SULT1A3 | ENSG00000261052 | NCBI 6818

Details for: SULT1A3

Gene ID: 6818

Symbol: SULT1A3

Ensembl ID: ENSG00000261052

Description: sulfotransferase family 1A member 3

Associated with

Biological oxidations
(R-HSA-211859)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cytosolic sulfonation of small molecules
(R-HSA-156584)
Drug adme
(R-HSA-9748784)
Ire1alpha activates chaperones
(R-HSA-381070)
Metabolism
(R-HSA-1430728)
Paracetamol adme
(R-HSA-9753281)
Phase ii - conjugation of compounds
(R-HSA-156580)
Unfolded protein response (upr)
(R-HSA-381119)
Xbp1(s) activates chaperone genes
(R-HSA-381038)
3'-phosphoadenosine 5'-phosphosulfate metabolic process
(GO:0050427)
Amine sulfotransferase activity
(GO:0047685)
Aryl sulfotransferase activity
(GO:0004062)
Cellular response to dopamine
(GO:1903351)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dopamine catabolic process
(GO:0042420)
Dopamine metabolic process
(GO:0042417)
Ethanol catabolic process
(GO:0006068)
Flavonoid metabolic process
(GO:0009812)
Protein binding
(GO:0005515)
Steroid metabolic process
(GO:0008202)
Sulfate binding
(GO:0043199)
Sulfation
(GO:0051923)
Sulfotransferase activity
(GO:0008146)
Xenobiotic metabolic process
(GO:0006805)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 27.5804
Cell Significance Index: -4.2900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 19.6339
Cell Significance Index: -4.9800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 4.1486
Cell Significance Index: -5.1200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 1.9150
Cell Significance Index: -5.1300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.3588
Cell Significance Index: 39.1500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.3167
Cell Significance Index: 250.5800
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.1194
Cell Significance Index: -2.4500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0229
Cell Significance Index: 61.4100
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.9106
Cell Significance Index: 7.7400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6425
Cell Significance Index: 13.9200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6241
Cell Significance Index: 67.8800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5782
Cell Significance Index: 26.2100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5415
Cell Significance Index: 53.5700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4426
Cell Significance Index: 399.6000
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.4294
Cell Significance Index: 4.4500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.3885
Cell Significance Index: 5.3000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3342
Cell Significance Index: 23.1200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3182
Cell Significance Index: 51.7600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.2596
Cell Significance Index: 3.8900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2423
Cell Significance Index: 5.1600
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.2357
Cell Significance Index: 4.8900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1838
Cell Significance Index: 9.5500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1755
Cell Significance Index: 95.8300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1671
Cell Significance Index: 10.5300
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.1382
Cell Significance Index: 1.9400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1339
Cell Significance Index: 15.6100
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.1319
Cell Significance Index: 1.8900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1306
Cell Significance Index: 26.2000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0748
Cell Significance Index: 2.0900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0639
Cell Significance Index: 22.9200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0563
Cell Significance Index: 1.9800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0523
Cell Significance Index: 9.4300
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.0495
Cell Significance Index: 0.6600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0483
Cell Significance Index: 2.7100
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.0450
Cell Significance Index: 0.6300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0316
Cell Significance Index: 0.8600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0276
Cell Significance Index: 3.2600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0230
Cell Significance Index: 2.8300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0197
Cell Significance Index: 2.7000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0174
Cell Significance Index: 1.1200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0156
Cell Significance Index: 6.9100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0114
Cell Significance Index: 0.6000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0076
Cell Significance Index: 0.5400
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0059
Cell Significance Index: 0.7600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0048
Cell Significance Index: 0.1200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0048
Cell Significance Index: 0.2400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0012
Cell Significance Index: -0.1400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0021
Cell Significance Index: -0.1000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0039
Cell Significance Index: -2.9700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0041
Cell Significance Index: -2.9800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0060
Cell Significance Index: -4.4600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0075
Cell Significance Index: -4.2100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0130
Cell Significance Index: -1.6800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0154
Cell Significance Index: -1.1900
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.0169
Cell Significance Index: -0.1800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0177
Cell Significance Index: -3.0200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0187
Cell Significance Index: -1.9100
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0191
Cell Significance Index: -3.7900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0223
Cell Significance Index: -1.0500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0254
