Details for: VAMP2

Gene ID: 6844

Symbol: VAMP2

Ensembl ID: ENSG00000220205

Description: vesicle associated membrane protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 540.0359
    Cell Significance Index: -84.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 290.6049
    Cell Significance Index: -73.7100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 225.4898
    Cell Significance Index: -92.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 190.7979
    Cell Significance Index: -90.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 171.3891
    Cell Significance Index: -88.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 134.8242
    Cell Significance Index: -90.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 74.9500
    Cell Significance Index: -92.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 29.9109
    Cell Significance Index: -91.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.8466
    Cell Significance Index: -94.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.2221
    Cell Significance Index: -59.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 17.3128
    Cell Significance Index: 4981.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 16.2375
    Cell Significance Index: 852.5300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 13.6432
    Cell Significance Index: 105.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.0519
    Cell Significance Index: 280.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 3.9213
    Cell Significance Index: 247.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5537
    Cell Significance Index: 512.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9591
    Cell Significance Index: 53.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9051
    Cell Significance Index: 122.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.8460
    Cell Significance Index: 236.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7577
    Cell Significance Index: 131.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6446
    Cell Significance Index: 589.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5493
    Cell Significance Index: 251.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.4911
    Cell Significance Index: 16.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2121
    Cell Significance Index: 149.0400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.1836
    Cell Significance Index: 14.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1683
    Cell Significance Index: 160.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1642
    Cell Significance Index: 209.8700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 1.1307
    Cell Significance Index: 9.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0986
    Cell Significance Index: 51.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0804
    Cell Significance Index: 139.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0124
    Cell Significance Index: 29.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9947
    Cell Significance Index: 439.8000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.9784
    Cell Significance Index: 17.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7100
    Cell Significance Index: 387.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6699
    Cell Significance Index: 66.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6156
    Cell Significance Index: 37.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5819
    Cell Significance Index: 20.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3894
    Cell Significance Index: 74.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3370
    Cell Significance Index: 36.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2810
    Cell Significance Index: 12.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1741
    Cell Significance Index: 12.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1490
    Cell Significance Index: 109.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1286
    Cell Significance Index: 6.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1233
    Cell Significance Index: 21.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0152
    Cell Significance Index: 11.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0388
    Cell Significance Index: -0.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0479
    Cell Significance Index: -90.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0601
    Cell Significance Index: -110.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0700
    Cell Significance Index: -8.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0718
    Cell Significance Index: -110.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0825
    Cell Significance Index: -112.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0833
    Cell Significance Index: -61.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1017
    Cell Significance Index: -70.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1283
    Cell Significance Index: -81.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1303
    Cell Significance Index: -3.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1308
    Cell Significance Index: -13.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1349
    Cell Significance Index: -6.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1385
    Cell Significance Index: -78.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1857
    Cell Significance Index: -115.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1975
    Cell Significance Index: -89.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2363
    Cell Significance Index: -12.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2651
    Cell Significance Index: -30.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2689
    Cell Significance Index: -6.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2765
    Cell Significance Index: -7.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2789
    Cell Significance Index: -11.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3887
    Cell Significance Index: -8.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4371
    Cell Significance Index: -50.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4451
    Cell Significance Index: -93.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.4728
    Cell Significance Index: -93.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5160
    Cell Significance Index: -11.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5542
    Cell Significance Index: -43.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5639
    Cell Significance Index: -18.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6136
    Cell Significance Index: -89.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6734
    Cell Significance Index: -37.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6817
    Cell Significance Index: -19.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7596
    Cell Significance Index: -58.2900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.7728
    Cell Significance Index: -6.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.8755
    Cell Significance Index: -52.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9122
    Cell Significance Index: -94.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9944
    Cell Significance Index: -25.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.0510
    Cell Significance Index: -22.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0658
    Cell Significance Index: -47.1400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.1404
    Cell Significance Index: -17.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1895
    Cell Significance Index: -14.1800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -1.2065
    Cell Significance Index: -13.6300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.2423
    Cell Significance Index: -11.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2591
    Cell Significance Index: -47.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.3758
    Cell Significance Index: -36.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.4080
    Cell Significance Index: -19.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4192
    Cell Significance Index: -95.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4293
    Cell Significance Index: -42.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4525
    Cell Significance Index: -89.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.5840
    Cell Significance Index: -46.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.7480
    Cell Significance Index: -37.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.7786
    Cell Significance Index: -26.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.7843
    Cell Significance Index: -38.0000
  • Cell Name: theca cell (CL0000503)
    Fold Change: -1.8230
    Cell Significance Index: -10.7100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.8273
    Cell Significance Index: -31.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.8770
    Cell Significance Index: -41.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.8986
    Cell Significance Index: -62.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** VAMP2 is a small, membrane-bound protein that belongs to the VAMP family of proteins. It is characterized by its ability to interact with other SNARE proteins, such as SNAP-25 and syntaxin, to form a complex that regulates vesicle fusion and membrane trafficking. VAMP2 is predominantly expressed in neurons, immune cells, and endocrine cells, where it plays a crucial role in the release of neurotransmitters, hormones, and other signaling molecules. Its expression is also found in various cell types, including epithelial cells, where it regulates the secretion of mucus and other proteins. **Pathways and Functions** VAMP2 is involved in various cellular processes, including: 1. **Neurotransmitter release**: VAMP2 facilitates the release of neurotransmitters such as glutamate, GABA, and dopamine from synaptic vesicles to the extracellular space. 2. **Hormone secretion**: VAMP2 regulates the release of hormones such as insulin and peptide hormones from endocrine cells. 3. **Immune response**: VAMP2 is involved in the regulation of immune responses, including the release of cytokines and other signaling molecules from immune cells. 4. **Membrane trafficking**: VAMP2 regulates the transport of proteins and lipids between compartments within the cell, including the Golgi apparatus and the plasma membrane. **Clinical Significance** Dysregulation of VAMP2 has been implicated in various clinical conditions, including: 1. **Neurodegenerative diseases**: VAMP2 mutations have been associated with neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Autoimmune conditions**: VAMP2 dysregulation has been implicated in autoimmune conditions such as multiple sclerosis and rheumatoid arthritis. 3. **Infectious diseases**: VAMP2 is involved in the regulation of immune responses to bacterial and viral infections, and its dysregulation has been implicated in the pathogenesis of diseases such as tuberculosis and HIV. 4. **Cancer**: VAMP2 has been implicated in the regulation of cancer cell growth and metastasis, and its dysregulation has been associated with various types of cancer. In conclusion, VAMP2 is a critical component of the exocytic machinery, playing a pivotal role in the regulation of vesicle fusion and membrane trafficking within the cell. Its dysregulation has been implicated in various clinical conditions, highlighting the importance of VAMP2 in maintaining cellular homeostasis and regulating immune responses.

