Details for: STX3

Gene ID: 6809

Symbol: STX3

Ensembl ID: ENSG00000166900

Description: syntaxin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 165.9646
    Cell Significance Index: -25.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.0941
    Cell Significance Index: -24.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.9050
    Cell Significance Index: -25.7800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 11.6374
    Cell Significance Index: 89.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4630
    Cell Significance Index: -25.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.1009
    Cell Significance Index: -21.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5889
    Cell Significance Index: -26.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.5509
    Cell Significance Index: -9.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.0170
    Cell Significance Index: 253.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.9927
    Cell Significance Index: 465.3000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 2.2659
    Cell Significance Index: 19.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1757
    Cell Significance Index: 59.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4557
    Cell Significance Index: 65.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4396
    Cell Significance Index: 288.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.3117
    Cell Significance Index: 68.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1830
    Cell Significance Index: 16.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1507
    Cell Significance Index: 24.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0661
    Cell Significance Index: 115.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0227
    Cell Significance Index: 29.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9484
    Cell Significance Index: 70.6900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9383
    Cell Significance Index: 14.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9340
    Cell Significance Index: 114.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8743
    Cell Significance Index: 142.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8328
    Cell Significance Index: 150.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8185
    Cell Significance Index: 293.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7286
    Cell Significance Index: 657.8700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6660
    Cell Significance Index: 8.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5837
    Cell Significance Index: 30.3200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.5647
    Cell Significance Index: 6.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5544
    Cell Significance Index: 71.6200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.5486
    Cell Significance Index: 7.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5336
    Cell Significance Index: 52.7800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.5216
    Cell Significance Index: 3.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4793
    Cell Significance Index: 13.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4555
    Cell Significance Index: 21.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3902
    Cell Significance Index: 269.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3472
    Cell Significance Index: 24.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3232
    Cell Significance Index: 8.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3038
    Cell Significance Index: 60.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2944
    Cell Significance Index: 6.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2889
    Cell Significance Index: 157.8000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.2554
    Cell Significance Index: 1.6700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.2013
    Cell Significance Index: 2.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1909
    Cell Significance Index: 24.4700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1841
    Cell Significance Index: 1.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1819
    Cell Significance Index: 8.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1673
    Cell Significance Index: 11.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1567
    Cell Significance Index: 69.2600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1425
    Cell Significance Index: 2.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1292
    Cell Significance Index: 1.5400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1190
    Cell Significance Index: 2.2000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.1142
    Cell Significance Index: 1.2900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0840
    Cell Significance Index: 2.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0749
    Cell Significance Index: 5.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0726
    Cell Significance Index: 2.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0695
    Cell Significance Index: 7.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0621
    Cell Significance Index: 84.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0592
    Cell Significance Index: 11.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0544
    Cell Significance Index: 83.7800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0485
    Cell Significance Index: 0.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0478
    Cell Significance Index: 0.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0469
    Cell Significance Index: 1.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0438
    Cell Significance Index: 7.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0388
    Cell Significance Index: 71.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0334
    Cell Significance Index: 4.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0275
    Cell Significance Index: 51.7000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0215
    Cell Significance Index: 0.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0106
    Cell Significance Index: 8.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0073
    Cell Significance Index: 4.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0155
    Cell Significance Index: -11.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0156
    Cell Significance Index: -7.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0160
    Cell Significance Index: -2.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0196
    Cell Significance Index: -12.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0305
    Cell Significance Index: -17.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0398
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0410
    Cell Significance Index: -8.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0495
    Cell Significance Index: -3.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0528
    Cell Significance Index: -2.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0788
    Cell Significance Index: -22.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0799
    Cell Significance Index: -2.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0857
    Cell Significance Index: -3.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0990
    Cell Significance Index: -11.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1113
    Cell Significance Index: -6.8400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1258
    Cell Significance Index: -1.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1494
    Cell Significance Index: -9.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1558
    Cell Significance Index: -4.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1961
    Cell Significance Index: -4.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2001
    Cell Significance Index: -20.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2162
    Cell Significance Index: -25.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2764
    Cell Significance Index: -21.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3014
    Cell Significance Index: -18.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3082
    Cell Significance Index: -8.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3209
    Cell Significance Index: -18.0100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3384
    Cell Significance Index: -4.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3477
    Cell Significance Index: -9.3000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3488
    Cell Significance Index: -3.6100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3515
    Cell Significance Index: -7.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3602
    Cell Significance Index: -10.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3805
    Cell Significance Index: -12.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** STX3 is a small, membrane-bound protein with a molecular weight of approximately 36 kDa. It belongs to the syntaxin family, which is characterized by its ability to facilitate the fusion of vesicles with the plasma membrane. STX3 is specifically involved in the exocytic insertion of neurotransmitter receptors to the postsynaptic membrane, a process essential for synaptic plasticity and learning. Additionally, STX3 is involved in the regulation of cell adhesion, proliferation, and chemotaxis, highlighting its role in immune response and tissue development. **Pathways and Functions** STX3 is involved in several key pathways, including: 1. **Neurotransmitter release**: STX3 facilitates the exocytic insertion of neurotransmitter receptors to the postsynaptic membrane, allowing for the transmission of neuronal signals. 2. **Cell-cell junctions**: STX3 is involved in the formation and maintenance of tight junctions, which are essential for maintaining epithelial integrity and regulating the exchange of ions and molecules between cells. 3. **Immune response**: STX3 is expressed in immune cells, including dendritic cells and T cells, and is involved in the regulation of immune cell adhesion, proliferation, and chemotaxis. 4. **Cytokine signaling**: STX3 is involved in the regulation of cytokine signaling, which is essential for the coordination of immune responses and inflammation. **Clinical Significance** Dysregulation of STX3 has been implicated in several neurological and psychiatric disorders, including: 1. **Autism spectrum disorder**: Studies have shown that mutations in the STX3 gene are associated with autism spectrum disorder, highlighting the importance of STX3 in neuronal development and function. 2. **Schizophrenia**: STX3 has been implicated in the pathophysiology of schizophrenia, with studies suggesting that abnormalities in STX3 expression and function may contribute to the development of the disorder. 3. **Neurodegenerative diseases**: STX3 has been implicated in the pathophysiology of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, highlighting the importance of STX3 in maintaining neuronal function and integrity. In conclusion, STX3 is a crucial protein involved in various cellular processes, including neurotransmitter release, cell signaling, and immune response. Its dysregulation has been implicated in several neurological and psychiatric disorders, highlighting the importance of further research into the functions and pathophysiology of STX3.

