Marker Score: 1211
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.68
    Marker Score: 498
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.68
    Marker Score: 1901
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2831
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.66
    Marker Score: 348
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 601
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.66
    Marker Score: 295
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.66
    Marker Score: 165
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.65
    Marker Score: 4145
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.64
    Marker Score: 195
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.64
    Marker Score: 3824
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.63
    Marker Score: 638
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.62
    Marker Score: 676
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.62
    Marker Score: 748
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.62
    Marker Score: 356
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.61
    Marker Score: 1511
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.61
    Marker Score: 190
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.6
    Marker Score: 433
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.59
    Marker Score: 1866
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.59
    Marker Score: 460
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.58
    Marker Score: 360
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.58
    Marker Score: 113
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.57
    Marker Score: 177
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.56
    Marker Score: 525
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 370
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.55
    Marker Score: 632
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.55
    Marker Score: 1345
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.55
    Marker Score: 153
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.55
    Marker Score: 5424
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.55
    Marker Score: 126
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.55
    Marker Score: 119
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.55
    Marker Score: 370
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.54
    Marker Score: 188
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.54
    Marker Score: 518
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.54
    Marker Score: 218
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 428
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 320
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.52
    Marker Score: 129
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.52
    Marker Score: 248
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.52
    Marker Score: 121
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.52
    Marker Score: 525
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.51
    Marker Score: 341
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.51
    Marker Score: 3084.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.5
    Marker Score: 2147
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.5
    Marker Score: 378
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.5
    Marker Score: 376
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.5
    Marker Score: 111.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.49
    Marker Score: 538
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.49
    Marker Score: 242
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.49
    Marker Score: 245
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 204
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.49
    Marker Score: 121
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.49
    Marker Score: 403
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.48
    Marker Score: 332
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.48
    Marker Score: 119
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.48
    Marker Score: 5614

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Other Information

**Key Characteristics:** STAT5A is a member of the STAT family of transcription factors, which are characterized by their ability to dimerize and bind to specific DNA sequences. STAT5A is specifically activated by a wide range of cytokines and growth factors, including erythropoietin, interleukins, and leukemia inhibitory factor (LIF). Once activated, STAT5A translocates to the nucleus, where it regulates gene expression by binding to target genes and influencing transcriptional activity. **Pathways and Functions:** STAT5A is involved in multiple signaling pathways, including: 1. **Cytokine-mediated signaling pathway:** STAT5A is activated by various cytokines, such as interleukin-2 (IL-2), interleukin-3 (IL-3), and interleukin-5 (IL-5), which regulate immune responses, cell growth, and differentiation. 2. **Growth hormone receptor signaling:** STAT5A is activated by growth hormone (GH), which regulates cell growth, differentiation, and metabolism. 3. **Flt3 signaling:** STAT5A is activated by the Flt3 tyrosine kinase receptor, which is involved in hematopoiesis and immune responses. 4. **Interleukin-15 signaling:** STAT5A is activated by interleukin-15 (IL-15), which regulates T cell development and function. STAT5A plays a crucial role in various cellular processes, including: 1. **Cell proliferation and differentiation:** STAT5A regulates cell growth and differentiation by influencing transcriptional activity. 2. **Immune response:** STAT5A is involved in the regulation of immune responses, including T cell development, function, and differentiation. 3. **Hematopoiesis:** STAT5A regulates hematopoiesis by influencing the proliferation and differentiation of hematopoietic stem cells. 4. **Metabolic regulation:** STAT5A regulates metabolic processes, including glucose and lipid metabolism. **Clinical Significance:** Dysregulation of STAT5A has been implicated in various diseases, including: 1. **Hematological malignancies:** Mutations in STAT5A have been associated with hematological malignancies, such as acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). 2. **Autoimmune diseases:** Dysregulation of STAT5A has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Metabolic disorders:** STAT5A regulates metabolic processes, and dysregulation of STAT5A has been associated with metabolic disorders, such as obesity and diabetes. In conclusion, STAT5A is a multifunctional transcription factor that plays a crucial role in various cellular processes, including immune response, cell growth, and differentiation. Understanding the complex signaling pathways and clinical significance of STAT5A is essential for the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 870958936

Symbol: STA5A_HUMAN

Name: Signal transducer and activator of transcription 5A

UniProtKB Accession Codes:

P42229 Q1KLZ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 3 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 30 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 22 RefSeq 4 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7719937

Title: Identification and purification of human Stat proteins activated in response to interleukin-2.