Genular Protein ID: 3950753732

Symbol: VAMP2_HUMAN

Name: Synaptobrevin-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1976629

Title: Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2.

PubMed ID: 1976629

DOI: 10.1016/s0021-9258(17)44898-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8760387

Title: Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.

PubMed ID: 8760387

DOI: 10.1042/bj3170945

PubMed ID: 7803399

Title: Differences in the protease activities of tetanus and botulinum B toxins revealed by the cleavage of vesicle-associated membrane protein and various sized fragments.

PubMed ID: 7803399

DOI: 10.1021/bi00255a017

PubMed ID: 7835332

Title: Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane.

PubMed ID: 7835332

DOI: 10.1002/j.1460-2075.1995.tb06994.x

PubMed ID: 17313651

Title: WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta.

PubMed ID: 17313651

DOI: 10.1111/j.1742-4658.2007.05702.x

PubMed ID: 10932255

Title: Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution.

PubMed ID: 10932255

DOI: 10.1038/77997

PubMed ID: 19578378

Title: Retraction: Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution.

PubMed ID: 19578378

DOI: 10.1038/nsmb0709-795

PubMed ID: 20798282

Title: Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.

PubMed ID: 20798282

DOI: 10.1126/science.1195227

PubMed ID: 22118466

Title: The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM.

PubMed ID: 22118466

DOI: 10.1016/j.cell.2011.10.038

PubMed ID: 21808019

Title: SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses.

PubMed ID: 21808019

DOI: 10.1073/pnas.1107067108

PubMed ID: 22289120

Title: Specificity of botulinum protease for human VAMP family proteins.

PubMed ID: 22289120

DOI: 10.1111/j.1348-0421.2012.00434.x

PubMed ID: 19543288

Title: Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F.

PubMed ID: 19543288

DOI: 10.1038/nsmb.1626

PubMed ID: 30929742

Title: Mutations in the Neuronal Vesicular SNARE VAMP2 Affect Synaptic Membrane Fusion and Impair Human Neurodevelopment.

PubMed ID: 30929742

DOI: 10.1016/j.ajhg.2019.02.016

Sequence Information:

  • Length: 116
  • Mass: 12663
  • Checksum: 9CD679C4F6F1B5A8
  • Sequence:
  • MSATAATAPP AAPAGEGGPP APPPNLTSNR RLQQTQAQVD EVVDIMRVNV DKVLERDQKL 
    SELDDRADAL QAGASQFETS AAKLKRKYWW KNLKMMIILG VICAIILIII IVYFST

Genular Protein ID: 700275446

Symbol: F8WCA0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 118
  • Mass: 12934
  • Checksum: CCC93D81D8785143
  • Sequence:
  • MDRSATAATA PPAAPAGEGG PPAPPPNLTS NRRLQQTQAQ VDEVVDIMRV NVDKVLERDQ 
    KLSELDDRAD ALQAGASQFE TSAAKLKRKY WWKNLKMMII LGVICAIILI IIIVYFST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.