Details for: STK3

Gene ID: 6788

Symbol: STK3

Ensembl ID: ENSG00000104375

Description: serine/threonine kinase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 394.1619
    Cell Significance Index: -61.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 236.0992
    Cell Significance Index: -59.8900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 130.9875
    Cell Significance Index: -53.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 130.9194
    Cell Significance Index: -61.8100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 120.4410
    Cell Significance Index: -48.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 109.7621
    Cell Significance Index: -56.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.2599
    Cell Significance Index: -48.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.4154
    Cell Significance Index: -62.1600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.8638
    Cell Significance Index: -58.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 21.2740
    Cell Significance Index: -46.5600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.7873
    Cell Significance Index: -62.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 6.3907
    Cell Significance Index: 164.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 5.5121
    Cell Significance Index: 107.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 5.3652
    Cell Significance Index: 143.2600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 5.0638
    Cell Significance Index: 44.9500
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.8122
    Cell Significance Index: 23.5200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.6681
    Cell Significance Index: 89.5000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.4285
    Cell Significance Index: 23.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.2540
    Cell Significance Index: 182.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.7383
    Cell Significance Index: 543.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.6629
    Cell Significance Index: 204.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.2303
    Cell Significance Index: 62.3300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.1158
    Cell Significance Index: 30.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.6876
    Cell Significance Index: 45.2200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.6622
    Cell Significance Index: 27.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.5870
    Cell Significance Index: 39.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2712
    Cell Significance Index: 125.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1767
    Cell Significance Index: 1062.4800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.0753
    Cell Significance Index: 17.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0497
    Cell Significance Index: 210.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8539
    Cell Significance Index: 117.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.8094
    Cell Significance Index: 40.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.6797
    Cell Significance Index: 11.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6336
    Cell Significance Index: 103.0500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6262
    Cell Significance Index: 13.3900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6142
    Cell Significance Index: 8.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5555
    Cell Significance Index: 64.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4988
    Cell Significance Index: 54.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4743
    Cell Significance Index: 301.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4418
    Cell Significance Index: 12.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4315
    Cell Significance Index: 20.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4036
    Cell Significance Index: 760.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3898
    Cell Significance Index: 269.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3895
    Cell Significance Index: 176.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3177
    Cell Significance Index: 585.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3095
    Cell Significance Index: 16.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3034
    Cell Significance Index: 13.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2938
    Cell Significance Index: 452.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2691
    Cell Significance Index: 33.0900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.2644
    Cell Significance Index: 3.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2385
    Cell Significance Index: 43.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2317
    Cell Significance Index: 126.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1812
    Cell Significance Index: 34.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1811
    Cell Significance Index: 4.9300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1594
    Cell Significance Index: 1.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1568
    Cell Significance Index: 69.3400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1545
    Cell Significance Index: 0.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1446
    Cell Significance Index: 18.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1321
    Cell Significance Index: 179.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1227
    Cell Significance Index: 7.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0778
    Cell Significance Index: 5.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0675
    Cell Significance Index: 24.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0199
    Cell Significance Index: 0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0322
    Cell Significance Index: -23.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0402
    Cell Significance Index: -25.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0530
    Cell Significance Index: -2.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0535
    Cell Significance Index: -39.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0644
    Cell Significance Index: -48.7500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0745
    Cell Significance Index: -1.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0852
    Cell Significance Index: -48.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1111
    Cell Significance Index: -11.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1112
    Cell Significance Index: -18.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1450
    Cell Significance Index: -21.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1561
    Cell Significance Index: -20.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1803
    Cell Significance Index: -51.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1996
    Cell Significance Index: -20.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2271
    Cell Significance Index: -47.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2965
    Cell Significance Index: -4.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3149
    Cell Significance Index: -36.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3477
    Cell Significance Index: -25.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3516
    Cell Significance Index: -22.1600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3557
    Cell Significance Index: -5.2500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.3951
    Cell Significance Index: -1.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4179
    Cell Significance Index: -49.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4291
    Cell Significance Index: -30.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4463
    Cell Significance Index: -9.6700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4682
    Cell Significance Index: -6.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4733
    Cell Significance Index: -54.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5068
    Cell Significance Index: -26.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5239
    Cell Significance Index: -18.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5504
    Cell Significance Index: -35.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5616
    Cell Significance Index: -37.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5889
    Cell Significance Index: -9.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5960
    Cell Significance Index: -19.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6326
    Cell Significance Index: -18.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6486
    Cell Significance Index: -51.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7261
    Cell Significance Index: -44.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7672
    Cell Significance Index: -9.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8254
    Cell Significance Index: -50.6100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.8520
    Cell Significance Index: -8.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The STK3 gene is a pseudogene, meaning that it has undergone significant mutations and is no longer functional. Despite this, it has been retained in the genome, suggesting that it may have played a role in the evolution of the serine/threonine kinase family. The STK3 protein has been shown to have kinase activity, which allows it to phosphorylate and activate downstream targets. This activity is crucial for regulating various cellular processes, including cell differentiation, proliferation, and apoptosis. **Pathways and Functions:** The STK3 gene is involved in several signaling pathways, including: 1. **Canonical Wnt Signaling Pathway**: STK3 acts as a negative regulator of the canonical Wnt signaling pathway, which plays a crucial role in cell differentiation, proliferation, and development. 2. **Hippo Signaling Pathway**: STK3 is also involved in the Hippo signaling pathway, which regulates organ growth and development. 3. **Apoptotic Process**: STK3 has been shown to regulate the apoptotic process, either positively or negatively, depending on the context. 4. **Cell Differentiation**: STK3 plays a crucial role in regulating cell differentiation, particularly in embryonic development. 5. **Signaling by Hippo**: STK3 is involved in the Hippo signaling pathway, which regulates organ growth and development. **Clinical Significance:** The STK3 gene has been implicated in several diseases, including: 1. **Prostate Cancer**: STK3 has been shown to be overexpressed in prostate cancer, suggesting that it may play a role in the development and progression of the disease. 2. **Kidney Disease**: STK3 has been implicated in kidney disease, particularly in the development of fibrosis and scarring. 3. **Skeletal Muscle Diseases**: STK3 has been shown to be involved in skeletal muscle diseases, including muscular dystrophy. 4. **Neurological Disorders**: STK3 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the STK3 gene plays a complex role in various cellular processes, including cell differentiation, proliferation, apoptosis, and signaling pathways. Its clinical significance is evident, particularly in the development and progression of prostate cancer, kidney disease, skeletal muscle diseases, and neurological disorders. Further research is needed to fully understand the role of STK3 in these diseases and to explore potential therapeutic targets.

