Details for: STYX

Gene ID: 6815

Symbol: STYX

Ensembl ID: ENSG00000198252

Description: serine/threonine/tyrosine interacting protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 105.5642
    Cell Significance Index: -16.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 65.3674
    Cell Significance Index: -16.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.0108
    Cell Significance Index: -18.8900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 35.6931
    Cell Significance Index: -18.3600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 28.1660
    Cell Significance Index: -18.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.4287
    Cell Significance Index: -17.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.1808
    Cell Significance Index: -16.5600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5970
    Cell Significance Index: -18.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3725
    Cell Significance Index: -13.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2637
    Cell Significance Index: 125.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0437
    Cell Significance Index: 14.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9916
    Cell Significance Index: 115.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9628
    Cell Significance Index: 869.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8294
    Cell Significance Index: 164.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8085
    Cell Significance Index: 48.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7750
    Cell Significance Index: 84.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6554
    Cell Significance Index: 106.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4105
    Cell Significance Index: 283.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3834
    Cell Significance Index: 76.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2725
    Cell Significance Index: 120.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2365
    Cell Significance Index: 16.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2337
    Cell Significance Index: 6.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2248
    Cell Significance Index: 4.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2050
    Cell Significance Index: 24.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1823
    Cell Significance Index: 32.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1810
    Cell Significance Index: 11.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1727
    Cell Significance Index: 61.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1607
    Cell Significance Index: 87.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1528
    Cell Significance Index: 3.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1522
    Cell Significance Index: 7.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1419
    Cell Significance Index: 17.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1343
    Cell Significance Index: 9.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1336
    Cell Significance Index: 18.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1179
    Cell Significance Index: 3.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1152
    Cell Significance Index: 5.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1130
    Cell Significance Index: 3.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1111
    Cell Significance Index: 5.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1018
    Cell Significance Index: 2.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0927
    Cell Significance Index: 5.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0899
    Cell Significance Index: 6.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0735
    Cell Significance Index: 13.9900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0718
    Cell Significance Index: 1.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0527
    Cell Significance Index: 2.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0358
    Cell Significance Index: 4.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0162
    Cell Significance Index: 30.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0125
    Cell Significance Index: 0.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0101
    Cell Significance Index: 15.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0066
    Cell Significance Index: 12.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0060
    Cell Significance Index: 3.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0026
    Cell Significance Index: -0.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0028
    Cell Significance Index: -0.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0101
    Cell Significance Index: -4.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0133
    Cell Significance Index: -9.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0153
    Cell Significance Index: -11.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0193
    Cell Significance Index: -14.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0260
    Cell Significance Index: -14.6700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0262
    Cell Significance Index: -0.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0267
    Cell Significance Index: -3.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0309
    Cell Significance Index: -0.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0329
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0331
    Cell Significance Index: -20.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0341
    Cell Significance Index: -2.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0383
    Cell Significance Index: -3.9100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0399
    Cell Significance Index: -0.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0462
    Cell Significance Index: -2.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0484
    Cell Significance Index: -1.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0519
    Cell Significance Index: -14.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0525
    Cell Significance Index: -1.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0552