PubMed ID: 7719937

DOI: 10.1016/1074-7613(95)90140-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11773439

Title: A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus.

PubMed ID: 11773439

DOI: 10.1210/mend.16.1.0761

PubMed ID: 24319783

Title: Retraction.

PubMed ID: 24319783

DOI: 10.1210/me.2013-1264

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 12954634

Title: NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain.

PubMed ID: 12954634

DOI: 10.1074/jbc.m303644200

PubMed ID: 12529425

Title: STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA.

PubMed ID: 12529425

DOI: 10.1091/mbc.e02-08-0454

PubMed ID: 14504097

Title: FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.

PubMed ID: 14504097

DOI: 10.1182/blood-2003-02-0418

PubMed ID: 15526160

Title: Signal transduction via the stem cell factor receptor/c-Kit.

PubMed ID: 15526160

DOI: 10.1007/s00018-004-4189-6

PubMed ID: 15534001

Title: The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone.

PubMed ID: 15534001

DOI: 10.1083/jcb.200403155

PubMed ID: 15677474

Title: Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.

PubMed ID: 15677474

DOI: 10.1074/jbc.m411596200

PubMed ID: 21135090

Title: Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells.

PubMed ID: 21135090

DOI: 10.1074/jbc.m110.182642

PubMed ID: 35939714

Title: Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells.

PubMed ID: 35939714

DOI: 10.1073/pnas.2208522119

Sequence Information:

  • Length: 794
  • Mass: 90647
  • Checksum: C64237295F88CFBE
  • Sequence:
    • MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRAQATQL 
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQKTYDR CPLELVRCIR HILYNEQRLV 
REANNCSSPA GILVDAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL 
RIQAQFAQLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL 
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL 
NVHMNPPQVK ATIISEQQAK SLLKNENTRN ECSGEILNNC CVMEYHQATG TLSAHFRNMS 
LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK TLSLPVVVIV HGSQDHNATA 
TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN 
SSSHLEDYSG LSVSWSQFNR ENLPGWNYTF WQWFDGVMEV LKKHHKPHWN DGAILGFVNK 
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSPERNL WNLKPFTTRD FSIRSLADRL 
GDLSYLIYVF PDRPKDEVFS KYYTPVLAKA VDGYVKPQIK QVVPEFVNAS ADAGGSSATY 
MDQAPSPAVC PQAPYNMYPQ NPDHVLDQDG EFDLDETMDV ARHVEELLRR PMDSLDSRLS 
PPAGLFTSAR GSLS

Genular Protein ID: 940485263

Symbol: Q59GY7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GY7

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 6 Gene3D 4 Genevisible 1 GenomeRNAi 1 InterPro 12 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 ProteomicsDB 1 RefSeq 4 RuleBase 1 SAM 1 SMART 2 SUPFAM 4

Sequence Information:

