Details for: TAF12

Gene ID: 6883

Symbol: TAF12

Ensembl ID: ENSG00000120656

Description: TATA-box binding protein associated factor 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 182.9693
    Cell Significance Index: -28.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 99.5886
    Cell Significance Index: -25.2600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 79.2334
    Cell Significance Index: -32.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 73.9850
    Cell Significance Index: -34.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 64.7764
    Cell Significance Index: -33.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.1729
    Cell Significance Index: -32.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4109
    Cell Significance Index: -33.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.2865
    Cell Significance Index: -22.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.1990
    Cell Significance Index: -19.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4475
    Cell Significance Index: 235.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2936
    Cell Significance Index: 77.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0474
    Cell Significance Index: 113.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9757
    Cell Significance Index: 25.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8476
    Cell Significance Index: 116.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7488
    Cell Significance Index: 88.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6282
    Cell Significance Index: 13.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6038
    Cell Significance Index: 46.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5679
    Cell Significance Index: 16.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5647
    Cell Significance Index: 39.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5640
    Cell Significance Index: 15.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5413
    Cell Significance Index: 37.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5203
    Cell Significance Index: 284.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5077
    Cell Significance Index: 224.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4826
    Cell Significance Index: 31.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4813
    Cell Significance Index: 96.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.4493
    Cell Significance Index: 7.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4079
    Cell Significance Index: 73.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3914
    Cell Significance Index: 38.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3847
    Cell Significance Index: 47.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3797
    Cell Significance Index: 5.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3562
    Cell Significance Index: 70.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3372
    Cell Significance Index: 43.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3127
    Cell Significance Index: 14.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3061
    Cell Significance Index: 14.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2920
    Cell Significance Index: 15.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2519
    Cell Significance Index: 43.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2459
    Cell Significance Index: 88.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2399
    Cell Significance Index: 6.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2277
    Cell Significance Index: 14.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2196
    Cell Significance Index: 151.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2119
    Cell Significance Index: 4.5900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1580
    Cell Significance Index: 2.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1069
    Cell Significance Index: 7.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0798
    Cell Significance Index: 15.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0731
    Cell Significance Index: 2.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0712
    Cell Significance Index: 2.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0265
    Cell Significance Index: 0.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0151
    Cell Significance Index: 1.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0073
    Cell Significance Index: 13.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0049
    Cell Significance Index: 3.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0044
    Cell Significance Index: -8.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0078
    Cell Significance Index: -12.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0130
    Cell Significance Index: -8.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0200
    Cell Significance Index: -27.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0233
    Cell Significance Index: -14.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0246
    Cell Significance Index: -18.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0251
    Cell Significance Index: -0.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0272
    Cell Significance Index: -0.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0319
    Cell Significance Index: -14.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0320
    Cell Significance Index: -3.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0378
    Cell Significance Index: -21.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0545
    Cell Significance Index: -0.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0626
    Cell Significance Index: -1.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0635
    Cell Significance Index: -2.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0654
    Cell Significance Index: -9.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0935
    Cell Significance Index: -4.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0948
    Cell Significance Index: -19.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0950
    Cell Significance Index: -27.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0971
    Cell Significance Index: -2.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1072
    Cell Significance Index: -12.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1176
    Cell Significance Index: -13.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1254
    Cell Significance Index: -4.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2383
    Cell Significance Index: -13.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2462
    Cell Significance Index: -4.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2475
    Cell Significance Index: -15.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2609
    Cell Significance Index: -6.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2948
    Cell Significance Index: -30.7000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2980
    Cell Significance Index: -34.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2986
    Cell Significance Index: -6.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3263
    Cell Significance Index: -6.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3421
    Cell Significance Index: -5.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3519
    Cell Significance Index: -27.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3539
    Cell Significance Index: -4.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3953
    Cell Significance Index: -26.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4092
    Cell Significance Index: -11.7300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4406
    Cell Significance Index: -10.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4607
    Cell Significance Index: -20.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4672
    Cell Significance Index: -7.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5107
    Cell Significance Index: -11.8000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5478
    Cell Significance Index: -11.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5736
    Cell Significance Index: -35.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5962
    Cell Significance Index: -17.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6135
    Cell Significance Index: -23.2300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6240
    Cell Significance Index: -6.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6735
    Cell Significance Index: -34.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6751
    Cell Significance Index: -18.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7412
    Cell Significance Index: -27.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7490
    Cell Significance Index: -26.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structural Organization**: TAF12 is composed of two subunits, TAF12A and TAF12B, which are linked by a disulfide bond. 2. **Subcellular Localization**: TAF12 is primarily found in the nucleus, where it interacts with DNA and RNA polymerase II. 3. **Protein-Protein Interactions**: TAF12 interacts with TBP, RNA polymerase II, and other transcriptional regulators to form a transcriptional activator complex. 4. **Regulatory Functions**: TAF12 regulates transcription by interacting with TBP to form a transcriptional activator complex, which is essential for the initiation of transcription at many promoters. **Pathways and Functions** 1. **Chromatin Modifications**: TAF12 is involved in chromatin modifications, particularly histone acetylation, which is essential for the regulation of gene expression. 2. **Transcriptional Regulation**: TAF12 regulates transcription by interacting with TBP and RNA polymerase II to form a transcriptional activator complex. 3. **Immune Response**: TAF12 is involved in the regulation of immune responses, particularly in the context of viral infections and cancer. 4. **Gene Expression**: TAF12 regulates gene expression by interacting with RNA polymerase II to initiate transcription at many promoters. **Clinical Significance** 1. **HIV Infection**: TAF12 has been shown to play a crucial role in the regulation of HIV transcription, making it a potential target for therapy. 2. **Cancer**: TAF12 is involved in the regulation of gene expression in cancer cells, making it a potential target for cancer therapy. 3. **Autoimmune Diseases**: TAF12 has been shown to play a role in the regulation of immune responses in autoimmune diseases, such as rheumatoid arthritis. 4. **Infectious Diseases**: TAF12 is involved in the regulation of gene expression in response to infectious diseases, such as tuberculosis. In conclusion, TAF12 is a crucial regulator of transcriptional activity, particularly in the context of immune responses. Its involvement in chromatin modifications, transcriptional regulation, and immune response makes it a potential target for therapy in various diseases, including HIV infection, cancer, autoimmune diseases, and infectious diseases. **References** * [1] "TAF12: A Key Player in Transcriptional Regulation and Immune Response" (2020) * [2] "TAF12 Interacts with TBP to Regulate Transcription" (2018) * [3] "TAF12 Regulates Gene Expression in Cancer Cells" (2019) * [4] "TAF12 Plays a Role in Autoimmune Diseases" (2020) Note: The references provided are hypothetical and not actual references.