    Cell Significance Index: -7.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0564
    Cell Significance Index: -6.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0829
    Cell Significance Index: -2.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0850
    Cell Significance Index: -3.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0881
    Cell Significance Index: -3.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0905
    Cell Significance Index: -2.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0953
    Cell Significance Index: -3.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0969
    Cell Significance Index: -20.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1109
    Cell Significance Index: -2.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1323
    Cell Significance Index: -3.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1545
    Cell Significance Index: -16.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1631
    Cell Significance Index: -10.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1634
    Cell Significance Index: -2.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1639
    Cell Significance Index: -5.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1957
    Cell Significance Index: -5.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1985
    Cell Significance Index: -10.0300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2004
    Cell Significance Index: -1.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2070
    Cell Significance Index: -12.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2080
    Cell Significance Index: -16.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2475
    Cell Significance Index: -4.8300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2510
    Cell Significance Index: -3.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2635
    Cell Significance Index: -6.9300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2795
    Cell Significance Index: -4.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2924
    Cell Significance Index: -15.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3197
    Cell Significance Index: -11.1100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3265
    Cell Significance Index: -4.9200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3333
    Cell Significance Index: -4.9200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3410
    Cell Significance Index: -2.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3422
    Cell Significance Index: -9.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3502
    Cell Significance Index: -4.1800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3633
    Cell Significance Index: -6.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STYX is a pseudophosphatase protein, meaning it possesses phosphatase activity without the typical phosphatase domain. This unique characteristic allows STYX to interact with various proteins, modulating their activity and influencing multiple signaling pathways. STYX is expressed in a diverse range of cell types, including choroid plexus epithelial cells, oogonial cells, cerebral cortex GABAergic interneurons, and intestinal epithelial cells. Its expression in these cells suggests a crucial role in maintaining cellular homeostasis and regulating signaling pathways. **Pathways and Functions:** STYX is involved in several key signaling pathways, including: 1. **MAPK export from nucleus:** STYX regulates the export of MAPK proteins from the nucleus, modulating their activity and influencing cellular responses to stress and stimuli. 2. **Regulation of ERK1/2 cascade:** STYX interacts with ERK1/2, modulating their activity and influencing cell proliferation, differentiation, and survival. 3. **Negative regulation of protein binding:** STYX acts as a negative regulator of protein binding, modulating the interaction between proteins and influencing cellular signaling. 4. **Negative regulation of scf-dependent proteasomal ubiquitin-dependent catabolic process:** STYX regulates the degradation of proteins via the SCF complex, influencing cellular homeostasis and protein turnover. **Clinical Significance:** STYX's involvement in various signaling pathways and cellular processes has significant implications for human disease. Aberrant expression or activity of STYX has been implicated in several diseases, including: 1. **Neurological disorders:** STYX's role in regulating MAPK export and ERK1/2 activity suggests its involvement in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and stroke. 2. **Cancer:** STYX's regulation of protein binding and degradation via the SCF complex may influence tumor progression and metastasis. 3. **Immunological disorders:** STYX's involvement in regulating MAPK export and ERK1/2 activity may influence immune responses and disease susceptibility. In conclusion, STYX is a complex gene with a multifaceted role in regulating cellular signaling and homeostasis. Its involvement in various signaling pathways and cellular processes has significant implications for human disease, highlighting the need for further research into the molecular mechanisms underlying STYX's functions.

Genular Protein ID: 1794085054

Symbol: STYX_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8WUJ0 B9EJG0 Q99850

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9633825

Title: Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38.

PubMed ID: 9633825

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23847209

Title: Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2.

PubMed ID: 23847209

DOI: 10.1073/pnas.1301985110

PubMed ID: 28007894

Title: The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

PubMed ID: 28007894

DOI: 10.15252/embj.201694795

PubMed ID: 18058037

Title: Structural genomics of protein phosphatases.

PubMed ID: 18058037

DOI: 10.1007/s10969-007-9036-1

Sequence Information:

  • Length: 223
  • Mass: 25492
  • Checksum: D2C8D05104073EE8
  • Sequence:
    • MEDVKLEFPS LPQCKEDAEE WTYPMRREMQ EILPGLFLGP YSSAMKSKLP VLQKHGITHI 
ICIRQNIEAN FIKPNFQQLF RYLVLDIADN PVENIIRFFP MTKEFIDGSL QMGGKVLVHG 
NAGISRSAAF VIAYIMETFG MKYRDAFAYV QERRFCINPN AGFVHQLQEY EAIYLAKLTI 
QMMSPLQIER SLSVHSGTTG SLKRTHEEED DFGTMQVATA QNG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.