Details for: VAMP2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 540.0359
Cell Significance Index: -84.0000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 290.6049
Cell Significance Index: -73.7100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 225.4898
Cell Significance Index: -92.8900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 190.7979
Cell Significance Index: -90.0800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 171.3891
Cell Significance Index: -88.1600 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 134.8242
Cell Significance Index: -90.4700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 74.9500
Cell Significance Index: -92.4100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 29.9109
Cell Significance Index: -91.8700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 23.8466
Cell Significance Index: -94.1000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 22.2221
Cell Significance Index: -59.5300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 17.3128
Cell Significance Index: 4981.4200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 16.2375
Cell Significance Index: 852.5300 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 13.6432
Cell Significance Index: 105.1600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.0519
Cell Significance Index: 280.2100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 3.9213
Cell Significance Index: 247.1500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.5537
Cell Significance Index: 512.2700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.9591
Cell Significance Index: 53.3300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.9051
Cell Significance Index: 122.9100 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.8460
Cell Significance Index: 236.6500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.7577
Cell Significance Index: 131.0000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.6446
Cell Significance Index: 589.8900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.5493
Cell Significance Index: 251.9900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.4911
Cell Significance Index: 16.9400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.2121
Cell Significance Index: 149.0400 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.1836
Cell Significance Index: 14.6800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.1683
Cell Significance Index: 160.4400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1642
Cell Significance Index: 209.8700 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 1.1307
Cell Significance Index: 9.9600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.0986
Cell Significance Index: 51.6400 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.0804
Cell Significance Index: 139.5900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.0124
Cell Significance Index: 29.0200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9947
Cell Significance Index: 439.8000 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.9784
Cell Significance Index: 17.2900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7100
Cell Significance Index: 387.7300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6699
Cell Significance Index: 66.2700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.6156
Cell Significance Index: 37.8400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.5819
Cell Significance Index: 20.2200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3894
Cell Significance Index: 74.1100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3370
Cell Significance Index: 36.6500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2810
Cell Significance Index: 12.7400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1741
Cell Significance Index: 12.3100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1490
Cell Significance Index: 109.2700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1286
Cell Significance Index: 6.5000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1233
Cell Significance Index: 21.0600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0152
Cell Significance Index: 11.5000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0388
Cell Significance Index: -0.6500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0479
Cell Significance Index: -90.2100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0601
Cell Significance Index: -110.7600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0700
Cell Significance Index: -8.2500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0718
Cell Significance Index: -110.5400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0825
Cell Significance Index: -112.2000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0833
Cell Significance Index: -61.7400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.1017
Cell Significance Index: -70.3200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1283
Cell Significance Index: -81.5100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1303
Cell Significance Index: -3.4800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1308
Cell Significance Index: -13.3600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1349
Cell Significance Index: -6.2900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1385
Cell Significance Index: -78.0900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1857
Cell Significance Index: -115.9900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1975
Cell Significance Index: -89.6300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2363
Cell Significance Index: -12.2800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2651
Cell Significance Index: -30.9000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2689
Cell Significance Index: -6.4500 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2765
Cell Significance Index: -7.2700 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2789
Cell Significance Index: -11.4300 - Cell Name: peg cell (CL4033014)
Fold Change: -0.3887
Cell Significance Index: -8.9800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4371
Cell Significance Index: -50.0800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4451
Cell Significance Index: -93.7500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.4728
Cell Significance Index: -93.8300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.5160
Cell Significance Index: -11.1800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5542
Cell Significance Index: -43.8900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5639
Cell Significance Index: -18.0600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.6136
Cell Significance Index: -89.2000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.6734
Cell Significance Index: -37.7900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.6817
Cell Significance Index: -19.6400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.7596
Cell Significance Index: -58.2900 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.7728
Cell Significance Index: -6.1700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.8755
Cell Significance Index: -52.5600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.9122
Cell Significance Index: -94.9800 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.9944
Cell Significance Index: -25.4000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.0510
Cell Significance Index: -22.0000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.0658
Cell Significance Index: -47.1400 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -1.1404
Cell Significance Index: -17.3200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.1895
Cell Significance Index: -14.1800 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -1.2065
Cell Significance Index: -13.6300 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -1.2423
Cell Significance Index: -11.8200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.2591
Cell Significance Index: -47.6800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.3758
Cell Significance Index: -36.8700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.4080
Cell Significance Index: -19.2100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.4192
Cell Significance Index: -95.4300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.4293
Cell Significance Index: -42.1000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.4525
Cell Significance Index: -89.0500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -1.5840
Cell Significance Index: -46.5200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.7480
Cell Significance Index: -37.1000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.7786
Cell Significance Index: -26.6500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.7843
Cell Significance Index: -38.0000 - Cell Name: theca cell (CL0000503)
Fold Change: -1.8230
Cell Significance Index: -10.7100 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.8273
Cell Significance Index: -31.5000 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.8770
Cell Significance Index: -41.1000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.8986
Cell Significance Index: -62.1600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3950753732
Symbol: VAMP2_HUMAN
Name: Synaptobrevin-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1976629
Title: Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2.
PubMed ID: 1976629
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8760387
Title: Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.
PubMed ID: 8760387
DOI: 10.1042/bj3170945
PubMed ID: 7803399
Title: Differences in the protease activities of tetanus and botulinum B toxins revealed by the cleavage of vesicle-associated membrane protein and various sized fragments.
PubMed ID: 7803399
DOI: 10.1021/bi00255a017
PubMed ID: 7835332
Title: Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane.
PubMed ID: 7835332
PubMed ID: 17313651
Title: WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta.
PubMed ID: 17313651
PubMed ID: 10932255
Title: Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution.
PubMed ID: 10932255
DOI: 10.1038/77997
PubMed ID: 19578378
Title: Retraction: Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution.
PubMed ID: 19578378
DOI: 10.1038/nsmb0709-795
PubMed ID: 20798282
Title: Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.
PubMed ID: 20798282
PubMed ID: 22118466
Title: The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM.
PubMed ID: 22118466
PubMed ID: 21808019
Title: SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses.
PubMed ID: 21808019
PubMed ID: 22289120
Title: Specificity of botulinum protease for human VAMP family proteins.
PubMed ID: 22289120
PubMed ID: 19543288
Title: Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F.
PubMed ID: 19543288
DOI: 10.1038/nsmb.1626
PubMed ID: 30929742
Title: Mutations in the Neuronal Vesicular SNARE VAMP2 Affect Synaptic Membrane Fusion and Impair Human Neurodevelopment.
PubMed ID: 30929742
Sequence Information:
- Length: 116
- Mass: 12663
- Checksum: 9CD679C4F6F1B5A8
- Sequence:
MSATAATAPP AAPAGEGGPP APPPNLTSNR RLQQTQAQVD EVVDIMRVNV DKVLERDQKL SELDDRADAL QAGASQFETS AAKLKRKYWW KNLKMMIILG VICAIILIII IVYFST
Genular Protein ID: 700275446
Symbol: F8WCA0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
Sequence Information:
- Length: 118
- Mass: 12934
- Checksum: CCC93D81D8785143
- Sequence:
MDRSATAATA PPAAPAGEGG PPAPPPNLTS NRRLQQTQAQ VDEVVDIMRV NVDKVLERDQ KLSELDDRAD ALQAGASQFE TSAAKLKRKY WWKNLKMMII LGVICAIILI IIIVYFST
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.