  • Length: 765
  • Mass: 87535
  • Checksum: 9C1359E4174275E0
  • Sequence:
    • TAMAGWIQAQ QLQGDALRQM QVLYGQHFPI EVRHYLAQWI ESQPWDAIDL DNPQDRAQAT 
QLLEGLVQEL QKKAEHQVGE DGFLLKIKLG HYATQLQKTY DRCPLELVRC IRHILYNEQR 
LVREANNCSS PAGILVDAMS QKHLQINQTF EELRLVTQDT ENELKKLQQT QEYFIIQYQE 
SLRIQAQFAQ LAQLSPQERL SRETALQQKQ VSLEAWLQRE AQTLQQYRVE LAEKHQKTLQ 
LLRKQQTIIL DDELIQWKRR QQLAGNGGPP EGSLDVLQSW CEKLAEIIWQ NRQQIRRAEH 
LCQQLPIPGP VEEMLAEVNA TITDIISALV TSTFIIEKQP PQVLKTQTKF AATVRLLVGG 
KLNVHMNPPQ VKATIISEQQ AKSLLKNENT RNECSGEILN NCCVMEYHQA TGTLSAHFRN 
MSLKRIKRAD RRGAESVTEE KFTVLFESQF SVGSNELVFQ VKGRVPFAVP DKVLWPQLCE 
ALNMKFKAEV QSNRGLTKEN LVFLAQKLFN NSSSHLEDYS GLSVSWSQFN RENLPGWNYT 
FWQWFDGVME VLKKHHKPHW NDGAILGFVN KQQAHDLLIN KPDGTFLLRF SDSEIGGITI 
AWKFDSPERN LWNLKPFTTR DFSIRSLADR LGDLSYLIYV FPDRPKDEVF SKYYTPVLAK 
AVDGYVKPQI KQVVPEFVNA SADAGGSSAT YMDQAPSPAV CPQAPYNMYP QNPDHVLDQD 
GEFDLDETMD VARHVEELLR RPMDSLDSRL SPPAGLFTSA RGSLS

Genular Protein ID: 1898510509

Symbol: K7EK35_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7EK35

Database IDs:

ARBA 13 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 4 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 12 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 4 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 763
  • Mass: 87362
  • Checksum: C7B1D8A7DDFFE969
  • Sequence:
    • MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRAQATQL 
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQKTYDR CPLELVRCIR HILYNEQRLV 
REANNCSSPA GILVDAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL 
RIQAQFAQLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL 
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL 
NVHMNPPQVK ATIISEQQAK SLLKNENTRN ECSGEILNNC CVMEYHQATG TLSAHFRNMS 
LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK GRVPFAVPDK VLWPQLCEAL 
NMKFKAEVQS NRGLTKENLV FLAQKLFNNS SSHLEDYSGL SVSWSQFNRE NLPGWNYTFW 
QWFDGVMEVL KKHHKPHWND GAILGFVNKQ QAHDLLINKP DGTFLLRFSD SEIGGITIAW 
KFDSPERNLW NLKPFTTRDF SIRSLADRLG DLSYLIYVFP DRPKDEVFSK YYTPVLAKAV 
DGYVKPQIKQ VVPEFVNASA DAGGSSATYM DQAPSPAVCP QAPYNMYPQN PDHVLDQDGE 
FDLDETMDVA RHVEELLRRP MDSLDSRLSP PAGLFTSARG SLS

Genular Protein ID: 992641356

Symbol: A8K6I5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K6I5

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 EMBL 2 GO 6 Gene3D 5 Genevisible 1 GenomeRNAi 1 InterPro 13 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 5 PharmGKB 1 RefSeq 4 RuleBase 1 SAM 1 SMART 2 SUPFAM 4

Sequence Information:

  • Length: 794
  • Mass: 90646
  • Checksum: B17B6BB224AC312C
  • Sequence:
    • MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRAQATQL 
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQKTYDR CPLELVRCIR HILYNEQRLV 
REANNCSSPA GILVDAMSQK HLQINQTFEE LRLVTQDTEN ELKELQQTQE YFIIQYQESL 
RIQAQFAQLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL 
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL 
NVHMNPPQVK ATIISEQQAK SLLKNENTRN ECSGEILNNC CVMEYHQATG TLSAHFRNMS 
LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK TLSLPVVVIV HGSQDHNATA 
TVLWDNAFAE PGRVPFAVPD KMLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN 
SSSHLEDYSG LSVSWSQFNR ENLPGWNYTF WQWFDGVMEV LKKHHKPHWN DGAILGFVNK 
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKLDSPERNL WNLKPFTTRD FSIRSLADRL 
GDLSYLIYVF PDRPKDEVFS KYYTPVLAKA VDGYVKPQIK QVVPEFVNAS ADAGGSSATY 
MDQAPSPAVC PQAPYNMYPQ NPDHVLDQDG EFDLDETMDV ARHVEELLRR PMDSLDSRLS 
PPAGLFTSAR GSLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.