Details for: HSPA13

Gene ID: 6782

Symbol: HSPA13

Ensembl ID: ENSG00000155304

Description: heat shock protein family A (Hsp70) member 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 168.4719
    Cell Significance Index: -26.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 105.1082
    Cell Significance Index: -26.6600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 63.0663
    Cell Significance Index: -25.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 59.3490
    Cell Significance Index: -28.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 56.3436
    Cell Significance Index: -22.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.9351
    Cell Significance Index: -27.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9987
    Cell Significance Index: -26.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0197
    Cell Significance Index: -27.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.4790
    Cell Significance Index: -19.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0724
    Cell Significance Index: 30.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0583
    Cell Significance Index: 172.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9806
    Cell Significance Index: 20.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9728
    Cell Significance Index: 878.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7600
    Cell Significance Index: 152.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7287
    Cell Significance Index: 19.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6609
    Cell Significance Index: 65.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6477
    Cell Significance Index: 70.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6157
    Cell Significance Index: 220.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5206
    Cell Significance Index: 31.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4431
    Cell Significance Index: 60.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3299
    Cell Significance Index: 42.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3154
    Cell Significance Index: 21.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3092
    Cell Significance Index: 17.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3058
    Cell Significance Index: 166.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2973
    Cell Significance Index: 6.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2886
    Cell Significance Index: 17.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2760
    Cell Significance Index: 7.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2246
    Cell Significance Index: 3.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2097
    Cell Significance Index: 39.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2026
    Cell Significance Index: 40.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1850
    Cell Significance Index: 22.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1842
    Cell Significance Index: 6.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1833
    Cell Significance Index: 11.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1746
    Cell Significance Index: 31.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1640
    Cell Significance Index: 12.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1105
    Cell Significance Index: 1.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1097
    Cell Significance Index: 3.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0938
    Cell Significance Index: 64.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0923
    Cell Significance Index: 40.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0889
    Cell Significance Index: 15.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0814
    Cell Significance Index: 2.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0408
    Cell Significance Index: 1.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0208
    Cell Significance Index: 0.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0205
    Cell Significance Index: 1.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0141
    Cell Significance Index: 0.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0051
    Cell Significance Index: 0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0016
    Cell Significance Index: 2.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0025
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0073
    Cell Significance Index: -5.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0128
    Cell Significance Index: -23.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0141
    Cell Significance Index: -8.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0143
    Cell Significance Index: -21.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0147
    Cell Significance Index: -11.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0148
    Cell Significance Index: -0.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0184
    Cell Significance Index: -25.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0191
    Cell Significance Index: -12.1200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0200
    Cell Significance Index: -0.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0205
    Cell Significance Index: -15.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0302
    Cell Significance Index: -17.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0416
    Cell Significance Index: -8.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0422
    Cell Significance Index: -19.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0463
    Cell Significance Index: -4.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0496
    Cell Significance Index: -1.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0523
    Cell Significance Index: -1.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0605
    Cell Significance Index: -7.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0663
    Cell Significance Index: -3.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0672
    Cell Significance Index: -7.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0707
    Cell Significance Index: -20.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0777
    Cell Significance Index: -9.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1057
    Cell Significance Index: -12.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1227
    Cell Significance Index: -3.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1319
    Cell Significance Index: -19.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1519
    Cell Significance Index: -3.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1681
    Cell Significance Index: -2.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1787
    Cell Significance Index: -12.6400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1901
    Cell Significance Index: -1.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2107
    Cell Significance Index: -4.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2132
    Cell Significance Index: -13.7600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2189
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2217
    Cell Significance Index: -25.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2427
    Cell Significance Index: -18.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2457
    Cell Significance Index: -12.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2476
    Cell Significance Index: -7.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2551
    Cell Significance Index: -5.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2602
    Cell Significance Index: -27.0900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3023
    Cell Significance Index: -2.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3159
    Cell Significance Index: -25.0200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3194
    Cell Significance Index: -1.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3309
    Cell Significance Index: -20.2900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4708
    Cell Significance Index: -3.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4750
    Cell Significance Index: -15.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4840
    Cell Significance Index: -5.7700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4901
    Cell Significance Index: -9.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5013
    Cell Significance Index: -13.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5017
    Cell Significance Index: -15.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5130
    Cell Significance Index: -15.0700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5466
    Cell Significance Index: -6.7800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5904
    Cell Significance Index: -12.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HSPA13 gene has several key characteristics that make it an important player in cellular stress response and protein homeostasis: 1. **Chaperone function**: HSPA13 is a molecular chaperone that assists in the folding and refolding of proteins, preventing protein aggregation and maintaining cellular homeostasis. 2. **Heat shock response**: HSPA13 is involved in regulating the heat shock response, a cellular response to heat stress that helps protect cells against protein denaturation and aggregation. 3. **Protein binding**: HSPA13 has a high affinity for binding to proteins, which helps to stabilize protein structures and prevent misfolding. 4. **Cellular localization**: HSPA13 is localized to various cellular compartments, including the cytosol, endoplasmic reticulum, and nucleus, highlighting its role in regulating protein homeostasis across different cellular environments. **Pathways and Functions** The HSPA13 gene is involved in several cellular pathways and functions, including: 1. **ATP-dependent protein folding chaperone pathway**: HSPA13 is part of the ATP-dependent protein folding chaperone pathway, which involves the use of ATP to drive protein folding and refolding processes. 2. **Heat shock protein binding pathway**: HSPA13 binds to heat shock proteins, which helps to regulate the heat shock response and protect cells against heat stress. 3. **Protein refolding pathway**: HSPA13 is involved in protein refolding, which is essential for maintaining protein homeostasis and preventing protein aggregation. 4. **Cellular responses to stimuli pathway**: HSPA13 is involved in regulating cellular responses to various stimuli, including heat stress, oxidative stress, and protein denaturation. **Clinical Significance** The HSPA13 gene has significant clinical implications, particularly in the context of neurodegenerative diseases and cancer: 1. **Neurodegenerative diseases**: HSPA13 has been implicated in several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, where protein misfolding and aggregation play a critical role. 2. **Cancer**: HSPA13 has been found to be overexpressed in several types of cancer, including breast cancer, lung cancer, and colon cancer, where it may contribute to tumorigenesis and cancer progression. 3. **Heat stress response**: HSPA13 plays a crucial role in regulating the heat shock response, which is essential for protecting cells against heat stress and preventing tissue damage. In conclusion, the HSPA13 gene is an important player in maintaining protein homeostasis and responding to cellular stress. Its involvement in various cellular pathways and functions highlights its significance in regulating cellular responses to stimuli and preventing protein misfolding and aggregation. The clinical implications of HSPA13 are significant, particularly in the context of neurodegenerative diseases and cancer, where its dysregulation may contribute to disease progression.

