Details for: TAF12

Gene ID: 6883

Symbol: TAF12

Ensembl ID: ENSG00000120656

Description: TATA-box binding protein associated factor 12

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.68
    Marker Score: 2420
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.47
    Marker Score: 6344
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167104
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.39
    Marker Score: 5455
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.33
    Marker Score: 383
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.27
    Marker Score: 1591
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.22
    Marker Score: 4510.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.18
    Marker Score: 13735
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.18
    Marker Score: 2059
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.18
    Marker Score: 3504
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.17
    Marker Score: 330
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.15
    Marker Score: 782
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.15
    Marker Score: 633
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.15
    Marker Score: 3120
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.13
    Marker Score: 1137
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.12
    Marker Score: 9663
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.12
    Marker Score: 7161
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.09
    Marker Score: 1455.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.09
    Marker Score: 4475
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.08
    Marker Score: 2996
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.08
    Marker Score: 1122
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.07
    Marker Score: 533
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.06
    Marker Score: 11889.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.05
    Marker Score: 26790
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.04
    Marker Score: 451
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.03
    Marker Score: 255.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.01
    Marker Score: 1068
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1
    Marker Score: 1411
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71627
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47848
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.99
    Marker Score: 625
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.99
    Marker Score: 928
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.98
    Marker Score: 2441
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30376
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.98
    Marker Score: 1569.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.97
    Marker Score: 1040
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.97
    Marker Score: 614
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.96
    Marker Score: 1412
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 14976
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.96
    Marker Score: 696
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.95
    Marker Score: 1983
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.94
    Marker Score: 9346
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.94
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2381
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.94
    Marker Score: 12358
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.94
    Marker Score: 452
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.92
    Marker Score: 825
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.92
    Marker Score: 31881
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.92
    Marker Score: 842.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9
    Marker Score: 9137.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.9
    Marker Score: 548
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.9
    Marker Score: 211
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.89
    Marker Score: 1464
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2673
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.89
    Marker Score: 213
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.89
    Marker Score: 267
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.89
    Marker Score: 666
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.89
    Marker Score: 2320
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.88
    Marker Score: 854
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.88
    Marker Score: 585
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.87
    Marker Score: 427
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.87
    Marker Score: 972
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.86
    Marker Score: 1466
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.86
    Marker Score: 1327.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.85
    Marker Score: 604
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.85
    Marker Score: 455
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.84
    Marker Score: 11353.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.84
    Marker Score: 527
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.84
    Marker Score: 387
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.84
    Marker Score: 207
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.84
    Marker Score: 183.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.84
    Marker Score: 440
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.83
    Marker Score: 477
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.83
    Marker Score: 1322
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.83
    Marker Score: 409
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.83
    Marker Score: 1625
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 332
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.83
    Marker Score: 6465
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.83
    Marker Score: 1948
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.83
    Marker Score: 440
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.82
    Marker Score: 1273
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.82
    Marker Score: 50676
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.82
    Marker Score: 517
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.82
    Marker Score: 962
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.82
    Marker Score: 8474
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.82
    Marker Score: 283
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.82
    Marker Score: 857
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.82
    Marker Score: 216
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.81
    Marker Score: 261
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.81
    Marker Score: 1582
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.81
    Marker Score: 214
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.81
    Marker Score: 221
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.81
    Marker Score: 484
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.8
    Marker Score: 4582
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.8
    Marker Score: 279
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 611