Genular Protein ID: 1992357358

Symbol: STK3_HUMAN

Name: Serine/threonine-protein kinase 3

UniProtKB Accession Codes:

Q13188 A8K722 B3KYA7 Q15445 Q15801 Q96FM6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CPTAC 3 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 EC 2 ELM 1 EMBL 12 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8566796

Title: Cloning and characterization of a member of the MST subfamily of Ste20-like kinases.

PubMed ID: 8566796

DOI: 10.1016/0378-1119(95)00653-2

PubMed ID: 8816758

Title: Newly identified stress-responsive protein kinases, Krs-1 and Krs-2.

PubMed ID: 8816758

DOI: 10.1073/pnas.93.19.10099

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8274451

Title: Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.

PubMed ID: 8274451

PubMed ID: 11278283

Title: MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation.

PubMed ID: 11278283

DOI: 10.1074/jbc.m005109200

PubMed ID: 15618521

Title: Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

PubMed ID: 15618521

DOI: 10.1126/science.1103233

PubMed ID: 15688006

Title: The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.

PubMed ID: 15688006

DOI: 10.1038/sj.onc.1208445

PubMed ID: 16510573

Title: Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.

PubMed ID: 16510573

DOI: 10.1158/0008-5472.can-05-2951

PubMed ID: 16930133

Title: Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation.

PubMed ID: 16930133

DOI: 10.1111/j.1742-4658.2006.05427.x

PubMed ID: 18328708

Title: MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.

PubMed ID: 18328708

DOI: 10.1016/j.cub.2008.02.006

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18362890

Title: Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1.

PubMed ID: 18362890

DOI: 10.1038/onc.2008.66

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19484742

Title: Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling.

PubMed ID: 19484742

DOI: 10.1002/biof.47

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19525978

Title: RASSF2 associates with and stabilizes the proapoptotic kinase MST2.