Genular Protein ID: 2407807201

Symbol: STX3_HUMAN

Name: Syntaxin-3

UniProtKB Accession Codes:

Q13277 B4DME0 O43750 O43751 Q15360

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 40 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9378770

Title: Human syntaxin 3 is localized apically in human intestinal cells.

PubMed ID: 9378770

DOI: 10.1242/jcs.110.18.2207

PubMed ID: 10080545

Title: Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1.

PubMed ID: 10080545

DOI: 10.1002/jlb.65.3.397

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24726755

Title: Loss of syntaxin 3 causes variant microvillus inclusion disease.

PubMed ID: 24726755

DOI: 10.1053/j.gastro.2014.04.002

PubMed ID: 29475951

Title: Soluble syntaxin 3 functions as a transcriptional regulator.

PubMed ID: 29475951

DOI: 10.1074/jbc.ra117.000874

PubMed ID: 25358429

Title: Autosomal recessive congenital cataract, intellectual disability phenotype linked to STX3 in a consanguineous Tunisian family.

PubMed ID: 25358429

DOI: 10.1111/cge.12489

PubMed ID: 29282386

Title: Microvillus Inclusion Disease Variant in an Infant with Intractable Diarrhea.

PubMed ID: 29282386

DOI: 10.1159/000479624

PubMed ID: 33974130

Title: Pathogenic STX3 variants affecting the retinal and intestinal transcripts cause an early-onset severe retinal dystrophy in microvillus inclusion disease subjects.

PubMed ID: 33974130

DOI: 10.1007/s00439-021-02284-1

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 289
  • Mass: 33155
  • Checksum: 0E12EBC7CBEDB81E
  • Sequence:
    • MKDRLEQLKA KQLTQDDDTD AVEIAIDNTA FMDEFFSEIE ETRLNIDKIS EHVEEAKKLY 
SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK HIEEDEVRSS ADLRIRKSQH 
SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ RQLEITGKKT TDEELEEMLE SGNPAIFTSG 
IIDSQISKQA LSEIEGRHKD IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV 
DHVEKARDET KKAVKYQSQA RKKLIIIIVL VVVLLGILAL IIGLSVGLN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.