Gene SULT1A3 - ENSG00000261052 | NCBI Gene ID: 6818

Details for: SULT1A3

Gene ID: 6818

Symbol: SULT1A3

Ensembl ID: ENSG00000261052

Description: sulfotransferase family 1A member 3

Associated with

Biological oxidations
(R-HSA-211859)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cytosolic sulfonation of small molecules
(R-HSA-156584)
Drug adme
(R-HSA-9748784)
Ire1alpha activates chaperones
(R-HSA-381070)
Metabolism
(R-HSA-1430728)
Paracetamol adme
(R-HSA-9753281)
Phase ii - conjugation of compounds
(R-HSA-156580)
Unfolded protein response (upr)
(R-HSA-381119)
Xbp1(s) activates chaperone genes
(R-HSA-381038)
3'-phosphoadenosine 5'-phosphosulfate metabolic process
(GO:0050427)
Amine sulfotransferase activity
(GO:0047685)
Aryl sulfotransferase activity
(GO:0004062)
Cellular response to dopamine
(GO:1903351)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dopamine catabolic process
(GO:0042420)
Dopamine metabolic process
(GO:0042417)
Ethanol catabolic process
(GO:0006068)
Flavonoid metabolic process
(GO:0009812)
Protein binding
(GO:0005515)
Steroid metabolic process
(GO:0008202)
Sulfate binding
(GO:0043199)
Sulfation
(GO:0051923)
Sulfotransferase activity
(GO:0008146)
Xenobiotic metabolic process
(GO:0006805)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.03
Marker Score: 786
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71816
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48041
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 498
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.96
Marker Score: 1480
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 452
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5314
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2734
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 316
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5286
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1273
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 387
Cell Name: brush cell (CL0002204)
Fold Change: 0.74
Marker Score: 676
Cell Name: goblet cell (CL0000160)
Fold Change: 0.74
Marker Score: 4889
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.72
Marker Score: 542.5
Cell Name: precursor cell (CL0011115)
Fold Change: 0.71
Marker Score: 172
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.69
Marker Score: 1372
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.69
Marker Score: 275
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 171
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.65
Marker Score: 2712.5
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.58
Marker Score: 726
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.57
Marker Score: 374
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.54
Marker Score: 298
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.45
Marker Score: 170
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.45
Marker Score: 289
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.44
Marker Score: 158
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.39
Marker Score: 600
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.38
Marker Score: 2832
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.32
Marker Score: 11243
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.31
Marker Score: 285
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.31
Marker Score: 125
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.29
Marker Score: 359
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.28
Marker Score: 888.5
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.27
Marker Score: 126
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.27
Marker Score: 2294
Cell Name: enterocyte (CL0000584)
Fold Change: 0.27
Marker Score: 1274
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.25
Marker Score: 117
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.25
Marker Score: 606
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.24
Marker Score: 2323
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.24
Marker Score: 14913
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.24
Marker Score: 237
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.23
Marker Score: 131
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.23
Marker Score: 62
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.23
Marker Score: 119
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.23
Marker Score: 8514
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.23
Marker Score: 2170
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.22
Marker Score: 276
Cell Name: germ cell (CL0000586)
Fold Change: 0.22
Marker Score: 386
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.21
Marker Score: 61
Cell Name: microglial cell (CL0000129)
Fold Change: 0.21
Marker Score: 385
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.21
Marker Score: 104
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.21
Marker Score: 520
Cell Name: acinar cell (CL0000622)
Fold Change: 0.21
Marker Score: 146
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.2
Marker Score: 176
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.2
Marker Score: 237
Cell Name: mast cell (CL0000097)
Fold Change: 0.19
Marker Score: 112
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.19
Marker Score: 738
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.19
Marker Score: 177
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.18
Marker Score: 192
Cell Name: stem cell (CL0000034)
Fold Change: 0.18
Marker Score: 439
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.18
Marker Score: 6851
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.18
Marker Score: 173
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.18
Marker Score: 699
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.18
Marker Score: 51
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.18
Marker Score: 185
Cell Name: blood cell (CL0000081)
Fold Change: 0.18
Marker Score: 2037
Cell Name: malignant cell (CL0001064)
Fold Change: 0.17
Marker Score: 2330
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.17
Marker Score: 145
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.17
Marker Score: 34
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.17
Marker Score: 53
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.17
Marker Score: 69
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.17
Marker Score: 102
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.17
Marker Score: 56
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.16
Marker Score: 684
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.16
Marker Score: 81
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.16
Marker Score: 1832
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.16
Marker Score: 160
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.16
Marker Score: 40
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.16
Marker Score: 3347
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.15
Marker Score: 45
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.15
Marker Score: 47
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.15
Marker Score: 163
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.15
Marker Score: 35
Cell Name: leukocyte (CL0000738)
Fold Change: 0.15
Marker Score: 86
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.15
Marker Score: 119
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.15
Marker Score: 29
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.15
Marker Score: 83
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.15
Marker Score: 1118
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.15
Marker Score: 32
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.15
Marker Score: 131
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.14
Marker Score: 96
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.14
Marker Score: 83
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.14
Marker Score: 280
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.14
Marker Score: 2852
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.14
Marker Score: 594
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.14
Marker Score: 59
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 0.14
Marker Score: 41