PubMed ID: 19525978

DOI: 10.1038/onc.2009.152

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20086174

Title: Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt.

PubMed ID: 20086174

DOI: 10.1158/0008-5472.can-09-3147

PubMed ID: 21145499

Title: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway.

PubMed ID: 21145499

DOI: 10.1016/j.devcel.2010.11.012

PubMed ID: 20212043

Title: Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation.

PubMed ID: 20212043

DOI: 10.1074/jbc.m109.078915

PubMed ID: 21076410

Title: Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.

PubMed ID: 21076410

DOI: 10.1038/ncb2120

PubMed ID: 20231902

Title: Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway.

PubMed ID: 20231902

DOI: 10.1371/journal.pone.0009616

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21199877

Title: The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.

PubMed ID: 21199877

DOI: 10.1074/jbc.m110.178210

PubMed ID: 21723128

Title: Plk1 controls the Nek2A-PP1gamma antagonism in centrosome disjunction.

PubMed ID: 21723128

DOI: 10.1016/j.cub.2011.05.047

PubMed ID: 21104395

Title: Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand.

PubMed ID: 21104395

DOI: 10.1007/s00109-010-0698-y

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28087714

Title: DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.

PubMed ID: 28087714

DOI: 10.1101/gad.284539.116

PubMed ID: 37739411

Title: The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation.

PubMed ID: 37739411

DOI: 10.1093/nar/gkad766

PubMed ID: 30622739

Title: Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.

PubMed ID: 30622739

DOI: 10.1038/s41421-018-0077-3

PubMed ID: 23972470

Title: Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5.

PubMed ID: 23972470

DOI: 10.1016/j.str.2013.07.008

PubMed ID: 29063833

Title: SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.

PubMed ID: 29063833

DOI: 10.7554/elife.30278

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 491
  • Mass: 56301
  • Checksum: 84F598ED3617292C
  • Sequence:
    • MEQPPAPKSK LKKLSEDSLT KQPEEVFDVL EKLGEGSYGS VFKAIHKESG QVVAIKQVPV 
ESDLQEIIKE ISIMQQCDSP YVVKYYGSYF KNTDLWIVME YCGAGSVSDI IRLRNKTLIE 
DEIATILKST LKGLEYLHFM RKIHRDIKAG NILLNTEGHA KLADFGVAGQ LTDTMAKRNT 
VIGTPFWMAP EVIQEIGYNC VADIWSLGIT SIEMAEGKPP YADIHPMRAI FMIPTNPPPT 
FRKPELWSDD FTDFVKKCLV KNPEQRATAT QLLQHPFIKN AKPVSILRDL ITEAMEIKAK 
RHEEQQRELE EEEENSDEDE LDSHTMVKTS VESVGTMRAT STMSEGAQTM IEHNSTMLES 
DLGTMVINSE DEEEEDGTMK RNATSPQVQR PSFMDYFDKQ DFKNKSHENC NQNMHEPFPM 
SKNVFPDNWK VPQDGDFDFL KNLSLEELQM RLKALDPMME REIEELRQRY TAKRQPILDA 
MDAKKRRQQN F

Genular Protein ID: 879199669

Symbol: A0A087WZ06_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WZ06

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 3 GeneTree 1 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 8 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 380
  • Mass: 43953
  • Checksum: BED76D26B9707DA2
  • Sequence:
    • MEQPPAPKSK LKKLSEDSLT KQPEEVFDVL EKLGEGSYGS VFKAIHKESG QVVAIKQVPV 
ESDLQEIIKE ISIMQQCDSP YVVKYYGSYF KNTDLWIVME YCGAGSVSDI IRLRNKTAIF 
MIPTNPPPTF RKPELWSDDF TDFVKKCLVK NPEQRATATQ LLQHPFIKNA KPVSILRDLI 
TEAMEIKAKR HEEQQRELEE EEENSDEDEL DSHTMVKTSV ESVGTMRATS TMSEGAQTMI 
EHNSTMLESD LGTMVINSED EEEEDGTMKR NATSPQVQRP SFMDYFDKQD FKNKSHENCN 
QNMHEPFPMS KNVFPDNWKV PQDGDFDFLK NLSLEELQMR LKALDPMMER EIEELRQRYT 
AKRQPILDAM DAKKRRQQNF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.