Cell Significance Index: -0.6800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0262
Cell Significance Index: -5.5100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0414
Cell Significance Index: -1.4400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0470
Cell Significance Index: -3.5000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0473
Cell Significance Index: -2.9000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0509
Cell Significance Index: -1.6300
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.0579
Cell Significance Index: -0.5600
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0585
Cell Significance Index: -1.4600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0690
Cell Significance Index: -4.6400
Cell Name: enterocyte (CL0000584)
Fold Change: -0.0725
Cell Significance Index: -0.4500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0783
Cell Significance Index: -4.8100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0805
Cell Significance Index: -2.0700
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0876
Cell Significance Index: -1.3200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0926
Cell Significance Index: -1.5500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0929
Cell Significance Index: -3.4100
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0951
Cell Significance Index: -1.6400
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.1001
Cell Significance Index: -1.7300
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.1055
Cell Significance Index: -1.3800
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.1064
Cell Significance Index: -1.8800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1071
Cell Significance Index: -1.9800
Cell Name: keratocyte (CL0002363)
Fold Change: -0.1072
Cell Significance Index: -1.7000
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1106
Cell Significance Index: -4.5300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1153
Cell Significance Index: -5.1000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1229
Cell Significance Index: -3.1400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1256
Cell Significance Index: -4.4000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1267
Cell Significance Index: -3.7200
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1319
Cell Significance Index: -4.3200
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.1342
Cell Significance Index: -1.9300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1349
Cell Significance Index: -5.1100
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1351
Cell Significance Index: -2.8200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1358
Cell Significance Index: -3.5700
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.1361
Cell Significance Index: -1.3700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1363
Cell Significance Index: -4.3400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1400
Cell Significance Index: -1.5900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1427
Cell Significance Index: -3.8100
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: -0.1459
Cell Significance Index: -1.3500
Cell Name: decidual cell (CL2000002)
Fold Change: -0.1471
Cell Significance Index: -2.3600
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.1474
Cell Significance Index: -2.1400
Cell Name: peg cell (CL4033014)
Fold Change: -0.1476
Cell Significance Index: -3.4100
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1486
Cell Significance Index: -3.1100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1501
Cell Significance Index: -4.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** 1. **Sulfotransferase activity**: SULT1A3 exhibits aryl and amine sulfotransferase activities, which enable it to catalyze the transfer of sulfate groups to a wide range of substrates, including xenobiotics, endogenous compounds, and neurotransmitters. 2. **Metabolic pathways**: SULT1A3 is involved in various metabolic pathways, including 3'-phosphoadenosine 5'-phosphosulfate (PAPS) metabolism, dopamine catabolism, and flavonoid metabolism. 3. **Cellular localization**: SULT1A3 is primarily localized to the cytosol, where it can interact with various substrates and participate in metabolic processes. 4. **Regulation**: The expression of SULT1A3 is regulated by various factors, including transcription factors, post-translational modifications, and environmental stimuli. **Pathways and Functions** 1. **Detoxification**: SULT1A3 plays a crucial role in the detoxification of xenobiotics, including environmental pollutants and drugs, by conjugating them with sulfate groups, which increases their water solubility and facilitates their excretion. 2. **Neurotransmitter metabolism**: SULT1A3 is involved in the catabolism of dopamine, a neurotransmitter that plays a crucial role in various physiological processes, including mood regulation and motor control. 3. **Flavonoid metabolism**: SULT1A3 is responsible for the sulfonation of flavonoids, which are plant-derived compounds that have antioxidant and anti-inflammatory properties. 4. **Protein binding**: SULT1A3 can bind to various proteins, including enzymes, receptors, and transcription factors, which can modulate their activity and regulate cellular responses. **Clinical Significance** 1. **Cancer**: Alterations in SULT1A3 expression have been associated with various cancers, including colorectal cancer, where it is often overexpressed. 2. **Neurological disorders**: SULT1A3 has been implicated in the pathogenesis of neurological disorders, including Parkinson's disease, where it is thought to play a role in dopamine metabolism and neuroprotection. 3. **Metabolic disorders**: SULT1A3 is involved in the metabolism of various endogenous compounds, including bilirubin, which is a byproduct of heme catabolism. Alterations in SULT1A3 expression may contribute to metabolic disorders, such as jaundice and liver disease. 4. **Pharmacology**: SULT1A3 is a target for various drugs, including paracetamol, which is metabolized by this enzyme. Alterations in SULT1A3 expression may affect the efficacy and toxicity of these drugs. In conclusion, SULT1A3 is a multifunctional enzyme that plays a crucial role in various physiological and pathological processes, including detoxification, neurotransmitter metabolism, flavonoid metabolism, and protein binding. Its clinical significance is evident in the association of SULT1A3 with various diseases, including cancer, neurological disorders, and metabolic disorders, as well as its role as a target for various drugs.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.