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Other Information

Description

**Key Characteristics** 1. **Sulfotransferase activity**: SULT1A3 exhibits aryl and amine sulfotransferase activities, which enable it to catalyze the transfer of sulfate groups to a wide range of substrates, including xenobiotics, endogenous compounds, and neurotransmitters. 2. **Metabolic pathways**: SULT1A3 is involved in various metabolic pathways, including 3'-phosphoadenosine 5'-phosphosulfate (PAPS) metabolism, dopamine catabolism, and flavonoid metabolism. 3. **Cellular localization**: SULT1A3 is primarily localized to the cytosol, where it can interact with various substrates and participate in metabolic processes. 4. **Regulation**: The expression of SULT1A3 is regulated by various factors, including transcription factors, post-translational modifications, and environmental stimuli. **Pathways and Functions** 1. **Detoxification**: SULT1A3 plays a crucial role in the detoxification of xenobiotics, including environmental pollutants and drugs, by conjugating them with sulfate groups, which increases their water solubility and facilitates their excretion. 2. **Neurotransmitter metabolism**: SULT1A3 is involved in the catabolism of dopamine, a neurotransmitter that plays a crucial role in various physiological processes, including mood regulation and motor control. 3. **Flavonoid metabolism**: SULT1A3 is responsible for the sulfonation of flavonoids, which are plant-derived compounds that have antioxidant and anti-inflammatory properties. 4. **Protein binding**: SULT1A3 can bind to various proteins, including enzymes, receptors, and transcription factors, which can modulate their activity and regulate cellular responses. **Clinical Significance** 1. **Cancer**: Alterations in SULT1A3 expression have been associated with various cancers, including colorectal cancer, where it is often overexpressed. 2. **Neurological disorders**: SULT1A3 has been implicated in the pathogenesis of neurological disorders, including Parkinson's disease, where it is thought to play a role in dopamine metabolism and neuroprotection. 3. **Metabolic disorders**: SULT1A3 is involved in the metabolism of various endogenous compounds, including bilirubin, which is a byproduct of heme catabolism. Alterations in SULT1A3 expression may contribute to metabolic disorders, such as jaundice and liver disease. 4. **Pharmacology**: SULT1A3 is a target for various drugs, including paracetamol, which is metabolized by this enzyme. Alterations in SULT1A3 expression may affect the efficacy and toxicity of these drugs. In conclusion, SULT1A3 is a multifunctional enzyme that plays a crucial role in various physiological and pathological processes, including detoxification, neurotransmitter metabolism, flavonoid metabolism, and protein binding. Its clinical significance is evident in the association of SULT1A3 with various diseases, including cancer, neurological disorders, and metabolic disorders, as well as its role as a target for various drugs.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.