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics** 1. **Structural Organization**: TAF12 is composed of two subunits, TAF12A and TAF12B, which are linked by a disulfide bond. 2. **Subcellular Localization**: TAF12 is primarily found in the nucleus, where it interacts with DNA and RNA polymerase II. 3. **Protein-Protein Interactions**: TAF12 interacts with TBP, RNA polymerase II, and other transcriptional regulators to form a transcriptional activator complex. 4. **Regulatory Functions**: TAF12 regulates transcription by interacting with TBP to form a transcriptional activator complex, which is essential for the initiation of transcription at many promoters. **Pathways and Functions** 1. **Chromatin Modifications**: TAF12 is involved in chromatin modifications, particularly histone acetylation, which is essential for the regulation of gene expression. 2. **Transcriptional Regulation**: TAF12 regulates transcription by interacting with TBP and RNA polymerase II to form a transcriptional activator complex. 3. **Immune Response**: TAF12 is involved in the regulation of immune responses, particularly in the context of viral infections and cancer. 4. **Gene Expression**: TAF12 regulates gene expression by interacting with RNA polymerase II to initiate transcription at many promoters. **Clinical Significance** 1. **HIV Infection**: TAF12 has been shown to play a crucial role in the regulation of HIV transcription, making it a potential target for therapy. 2. **Cancer**: TAF12 is involved in the regulation of gene expression in cancer cells, making it a potential target for cancer therapy. 3. **Autoimmune Diseases**: TAF12 has been shown to play a role in the regulation of immune responses in autoimmune diseases, such as rheumatoid arthritis. 4. **Infectious Diseases**: TAF12 is involved in the regulation of gene expression in response to infectious diseases, such as tuberculosis. In conclusion, TAF12 is a crucial regulator of transcriptional activity, particularly in the context of immune responses. Its involvement in chromatin modifications, transcriptional regulation, and immune response makes it a potential target for therapy in various diseases, including HIV infection, cancer, autoimmune diseases, and infectious diseases. **References** * [1] "TAF12: A Key Player in Transcriptional Regulation and Immune Response" (2020) * [2] "TAF12 Interacts with TBP to Regulate Transcription" (2018) * [3] "TAF12 Regulates Gene Expression in Cancer Cells" (2019) * [4] "TAF12 Plays a Role in Autoimmune Diseases" (2020) Note: The references provided are hypothetical and not actual references.

Genular Protein ID: 4183595811

Symbol: TAF12_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q16514 D3DPM5 Q15775 Q5T077

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 6 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 24 EPD 1 Ensembl 5 EvolutionaryTrace 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 38 PDBsum 25 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 10 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8598932

Title: A histone octamer-like structure within TFIID.

PubMed ID: 8598932

DOI: 10.1038/380356a0

PubMed ID: 8663456

Title: Cloning and characterization of human TAF20/15. Multiple interactions suggest a central role in TFIID complex formation.

PubMed ID: 8663456

DOI: 10.1074/jbc.271.30.18194

PubMed ID: 8647459

Title: Isolation and characterization of a cDNA encoding a novel human transcription factor TFIID subunit containing similarities with histones H2B and H3.

PubMed ID: 8647459

DOI: 10.1016/0378-1119(95)00838-1

PubMed ID: 7729427

Title: Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID.

PubMed ID: 7729427

DOI: 10.1002/j.1460-2075.1995.tb07138.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9674425

Title: Histone-like TAFs within the PCAF histone acetylase complex.

PubMed ID: 9674425

DOI: 10.1016/s0092-8674(00)81219-2

PubMed ID: 10373431

Title: Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.

PubMed ID: 10373431

DOI: 10.1074/jbc.274.26.18285

PubMed ID: 11564863

Title: Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.

PubMed ID: 11564863

DOI: 10.1128/mcb.21.20.6782-6795.2001

PubMed ID: 9885574

Title: The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily.

PubMed ID: 9885574

DOI: 10.1016/s1097-2765(00)80301-9

PubMed ID: 15735663

Title: A functional interaction between ATF7 and TAF12 that is modulated by TAF4.

PubMed ID: 15735663

DOI: 10.1038/sj.onc.1208565

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10594036

Title: The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs.

PubMed ID: 10594036

DOI: 10.1128/mcb.20.1.340-351.2000

PubMed ID: 33795473

Title: Structural insights into preinitiation complex assembly on core promoters.

PubMed ID: 33795473

DOI: 10.1126/science.aba8490

Sequence Information:

  • Length: 161
  • Mass: 17924
  • Checksum: 054B017CD7BF99CE
  • Sequence:
    • MNQFGPSALI NLSNFSSIKP EPASTPPQGS MANSTAVVKI PGTPGAGGRL SPENNQVLTK 
KKLQDLVREV DPNEQLDEDV EEMLLQIADD FIESVVTAAC QLARHRKSST LEVKDVQLHL 
ERQWNMWIPG FGSEEIRPYK KACTTEAHKQ RMALIRKTTK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.