Genular Protein ID: 1071385963

Symbol: HSP13_HUMAN

Name: Heat shock 70 kDa protein 13

UniProtKB Accession Codes:

P48723 B2R616 Q8NE40

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8131751

Title: Stch encodes the 'ATPase core' of a microsomal stress 70 protein.

PubMed ID: 8131751

DOI: 10.1002/j.1460-2075.1994.tb06371.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10675567

Title: A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch.

PubMed ID: 10675567

DOI: 10.1016/s0014-5793(00)01135-2

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 471
  • Mass: 51927
  • Checksum: C78028E7CB0D03F3
  • Sequence:
    • MAREMTILGS AVLTLLLAGY LAQQYLPLPT PKVIGIDLGT TYCSVGVFFP GTGKVKVIPD 
ENGHISIPSM VSFTDNDVYV GYESVELADS NPQNTIYDAK RFIGKIFTAE ELEAEIGRYP 
FKVLNKNGMV EFSVTSNETI TVSPEYVGSR LLLKLKEMAE AYLGMPVANA VISVPAEFDL 
KQRNSTIEAA NLAGLKILRV INEPTAAAMA YGLHKADVFH VLVIDLGGGT LDVSLLNKQG 
GMFLTRAMSG NNKLGGQDFN QRLLQYLYKQ IYQTYGFVPS RKEEIHRLRQ AVEMVKLNLT 
LHQSAQLSVL LTVEEQDRKE PHSSDTELPK DKLSSADDHR VNSGFGRGLS DKKSGESQVL 
FETEISRKLF DTLNEDLFQK ILVPIQQVLK EGHLEKTEID EVVLVGGSTR IPRIRQVIQE 
FFGKDPNTSV DPDLAVVTGV AIQAGIDGGS WPLQVSALEI PNKHLQKTNF N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.