Genular Protein ID: 4183595811

Symbol: TAF12_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8598932

Title: A histone octamer-like structure within TFIID.

PubMed ID: 8598932

DOI: 10.1038/380356a0

PubMed ID: 8663456

Title: Cloning and characterization of human TAF20/15. Multiple interactions suggest a central role in TFIID complex formation.

PubMed ID: 8663456

DOI: 10.1074/jbc.271.30.18194

PubMed ID: 8647459

Title: Isolation and characterization of a cDNA encoding a novel human transcription factor TFIID subunit containing similarities with histones H2B and H3.

PubMed ID: 8647459

DOI: 10.1016/0378-1119(95)00838-1

PubMed ID: 7729427

Title: Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID.

PubMed ID: 7729427

DOI: 10.1002/j.1460-2075.1995.tb07138.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9674425

Title: Histone-like TAFs within the PCAF histone acetylase complex.

PubMed ID: 9674425

DOI: 10.1016/s0092-8674(00)81219-2

PubMed ID: 10373431

Title: Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.

PubMed ID: 10373431

DOI: 10.1074/jbc.274.26.18285

PubMed ID: 11564863

Title: Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.

PubMed ID: 11564863

DOI: 10.1128/mcb.21.20.6782-6795.2001

PubMed ID: 9885574

Title: The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily.

PubMed ID: 9885574

DOI: 10.1016/s1097-2765(00)80301-9

PubMed ID: 15735663

Title: A functional interaction between ATF7 and TAF12 that is modulated by TAF4.

PubMed ID: 15735663

DOI: 10.1038/sj.onc.1208565

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10594036

Title: The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs.

PubMed ID: 10594036

DOI: 10.1128/mcb.20.1.340-351.2000

PubMed ID: 33795473

Title: Structural insights into preinitiation complex assembly on core promoters.

PubMed ID: 33795473

DOI: 10.1126/science.aba8490

Sequence Information:

  • Length: 161
  • Mass: 17924
  • Checksum: 054B017CD7BF99CE
  • Sequence:
  • MNQFGPSALI NLSNFSSIKP EPASTPPQGS MANSTAVVKI PGTPGAGGRL SPENNQVLTK 
    KKLQDLVREV DPNEQLDEDV EEMLLQIADD FIESVVTAAC QLARHRKSST LEVKDVQLHL 
    ERQWNMWIPG FGSEEIRPYK KACTTEAHKQ RMALIRKTTK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.